分类： ProSpec

ProSpec,CD27 Human,CD27 人重组PRO-1213

ProSpec,CD27 Human,CD27 人重组PRO-1213,在大肠杆菌中产生的 CD27 Human Recombinant 是单条多肽链，包含 196 个氨基酸，分子量为 21.8 kDa。

  • CD27 Human

  • CD27 Human Recombinant
  • PRO-1213

Catalogue number

PRO-1213

Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 7,T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen,T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.

Introduction

CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.
CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。

Description

CD27 Human Recombinant produced in E. coli is a single polypeptide chain containing 196 amino acids and having a molecular mass of 21.8 kDa.
CD27 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD27 Human Recombinant 是单条多肽链，包含 196 个氨基酸，分子量为 21.8 kDa。
CD27 在 N 端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD27 solution contains 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTPAPK SCPERHYWAQ GKLCCQMCEP GTFLVKDCDQ HRKAAQCDPC IPGVSFSPDH HTRPHCESCR HCNSGLLVRN CTITANAECA CRNGWQCRDK ECTECDPLPN PSLTARSSQA LSPHPQPTHL PYVSEMLEAR TAGHMQTLAD FRQLPARTLS THWPPQRSLC SSDFIR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD27 Human, sf9
  • CD27 Human, HEK

ProSpec-Eotaxin 2 Rat,Eotaxin-2 大鼠重组 CHM-282

ProSpec-Eotaxin 2 Rat,Eotaxin-2 大鼠重组 CHM-282,Eotaxin-2，也称为 MPIF2 和 Ckb6，是一种由活化的单核细胞和 T 淋巴细胞产生的新型 CC 趋化因子。

  • Eotaxin 2 Rat

  • Eotaxin-2 Rat Recombinant
  • CHM-282

Catalogue number

CHM-282

Synonyms

C-C motif chemokine 24, Small-inducible cytokine A24, Myeloid progenitor inhibitory factor 2, CK-beta-6, Eosinophil chemotactic protein 2, Eotaxin-2, CCL24, Ckb-6, MPIF2, MPIF-2, SCYA24, Eotaxin2, CCL-24.

Introduction

Eotaxin-2，也称为 MPIF2 和 Ckb6，是一种由活化的单核细胞和 T 淋巴细胞产生的新型 CC 趋化因子。 Eotaxin-2 选择性地趋化表达 CCR3 的细胞，包括嗜酸性粒细胞、嗜碱性粒细胞、Th2 T 细胞、肥大细胞和某些树突状细胞亚群。 此外，Eotaxin-2 抑制多能造血祖细胞的增殖。 包含 C 末端截短的成熟蛋白质包含 78 个氨基酸。
CCL24 用作静息 t 淋巴细胞和嗜酸性粒细胞的趋化因子。 CCL24 对中性粒细胞具有较低的趋化活性，但对单核细胞和活化的淋巴细胞则没有。 CCL24 是多能造血祖细胞系形成集落的强抑制因子，并与 CCR3 结合。

Description

CCL24 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of 10.2kDa.
The CCL24 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CCL24 Rat Recombinant in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Eotaxin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL24 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VTIPSSCCVT FISKKIPVNR VISYQLANGS ICPKAGVIFI TKKGHKICTD PKLPWVQKHI KNLDAKRNQP SEGAKALGPK FVIQKLRGNS TKV.

Biological Activity

Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin 2 Human
  • Eotaxin 2 Mouse

ProSpec,CD27 Human HEK,CD27 人重组体HEK PRO-2751

CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。ProSpec,CD27 Human HEK,CD27 人重组体HEK PRO-2751

  • CD27 Human, HEK

  • CD27 Human Recombinant, HEK
  • PRO-2751

Catalogue number

PRO-2751

Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 7, T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen, T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.

Introduction

CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.

CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。

Description

CD27 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing a total of 411 amino acids, having a molecular mass of 46.2kDa.
CD27 is fused to a 239 amino acid hIgG-His-Tag at C-terminus,and is purified by proprietary chromatographic techniques.

Source

HEK293 Cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD27 solution contains 10% Glycerol and Phosphate-Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Biological Activity

ED50 range is ≤ 0.8 ug/ml. Defined by its binding ability in a functional ELISA with Human CD27 Ligand/TNFSF7 .

Amino acid sequence

ATPAPKSCPE RHYWAQGKLC CQMCEPGTFL VKDCDQHRKA AQCDPCIPGV SFSPDHHTRP HCESCRHCNS GLLVRNCTIT ANAECACRNG WQCRDKECTE CDPLPNPSLT ARSSQALSPH PQPTHLPYVS EMLEARTAGH MQTLADFRQL PARTLSTHWP PQRSLCSSDF IRLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD27 Human

ProSpec-Eotaxin 3 Human,Eotaxin-3 人重组体 CHM-362

Eotaxin-3 是一种小细胞因子，属于 CC 趋化因子家族，也称为 TARC。 CCL26 是由肺泡上皮细胞产生和释放的主要趋化因子，参与 CCR3 受体和其他趋化因子的自动调节。ProSpec-Eotaxin 3 Human,Eotaxin-3 人重组体 CHM-362

  • Eotaxin 3 Human

  • Eotaxin-3 Human Recombinant
  • CHM-362

Catalogue number

CHM-362

Synonyms

C-C motif chemokine 26, Small-inducible cytokine A26, Eotaxin-3, Macrophage inflammatory protein 4-alpha, MIP-4-alpha, Thymic stroma chemokine-1, TSC-1, CC chemokine IMAC, CCL26, SCYA26, IMAC, MIP-4a, MGC126714, MIP-4alpha.

Introduction

Eotaxin-3 是一种小细胞因子，属于 CC 趋化因子家族，也称为 TARC。 CCL26 是由肺泡上皮细胞产生和释放的主要趋化因子，参与 CCR3 受体和其他趋化因子的自动调节。 Eotaxin-3 参与免疫调节和炎症过程。 Eotaxin-3 特异性结合并刺激 T 细胞中的趋化性，并通过与趋化因子受体 CCR4 相互作用引发其作用。 CCL26 对正常外周血嗜酸性粒细胞和嗜碱性粒细胞表现出趋化活性。 Eotaxin-3 可能在特应性疾病中的嗜酸性粒细胞积累中发挥作用。 Eotaxin-3 在嗜酸性食管炎中过度表达，表达水平与疾病严重程度相关。 Eotaxin-3 在胸腺中组成型表达，但仅在植物血凝素刺激的外周血单核细胞中短暂表达。 CCL26 是聚集在 7 号染色体 q 臂上的两个 Cys-Cys 细胞因子基因之一。

Description

在大肠杆菌中产生的 Eotaxin-3 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 71 个氨基酸，分子量为 8.4kDa。
Eotaxin-3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized Eotaxin-3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Eotaxin-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL26 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by: Analysis by RP-HPLC. Analysis by -PAGE.

Amino acid sequence

TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L.

Biological Activity

Determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CCR3. The ED50 for this effect is typically 0.1-1.0 μg/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpecCD27 Human sf9,CD27 人重组sf9 PRO-2345

ProSpecCD27 Human sf9,CD27 人重组sf9 PRO-2345,CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。

  • CD27 Human, sf9

  • CD27 Human Recombinant, sf9
  • PRO-2345

Catalogue number

PRO-2345

Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 7, T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen, T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.

Introduction

CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.
CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。

Description

CD27 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 413 amino acids and having a molecular mass of 46.4kDa .
CD27 is fused with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD27 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

ADPTPAPKSC PERHYWAQGK LCCQMCEPGT FLVKDCDQHR KAAQCDPCIP GVSFSPDHHT RPHCESCRHC NSGLLVRNCT ITANAECACR NGWQCRDKEC TECDPLPNPS LTARSSQALS PHPQPTHLPY VSEMLEARTA GHMQTLADFR QLPARTLSTH WPPQRSLCSS DFIRLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD27 Human

ProSpec-Eotaxin Human CHM-256,Eotaxin 人重组

ProSpec-Eotaxin Human CHM-256,Eotaxin 人重组,趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。

  • Eotaxin Human

  • Eotaxin Human Recombinant
  • CHM-256

Catalogue number

CHM-256

Synonyms

Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine ligand 11, SCYA11, MGC22554.

Introduction

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。 CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。 人类 CCL11 的基因在三个外显子上编码，位于第 17 号染色体上。

Description

Eotaxin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8345.9 Dalton.
The CCL11 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized Eotaxin Human Recombinant in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL11 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDICADPKKKWVQD

SMKYLDQKSP TPKP.

Biological Activity

The activity is determined by the chemoattract of human PBE at a concentration between 0.1-10 ng/ml corresponding to a Specific Activity of 100,000-10,000,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The products may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin Human, His
  • Eotaxin Mouse
  • Eotaxin Rhesus Macaque
  • Eotaxin 1 Antibody
  • Eotaxin Rat

ProSpec,CD23 Human Sf9,CD23 人重组体Sf9 PRO-2499

ProSpec,CD23 Human Sf9,CD23 人重组体Sf9 PRO-2499,FCER2 是一种 C 型凝集素，与许多抗体受体相反。 FCER2 位于活化的巨噬细胞、成熟 B 细胞、滤泡树突细胞、血小板和嗜酸性粒细胞上。

  • CD23 Human, Sf9

  • CD23 Human Recombinant, Sf9
  • PRO-2499

Catalogue number

PRO-2499

Synonyms

Low affinity immunoglobulin epsilon Fc receptor isoform a, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, C-type lectin domain family 4 member J, Immunoglobulin E-binding factor, Lymphocyte IgE receptor.

Introduction

FCER2, or Fc epsilon RII, is a receptor for IgE with low affinity, which is critical to regulation of IgE levels. IgE is an antibody isotype that attached to allergy and resistance to parasites. FCER2 is a C-type lectin, contrary to many of the receptors for antibodies. FCER2 is located on activated macrophages, mature B cells, follicular dendritic cells, platelets and eosinophils.

