Lect1编码一种糖基化跨膜蛋白，该蛋白被裂解形成成熟的分泌蛋白。前体蛋白的n端与其他表面活性剂蛋白具有相同的特征，有时被称为软骨表面活性剂蛋白，尽管尚未确定其生物活性。前体蛋白的c端含有一个25 kDa的成熟蛋白，称为白细胞来源的趋化素-1或软骨调素-1。成熟蛋白促进软骨细胞生长，抑制血管生成。该基因在肥厚前软骨无血管区表达，在软骨细胞肥厚和血管侵犯时表达降低。成熟蛋白可能通过允许软骨anlagen血管化并被骨取代而在软骨内骨发育中发挥作用。它也可能参与发育过程中组织血管化的广泛控制。选择性剪接导致编码不同异构体的多个转录本变体。
Cosmo Bio抗体,Anti Chondromodulin-I (ChM-I) mAb (Clone hCHM-5),CAC-TCS-005
Application: IHC(f), IP, WB
Clonality: Monoclonal
Host: Mouse
Purification: Purified – Affinity
Reactivity: Bovine, Mouse, Rat, Human
Lect1 encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage, and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may also be involved in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Cosmo Bio抗体,Anti Chondromodulin-I (ChM-I) mAb (Clone hCHM-5),CAC-TCS-005