标签： 巨噬细胞炎症蛋白 4 人重组CHM-322

Small inducible cytokine A18, CCL18, Macrophage inflammatory protein 4, MIP-4, Pulmonary and activation-regulated chemokine, CC chemokine PARC, Alternative macrophage activation-associated CC chemokine 1, AMAC-1, Dendritic cell chemokine 1, DC-CK1, chemokine ligand 18, CKb7, PARC, AMAC1, DCCK1, SCYA18.

Chemokine ligand 18 is a small cytokine belonging to the CC chemokine family that was previously called PARC . MIP-4 is approximately 60% identical in amino acid sequence to CCL3. MIP-4 is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and non activated lymphocytes. The gene for human CCL18 contains three exons and is located on chromosome 17.

趋化因子配体 18 是一种小细胞因子，属于 CC 趋化因子家族，以前称为 PARC。 MIP-4 在氨基酸序列上与 CCL3 的相同性约为 60%。 MIP-4 在肺中以高水平表达，而在某些淋巴组织（例如淋巴结）中表达水平较低，并且对活化的 T 细胞和未活化的淋巴细胞具有趋化性。 人类 CCL18 的基因包含三个外显子，位于第 17 号染色体上。

Macrophage Inflammatory Protein-4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7813 Dalton.
The MIP-4 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白 4 人重组体是一种单一的、非糖基化的多肽链，包含 69 个氨基酸，分子量为 7813 道尔顿。
MIP-4 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

MIP-4 protein is lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.

It is recommended to reconstitute the lyophilized MIP-4 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized MIP-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIP-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

The sequence of the first five N-terminal amino acids of MIP-4 was determined and found to be Ala-Gln-Val-Gly-Thr.

The Activity MIP-4 is calculated by the ability to chemoattract Human T lymphocytes at 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.