标签： 上皮中性粒细胞激活蛋白 78 人重组/CHM-331

Small inducible cytokine B5, CXCL5, Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, ENA-78, chemokine ligand 5, SCYB5.

趋化因子配体 5 是一种小细胞因子，属于 CXC 趋化因子家族，也称为上皮衍生的中性粒细胞激活肽 78。 它是在用炎性细胞因子 IL-1 或肿瘤坏死因子-α 刺激细胞后产生的。 在嗜酸性粒细胞中也观察到了 CXCL5 的表达，并且可以被 II 型 IFN 抑制。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。 CXCL5 基因在四个外显子上编码，位于人类第 4 号染色体上，与其他几个 CXC 趋化因子基因一起。 CXCL5 与结缔组织重塑有关。

在大肠杆菌中产生的上皮中性粒细胞激活蛋白 78 人重组体是一种单一的、非糖基化的多肽链，含有 74 个氨基酸，分子量为 8020 道尔顿。
CXCL5 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

The CXCL5 was lyophilized from a concentrated solution in water containing no additives.

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized ENA78 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala- Ala -Val-Leu-Arg.

The biological activity was determined by measuring the dose dependent mobilization of intracellular calcium with human neutrophils. Significant calcium mobilization is observed with 100ng/mL   of recombinant human ENA-78.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.