标签： 4 1BBR Human

Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor T-cell, antigen 4-1BB homolog, T-cell antigen ILA, CD137 antigen, CDw137, ILA, 4-1BB, MGC2172, 4-1BBR, TNFRSF9.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

该基因编码的蛋白质是 TNF 受体超家族的成员。 该受体有助于 T 细胞的克隆扩增、存活和发育。 它还可以诱导外周单核细胞增殖，增强 TCR/CD3 触发激活诱导的 T 细胞凋亡，并调节 CD28 共刺激以促进 Th1 细胞反应。 这种受体的表达是由淋巴细胞激活诱导的。 已显示 TRAF 衔接蛋白与该受体结合并转导导致 NF-kappaB 激活的信号。

4-1BB Soluble Receptor Recombinant Human also called Tumor necrosis factor receptor superfamily member 9 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids, having a molecular mass of 17718 Dalton and containing the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. The 4-1BB Receptor is purified by proprietary chromatographic techniques.

4-1BB Soluble Receptor Recombinant Human 也称为肿瘤坏死因子受体超家族成员 9 由大肠杆菌产生，是一个单一的、非糖基化的多肽链，含有 167 个氨基酸，分子量为 17718 道尔顿，含有富含半胱氨酸的 TNFR 样 4-1BB 受体的细胞外结构域。 4-1BB 受体通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a concentrated solution in water containing no additives.

从不含添加剂的水中浓缩溶液冻干而成。

It is recommended to reconstitute the lyophilized 4-1BB Receptor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的 4-1BB 受体在不低于 100μg/ml 的无菌 18MΩ-cm H2O 中复溶，然后可以进一步稀释成其他水溶液。

Lyophilized 4-1BB Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4-1BBR should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein . Please prevent freeze-thaw cycles.

冻干的 4-1BB 受体虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，4-1BBR 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。 请防止冻融循环。

Greater than 98.0% as determined by: Analysis by RP-HPLC. Analysis by -PAGE.

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Arg-Thr-Arg.

The activity was determined by the inhibition of 4-1BB ligand mediated stimulation of IL-8 production by human PBMC. Results: 90% inhibition using 1µg for both 4-1BB ligand and 4-1BB receptor.

通过抑制 4-1BB 配体介导的人 PBMC 产生 IL-8 的刺激来确定活性。 结果：使用 1µg 对 4-1BB 配体和 4-1BB 受体有 90% 的抑制作用。

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