FCER2 或 Fc epsilon RII 是一种低亲和力的 IgE 受体，对 IgE 水平的调节至关重要。 IgE 是一种抗体同种型，与过敏和对寄生虫的抵抗力有关。 FCER2 是一种 C 型凝集素，与许多抗体受体相反。 FCER2 位于活化的巨噬细胞、成熟 B 细胞、滤泡树突细胞、血小板和嗜酸性粒细胞上。

Description

CD23 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 283 amino acids and having a molecular mass of 32.0kDa.
CD23 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD23 是单条糖基化多肽链，包含 283 个氨基酸，分子量为 32.0kDa。
CD23 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD23 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPDTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR
NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT
PSAPLHSHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • sCD23 Human

ProSpec-Eotaxin Human, His,嗜酸性粒细胞趋化素人重组体 CHM-344

  • Eotaxin Human, His

  • Eotaxin Human Recombinant , His Tag
  • CHM-344

Catalogue number

CHM-344

Synonyms

Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine ligand 11, SCYA11, MGC22554.

Introduction

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。 CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。 人类 CCL11 的基因在三个外显子上编码，位于第 17 号染色体上。

Description

Eotaxin His Tag Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids fragment corresponding to the mature Eotaxin protein and having a molecular mass of 8345.9 Dalton with an amino-terminal hexahistidine tag.
The Eotaxin-His is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

Eotaxin-His is supplied liquid In Phosphate Buffered Saline pH7.4 containing 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGPASVPTTC CFNLANRKIP LQRLESYRRI TSGKCPQKAV IFKTKLAKDI CADPKKKWVQ DSMKYLDQKS PTPKP

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin Mouse
  • Eotaxin Human
  • Eotaxin Rhesus Macaque
  • Eotaxin Rat
  • Eotaxin 1 Antibody

ProSpec,sCD23 Human,可溶性 CD23 人重组体PRO-1789

CD23 是一种 45kDa 糖蛋白，存在于新鲜分离的外周血和扁桃体 B 细胞亚群中，并在 EBV 转化的 B 淋巴母细胞上强烈表达。 CD23 分子与 B 细胞上发现的低亲和力 IgE 受体相同,ProSpec,sCD23 Human,可溶性 CD23 人重组体PRO-1789

  • sCD23 Human

  • Soluble CD23 Human Recombinant
  • PRO-1789

Catalogue number

PRO-1789

Synonyms

Low affinity immunoglobulin epsilon Fc receptor, Lymphocyte IgE receptor, Fc-epsilon-RII, BLAST-2, Immunoglobulin E-binding factor, CD23 antigen, FCER2, CD23, FCE2, CD23A, IGEBF, CLEC4J.

Introduction

CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma.
CD23 是一种 45kDa 糖蛋白，存在于新鲜分离的外周血和扁桃体 B 细胞亚群中，并在 EBV 转化的 B 淋巴母细胞上强烈表达。 CD23 分子与 B 细胞上发现的低亲和力 IgE 受体相同。 已在 B 细胞慢性淋巴细胞白血病病例和一些中心母细胞/中心细胞淋巴瘤病例的肿瘤细胞中检测到 CD23 的表达。

Description

sCD23 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.2kDa.
The sCD23 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Amino acid sequence

MELQVSSGFV CNTCPEKWIN FQRKCYYFGK GTKQWVHARY ACDDMEGQLV SIHSPEEQDF LTKHASHTGS WIGLRNLDLK GEFIWVDGSH VDYSNWAPGE PTSRSQGEDC VMMRGSGRWN DAFCDRKLGA WVCDRLATCT PPASEGSAES MGPDSRPDPD GRLPTPSAPL HS

Solubility

It is recommended to reconstitute the lyophilized sCD23 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Stability

Lyophilized sCD23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sCD23 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein . Please prevent freeze-thaw cycles.

Biological Activity

The ED50 is determined by its ability to induce TNF-alpha production by human PBMCs.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD23 Human, Sf9

ProSpec-Eotaxin Mouse,趋化因子小鼠重组CHM-308

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。ProSpec-Eotaxin Mouse,趋化因子小鼠重组CHM-308

  • Eotaxin Mouse

  • Eotaxin Mouse Recombinant
  • CHM-308

Catalogue number

CHM-308

Synonyms

Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine ligand 11, SCYA11.

Introduction

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。 CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。 人类 CCL11 的基因在三个外显子上编码，位于第 17 号染色体上。

Description

Eotaxin Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8403.2 Dalton.
The CCL11 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Eotaxin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL11 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be His-Pro-Gly-Ser-Ile.

Biological Activity

The Biological activity was determined by measuring the dose dependent phosphorylation of ERK1 and ERK2 in CCR3 transfected 293 cells. Significant ERK phosphorylation is observed with >100 ng/ml of recombinant mouse eotaxin.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USEONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin Rat
  • Eotaxin 1 Antibody
  • Eotaxin Human
  • Eotaxin Human, His
  • Eotaxin Rhesus Macaque

ProSpec,CD274 Human,CD274 人重组PRO-1103

ProSpec,CD274 Human,CD274 人重组PRO-1103,在大肠杆菌中产生的 CD274 Human Recombinant 是单条多肽链，含有 245 个氨基酸，分子量为 27.9kDa。

  • CD274 Human

  • CD274 Human Recombinant
  • PRO-1103

Catalogue number

PRO-1103

Synonyms

CD274 molecule, CD274 antigen, programmed cell death 1 ligand 1, PD-L1, PDCD1L1, PDCD1LG1, PDCD1 ligand 1, B7 homolog 1, B7H1.

Introduction

CD274 takes part in the costimulatory signal, vital for T-cell proliferation and creation of IL10 and IFNG, in a PDCD1-independent and an IL2-dependent manner. CD274 collaboration with PDCD1 inhibits cytokine production and T-cell proliferation.
CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

Description

CD274 Human Recombinant produced in E. coli is a single polypeptide chain containing 245 amino acids and having a molecular mass of 27.9kDa .
CD274 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD274 Human Recombinant 是单条多肽链，含有 245 个氨基酸，分子量为 27.9kDa。
CD274 在 N 末端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD274 solution contains 20mM Tris-HCl buffer , 1mM DTT and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMFTVTV PKDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNER.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD274 Mouse
  • CD274 Human, Sf9

ProSpec-Eotaxin Rat,Eotaxin 大鼠重组 CHM-260

ProSpec-Eotaxin Rat,Eotaxin 大鼠重组 CHM-260,CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。

  • Eotaxin Rat

  • Eotaxin Rat Recombinant
  • CHM-260

Catalogue number

CHM-260

Synonyms

Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine ligand 11, SCYA11.

Introduction

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。 CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。 人类 CCL11 的基因在三个外显子上编码，位于第 17 号染色体上。

Description

Eotaxin Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8.4kDa. The CCL11 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Filtered and lyophilized from a concentrated solution in in 1×PBS, pH7.4.

Solubility

It is recommended to reconstitute the lyophilized Eotaxin in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 Eotaxin 虽然在室温下可稳定保存 3 周，但应在 -18C 以下干燥储存。 复溶后，CCL11 应在 4C 下储存 2-7 天，以备将来在 -18C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

HPGSIPTSCC FTMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTKLGKEICADPKKKWVQD ATKHLDQKLQ TPKP.

Biological Activity

Determined by its ability to chemoattract purified blood eosinophils using a concentration range of 0.1-1.0 ug/ml, corresponding to a Specific Activity of 10-100IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USEONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin Human, His
  • Eotaxin Mouse
  • Eotaxin Rhesus Macaque
  • Eotaxin Human

ProSpec-CD274 Human Sf9,CD274 人重组体Sf9 PRO-2453

ProSpec-CD274 Human Sf9,CD274 人重组体Sf9 PRO-2453,CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

  • CD274 Human, Sf9

  • CD274 Human Recombinant, Sf9
  • PRO-2453

Catalogue number

PRO-2453

Synonyms

CD274 molecule, CD274 antigen, programmed cell death 1 ligand 1, PD-L1, PDCD1L1, PDCD1LG1, PDCD1 ligand 1, B7 homolog 1, B7H1.

Introduction

CD274 takes part in the costimulatory signal, vital for T-cell proliferation and creation of IL10 and IFNG, in a PDCD1-independent and an IL2-dependent manner. CD274 collaboration with PDCD1 inhibits cytokine production and T-cell proliferation.

CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

Description

CD274 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 462 amino acids and having a molecular mass of 52.5kDa . CD274 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD274 Human Recombinant 是单条糖基化多肽链，包含 462 个氨基酸，分子量为 52.5kDa。 CD274 在 C 末端用 239 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD274 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

ADLFTVTVPK DLYVVEYGSN MTIECKFPVE KQLDLAALIV YWEMEDKNII QFVHGEEDLK VQHSSYRQRA RLLKDQLSLG NAALQITDVK LQDAGVYRCM ISYGGADYKR ITVKVNAPYN KINQRILVVD PVTSEHELTC QAEGYPKAEV IWTSSDHQVL SGKTTTTNSK REEKLFNVTS TLRINTTTNE IFYCTFRRLD PEENHTAELV IPELPLAHPP NERLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD274 Human
  • CD274 Mouse

ProSpec-Eotaxin Rhesus Macaque,Eotaxin 恒河猴重组体 CHM-022

ProSpec-Eotaxin Rhesus Macaque,Eotaxin 恒河猴重组体 CHM-022,趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关

  • Eotaxin Rhesus Macaque

  • Eotaxin Rhesus Macaque Recombinant
  • CHM-022

Catalogue number

CHM-022

Synonyms

Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine ligand 11, SCYA11, MGC22554.

