ProSpec,MCP1 Human HEK CHM-048,CHM-048,单核细胞趋化蛋白 1/MCAF 人重组体HEK

ProSpec,MCP1 Human HEK CHM-048,CHM-048,单核细胞趋化蛋白 1/MCAF 人重组体HEK,它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5

MCP1 Human, HEK
Monocyte Chemotactic Protein-1/MCAF Human Recombinant, HEK
CHM-048
2µg

10µg

100µg

Catalogue number

CHM-048

Synonyms

CCL2, C-C motif chemokine 2, GDCF-2, HSMCR30, JE, HC11, MCAF, MCP-1, MCP1, Scya2, Sigje, SMC-CF, Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Small-inducible cytokine A2.

Introduction

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B .CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection.This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans.The cell surface receptors that bind CCL2 are CCR2 and CCR5

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。它存在于牙齿萌出和骨骼退化的部位。在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 ?B 的控制。CCL2 将免疫细胞（如单核细胞）募集到组织损伤和感染部位。这种趋化因子作为含有信号的蛋白质前体产生 23个氨基酸的肽和76个氨基酸的成熟肽。它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5

Description

MCP1 Human HEK Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 82 amino acids and having a molecular mass of 9.5 kDa.
MCP1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 HEK293 细胞中产生的 MCP1 Human HEK Recombinant 是一条糖基化多肽链，包含 82 个氨基酸，分子量为 9.5 kDa。
MCP1 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

HEK293 Cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The MCP1 solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Biological Activity

Measured its ability to chemoattract using THP-1 human acute monocytic leukemia cells. The ED50 range ≤ 30 ng/ml.

Amino acid sequence

QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKTHHHH HH

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP1 Rat Sf9 CHM-044,单核细胞趋化蛋白 1 大鼠重组体Sf9

ProSpec,MCP1 Rat Sf9 CHM-044,单核细胞趋化蛋白 1 大鼠重组体Sf9,MCP 1 作为蛋白质前体产生，含有 23 个氨基酸的信号肽和 76 个氨基酸的成熟肽。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。

MCP1 Rat, Sf9
Monocyte Chemotactic Protein-1 Rat Recombinant, Sf9
CHM-044
2µg

10µg

1mg

Catalogue number

CHM-044

Synonyms

Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11

Introduction

Chemokine ligand 2 is a small cytokine belongs to the CC chemokine family which is also known as monocyte chemotactic protein-1 . MCP 1 is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts. CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. MCP 1is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

趋化因子配体 2 是一种小细胞因子，属于 CC 趋化因子家族，也称为单核细胞趋化蛋白 1。 MCP 1 存在于牙齿萌出和骨骼退化的部位。在骨骼中，CCL2 由成熟的破骨细胞表达。 CCL2 将免疫细胞（例如单核细胞）募集到组织损伤和感染部位。 MCP 1 作为蛋白质前体产生，含有 23 个氨基酸的信号肽和 76 个氨基酸的成熟肽。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

Description

MCP1 Rat Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15.1kDa.
MCP1 is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 MCP1 大鼠重组体是单条糖基化多肽链，含有 134 个氨基酸，分子量为 15.1kDa。
MCP1 在 C 末端与 6 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells

Physical Appearance

Sterile filtered colorless solution.

Formulation

The MCP1 Rat protein solution contains 10% glycerol and Phosphate-Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

ADPQPDAVNA PLTCCYSFTG KMIPMSRLEN YKRITSSRCP KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT VFYKIASTLR TSAPLNVNLT HKSEANASTL FSTTTSSTSV EVTSMTENHH HHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec CHM-250,MDC Human,巨噬细胞衍生的趋化因子人重组CHM-250

ProSpec CHM-250,MDC Human,巨噬细胞衍生的趋化因子人重组CHM-250,CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。

MDC Human
Macrophage-Derived Chemokine Human Recombinant
CHM-250
5µg

20µg

1mg

Catalogue number

CHM-250

Synonyms

C-C motif chemokine 22, Small-inducible cytokine A22, Macrophage-derived chemokine, MDC, Stimulated T-cell chemotactic protein 1, CC chemokine STCP-1, CCL22, MDC, SCYA22, ABCD-1, DC/B-CK, MGC34554, A-152E5.1.

