… from ZirChrom
Porous zirconia based materials
Unique selectivity relative to conventional silica based columns…
Zirconia bonded phases, manufactured by ZirChrom Separations, Inc offer unique selectivity relative to conventional silica based columns, combined with extreme chemical and thermal stability. Unlike polymeric phases, zirconia does not shrink or swell as a function of eluent organic or ionic strength.
ZirChrom
- Porous zirconia based materials
- High pH and temperature stability
- High efficiency
- Fast solvent equilibration
- Long column lifetimes
ZirChrom Phases
ZirChrom Phase
|
 |
Mode |
|
Particle Size (μm) |
|
Pore size (Å)
|
|
Surface Area (m2/g)
|
|
Carbon Load (%)
|
|
pH Range
|
|
Temperature Limit (OC)
|
 |
| PBD |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
2.5 |
|
1 – 14 |
|
150 |
|
| PS |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
1.0 |
|
1 – 13 |
|
150 |
|
| EZ |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
2.7 |
|
1 – 10 |
|
50 |
|
| MS |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
3.1 |
|
1 – 10 |
|
80 |
|
| SELECT |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
– |
|
1 – 10 |
|
80 |
|
| CARB |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
– |
|
1 – 14 |
|
150 |
|
| DiamondBond-C18 |
|
RP |
|
3,5 |
|
300 |
|
30 |
|
3.5 |
|
1 – 14 |
|
200 |
|
| PHASE |
|
NP |
|
3 |
|
300 |
|
30 |
|
– |
|
1 – 14 |
|
150 |
|
| SAX |
|
Strong Anion – exchange |
|
3 |
|
300 |
|
30 |
|
1.2 |
|
1 – 12 |
|
80 |
|
| SHAX |
|
Strong Anion – exchange |
|
3 |
|
300 |
|
30 |
|
0.9 |
|
1 – 12 |
|
80 |
|
| WAX |
|
Weak Anion – exchange |
|
3 |
|
300 |
|
30 |
|
1.3 |
|
3 – 9 |
|
50 |
|
| WCX |
|
Weak Cation – exchange |
|
3 |
|
300 |
|
30 |
|
– |
|
1 – 10 |
|
50 |
|
| PEZ |
|
Cation – exchange |
|
3 |
|
300 |
|
30 |
|
– |
|
1 – 10 |
|
50 |
|
| Sachtopore-RP1 |
|
RP |
|
3,5 |
|
300 |
|
15 |
|
– |
|
1 – 12 |
|
100 |
|
| Sachtopore-NP1 |
|
NP |
|
3,5 |
|
300 |
|
15 |
|
– |
|
1 – 14 |
|
100 |
|
1 Other pore sizes available
 |
|
|
|
|
Reversed-Phase Materials
|
|
Ion-Exchange Materials
|
|
|
ZirChrom-PBD is produced by coating ultra-stable zirconia particles with an extremely thin layer of crosslinked polybutadiene. The chemical selectivity and efficiency of ZirChrom-PBD is similar to that of traditional C8 or C18 silica based columns for non-ionic analytes. However ZirChrom-PBD has greater stability than silica phases and higher efficiencies than polymer phases. Selectivity can be modified by the addition of a strong Lewis base, such as fluoride, phosphate or hydroxide, to the eluent.
|
|
ZirChrom-SAX is a highly efficient strong anion-exchanger, created by coating zirconia particles with a thin layer of crosslinked polyethyleneimine. It is useful for the separation of inorganic anions, organic anions and biomolecules such as nucleotides, nucleosides, amino acids and peptides.
|
 |
|
|
|
|
|
DiamondBond-C18 uses a proprietary covalent bonding technology to graft C18 groups to a carbon-clad zirconia, giving it outstanding stability for LC-MS applications. DiamondBond-C18 has selectivity that is intermediate between ODS silica and unbonded carbon supports for non-electrolytes.
|
|
ZirChrom-WAX is a highly efficient weak anion-exchanger, produced by coating zirconia particles with a thin layer of crosslinked polyethyleneimine. In addition to separating inorganic anions, organic anions and biomolecules, it is an extremely stable amino phase for the separation of carbohydrates.
|
|
|
|
|
|
|
ZirChrom-CARB is produced by coating zirconia particles with a thin layer of elemental carbon. It is an alternative to porous graphitic carbon (PGC) supports for the separation of geometrical isomers, diastereomers and other closely related molecules. It offers very different selectivity to ODS or polymeric materials, making it an excellent choice for orthogonal screening in drug discovery.