Introduction

趋化因子配体 11 是一种小细胞因子，属于 CC 趋化因子家族，也称为 eotaxin。 CCL11 通过诱导其趋化性选择性地募集嗜酸性粒细胞，因此与过敏反应有关。 CCL11 的作用是通过其与称为趋化因子受体的 G 蛋白连接受体的结合来介导的。 CCL11为其配体的趋化因子受体包括CCR2、CCR3和CCR5。 人类 CCL11 的基因在三个外显子上编码，位于第 17 号染色体上。

Description

Recombinant Eotaxin Rhesus Macaque produced in E.coli cells is a non-glycosylated, homodimeric protein containing 74 amino acid chain and having a molecular mass of 8.4kDa. The Eotaxin is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The Eotaxin was lyophilized from a 0.2µm filtered concentrated solution in 2×PBS, pH 7.0.

Solubility

It is recommended to reconstitute the lyophilized Eotaxin Recombinant in sterile distilled H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 Eotaxin 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，Eotaxin 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPDSVATTCC FTLTNKKIPL QRLESYRRII SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDRKSP TPKP

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml corresponding to a specific activity of 1.0 × 105 – 1.0 × 107 IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The products may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin Rat
  • Eotaxin Human
  • Eotaxin Human, His
  • Eotaxin Mouse

ProSpec,CD274 Mouse,CD274 小鼠重组PRO-1164

ProSpec,CD274 Mouse,CD274 小鼠重组PRO-1164,CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

  • CD274 Mouse

  • CD274 Mouse Recombinant
  • PRO-1164

Catalogue number

PRO-1164

Synonyms

Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, A530045L16Rik.

Introduction

CD274 takes part in the costimulatory signal, vital for T-cell proliferation and creation of IL10 and IFNG, in a PDCD1-independent and an IL2-dependent manner. CD274 collaboration with PDCD1 inhibits cytokine production and T-cell proliferation.
CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

Description

CD274 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 246 amino acids and having a molecular mass of 27.6kDa .
CD274 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD274 protein solution containing 20mM Tris-HCl buffer , 10% glycerol and 0.15M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMFTITA PKDLYVVEYG SNVTMECRFP VERELDLLAL VVYWEKEDEQ VIQFVAGEED LKPQHSNFRG RASLPKDQLL KGNAALQITD VKLQDAGVYC CIISYGGADY KRITLKVNAP YRKINQRISV DPATSEHELI CQAEGYPEAE VIWTNSDHQP
VSGKRSVTTS RTEGMLLNVT SSLRVNATAN DVFYCTFWRS QPGQNHTAEL IIPELPATHP PQNRTH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD274 Human
  • CD274 Human, Sf9

ProSpec-Exodus 2 Human,Exodus-2 人类重组CHM-332

ProSpec-Exodus 2 Human,Exodus-2 人类重组CHM-332,CCL21 的基因位于人类第 9 号染色体上。CCL21 通过与称为 CCR7 的细胞表面趋化因子受体结合来引发其作用。

  • Exodus 2 Human

  • Exodus-2 Human Recombinant
  • CHM-332

Catalogue number

CHM-332

Synonyms

Small inducible cytokine A21, CCL21, Beta chemokine exodus-2, 6Ckine, Secondary lymphoid-tissue chemokine, SLC, chemokine ligand 21, ECL, CKb9, TCA4, SCYA21, MGC34555.

Introduction

趋化因子配体 21 是属于 CC 趋化因子家族的小细胞因子。 这种趋化因子也称为 6Ckine、exodus-2 和次级淋巴组织趋化因子。 CCL21 主要在淋巴结中表达，与其他 CC 趋化因子相比，它对淋巴细胞具有趋化性。 CCL21 的基因位于人类第 9 号染色体上。CCL21 通过与称为 CCR7 的细胞表面趋化因子受体结合来引发其作用。

Description

Exodus-2 Human Recombinant 在大肠杆菌中产生，为单一的非糖基化多肽链，包含 111 个氨基酸，分子量为 12219 道尔顿。
CCL21 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM Phosphate Buffer, pH 7.4 and 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized Exodus2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Exodus-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P.

Biological Activity

Determined by its ability to chemoattract human total lymphocyte population using a concentration range of 10-100ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Exodus 2 Mouse
  • Exodus-2 Mouse, Sf9

ProSpec,CD247 Human,CD247 人重组PRO-1335

T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。ProSpec,CD247 Human,CD247 人重组PRO-1335

  • CD247 Human

  • CD247 Human Recombinant
  • PRO-1335

Catalogue number

PRO-1335

Synonyms

T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD3Z, T3Z, TCRZ, CD3H, CD3Q, CD3-ZETA.

Introduction

T-cell surface glycoprotein CD3 zeta chain is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.
T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。 zeta 链在将抗原识别与几种细胞内信号转导途径偶联方面具有核心作用。 CD247 抗原的低表达导致免疫反应受损。

Description

CD247 Human Recombinant produced in E. coli is a single polypeptide chain containing 136 amino acids and having a molecular mass of 15.4kDa.
CD247 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD247 solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD247 Human, Sf9

ProSpec-Exodus 2 Mouse,Exodus-2 小鼠重组CHM-371

ProSpec-Exodus 2 Mouse,Exodus-2 小鼠重组CHM-371,CCL21 的基因位于人类第 9 号染色体上。CCL21 通过与称为 CCR7 的细胞表面趋化因子受体结合来引发其作用。

  • Exodus 2 Mouse

  • Exodus-2 Mouse Recombinant
  • CHM-371

Catalogue number

CHM-371

Synonyms

Small inducible cytokine A21, CCL21, Beta chemokine exodus-2, 6Ckine, Secondary lymphoid-tissue chemokine, SLC, chemokine ligand 21, ECL, CKb9, TCA4, SCYA21, MGC34555.

Introduction

趋化因子配体 21 是属于 CC 趋化因子家族的小细胞因子。 这种趋化因子也称为 6Ckine、exodus-2 和次级淋巴组织趋化因子。 CCL21 主要在淋巴结中表达，与其他 CC 趋化因子相比，它对淋巴细胞具有趋化性。 CCL21 的基因位于人类第 9 号染色体上。CCL21 通过与称为 CCR7 的细胞表面趋化因子受体结合来引发其作用。

Description

Exodus-2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 110 amino acids and having a molecular mass of 12kDa.
The CCL21 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing 20mM Phosphate buffer and 0.15M NaCl pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized Exodus2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions

Stability

Lyophilized Exodus-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein . Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by -PAGE & RP-HPLC.

Amino acid sequence

SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG.

Biological Activity

Determined  by its ability to chemoattract total murine T cell population using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Exodus 2 Human
  • Exodus-2 Mouse, Sf9

ProSpec,CD247 Human Sf9,CD247 人重组体Sf9 PRO-2529

ProSpec,CD247 Human Sf9,CD247 人重组体Sf9 PRO-2529,T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。

    • CD247 Human, Sf9

    • CD247 Human Recombinant, Sf9
    • PRO-2529

Catalogue number

PRO-2529

Synonyms

CD247 Molecule, T-Cell Surface Glycoprotein CD3 Zeta Chain, T-Cell Receptor T3 Zeta Chain, CD247 Antigen, CD3Z, TCRZ, T3Z, T-Cell Antigen Receptor Complex, Zeta Subunit Of CD3, CD3Z Antigen, Zeta Polypeptide , CD3z Antigen, Zeta Polypeptide , CD247 Antigen, Zeta Subunit , TCR Zeta Chain, CD3zeta Chain, CD3-ZETA, IMD25, CD3H, CD3Q.

Introduction

T-cell surface glycoprotein CD3 zeta chain is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.

T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。 zeta 链在将抗原识别与几种细胞内信号转导途径偶联方面具有核心作用。 CD247 抗原的低表达导致免疫反应受损。

Description

CD247 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 122 amino acids and having a molecular mass of 14.1kDa. . CD247 is expressed with an 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD247 protein solution contains 20mM Tris-HCl buffer , 50% glycerol, 1mM DTT, 1mM EDTA and  0.1M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPRHHHH HH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD247 Human

ProSpec-Exodus-2 Mouse, Sf9,Exodus-2 小鼠重组体，Sf9 CHM-043

ProSpec-Exodus-2 Mouse, Sf9,Exodus-2 小鼠重组体，Sf9 CHM-043,Exodus-2 蛋白或 CCL21 是一种细胞因子，是 CC 趋化因子亚组的一部分。 由于其半胱氨酸氨基酸的6个保守残基，该蛋白质也被命名为6Ckine和SLC。

  • Exodus-2 Mouse, Sf9

  • Exodus-2 Mouse Recombinant, Sf9
  • CHM-043

Catalogue number

CHM-043

Synonyms

Ccl21a, C-C motif chemokine 21a, 6Ckine, Beta-chemokine exodus-2, Small-inducible cytokine A21a,Thymus-derived chemotactic agent 4, TCA4, Ccl21a, Scya21, Scya21a, 6CKBAC2, 6Ckine, ALP,AW987545, CKb9, plt, Scya21b, SLC.

Introduction

Exodus-2 蛋白或 CCL21 是一种细胞因子，是 CC 趋化因子亚组的一部分。 由于其半胱氨酸氨基酸的6个保守残基，该蛋白质也被命名为6Ckine和SLC。 编码这种蛋白质的基因位于人类的第 9 号染色体上。 Exodus-2 与 CCR7 受体结合，这是一种位于细胞表面的趋化因子受体。

Description

在 Sf9 杆状病毒细胞中产生的 Exodus-2 小鼠重组体是一条含有 119 个氨基酸且分子量为 13.1kDa 的糖基化多肽链。
Exodus-2 在 C 末端与 9 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The  Exodus-2 solution contains  Phosphate-Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRGHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Exodus 2 Human
  • Exodus 2 Mouse

ProSpec,CD3e Human,CD3e人重组PRO-1317

ProSpec,CD3e Human,CD3e人重组PRO-1317,CD3-ε 多肽与 CD3-γ、-δ 和 -zeta 以及 T 细胞受体 α/β 和 γ/δ 异二聚体一起产生 T 细胞受体-CD3 复合物。 这种复合物在将抗原识别与许多细胞内信号转导途径耦合方面具有重要作用。

  • CD3e Human

  • CD3e Human Recombinant
  • PRO-1317

Catalogue number

PRO-1317

Synonyms

T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E, TCRE.