Introduction

MDC is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys cytokine genes clustered on the q arm of chromosome 16.
MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4.
CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph node CCL22 is expressed in a mature subset of Langerhans’ cells .
Furthermore, CCL22 is expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. In addition, MDC has a role in hindering progression of lung cancer. Moreover, significantly higher CCL22 expression is linked to gastric cancer.

MDC是属于CC趋化因子家族的小细胞因子。 CCL22 是聚集在 16 号染色体 q 臂上的几个 Cys-Cys 细胞因子基因之一。
MDC 对自然杀伤细胞、慢性活化的 T 淋巴细胞、单核细胞和树突状细胞具有趋化活性。另一方面，MDC 对原代活化的 T 淋巴细胞表现出温和的活性，对中性粒细胞、嗜酸性粒细胞和静息 T 淋巴细胞没有趋化活性。 MDC 还可能在活化 T 淋巴细胞向炎症部位的运输和活化 T 淋巴细胞生理学的其他方面发挥作用。 MDC 与细胞表面趋化因子受体 CCR4 相互作用。
CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。 CCL22在肺和脾中的表达较低，在小肠中表达非常弱。在淋巴结中，CCL22 在成熟的朗格汉斯细胞亚群中表达。
此外，CCL22 在表皮和真皮的特应性皮炎、过敏性接触性皮炎皮肤和牛皮癣中均有表达。此外，MDC 具有阻碍肺癌进展的作用。此外，显着更高的 CCL22 表达与胃癌有关。

Description

MDC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 69 amino acids and having a molecular mass of 8.1 kDa.
The MDC is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized powder.

Formulation

CCL22 filtered and lyophilized from a concentrated solution containing 20mM phosphate buffer & 500mM NaCl pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized CCL22 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Stability

Lyophilized CCL22 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL22 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Biological Activity

Determined by its ability to chemoattract human T cells using a concentration range of 10ng-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTCPRPG VVLLTFRDKE ICADPRVPWV KMILNKLSQ.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec CHM-367,MDC Human His,巨噬细胞衍生的趋化因子人重组体CHM-367

ProSpec CHM-367,MDC Human His,巨噬细胞衍生的趋化因子人重组体CHM-367,MDC 还可能在活化 T 淋巴细胞向炎症部位的运输和活化 T 淋巴细胞生理学的其他方面发挥作用。 MDC 与细胞表面趋化因子受体 CCR4 相互作用。

MDC Human, His
Macrophage-Derived Chemokine Human Recombinant , His Tag
CHM-367
5µg

20µg

1mg

Catalogue number

CHM-367

Synonyms

Introduction

MDC is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4.
CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph node CCL22 is expressed in a mature subset of Langerhans’ cells .
Furthermore, CCL22 is expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. In addition, MDC has a role in hindering progression of lung cancer. Moreover, significantly higher CCL22 expression is linked to gastric cancer.

MDC是属于CC趋化因子家族的小细胞因子。 CCL22 是聚集在 16 号染色体 q 臂上的几个 Cys-Cys 细胞因子基因之一。MDC 显示出对自然杀伤细胞、慢性活化的 T 淋巴细胞、单核细胞和树突细胞的趋化活性。另一方面，MDC 对原代活化的 T 淋巴细胞表现出温和的活性，对中性粒细胞、嗜酸性粒细胞和静息 T 淋巴细胞没有趋化活性。 MDC 还可能在活化 T 淋巴细胞向炎症部位的运输和活化 T 淋巴细胞生理学的其他方面发挥作用。 MDC 与细胞表面趋化因子受体 CCR4 相互作用。
CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。 CCL22在肺和脾中的表达较低，在小肠中表达非常弱。在淋巴结中，CCL22 在成熟的朗格汉斯细胞亚群中表达。
此外，CCL22 在表皮和真皮的特应性皮炎、过敏性接触性皮炎皮肤和牛皮癣中均有表达。此外，MDC 具有阻碍肺癌进展的作用。此外，显着更高的 CCL22 表达与胃癌有关。

Description

MDC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 90 amino acids and having a molecular mass of 10.3 kDa.
The MDC is fused to 21 amino acid His-Tag at N-terminus purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The MDC protein contains phosphate-buffered Saline pH7.4 and 10% glycerol.