|
|
ZirChrom-WCX is a phosphate-coated zirconia phase for weak cation-exchange. It is useful for protein chromatography
|
|
|
|
|
|
|
ZirChrom-EZ is a highly efficient phase created by first coating zirconia particles with an extremely thin layer of crosslinked polybutadiene and then deactivating the Lewis acid sites by applying a strong metal chelator. This enables Lewis base analytes such as carboxylates, sulphates and phosphates to be analysed throughout the pH range of 1 – 10 using conventional LC-MS buffers such as acetate or formate.
|
|
ZirChrom-PEZ is a EDTPA-coated zirconia phase for the cation-exchange chromatography of proteins and the separation of monoclonal antibodies.
|
|
|
|
|
|
|
ZirChrom-MS is designed specifically for LC-MS, particularly applications involving basic pharmaceuticals. It has the same deactivation chemistry as ZirChrom-EZ but with a covalent
attachment for low bleed and is approximately 2.5 times more retentive for simple compounds. The phase exhibits mixed mode retention characteristics – reversed-phase and cation-exchange.
|
|
|
|
|
|
|
|
|
ZirChrom-PS consists of zirconia coated with an extremely thin layer of polystyrene. The phase offers an alternative selectivity and less retention than ZirChrom-PBD making it ideal for non-polar analytes, or where highly aqueous eluents are necessary.
|
|
|
|
|
|
|
|
|
ZirChrom-SELECT is a Lewis acid site ‘deactivated’
carbon-coated zirconia phase. This deactivation reduces solute interactions with the zirconia surface, leading to improved peak shape and wider pharmaceutical compound applicability.
|
|
|
|
|
|
|
|
 |
Sachtopore
|
|
|
- Highly stable titania based particles
- Reversed-phase and normal-phase
- Ideal for preparative scale-up
Sachtopore Phases
|
RP |
NP |
| Bonded Phase |
Polyethylene coated TiO2 |
Unbonded TiO2 |
| Particle Size (μm) |
3, 5 |
3, 5 |
| Pore Size (Å)1 |
300 |
300 |
| pH Range |
1 – 12 |
1 – 14 |
| Maximum Temperature |
100°C |
100°C |
|
|
|
|
Sachtopore phases from ZirChrom Separations are based on
porous, spherical titania (TiO2) particles. Sachtopore-NP
(normal-phase) is bare titania, whereas Sachtopore-RP
(reversed-phase) is polyethylene coated titania. This phase
shows similar selectivity to ZirChrom-PBD. Both Sachtopore
phases are very chemically and thermally
stable and offer unique chromatographic selectivity.
1 Other pore sizes available
|
|
 |
Please contact Hicrom for further information
Partisil Ultrasphere ACT ACE Hichrom HPLC UHPLC SCX C18 HPLC chromatography LC/MS column AMT SILIC Sequant HILIC accessories solvents Chromatography HPLC-Training Tosoh TSK Shodex High Performance Liquid Chromatography HPLC Microsolv HPLC Training
Hichrom Limited – the HicHrOM(E)of chromatography: HPLC Column Manufacturer and Supplier of the world’s largest range of HPLC columns
上海金畔生物科技有限公司提供生命科学研究领域系列产品，包括生化试剂、色谱标准品和实验仪器耗材。主营Lumiprobe Cy系列活性荧光染料；修饰性PEG（Laysan bio、NANOCS、Avanti等进口品牌PEG以及定制合成修饰性聚乙二醇、单分散小分量PEG）；WAKO日本和光纯药；日本关东化学Kanto试剂；Megazyme食品分析检测试剂盒、Harlan、Bio-serv品牌的动物饲料；Sigma、Amresco、TCI、MP bio生化试剂；Oxoid、Nissui日水、BD difco、Himedia品牌微生物培养基；免疫诊断试剂包括:Abcam、CST、Santa Cruz、Bethyl抗体；Biolegend流式抗体；Roche、TOYOBO、NEB品牌的酶；中检所、TRC、药典USP、EP、Reagecon标准品；耗材和仪器包括Whatman、Millipore品牌的各种滤膜、滤器和柱子填料等、Hampton蛋白结晶试剂耗材、老鼠软管灌胃针、动物毛发记号笔、Labnet、Bio-Rad伯乐、康宁Corning、Axygen、Falcon 、Eppendorf、Nunc、Nalgene、Nest品牌的培养皿、培养板、离心机、离心管、移液枪及枪头等实验室常用仪器耗材。
服务热线:18301939375
