层蛋白是细胞外基质糖蛋白的一个家族，是基膜的主要非胶原成分。它们涉及多种生物过程，包括细胞粘附、分化、迁移、信号转导、神经突生长和转移。层合蛋白是由三条不相同的链组成的异源三聚体，采用十字形结构，有三条短臂，每条短臂由一条不同的链组成，长臂由所有三条链组成。每个层粘连蛋白链都是由一个不同的基因编码的多结构域蛋白质，在某些情况下，通过选择性剪接产生单独的链变体。
Cosmo Bio抗体,Anti Laminin Alpha-4 mAb (Clone 652C4),CAC-PRPG-LA4-M01
Application: IP, IHC(f), IHC(p)
Clonality: Monoclonal
Host: Mouse
Purification: Supernatant
Reactivity: Human
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituents of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are heterotrimers composed of 3 non-identical chains that adopt a cruciform structure with 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene and in some cases undergoes alternative splicing to give rise to separate chain variants.