Stability

Purity

Greater than 95% as determined by Analysis by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGPYGANMED SVCCRDYVRY RLPLRVVKHF YWTCPRP GVVLLTFRDK EICADPRVPW VKMILNKLSQ.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MDC Mouse,巨噬细胞衍生的趋化因子小鼠重组CHM-370

ProSpec,MDC Mouse,巨噬细胞衍生的趋化因子小鼠重组CHM-370,CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。

MDC Mouse
Macrophage-Derived Chemokine Mouse Recombinant
CHM-370
5µg

20µg

1mg

Catalogue number

CHM-370

Synonyms

Introduction

MDC is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4. CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph

MDC是属于CC趋化因子家族的小细胞因子。 CCL22 是聚集在 16 号染色体 q 臂上的几个 Cys-Cys 细胞因子基因之一。MDC 显示出对自然杀伤细胞、慢性活化的 T 淋巴细胞、单核细胞和树突细胞的趋化活性。另一方面，MDC 对原代活化的 T 淋巴细胞表现出温和的活性，对中性粒细胞、嗜酸性粒细胞和静息 T 淋巴细胞没有趋化活性。 MDC 还可能在活化 T 淋巴细胞向炎症部位的运输和活化 T 淋巴细胞生理学的其他方面发挥作用。 MDC 与细胞表面趋化因子受体 CCR4 相互作用。 CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。 CCL22在肺和脾中的表达较低，在小肠中表达非常弱。在淋巴

Description

CCL22 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. The Mouse CCL22 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized powder.

Formulation

CCL22 filtered and lyophilized from a concentrated solution containing 20mM phosphate buffer & 150mM NaCl pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized CCL22 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干的 CCL22，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized CCL22 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL22 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Biological Activity

Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Purity

Greater than 97.0% as determined by: Analysis by RP-HPLC. Analysis by -PAGE.

Amino acid sequence

GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MDC Rat,巨噬细胞衍生的趋化因子大鼠重组CHM-279

CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。ProSpec,MDC Rat,巨噬细胞衍生的趋化因子大鼠重组CHM-279

MDC Rat
Macrophage-Derived Chemokine Rat Recombinant
CHM-279
5µg

20µg

1mg

Catalogue number

CHM-279

Synonyms

Introduction

Description

CCL22 Rat Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.9kDa.
The Rat CCL22 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH7.4.

Solubility

It is recommended to reconstitute the lyophilized MDC in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MDC although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution MDC should be stored at 4C between 2-7 days and for future use below -18C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPYGANVEDS ICCQDYIRHP LPPRFVKEFY WTSKSCRKPG VVLITIKNRD ICADPRMLWV KKILHKLA.

Biological Activity

Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10.0-100.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CCL28 Human,黏膜相关上皮趋化因子人重组CHM-353

ProSpec,CCL28 Human,黏膜相关上皮趋化因子人重组CHM-353,CCL28 与 CCL27/CTACK 的同源性最高。发现人和小鼠 CCL28 RNA 表达在正常和病理结肠中最高，该蛋白质由上皮细胞表达。

CCL28 Human
Mucosae-Associated Epithelial Chemokine Human Recombinant
CHM-353
5µg

20µg

1mg

Catalogue number

CHM-353

Synonyms

MEC, CCK1, SCYA28, MGC71902, CCL28, C-C motif chemokine 28, Small-inducible cytokine A28, Mucosae-associated epithelial chemokine, Protein CCK1.

Introduction

CCL28 is part of the subfamily of small cytokine CC genes. CCL28 shows chemotactic activity for resting CD4 or CD8 T cells and eosinophils. CCL28 binds to chemokine receptors CCR3 and CCR10. CCL28 is involved in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28 is involved in the pathogenesis of inflammatory skin diseases.
Human CCL28 cDNA encodes a 127 amino acid residue precursor protein with a putative 22 amino acid residue signal peptide that is cleaved to produce the 105 amino acid residue mature protein. Human and mouse CCL28 are highly conserved, sharing 83% amino acid identity in their mature regions. CCL28 shares the most homology with CCL27/CTACK. Human and mouse CCL28 RNA expression was found to be highest in normal and pathologic colon with the protein being expressed by epithelial cells. Human CCL28 RNA was also present in normal and asthmatic lung tissues.