Introduction

CD3-epsilonpolypeptide along with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, creates the T-cell receptor-CD3 complex. This complex has an imperative role in coupling antigen recognition to a number of intracellular signal-transduction pathways. The genes encoding the epsilon, gamma delta polypeptides are found in the same cluster on chromosome 11. The epsilon polypeptide plays a vital role in T-cell development. CD3E gene defects cause immunodeficiency. CD3E is also linked to a susceptibility to type I diabetes in women.
CD3-ε 多肽与 CD3-γ、-δ 和 -zeta 以及 T 细胞受体 α/β 和 γ/δ 异二聚体一起产生 T 细胞受体-CD3 复合物。 这种复合物在将抗原识别与许多细胞内信号转导途径耦合方面具有重要作用。 在 11 号染色体上的同一簇中发现了编码 epsilon、gamma delta 多肽的基因。epsilon 多肽在 T 细胞发育中起着至关重要的作用。 CD3E基因缺陷导致免疫缺陷。 CD3E 还与女性对 I 型糖尿病的易感性有关。

Description

CD3e Human Recombinant produced in E. coli is a single polypeptide chain containing 127 amino acids and having a molecular mass of 14.1kDa.
CD3e is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD3e Human Recombinant 是单条多肽链，含有 127 个氨基酸，分子量为 14.1kDa。
CD3e 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD3e solution contains 20mM Tris-HCl buffer , 0.2M NaCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMD.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD3E Antibody

ProSpec-Fractalkine Human,Fractalkine 人重组体CHM-235

ProSpec-Fractalkine Human,Fractalkine 人重组体CHM-235,Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。 Natural Human Fractalkine 是一种长蛋白，具有延伸的粘蛋白样茎和顶部的趋化因子结构域。

  • Fractalkine Human

  • Fractalkine Human Recombinant
  • CHM-235

Catalogue number

CHM-235

Synonyms

Fractalkine, CX3CL1, Neurotactin, CX3C membrane-anchored chemokine, Small inducible cytokine D1, NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine.

Introduction

Fractalkine 可溶形式对 t 细胞和单核细胞具有趋化性，但对中性粒细胞不具有趋化性。 Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附。 Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。 Natural Human Fractalkine 是一种长蛋白，具有延伸的粘蛋白样茎和顶部的趋化因子结构域。 粘蛋白样茎允许它与细胞表面结合。 Fractalkine 基因与一些称为 CCL17 和 CCL22 的 CC 趋化因子一起位于人类第 16 号染色体上。

Description

Fractalkine Human Recombinant- produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 76 amino acids and having a molecular mass of 8638 Dalton.
The Fractalkine is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CX3CL1 was lyophilized from a 0.2μm filtered concentrated solution in 20mM Phosphate buffer, pH 7.4, 50mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CX3CL1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CX3CL1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CX3CL1 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQW VKDAMQHLDRQAAALTRNG.

Biological Activity

The Biological activity is calculated by its ability to chemoattract human T-Lymphocytes using a concentration range of 5.0-10.0 ng/ml corresponding to a Specific Activity of 100,000-200,000IU/mg.

References

Title: Glial Cell Line-Derived Neurotrophic Factor and Neurturin Inhibit Neurite Outgrowth and Activate RhoA through GFR?2b, an Alternatively Spliced Isoform of GFR?2.
Publication: The Journal of Neuroscience, 23 May 2007, 27: 5603-5614; doi: 10.1523/?JNEUROSCI.4552-06.2007.
Link: http://www.jneurosci.org/content/27/21/5603.full
Applications: GFR?2  when activated by NTN, it inhibits neurite outgrowth induced by GFR?1a, GFR?2a, and GFR?2c isoforms.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Fractalkine Human, His
  • Fractalkine Rat
  • Fractalkine Mouse
  • Fractalkine Human, Sf9

ProSpec PRO-2412,CD3G Human,CD3G人重组PRO-2412

ProSpec PRO-2412,CD3G Human,CD3G人重组PRO-2412,CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。 T 细胞受体-CD3 复合物参与将抗原识别与许多细胞内信号转导途径偶联

  • CD3G Human

  • CD3G Human Recombinant
  • PRO-2412

Catalogue number

PRO-2412

Synonyms

T-cell surface glycoprotein CD3 gamma chain, CD3-GAMMA, T3G, CD3G

Introduction

CD3-gamma polypeptide is encoded by CD3 Gamma which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, configures the T-cell receptor-CD3 complex. The T-cell receptor-CD3 complex takes part in coupling antigen recognition to numerous intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Deficiencies in this gene are associated with T cell immunodeficiency.
CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。 T 细胞受体-CD3 复合物参与将抗原识别与许多细胞内信号转导途径偶联。 编码ε、γ和δ多肽的基因位于11号染色体上的同一簇中。该基因的缺陷与T细胞免疫缺陷有关。

Description

CD3G Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.8kDa .
CD3G is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Insect cells.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD3G protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

ADPQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATISHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD3G Protein

ProSpec-Fractalkine Human, His,Fractalkine人重组体CHM-360

ProSpec-Fractalkine Human, His,Fractalkine人重组体CHM-360,Natural Human Fractalkine 是一种长蛋白，具有延伸的粘蛋白样茎和顶部的趋化因子结构域。 粘蛋白样茎允许它与细胞表面结合。

  • Fractalkine Human, His

  • Fractalkine Human Recombinant , His Tag
  • CHM-360

Catalogue number

CHM-360

Synonyms

Fractalkine, CX3CL1, Neurotactin, CX3C membrane-anchored chemokine, Small inducible cytokine D1, NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine.

Introduction

Fractalkine 可溶形式对 t 细胞和单核细胞具有趋化性，但对中性粒细胞不具有趋化性。 Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附。 Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。 Natural Human Fractalkine 是一种长蛋白，具有延伸的粘蛋白样茎和顶部的趋化因子结构域。 粘蛋白样茎允许它与细胞表面结合。 Fractalkine 基因与一些称为 CCL17 和 CCL22 的 CC 趋化因子一起位于人类第 16 号染色体上。

Description

Fractalkine Human Recombinant 在 E.Coli 中产生的 N 端融合了 20 个氨基酸的 His 标签，是一条含有 97 个氨基酸且分子量为 10.9kDa 的单一非糖基化多肽链。
Fractalkine 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The Fractalkine solution contains Phosphate Buffered Saline pH7.4 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MQHHGVTKCN ITCSKMTSKI PVALLIHYQQ NQASCGKRAI ILETRQHRLF CADPKEQWVK DAMQHLDRQA AALTRNG.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Fractalkine Mouse
  • Fractalkine Rat
  • Fractalkine Human
  • Fractalkine Human, Sf9

ProSpec,CD3G Protein PRO-1392,CD3 Gamma 人类重组PRO-1392

ProSpec,CD3G Protein PRO-1392,CD3 Gamma 人类重组PRO-1392,CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。

  • CD3G Protein

  • CD3 Gamma Human Recombinant
  • PRO-1392

Catalogue number

PRO-1392

Synonyms

T-cell surface glycoprotein CD3 gamma chain, CD3-GAMMA, T3G, CD3G.

Introduction

CD3-gamma polypeptide is encoded by CD3 Gamma which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, configures the T-cell receptor-CD3 complex. The T-cell receptor-CD3 complex takes part in coupling antigen recognition to numerous intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Deficiencies in this gene are associated with T cell immunodeficiency.
CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。 T 细胞受体-CD3 复合物参与将抗原识别与许多细胞内信号转导途径偶联。 编码ε、γ和δ多肽的基因位于11号染色体上的同一簇中。该基因的缺陷与T细胞免疫缺陷有关。

Description

CD3G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids and having a molecular mass of 13.1kDa. CD3G is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD3G protein solution containing 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATIS.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD3G Human

ProSpec-Fractalkine Human, Sf9,Fractalkine 人重组体，Sf9 CHM-042

ProSpec-Fractalkine Human, Sf9,Fractalkine 人重组体，Sf9 CHM-042,Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附。 Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。

  • Fractalkine Human, Sf9

  • Fractalkine Human Recombinant, Sf9
  • CHM-042

Catalogue number

CHM-042

Synonyms

Fractalkine, CX3CL1, Neurotactin, CX3C membrane-anchored chemokine, Small inducible cytokine D1, NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine.

Introduction

Fractalkine 可溶形式对 t 细胞和单核细胞具有趋化性，但对中性粒细胞不具有趋化性。 Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附。 Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。 Fractalkine 基因与一些称为 CCL17 和 CCL22 的 CC 趋化因子一起位于人类第 16 号染色体上。

Description

Fractalkine Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 323 amino acids and having a molecular mass of 34.3kDa.
Fractalkine is fused to a 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The Fractalkine solution contains 10% Glycerol and Phosphate Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD
AMQHLDRQAA ALTRNGGTFE KQIGEVKPRT TPAAGGMDES VVLEPEATGE SSSLEPTPSS
QEAQRALGTS PELPTGVTGS SGTRLPPTPK AQDGGPVGTE LFRVPPVSTA ATWQSSAPHQ
PGPSLWAEAK TSEAPSTQDP STQASTASSP APEENAPSEG QRVWGQGQSP RPENSLEREE
MGPVPAHTDA FQDWGPGSMA HVSVVPVSSE GTPSREPVAS GSWTPKAEEP IHATMDPQRL GVLITPVPDA QAATRLEHHH HHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Fractalkine Human
  • Fractalkine Human, His

ProSpec,CD33 Human,CD33 人重组PRO-1887

ProSpec,CD33 Human,CD33 人重组PRO-1887,在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。

  • CD33 Human

  • CD33 Human Recombinant
  • PRO-1887

Catalogue number

PRO-1887

Synonyms

CD33Molecule, CD33Antigen , Sialic Acid Binding Ig-Like Lectin 3, Sialic Acid-Binding Ig-Like Lectin 3, SIGLEC3, gp67, SIGLEC-3, Myeloid Cell Surface AntigenCD33, p67, Siglec-3, CD33Antigen.

