标签： 趋化因子小鼠重组CHM-308

Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine ligand 11, SCYA11.

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。 CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。 人类 CCL11 的基因在三个外显子上编码，位于第 17 号染色体上。

Eotaxin Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8403.2 Dalton.
The CCL11 is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a concentrated solution in water containing no additives.

It is recommended to reconstitute the lyophilized Eotaxin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL11 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

The sequence of the first five N-terminal amino acids was determined and was found to be His-Pro-Gly-Ser-Ile.

The Biological activity was determined by measuring the dose dependent phosphorylation of ERK1 and ERK2 in CCR3 transfected 293 cells. Significant ERK phosphorylation is observed with >100 ng/ml of recombinant mouse eotaxin.

Prospec’s products are furnished for LABORATORY RESEARCH USEONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.