标签： 胸腺表达趋化因子人重组体CHM-032

C-C motif chemokine 25, Small-inducible cytokine A25, Thymus-expressed chemokine, Chemokine TECK, CCL25, SCYA25, TECK, Ckb15, MGC150327.

CCL25 is a novel CC chemokine, which is distantly related to other CC chemokines. The mouse CCL25 cDNA has also been cloned and shown to encode a 144 a.a. protein, which exhibits 49% a.a. sequence identity to the human CCL25. Human and mouse CCL25 expression was shown to be greatly restricted to the thymus and small intestine. While dendritic cells are identified as the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. CCL25 signals through the CCR9 receptor. Teck is possibly involved in T-cell development.
Recombinant human and mouse Teck were shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. The recombinant protein demonstrates chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritic cells but is inactive on peripheral blood lymphocytes and neutrophils.

CCL25是一种新型CC趋化因子，与其他CC趋化因子关系较远。 小鼠 CCL25 cDNA 也已被克隆并显示编码 144 a.a. 蛋白质，显示 49% a.a. 与人 CCL25 的序列同一性。 人和小鼠的 CCL25 表达被证明极大地局限于胸腺和小肠。 虽然树突细胞被确定为胸腺中 CCL25 产生的来源，但源自骨髓的树突细胞不表达 CCL25。 CCL25 通过 CCR9 受体发出信号。 Teck 可能参与了 T 细胞的发育。
重组人和小鼠 Teck 被证明对活化的巨噬细胞、树突细胞和胸腺细胞具有趋化性。 重组蛋白对胸腺细胞、巨噬细胞、THP-1 细胞和树突状细胞具有趋化活性，但对外周血淋巴细胞和中性粒细胞无活性。

TECK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids and having a molecular mass of 16.8kDa.
TECK is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Escherichia Coli.

Filtered colorless solution.

TECK protein solution containing 20mM Tris-HCl buffer and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

MGSSHHHHHH SSGLVPRGSH MGSHMQGVFE DCCLAYHYPI GWAVLRRAWT YRIQEVSGSC NLPAAIFYLP KRHRKVCGNP KSREVQRAMK LLDARNKVFA KLHHNTQTFQ AGPHAVKKLS SGNSKLSSSK FSNPISSSKR NVSLLISANS GL.

Greater than 90.0% as determined by -PAGE.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.