Introduction

CD33 is putative adhesion molecule of myelomonocytic-derived cells which mediates sialic-acid dependent binding to cells. CD33 prefers to bind to alpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 perform as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases through their SH2 domains which block signal transduction through dephosphorylation of signaling molecules. In addition, CD33 induces apoptosis in acute myeloid leukemia.
CD33 是骨髓单核细胞衍生细胞的推定粘附分子，它介导唾液酸依赖性与细胞的结合。 CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。 在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。 此外，CD33 在急性髓性白血病中诱导细胞凋亡。

Description

CD33 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids and having a molecular mass of 29.1kDa.

CD33 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD33 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea, and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD33 Human, Sf9

ProSpec-Fractalkine Mouse,Fractalkine 小鼠重组体 CHM-017

ProSpec-Fractalkine Mouse,Fractalkine 小鼠重组体 CHM-017,Fractalkine 基因与一些称为 CCL17 和 CCL22 的 CC 趋化因子一起位于人类第 16 号染色体上。

  • Fractalkine Mouse

  • Fractalkine Mouse Recombinant
  • CHM-017

Catalogue number

CHM-017

Synonyms

Fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1, Cx3cl1, Cx3c, Fkn, Scyd1, CX3C, ABCD-3, AB030188, AI848747, D8Bwg0439e.

Introduction

Fractalkine 可溶形式对 t 细胞和单核细胞具有趋化性，但对中性粒细胞不具有趋化性。 Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附。 Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。 Natural Human Fractalkine 是一种长蛋白，具有延伸的粘蛋白样茎和顶部的趋化因子结构域。 粘蛋白样茎允许它与细胞表面结合。 Fractalkine 基因与一些称为 CCL17 和 CCL22 的 CC 趋化因子一起位于人类第 16 号染色体上。

Description

在大肠杆菌中产生的 Fractalkine Mouse Recombinant 是一条单一的、非糖基化的多肽链，包含 76 个氨基酸，分子量为 8.7kDa。
CX3CL1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CX3CL1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CX3CL1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CX3CL1 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QHLGMTKCEI MCGKMTSRIP VALLIRYQLN QESCGKRAIV LETTQHRRFC ADPKEKWVQD AMKHLDHQAA ALTKNG.

Biological Activity

The ED50as determined by a cell proliferation assay using human peripheral blood lymphocytes is less than 0.5 µg/ml, corresponding to a specific activity of > 2000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Fractalkine Human, His
  • Fractalkine Rat
  • Fractalkine Human

ProSpec,CD33 Human Sf9,CD33 人重组体Sf9 PRO-2492

在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。ProSpec,CD33 Human Sf9,CD33 人重组体Sf9 PRO-2492

  • CD33 Human, Sf9

  • CD33 Human Recombinant, Sf9
  • PRO-2492

Catalogue number

PRO-2492

Synonyms

Myeloid cell surface antigen CD33 isoform 1, CD33, FLJ00391, p67, SIGLEC-3, SIGLEC3, gp67.

Introduction

CD33 is putative adhesion molecule of myelomonocytic-derived cells which mediates sialic-acid dependent binding to cells. CD33 prefers to bind to alpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 perform as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases through their SH2 domains which block signal transduction through dephosphorylation of signaling molecules. In addition, CD33 induces apoptosis in acute myeloid leukemia.

CD33 是骨髓单核细胞衍生细胞的推定粘附分子，它介导唾液酸依赖性与细胞的结合。 CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。 在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。 此外，CD33 在急性髓性白血病中诱导细胞凋亡。

Description

CD33 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 239 aa hIgG-His Tag at C-terminus containing a total of 484 amino acids and having a molecular mass of 54kDa. CD33 shows multiple bands between 50-70kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD33 protein solution contains Phosphate buffered saline & 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADLDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVHLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD33 Human

ProSpec-Fractalkine Rat,Fractalkine 大鼠重组 CHM-005

ProSpec-Fractalkine Rat,Fractalkine 大鼠重组 CHM-005,Fractalkine 可溶形式对 t 细胞和单核细胞具有趋化性，但对中性粒细胞不具有趋化性。 Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附

  • Fractalkine Rat

  • Fractalkine Rat Recombinant
  • CHM-005

Catalogue number

CHM-005

Synonyms

Fractalkine, CX3CL1, Neurotactin, CX3C membrane-anchored chemokine, Small inducible cytokine D1, NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine.

Introduction

Fractalkine 可溶形式对 t 细胞和单核细胞具有趋化性，但对中性粒细胞不具有趋化性。 Fractalkine 膜结合形式促进这些白细胞与内皮细胞的粘附。 Fractalkine 调节内皮的白细胞粘附和迁移过程并与 CX3CR1 结合。 Natural Human Fractalkine 是一种长蛋白，具有延伸的粘蛋白样茎和顶部的趋化因子结构域。 粘蛋白样茎允许它与细胞表面结合。 Fractalkine 基因与一些称为 CCL17 和 CCL22 的 CC 趋化因子一起位于人类第 16 号染色体上。

Description

Fractalkine Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids and having a molecular mass of 8.7kDa.
The Fractalkine is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized Fractalkine in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 97.0% as determined by -PAGE.

Stability

Lyophilized FractalkineRat although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Fractalkine should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Amino acid sequence

QHLGMTKCNI TCHKMTSPIP VTLLIHYQLN QESCGKRAII LETRQHRHFC ADPKEKWVQD AMKHLDHQTA ALTRNG

Biological Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-10.0 ng/ml, corresponding to a specific activity of 100,000-200,000units/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Fractalkine Human, His
  • Fractalkine Human
  • Fractalkine Mouse

ProSpec,CD300A Human,CD300A 人重组PRO-1618

CD300A 属于 CD300 家族，包含 1 个 Ig 样 V 型结构域。 该蛋白质不仅由自然杀伤细胞表达，而且由 T 细胞亚群、B 细胞、树突细胞、肥大细胞、粒细胞和单核细胞表达。ProSpec,CD300A Human,CD300A 人重组PRO-1618

  • CD300A Human

  • CD300A Human Recombinant
  • PRO-1618

Catalogue number

PRO-1618

Synonyms

CD300a Molecule, CD300a Antigen, IRp60, CD300 Antigen-Like Family Member A, NK Inhibitory Receptor, Immunoglobulin Superfamily Member 12, CMRF35-Like Molecule 8, CMRF35-H, Inhibitory Receptor Protein 60, CMRF-35-H9, CMRF-35H, CLM-8, IRC1, IRC2, CMRF35H Leukocyte Immunoglobulin-Like Receptor, Leukocyte Membrane Antigen, IgSF12.
CD300a 分子、CD300a 抗原、IRp60、CD300 抗原样家族成员 A、NK 抑制性受体、免疫球蛋白超家族成员 12、CMRF35 样分子 8、CMRF35-H、抑制性受体蛋白 60、CMRF-35-H9、CMRF-35H、 CLM-8、IRC1、IRC2、CMRF35H 白细胞免疫球蛋白样受体、白细胞膜抗原、IgSF12。

Introduction

CD300A belongs to the CD300 family and contains 1 Ig-like V-type domain. The protein is expressed not only by natural killer cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer cells, and to the down-regulation of mast cell degranulation.
CD300A 属于 CD300 家族，包含 1 个 Ig 样 V 型结构域。 该蛋白质不仅由自然杀伤细胞表达，而且由 T 细胞亚群、B 细胞、树突细胞、肥大细胞、粒细胞和单核细胞表达。 CD300A 是抑制性受体，可能有助于下调自然杀伤细胞的溶细胞活性，并有助于下调肥大细胞脱粒。

Description

CD300A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 14.7kDa.
CD300A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD300A 人重组体是一条单一的、非糖基化的多肽链，含有 134 个氨基酸，分子量为 14.7kDa。
CD300A 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The CD300A solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 1mM DTT and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSLSKCRTV AGPVGGSLSV QCPYEKEHRT LNKYWCRPPQ IFLCDKIVET KGSAGKRNGR VSIRDSPANL SFTVTLENLT EEDAGTYWCG VDTPWLRDFH DPVVEVEVSV FPAS

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO a Human,GRO-Alpha 人类重组CHM-329

ProSpec-GRO a Human,GRO-Alpha 人类重组CHM-329,它由人类黑色素瘤细胞分泌，具有促有丝分裂特性，并与黑色素瘤发病机制有关。 CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达，具有中性粒细胞趋化活性。

  • GRO a Human

  • GRO-Alpha Human Recombinant
  • CHM-329

Catalogue number

CHM-329

Synonyms

Growth-regulated protein alpha, CXCL1, Melanoma growth stimulatory activity, MGSA, Neutrophil-activating protein 3, NAP-3, GRO-alpha , chemokine ligand 1, GRO1, GROa, SCYB1, MGSA-a, MGSA alpha.

Introduction

趋化因子配体 1 是一种小细胞因子，属于 CXC 趋化因子家族，以前称为 GRO1 致癌基因、中性粒细胞激活蛋白 3 和黑色素瘤生长刺激活性α。 它由人类黑色素瘤细胞分泌，具有促有丝分裂特性，并与黑色素瘤发病机制有关。 CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达，具有中性粒细胞趋化活性。 CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。 这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。 CXCL1 基因位于人类第 4 号染色体上，位于其他 CXC 趋化因子基因中。

Description

在大肠杆菌中产生的 GRO Alpha Human Recombinant 是一种单一的、非糖基化的多肽链，含有 73 个氨基酸，分子量为 7811 道尔顿。
GRO-alpha 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 50mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GRO-alpha although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Ser-Val-Ala-Thr.