CCL28 是小细胞因子 CC 基因亚家族的一部分。 CCL28 显示对静息 CD4 或 CD8 T 细胞和嗜酸性粒细胞的趋化活性。 CCL28 与趋化因子受体 CCR3 和 CCR10 结合。 CCL28 参与皮外上皮组织的生理学，包括多种黏膜器官。 CCL28 在 HIV 暴露和感染中介导黏膜免疫。 CCL28 参与炎症性皮肤病的发病机制。
人 CCL28 cDNA 编码一个 127 个氨基酸残基的前体蛋白和一个推定的 22 个氨基酸残基信号肽，该信号肽被切割以产生 105 个氨基酸残基的成熟蛋白。人和小鼠 CCL28 高度保守，在其成熟区域共享 83% 的氨基酸同一性。 CCL28 与 CCL27/CTACK 的同源性最高。发现人和小鼠 CCL28 RNA 表达在正常和病理结肠中最高，该蛋白质由上皮细胞表达。人 CCL28 RNA 也存在于正常和哮喘肺组织中。

Description

CCL28 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids and having a molecular mass of 12.3 kDa.
The CCL28 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing 20mM PBS and 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CCL28 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干的 CCL28，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized CCL28 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL28 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY.

Biological Activity

Determined by its ability to chemoattract human lymphocytes using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CCL28 Human His CHM-366,黏膜相关上皮趋化因子人重组体CHM-366

ProSpec,CCL28 Human His CHM-366,黏膜相关上皮趋化因子人重组体CHM-366,CCL28 是小细胞因子 CC 基因亚家族的一部分。 CCL28 显示对静息 CD4 或 CD8 T 细胞和嗜酸性粒细胞的趋化活性。 CCL28 与趋化因子受体 CCR3 和 CCR10 结合。

CCL28 Human, His
Mucosae-Associated Epithelial Chemokine Human Recombinant , His Tag
CHM-366
5µg

20µg

1mg

Catalogue number

CHM-366

Synonyms

MEC, CCK1, SCYA28, MGC71902, CCL28, C-C motif chemokine 28, Small-inducible cytokine A28, Mucosae-associated epithelial chemokine, Protein CCK1.

Introduction

Description

CCL28 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 126 amino acids and having a molecular mass of 14.3 kDa.
The CCL28 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The CCL28 protein contains 10mM Sodium Citrate pH3.5 and 10% Glycerol.

Stability

Purity

Greater than 90% as determined by Analysis by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MILPIASSCC TEVSHHISRR LLERVNMCRI QRADGDCDLA AVILHVKRRR ICVSPHNHTV KQWMKVQAAK KNGKGNVCHR KKHHGKRNSN RAHQGKHETY GHKTPY.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CCL28 Mouse CHM-369,粘膜相关上皮趋化因子小鼠重组CHM-369

ProSpec,CCL28 Mouse CHM-369,粘膜相关上皮趋化因子小鼠重组CHM-369,CCL28 是小细胞因子 CC 基因亚家族的一部分。 CCL28 显示对静息 CD4 或 CD8 T 细胞和嗜酸性粒细胞的趋化活性。 CCL28 与趋化因子受体 CCR3 和 CCR10 结合

CCL28 Mouse
Mucosae-Associated Epithelial Chemokine Mouse Recombinant
CHM-369
5µg

20µg

1mg

Catalogue number

CHM-369

Synonyms

MEC, CCK1, SCYA28, MGC71902, CCL28, C-C motif chemokine 28, Small-inducible cytokine A28, Mucosae-associated epithelial chemokine, Protein CCK1.

Introduction

Description

CCL28 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids and having a molecular mass of 12.6 kDa.
The CCL28 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing 20mM Phosphate buffer pH-7.4 and 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CCL28 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 CCL28 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL28 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SEAILPMASS CCTEVSHHVS GRLLERVSSC SIQRADGDCD LAAVILHVKR RRICISPHNR TLKQWMRASE VKKNGRENVC SGKKQPSRKD RKGHTTRKHR TRGTHRHEAS R.

Biological Activity

Determined by its ability to chemoattract mouse lymphocytes using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CCL28 Rat CHM-278,粘膜相关上皮趋化因子大鼠重组CHM-278

ProSpec,CCL28 Rat CHM-278,粘膜相关上皮趋化因子大鼠重组CHM-278,CCL28 是小细胞因子 CC 基因亚家族的一部分。 CCL28 显示对静息 CD4 或 CD8 T 细胞和嗜酸性粒细胞的趋化活性。 CCL28 与趋化因子受体 CCR3 和 CCR10 结合。

CCL28 Rat
Mucosae-Associated Epithelial Chemokine Rat Recombinant
CHM-278
5µg

20µg

1mg

Catalogue number

CHM-278

Synonyms

MEC, CCK1, SCYA28, MGC71902, CCL28, C-C motif chemokine 28, Small-inducible cytokine A28, Mucosae-associated epithelial chemokine, Protein CCK1.

