标签： BCA1猕猴/CHM-035

C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ANGIE2.

BCA-1是一种CXC趋化因子，在次级淋巴器官中高度表达，例如脾脏、淋巴结和派尔氏斑的滤泡。 CXCL13 通过刺激钙流入并趋化表达伯基特淋巴瘤受体 1 的细胞，从而促进 B 淋巴细胞的迁移。 因此，BCA1 在 B 淋巴细胞归巢到滤泡中起作用。 人 BCA-1 与小鼠蛋白质具有 64% 的氨基酸序列相似性，与其他已知的 CXC 趋化因子具有 23-34% 的氨基酸序列同一性。 重组或化学合成的 BCA1 对 B 淋巴细胞是一种有效的化学引诱物，但对 T 淋巴细胞、单核细胞或中性粒细胞没有。 BLR1 是一种 G 蛋白偶联受体，最初是从 Burkitt 淋巴瘤细胞中分离出来的，现在已被证明是 BCA1 的特异性受体。 在造血谱系的细胞中，BLR-1（现在称为 CXCR-5）的表达仅限于 B 淋巴细胞和 T 辅助记忆细胞的一个亚群。

BCA-1/ BLC Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 87 amino acid and having a molecular mass of approximately 10.3kDa.
BCA1 is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2μm filtered concentrated solution in 20mM Tris-HCl, pH 8.0 and 300mM NaCl.

It is recommended to reconstitute the lyophilized BCA-1/ BLC Rhesus Macaque in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BCA-1/ BLC Rhesus Macaque should be stored at 4°C between 2-7 days and for future use below -18°C.

Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

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ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.