Biological Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

References

Title:Deficient inflammatory response to UV radiation in neonatal mice.
Publication:Published online before print March 16, 2007, doi: 10.1189/jlb.1206729 June 2007 Journal of Leukocyte Biology vol. 81 no. 6 1352-1361
Link:http://www.jleukbio.org/content/81/6/1352.full

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO b Human, His
  • GRO a Human, His
  • MIP2 Viral
  • GRO g Human
  • GRO b Rat
  • GRO g Human, His
  • GRO a Rat
  • GRO b Human
  • GRO1/KC Mouse
  • GRO1/KC Mouse, His
  • GRO b Mouse

ProSpec,CD300C Human,CD300C 人重组PRO-273

ProSpec,CD300C Human,CD300C 人重组PRO-273,CMRF35 样分子 6 ，是 CD300 家族的成员。 CMRF35 抗原通过与单克隆抗体的反应性进行鉴定，并存在于单核细胞、中性粒细胞和一些 T 和 B 淋巴细胞上。

  • CD300C Human

  • CD300C Human Recombinant
  • PRO-273

Catalogue number

PRO-273

Synonyms

CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR, CMRF35-like molecule 6, CD300 antigen-like family member C, Immunoglobulin superfamily member 16.

Introduction

CMRF35-like molecule 6 , is a member of the CD300 family. The CMRF35 antigen was identified by reactivity with a monoclonal antibody and present on monocytes, neutrophils, and some T and B lymphocytes.
CMRF35 样分子 6 ，是 CD300 家族的成员。 CMRF35 抗原通过与单克隆抗体的反应性进行鉴定，并存在于单核细胞、中性粒细胞和一些 T 和 B 淋巴细胞上。

Description

CD300C Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 186 amino acids and having a molecular mass of 20.2kDa. CD300C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD300C Human Recombinant 是一条单一的、非糖基化的多肽链，包含 186 个氨基酸，分子量为 20.2kDa。 CD300C 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD300C protein solution containing 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSGYFPLSH PMTVAGPVGG SLSVQCRYEK EHRTLNKFWC RPPQILRCDK IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT YWCGVDTPWL RDFHDPIVEV EVSVFPAGTT TASSPQSSMG TSGPPTKLPV HTWPSVTRKD SPEPSPHPGS
LFSNVR.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD300C Human, Sf9

ProSpec-GRO a Human, His CHM-242

ProSpec-GRO a Human, His CHM-242,XCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。 这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。

  • GRO a Human, His

  • GRO-Alpha/MGSA Human Recombinant , His Tag
  • CHM-242

Catalogue number

CHM-242

Synonyms

Growth-regulated protein alpha, CXCL1, Melanoma growth stimulatory activity, MGSA, Neutrophil-activating protein 3, NAP-3, GRO-alpha, chemokine ligand 1, GRO1, GROa, SCYB1, MGSA-a, MGSA alpha.

Introduction

趋化因子配体 1 是一种小细胞因子，属于 CXC 趋化因子家族，以前称为 GRO1 致癌基因、中性粒细胞激活蛋白 3 和黑色素瘤生长刺激活性α。 它由人类黑色素瘤细胞分泌，具有促有丝分裂特性，并与黑色素瘤发病机制有关。 CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达，具有中性粒细胞趋化活性。 CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。 这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。 CXCL1 基因位于人类第 4 号染色体上，位于其他 CXC 趋化因子基因中。

Description

在大肠杆菌中产生的 CXCL1 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 94 个氨基酸，分子量为 10.1 kDa。 CXCL1 在 N 末端与 20 个氨基酸的 His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CXCL1 in 20mM Tris-HCL pH-8 and 10% glycerol.

Stability

Liquid CXCL1 although stable at 10°C for 1 week, should be stored below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MASVATELRC QCLQTLQGIH PKNIQSVNVK SPGPHCAQTE VIATLKNGRK ACLNPASPIV KKIIEKMLNS DKSN.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO a Human
  • GRO b Human, His
  • MIP2 Viral
  • GRO a Rat
  • GRO g Human
  • GRO b Rat
  • GRO g Human, His
  • GRO1/KC Mouse, His
  • GRO b Mouse
  • GRO1/KC Mouse
  • GRO b Human

ProSpec-CD300C Human Sf9,CD300C 人重组体PRO-2401

ProSpec-CD300C Human Sf9,CD300C 人重组体PRO-2401,在 Sf9 杆状病毒细胞中产生的 CD300C Human Recombinant 是单条糖基化多肽链，包含 163 个氨基酸，分子量为 18kDa。 CD300C 在 C 末端带有 8 个氨基酸的 His 标签，并通过专有色谱技术进行纯化。

  • CD300C Human, Sf9

  • CD300C Human Recombinant, Sf9
  • PRO-2401

Catalogue number

PRO-2401

Synonyms

CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR, CMRF35-like molecule 6, CD300 antigen-like family member C, Immunoglobulin superfamily member, CD300C.

Introduction

CMRF35-like molecule 6 , is a member of the CD300 family. The CMRF35 antigen was identified by reactivity with a monoclonal antibody and present on monocytes, neutrophils, and some T and B lymphocytes.

Description

CD300C Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 163 amino acids and having a molecular mass of 18kDa . CD300C is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD300C Human Recombinant 是单条糖基化多肽链，包含 163 个氨基酸，分子量为 18kDa。 CD300C 在 C 末端带有 8 个氨基酸的 His 标签，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD300C protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MTVAGPVGGS LSVQCRYEKE HRTLNKFWCR PPQILRCDKI VETKGSAGKR NGRVSIRDSP ANLSFTVTLE NLTEEDAGTY WCGVDTPWLR DFHDPIVEVE VSVFPAGTTT ASSPQSSMGT SGPPTKLPVH TWPSVTRKDS PEPSPHPGSL FSNVRLEHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD300C Human

ProSpec-GRO a Rat,GRO-Alpha 大鼠重组 CHM-375

ProSpec-GRO a Rat,GRO-Alpha 大鼠重组 CHM-375,CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。

  • GRO a Rat

  • GRO-Alpha Rat Recombinant
  • CHM-375

Catalogue number

CHM-375

Synonyms

Growth-regulated protein alpha, CXCL1, Melanoma growth stimulatory activity, MGSA, Neutrophil-activating protein 3, NAP-3, GRO-alpha, chemokine ligand 1, GRO1, GROa, SCYB1, MGSA-a, MGSA alpha.

Introduction

趋化因子配体 1 是一种小细胞因子，属于 CXC 趋化因子家族，以前称为 GRO1 致癌基因、中性粒细胞激活蛋白 3 和黑色素瘤生长刺激活性α。 它由人类黑色素瘤细胞分泌，具有促有丝分裂特性，并与黑色素瘤发病机制有关。 CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达，具有中性粒细胞趋化活性。 CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。 这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。 CXCL1 基因位于人类第 4 号染色体上，位于其他 CXC 趋化因子基因中。

Description

CXCL1 Rat Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7.8 kDa.
The Rat CXCL1 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH 7.4, and 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 CXCL1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，CXCL1 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK.

Biological Activity

Determined by its ability to chemoattract rat neutrophils using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO1/KC Mouse, His
  • GRO1/KC Mouse
  • GRO a Human
  • GRO a Human, His

ProSpec,CD300E Human,CD300E 人重组PRO-2114

ProSpec,CD300E Human,CD300E 人重组PRO-2114,CMRF35 样分子 2 前体是 CD300 家族的成员。 CD300E 是一种 205 个氨基酸的单通道 I 型膜蛋白，包含一个 Ig 样 V 型结构域。 在与 DAP12 相互作用时，CD300E 可能作为一种激活受体发挥作用。

  • CD300E Human

  • CD300E Human Recombinant
  • PRO-2114

Catalogue number

PRO-2114

Synonyms

CD300e Molecule, CD300e Antigen, CD300LE, IREM2, CLM2, Immune Receptor Expressed On Myeloid Cells 2, Polymeric Immunoglobulin Receptor 2,CD300 Antigen Like Family Member E, CD300 Antigen-Like Family Member E,Poly-Ig Receptor 2, CMRF35-A5, PIgR2, CMRF35-Like Molecule 2, CMRF35A5, CD300E.

Introduction

CMRF35-like molecule 2 precursor is a member of the CD300 family. CD300E is a 205 amino acid single-pass type I membrane protein which contains one Ig-like V-type domain. While interacting with DAP12, CD300E probably performs as an activating receptor. CD300E is present on the surface of mature hematopoietic cells of the monocyte & myeloid lineages.
CMRF35 样分子 2 前体是 CD300 家族的成员。 CD300E 是一种 205 个氨基酸的单通道 I 型膜蛋白，包含一个 Ig 样 V 型结构域。 在与 DAP12 相互作用时，CD300E 可能作为一种激活受体发挥作用。 CD300E 存在于单核细胞和骨髓谱系的成熟造血细胞表面。

Description

CD300E Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.9kDa.
CD300E is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD300E protein solution containing 20mM Tris-HCl buffer .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSLKGPGSV TGTAGDSLTV WCQYESMYKG YNKYWCRGQY DTSCESIVET KGEEKVERNG RVSIRDHPEA LAFTVTMQNL NEDDAGSYWC KIQTVWVLDS WSRDPSDLVR VYVSPAITTP RRTTHPATPP IFLVVNPGRN LSTGEVLTQN SGFRLSSPH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO b Human,GRO-Beta人重组CHM-309

ProSpec-GRO b Human,GRO-Beta人重组CHM-309,这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。

  • GRO b Human

  • GRO-Beta Human Recombinant
  • CHM-309

Catalogue number

CHM-309

Synonyms

Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta.

Introduction

Chemokine ligand 2 is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha , Growth-regulated protein beta and Gro oncogene-2 . CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
趋化因子配体 2 是属于 CXC 趋化因子家族的一种小细胞因子，也称为巨噬细胞炎症蛋白 2-α、生长调节蛋白 β 和 Gro oncogene-2。 CXCL2 在氨基酸序列上与相关趋化因子 CXCL1 有 90% 相同。 这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。 CXCL2 通过与称为 CXCR2 的细胞表面趋化因子受体相互作用来动员细胞。

Description

GRO-Beta Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7908 Dalton.
The CXCL2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized with no additives.