Introduction

Description

MEC Rat Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 116 amino acids and having a molecular mass of 13.1kDa.
The Rat MEC is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4 and150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MEC in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MEC although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution MEC should be stored at 4C between 2-7 days and for future use below -18C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SEAILPIASS CCTEVSHHIP RRLLERVNSC SIQRADGDCD LAAVILHVKR RRICVSPHNP TLKRWMSASE MKNGKENLCP RKKQDSGKDR KGHTPRKHGK HGTRRIHGTH DHEAPR.

Biological Activity

Determined by its ability to chemoattract murine lymphocytes using a concentration range of 1.0-10.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIG Bovine CHM-041,MIG 牛重组CHM-041

ProSpec,MIG Bovine CHM-041,MIG 牛重组CHM-041,CXCL9 与另外两种称为 CXCL10 和 CXCL11 的 CXC 趋化因子密切相关，它们的基因位于人类 4 号染色体上的 CXCL9 基因附近。

MIG Bovine
MIG Bovine Recombinant
CHM-041
50µg

100µg

1mg

Catalogue number

CHM-041

Synonyms

Small inducible cytokine B9, CXCL9, Gamma INF-induced monokine, MIG, chemokine ligand 9, CMK, Humig, SCYB9, crg-10, monokine induced by gamma-INF.

Introduction

Chemokine ligand 9 is a small cytokine belongs to the CXC chemokine family that is also known as Monokine induced by gamma INF . CXCL9 is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.

趋化因子配体 9 是一种小细胞因子，属于 CXC 趋化因子家族，也称为由 γ INF 诱导的 Monokine。 CXCL9 与另外两种称为 CXCL10 和 CXCL11 的 CXC 趋化因子密切相关，它们的基因位于人类 4 号染色体上的 CXCL9 基因附近。CXCL9、CXCL10 和 CXCL11 都通过与趋化因子受体 CXCR3 相互作用而引发其趋化功能。

Description

MIG BovineRecombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 104 amino acids and having a molecular mass of approximately 18.0kDa.
MIG is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0.

Solubility

It is recommended to reconstitute the lyophilized MIG in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIG should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 96.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VPAIRNGRCS CINTSQGMIH PKSLKDLKQF APSPSCEKTE IIATMKNGNE ACLNPDLPEV KELIKEWEKQ VNQKKKQRKG KKYKKTKKVP KVKRSQRPSQ KKTT.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human lymphocytes is 0.1-1.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIG Human CHM-333,MIG 人重组CHM-333

ProSpec,MIG Human CHM-333,MIG 人重组CHM-333,它与另外两种称为 CXCL10 和 CXCL11 的 CXC 趋化因子密切相关，它们的基因位于人类 4 号染色体上的 CXCL9 基因附近。

MIG Human
MIG Human Recombinant
CHM-333
5µg

20µg

1mg

Catalogue number

CHM-333

Synonyms

Small inducible cytokine B9, CXCL9, Gamma INF-induced monokine, MIG, chemokine ligand 9, CMK, Humig, SCYB9, crg-10, monokine induced by gamma-INF.

Introduction

Chemokine ligand 9 is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma INF . CXCL9 is a T-cell chemoattractant, which is induced by IFN-?. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.

趋化因子配体 9 是一种小细胞因子，属于 CXC 趋化因子家族，也称为由 γ INF 诱导的 Monokine。 CXCL9 是一种 T 细胞趋化剂，由 IFN-α 诱导。它与另外两种称为 CXCL10 和 CXCL11 的 CXC 趋化因子密切相关，它们的基因位于人类 4 号染色体上的 CXCL9 基因附近。CXCL9、CXCL10 和 CXCL11 都通过与趋化因子受体 CXCR3 相互作用而引发其趋化功能。

Description

MIG Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 103 amino acids and having a molecular mass of 11700 Dalton. The MIG is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH 7.4, 50mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MIG in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干 MIG，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized MIG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL9 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

TPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEKIEIIATLKNGVQTCLNPDS
ADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSRQKKTT.

Biological Activity

Determined by its ability to chemoattract human peripheral blood T-Lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIG Human CHM-016, His,MIG人重组体CHM-016

ProSpec,MIG Human CHM-016, His,MIG人重组体CHM-016,CXCL9、CXCL10 和 CXCL11 通过与趋化因子受体 CXCR3 相互作用获得它们的趋化功能。

MIG Human, His
MIG Human Recombinant , His Tag
CHM-016
5µg

20µg

1mg

Catalogue number

CHM-016

Synonyms

C-X-C motif chemokine 9, CMK, crg-10, Humig, MIG, SCYB9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, Small-inducible cytokine B9, CXCL9.

Introduction

MIG is a small cytokine which is part of the CXC chemokine family. MIG, which is also recognized as monokine is induced by gamma interferon. MIG is related to 2 other CXC chemokines named CXCL10 and CXCL11, whose genes are located next to the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 obtain their chemotactic functions by interacting with the chemokine receptor CXCR3.

MIG 是一种小细胞因子，是 CXC 趋化因子家族的一部分。也被认为是单核因子的 MIG 是由 γ 干扰素诱导的。 MIG 与其他 2 种 CXC 趋化因子相关，即 CXCL10 和 CXCL11，它们的基因位于人类 4 号染色体上的 CXCL9 基因旁边。CXCL9、CXCL10 和 CXCL11 通过与趋化因子受体 CXCR3 相互作用获得它们的趋化功能。

Description

MIG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids and having a molecular mass of 14kDa.
MIG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

MIG protein solution contains 20mM Tris-HCl buffer , 0.15M NaCl and 30% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSTPVVRKG RCSCISTNQG TIHLQSLKDL KQFAPSPSCE KIEIIATLKN GVQTCLNPDS ADVKELIKKW EKQVSQKKKQ KNGKKHQKKK VLKVRKSQRS RQKKTT.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIG Mouse CHM-337,MIG 小鼠重组CHM-337

ProSpec,MIG Mouse CHM-337,MIG 小鼠重组CHM-337,CXCL9 是一种 T 细胞趋化剂。它与另外两种称为 CXCL10 和 CXCL11 的 CXC 趋化因子密切相关

MIG Mouse
MIG Mouse Recombinant
CHM-337
5µg

20µg

1mg

Catalogue number

CHM-337

Synonyms

Small inducible cytokine B9, CXCL9, MIG, chemokine ligand 9, CMK, Humig, SCYB9, crg-10, M119.

Introduction

Chemokine ligand 9 is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by MIG. CXCL9 is a T-cell chemoattractant. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.

趋化因子配体 9 是一种小细胞因子，属于 CXC 趋化因子家族，也称为 MIG 诱导的 Monokine。 CXCL9 是一种 T 细胞趋化剂。它与另外两种称为 CXCL10 和 CXCL11 的 CXC 趋化因子密切相关，它们的基因位于人类 4 号染色体上的 CXCL9 基因附近。CXCL9、CXCL10 和 CXCL11 都通过与趋化因子受体 CXCR3 相互作用而引发其趋化功能。

Description

MIG Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 105 amino acids and having a molecular mass of 12208 Dalton. The MIG is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MIG Mouse Recombinant 是单一的、非糖基化的多肽链，包含 105 个氨基酸，分子量为 12208 道尔顿。 MIG 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Filtered and lyophilized from a concentrated solution in 20mM PB, pH7.4 and 100mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MIG in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Thr-Leu-Val-Ile-Arg.

Biological Activity

The Activity is calculated by the ability to chemoattract Human lymphocytes using a concentration of 0.1-1 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,LAG-1 Human CHM-018,LAG-1 人重组CHM-018

ProSpec,LAG-1 Human CHM-018,LAG-1 人重组CHM-018,冻干的 LAG-1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL4L1 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

LAG-1 Human
LAG-1 Human Recombinant
CHM-018
5µg

20µg

1mg

Catalogue number

CHM-018

Synonyms

C-C motif chemokine 4-like, Lymphocyte activation gene 1 protein, LAG-1, Macrophage inflammatory protein 1-beta, MIP-1-beta, Monocyte adherence-induced protein 5-alpha, Small-inducible cytokine A4-like, CCL4L1, CCL4L, LAG1, SCYA4L1, CCL4L2, SCYA4L2, AT744.2.