Solubility

It is recommended to reconstitute the lyophilized GRO-beta Human in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 CXCL2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CXCL2 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Leu-Ala-Thr.

Biological Activity

The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO a Human
  • GRO b Mouse
  • GRO a Human, His
  • GRO b Human, His
  • MIP2 Viral
  • GRO g Human, His
  • GRO b Rat
  • GRO1/KC Mouse
  • GRO g Human

ProSpec,CD34 Human,CD34人重组PRO-1363

ProSpec,CD34 Human,CD34人重组PRO-1363,在大肠杆菌中产生的 CD34 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 280 个氨基酸，分子量为 29.7kDa。 CD34 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

  • CD34 Human

  • CD34 Human Recombinant
  • PRO-1363

Catalogue number

PRO-1363

Synonyms

CD34 molecule, Hematopoietic progenitor cell antigen CD34, CD34 Antigen, CD34.

Introduction

CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells.
CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Description

CD34 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 280 amino acids and having a molecular mass of 29.7kDa. CD34 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD34 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 280 个氨基酸，分子量为 29.7kDa。 CD34 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD34 protein solution containing 20mM Tris-HCl buffer , 0.1M NaCl, 20% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSLDNNGTAT PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD34 Antibody
  • CD34 Human, GST
  • CD34 Human, Sf9
  • CD34 PAT3B6AT Antibody

ProSpec-GRO b Human His CHM-356,GRO-Beta Human Recombinant , His Tag

ProSpec-GRO b Human His CHM-356,GRO-Beta Human Recombinant , His Tag,CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。 CXCL2 通过与称为 CXCR2 的细胞表面趋化因子受体相互作用来动员细胞。

    • GRO b Human, His

    • GRO-Beta Human Recombinant , His Tag
    • CHM-356

Catalogue number

CHM-356

Synonyms

Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta.

Introduction

趋化因子配体 2 是属于 CXC 趋化因子家族的一种小细胞因子，也称为巨噬细胞炎症蛋白 2-α、生长调节蛋白 β 和 Gro oncogene-2。 CXCL2 在氨基酸序列上与相关趋化因子 CXCL1 有 90% 相同。 这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。 CXCL2 通过与称为 CXCR2 的细胞表面趋化因子受体相互作用来动员细胞。

Description

GRO-Beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids and having a molecular mass of 10.1 kDa. The GRO-b is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The Human CXCL2 protein solution contains 20mM Tris HCl .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MAPLATELRC QCLQTLQGIH LKNIQSVKVK SPGPHCAQTE VIATLKNGQK ACLNPASPMV KKIIEKMLKNGKSN.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO b Mouse
  • GRO b Human
  • GRO1/KC Mouse
  • GRO a Human
  • MIP2 Viral
  • GRO a Human, His
  • GRO g Human
  • GRO b Rat
  • GRO g Human, His

ProSpec,CD34 Human GST,CD34 人重组PRO-292

CD34 是一种单链跨膜糖蛋白，在人淋巴和骨髓造血祖细胞上选择性表达。ProSpec,CD34 Human GST,CD34 人重组PRO-292

  • CD34 Human, GST

  • CD34 Human Recombinant, GST Tag
  • PRO-292

Catalogue number

PRO-292

Synonyms

Hematopoietic progenitor cell antigen CD34, CD34.

Introduction

CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells.
CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
CD34 是一种单链跨膜糖蛋白，在人淋巴和骨髓造血祖细胞上选择性表达。
CD34 已被用于测量血管生成，据报道可预测肿瘤复发。

Description

CD34 Human Recombinant full length expressed in E.coli, CD34 is antibody reactive.
The CD34 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD34 in 50mM Tris-HCl, pH7.5, 10mM L-glutathione .

Stability

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD34 Human, Sf9
  • CD34 Human
  • CD34 Antibody
  • CD34 PAT3B6AT Antibody

ProSpec-GRO b Mouse,GRO-Beta 小鼠重组CHM-338

ProSpec-GRO b Mouse,GRO-Beta 小鼠重组CHM-338,趋化因子配体 2 是属于 CXC 趋化因子家族的一种小细胞因子，也称为巨噬细胞炎症蛋白 2-α、生长调节蛋白 β 和 Gro oncogene-2。 CXCL2 在氨基酸序列上与相关趋化因子 CXCL1 有 90% 相同。

  • GRO b Mouse

  • GRO-Beta Mouse Recombinant
  • CHM-338

Catalogue number

CHM-338

Synonyms

Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta.

Introduction

趋化因子配体 2 是属于 CXC 趋化因子家族的一种小细胞因子，也称为巨噬细胞炎症蛋白 2-α、生长调节蛋白 β 和 Gro oncogene-2。 CXCL2 在氨基酸序列上与相关趋化因子 CXCL1 有 90% 相同。 这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。 CXCL2 通过与称为 CXCR2 的细胞表面趋化因子受体相互作用来动员细胞。

Description

GRO-Beta Mouse Recombinant also caled mouse MIP-2 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7849 Dalton.
The CXCL2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized GRO-beta Mouse in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN.

Biological Activity

The Biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 105-106units/mg.

Protein content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 0.015 as the extinction coefficient for a 0.1% solution. This value is calculated by the PC GENE computer analysis program of protein sequences .
2. Analysis by RP-HPLC, using a standard solution of GRO-b as a Reference Standard.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO b Rat
  • GRO g Human, His
  • GRO1/KC Mouse
  • GRO g Human
  • GRO b Human
  • GRO a Human
  • GRO b Human, His
  • GRO a Human, His
  • MIP2 Viral

ProSpec,CD34 Human Sf9,CD34人重组PRO-2358

ProSpec,CD34 Human Sf9,CD34人重组PRO-2358,在 Sf9 杆状病毒细胞中产生的 CD34 Human Recombinant 是单条糖基化多肽链，包含 268 个氨基酸，分子量为 28.6kDa。

  • CD34 Human, Sf9

  • CD34 Human Recombinant, Sf9
  • PRO-2358

Catalogue number

PRO-2358

Synonyms

CD34 molecule, Hematopoietic progenitor cell antigen CD34, CD34 Antigen, CD34.

Introduction

CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells. CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Description

CD34 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 268 amino acids and having a molecular mass of 28.6kDa .
CD34 is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD34 Human Recombinant 是单条糖基化多肽链，包含 268 个氨基酸，分子量为 28.6kDa。
CD34 在 C 末端与 6 个氨基酸 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD34 protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADLSLDNNGT ATPELPTQGT FSNVSTNVSY QETTTPSTLG STSLHPVSQH GNEATTNITE TTVKFTSTSV ITSVYGNTNS SVQSQTSVIS TVFTTPANVS TPETTLKPSL SPGNVSDLST TSTSLATSPT KPYTSSSPIL SDIKAEIKCS GIREVKLTQG ICLEQNKTSS CAEFKKDRGE GLARVLCGEE QADADAGAQV CSLLLAQSEV RPQCLLLVLA NRTEISSKLQ LMKKHQSDLK KLGILDFTEQ DVASHQSYSQ KTHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD34 Human
  • CD34 Human, GST
  • CD34 Antibody
  • CD34 PAT3B6AT Antibody

ProSpec-GRO b Rat,GRO-beta/MIP-2 大鼠重组CHM-372

ProSpec-GRO b Rat,GRO-beta/MIP-2 大鼠重组CHM-372,这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。

  • GRO b Rat

  • GRO-beta/MIP-2 Rat Recombinant
  • CHM-372

Catalogue number

CHM-372

Synonyms

Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta, CINC-3.

Introduction

趋化因子配体 2 是属于 CXC 趋化因子家族的一种小细胞因子，也称为巨噬细胞炎症蛋白 2-α、生长调节蛋白 β 和 Gro oncogene-2。 CXCL2 在氨基酸序列上与相关趋化因子 CXCL1 有 90% 相同。 这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。 CXCL2 通过与称为 CXCR2 的细胞表面趋化因子受体相互作用来动员细胞。

Description

GRO-Beta Rat Recombinant also called Rat MIP-2 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7923 Dalton.
The GRO-b is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized GRO-beta Rat in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GRO-b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein . Please prevent freeze-thaw cycles.

Purity

Greater than 99.0% as determined by -PAGE.

Amino acid sequence

VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN.

Biological Activity

The biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • MIP2 Viral
  • GRO a Human, His
  • GRO g Human, His
  • GRO g Human
  • GRO b Mouse
  • GRO b Human
  • GRO1/KC Mouse
  • GRO a Human
  • GRO b Human, His

ProSpec,CD36 Human,CD36 人重组PRO-2533

CD36 是在多种哺乳动物细胞类型中发现的完整膜蛋白，它是 B 类清道夫受体家族的一部分。 在人类中，它由 CD36 基因编码。ProSpec,CD36 Human,CD36 人重组PRO-2533

  • CD36 Human

  • CD36 Human Recombinant
  • PRO-2533

Catalogue number

PRO-2533

Synonyms

Platelet glycoprotein 4 isoform 1, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, Glycoprotein IIIb, GPIIIB, Leukocyte differentiation antigen CD36, PAS-4, Platelet collagen receptor, Platelet glycoprotein IV, Thrombospondin receptor.

Introduction

CD36 is an integral membrane protein found in a variety cell types of mammals, it is part of the class B scavenger receptor family. In humans it is encoded by the CD36 gene. The protein binds to ligands such as native lipoproteins, collagen, long-chain fatty acids, thrombospondin etc. CD36 plays a crucial role in transporting fatty acids into the cell.

CD36 是在多种哺乳动物细胞类型中发现的完整膜蛋白，它是 B 类清道夫受体家族的一部分。 在人类中，它由 CD36 基因编码。 该蛋白质与天然脂蛋白、胶原蛋白、长链脂肪酸、血小板反应蛋白等配体结合。CD36 在将脂肪酸转运到细胞中起关键作用。

Description

CD36 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 652 amino acids and having a molecular mass of 73.9kDa. .
CD36 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD36 是单条糖基化多肽链，包含 652 个氨基酸，分子量为 73.9kDa。 .
CD36 在 C 末端用 242 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD36 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

 

Amino acid sequence

ADLGDLLIQK TIKKQVVLEE GTIAFKNWVK TGTEVYRQFW IFDVQNPQEV MMNSSNIQVK QRGPYTYRVR FLAKENVTQD AEDNTVSFLQ PNGAIFEPSL SVGTEADNFT VLNLAVAAAS HIYQNQFVQM ILNSLINKSK SSMFQVRTLR ELLWGYRDPF LSLVPYPVTT TVGLFYPYNN
TADGVYKVFN GKDNISKVAI IDTYKGKRNL SYWESHCDMI NGTDAASFPP FVEKSQVLQF FSSDICRSIY AVFESDVNLK GIPVYRFVLP SKAFASPVEN PDNYCFCTEK IISKNCTSYG VLDISKCKEG RPVYISLPHF LYASPDVSEP IDGLNPNEEE HRTYLDIEPI TGFTLQFAKR
LQVNLLVKPS EKIQVLKNLK RNYIVPILWL NETGTIGDEK ANMFRSQVTG KINLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD36 Mouse

ProSpec-GRO g Human,GRO-伽玛人类重组CHM-310

ProSpec-GRO g Human,GRO-伽玛人类重组CHM-310,CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

  • GRO g Human

  • GRO-Gamma Human Recombinant
  • CHM-310

Catalogue number

CHM-310

Synonyms

Macrophage inflammatory protein 2-beta, MIP2-beta, CXCL3, Growth-regulated protein gamma, GRO-gamma, GRO-gamma, GRO3, GROg, MIP2B, SCYB3, MIP-2b, CINC-2b, MGSA gamma.

Introduction

趋化因子配体 3 是属于 CXC 趋化因子家族的小细胞因子，也称为 GRO3 癌基因、GRO 蛋白 γ 和巨噬细胞炎症蛋白-2-β。 CXCL3 控制单核细胞的迁移和粘附，并通过与称为 CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

Description

GRO-Gamma Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7902 Dalton.
The CXCL3 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized with no additives.

Solubility

It is recommended to reconstitute the lyophilized CXCL3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Ser-Val-Val-Thr.

Biological Activity

The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO g Human, His
  • GRO b Rat
  • GRO b Mouse
  • GRO b Human
  • GRO1/KC Mouse
  • GRO a Human
  • GRO g/CINC-2a Rat
  • GRO b Human, His
  • GRO-g/CINC-2b Rat
  • GRO g Mouse
  • GRO a Human, His
  • GRO g Mouse, His

ProSpec,CD4 (26-396) Human,CD4人重组CYT-885

在大肠杆菌中产生的 CD4 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 396 个氨基酸，分子量为 44kDa。ProSpec,CD4 (26-396) Human,CD4人重组CYT-885

  • CD4 Human

  • CD4 Human Recombinant
  • CYT-885

Catalogue number

CYT-885

Synonyms

CD4 Molecule, T-Cell Surface Glycoprotein CD4, T-Cell Surface Antigen T4/Leu-3, CD4 Antigen , CD4 Receptor, CD4 Antigen, CD4mut, T-cell surface glycoprotein CD4.

Introduction

CD4 is a cell-surface glycoprotein found on the mature helper T cells and immature thymocytes, as well as on monocytes and macrophages. Normally, about 65% of T cells in the blood are CD4+ . A mature T cell with either have CD4 or CD8, but not both. During one stage of development T cells develop CD4 and CD8 receptors, but they eventually are differentiated in the thymus and become more specialized.

CD4 是一种细胞表面糖蛋白，存在于成熟的辅助 T 细胞和未成熟的胸腺细胞以及单核细胞和巨噬细胞上。 正常情况下，血液中约 65% 的 T 细胞是 CD4+。 具有 CD4 或 CD8 的成熟 T 细胞，但不是两者兼有。 在发育的一个阶段，T 细胞会产生 CD4 和 CD8 受体，但它们最终会在胸腺中分化并变得更加特化。

Description

CD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 396 amino acids and having a molecular mass of 44kDa.

CD4 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CD4 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 396 个氨基酸，分子量为 44kDa。

CD4 在 N 末端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD4 protein solution containing 20mM Tris Hcl, PH8.0 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV LNPEAGMWQC LLGQVLL ESNIKVLPTW STPVQP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD4 Human
  • CD4 Human
  • CD4 Human, Sf9

ProSpec-GRO g Human His CHM-244

ProSpec-GRO g Human His CHM-244,CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

  • GRO g Human, His

  • GRO-Gamma Human Recombinant , His Tag
  • CHM-244

Catalogue number

CHM-244

Synonyms

Macrophage inflammatory protein 2-beta, MIP2-beta, CXCL3, Growth-regulated protein gamma, GRO-gamma, GRO-gamma, GRO3, GROg, MIP2B, SCYB3, MIP-2b, CINC-2b, MGSA gamma.

Introduction

趋化因子配体 3 是属于 CXC 趋化因子家族的小细胞因子，也称为 GRO3 癌基因、GRO 蛋白 γ 和巨噬细胞炎症蛋白-2-β。 CXCL3 控制单核细胞的迁移和粘附，并通过与称为 CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

Description

在大肠杆菌中产生的 GRO-Gamma Human Recombinant 是一种单一的、非糖基化的多肽链，含有 94 个氨基酸，分子量为 7902 道尔顿。 GRO-g 在 N 末端与 20 个氨基酸 His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CXCL3 protein is formulated in 20mM Tris-HCl buffer pH-8, 1mM DTT and 20% glycerol.

Stability

Liquid CXCL3 although stable at 10°C for 1 week, should be stored below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MASVVTELRC QCLQTLQGIH LKNIQSVNVR SPGPHCAQTE VIATLKNGKK ACLNPASPMV QKIIEKILNKGSTN.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO a Human
  • GRO-g/CINC-2b Rat
  • GRO b Human, His
  • GRO g Mouse
  • GRO g Mouse, His
  • GRO a Human, His
  • GRO g Human
  • GRO b Rat
  • GRO b Mouse
  • GRO1/KC Mouse
  • GRO b Human

ProSpec-CD4 (26-396) Human Sf9,CD4人重组CYT-978

ProSpec-CD4 (26-396) Human Sf9,CD4人重组CYT-978,Sf9 昆虫细胞中产生的 CD4 是单条糖基化多肽链，含有 377 个氨基酸，分子量为 42.1kDa。

  • CD4 Human, Sf9

  • CD4 Human Recombinant, Sf9
  • CYT-978

Catalogue number

CYT-978

Synonyms

CD4 Molecule, T-Cell Surface Antigen T4/Leu-3, CD4 Antigen , T-Cell Surface Glycoprotein CD4, CD4 Receptor, CD4 Antigen, CD4mut.

Introduction

CD4 is a cell-surface glycoprotein found on the mature helper T cells and immature thymocytes, as well as on monocytes and macrophages. Normally, about 65% of T cells in the blood are CD4+ . A mature T cell with either have CD4 or CD8, but not both. During one stage of development T cells develop CD4 and CD8 receptors, but they eventually are differentiated in the thymus and become more specialized.
CD4 是一种细胞表面糖蛋白，存在于成熟的辅助 T 细胞和未成熟的胸腺细胞以及单核细胞和巨噬细胞上。 正常情况下，血液中约 65% 的 T 细胞是 CD4+。 具有 CD4 或 CD8 的成熟 T 细胞，但不是两者兼有。 在发育的一个阶段，T 细胞会产生 CD4 和 CD8 受体，但它们最终会在胸腺中分化并变得更加特化。

Description

CD4 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 377 amino acids and having a molecular mass of 42.1kDa .
CD4 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9 昆虫细胞中产生的 CD4 是单条糖基化多肽链，含有 377 个氨基酸，分子量为 42.1kDa。
CD4 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD4 a protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

KKVVLGKKGD TVELTCTASQ KKSIQFHWKN SNQIKILGNQ GSFLTKGPSK LNDRADSRRS LWDQGNFPLI IKNLKIEDSD TYICEVEDQK EEVQLLVFGL TANSDTHLLQ GQSLTLTLES PPGSSPSVQC RSPRGKNIQG GKTLSVSQLE LQDSGTWTCT VLQNQKKVEF KIDIVVLAFQ KASSIVYKKE GEQVEFSFPL AFTVEKLTGS GELWWQAERA SSSKSWITFD LKNKEVSVKR VTQDPKLQMG KKLPLHLTLP QALPQYAGSG NLTLALEAKT GKLHQEVNLV VMRATQLQKN LTCEVWGPTS PKLMLSLKLE NKEAKVSKRE KAVWVLNPEA GMWQCLL GQVLLESNIK VLPTWSTPVQ PHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD4 Human

ProSpec-GRO g Mouse,GRO-伽玛小鼠重组CHM-255

ProSpec-GRO g Mouse,GRO-伽玛小鼠重组CHM-255,CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

  • GRO g Mouse

  • GRO-Gamma Mouse Recombinant
  • CHM-255

Catalogue number

CHM-255

Synonyms

C-X-C motif chemokine 3, Dendritic cell inflammatory protein 1, Cxcl3, Dcip1, Gm1960.

Introduction

趋化因子配体 3 是属于 CXC 趋化因子家族的小细胞因子，也称为 GRO3 癌基因、GRO 蛋白 γ 和巨噬细胞炎症蛋白-2-β。 CXCL3 控制单核细胞的迁移和粘附，并通过与称为 CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

Description

GRO-g Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7.7kDa.
The CXCL3 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The Mouse CXCL3 lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized GRO-gamma in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 GRO-γ 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，CXCL3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SELRCQCLNT LPRVDFETIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QGPRLQIIIK KILKSGKSS.

Biological Activity

Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml, corresponding to a specific activity of 10,000-100,000 units/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GRO g Mouse, His
  • GRO g/CINC-2a Rat
  • GRO g Human, His
  • GRO g Human
  • GRO-g/CINC-2b Rat