Introduction

CCL4L1 is a member of to intercrine beta family. The CCL4L1 protein is similar to CCL4 which inhibits HIV replication in peripheral blood monocytes which express CCR5.

Description

LAG-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 69 amino acids and having a molecular mass of 7.8kDa.
The CCL4L1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 LAG-1 Human Recombinant 是单一的、非糖基化的多肽链，含有 69 个氨基酸，分子量为 7.8kDa。
CCL4L1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

LAG-1 was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized LAG-1 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized LAG-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL4L1 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

冻干的 LAG-1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL4L1 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN.

Biological Activity

The ED₅₀as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 × 10⁵ IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,LAG-1 Human His,LAG-1人类重组CHM-272

ProSpec,LAG-1 Human His,LAG-1人类重组CHM-272,在大肠杆菌中产生的 LAG-1 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 94 个氨基酸，分子量为 10.5kDa。

LAG-1 Human, His
LAG-1 Human Recombinant, His Tag
CHM-272
5µg

20µg

1mg

Catalogue number

CHM-272

Synonyms

Introduction

CCL4L1 is a member of to intercrine beta family. The CCL4L1 protein is similar to CCL4 which inhibits HIV replication in peripheral blood monocytes which express CCR5.

Description

LAG-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 94 amino acids and having a molecular mass of 10.5kDa .
LAG-1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 LAG-1 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 94 个氨基酸，分子量为 10.5kDa。
LAG-1 在 N 末端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

LAG-1 protein solution containing 10mM sodium citrate and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAPMGS DPPTACCFSY TARKLPRNFV VDYYETSSLC SQPAVVFQTK RGKQVCADPS ESWVQEYVYD LELN.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1a Human,巨噬细胞炎症蛋白-1 Alpha 人类重组CHM-233

ProSpec,MIP 1a Human,巨噬细胞炎症蛋白-1 Alpha 人类重组CHM-233,巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。在人类中，有两种主要形式，MIP-1a 和 MIP-1b，现在分别正式命名为 CCL3 和 CCL4。

MIP 1a Human
Macrophage Inflammatory Protein-1 Alpha Human Recombinant
CHM-233
5µg

20µg

1mg

Catalogue number

CHM-233

Synonyms

Small inducible cytokine A3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Tonsillar lymphocyte LD78 alpha protein, G0/G1 switch regulatory protein 19-1, G0S19-1 protein, SIS-beta, PAT 464.1, chemokine ligand 3, MIP1A, SCYA3, G0S19-1, LD78ALPHA.

Introduction

Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 , IL-6 and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.

巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。在人类中，有两种主要形式，MIP-1a 和 MIP-1b，现在分别正式命名为 CCL3 和 CCL4。两者都是巨噬细胞受到细菌内毒素刺激后产生的主要因子。它们激活可导致急性中性粒细胞炎症的人类粒细胞。它们还诱导成纤维细胞和巨噬细胞合成和释放其他促炎细胞因子，例如白细胞介素1、IL-6和TNF-α。 CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

Description

Macrophage Inflammatory Protein-1 alpha Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7820 Dalton.
The MIP-1a is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白-1 α 人重组体是一种单一的、非糖基化的多肽链，包含 70 个氨基酸，分子量为 7820 道尔顿。
MIP-1a 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from 0.55 mg/ml solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Ser-Leu-Ala-Ala.

Biological Activity

The Activity is calculated by the ability of chemo-attraction of Human monocytes using 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1a Human His CHM-347,巨噬细胞炎症蛋白-1 Alpha 人类重组CHM-347

ProSpec,MIP 1a Human His CHM-347,巨噬细胞炎症蛋白-1 Alpha 人类重组CHM-347,它们激活可导致急性中性粒细胞炎症的人类粒细胞。它们还诱导成纤维细胞和巨噬细胞合成和释放其他促炎细胞因子，例如白细胞介素1、IL-6和TNF-α。 CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

MIP 1a Human, His
Macrophage Inflammatory Protein-1 Alpha Human Recombinant , His Tag
CHM-347
2µg

10µg

1mg

Catalogue number

CHM-347

Synonyms

Introduction

Description

MIP-1a Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 90 amino acids and having a molecular mass of 10.0kDa. MIP-1a is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MIP-1a 小鼠重组体是一条含有 90 个氨基酸且分子量为 10.0kDa 的单一非糖基化多肽链。 MIP-1a 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

MIP-1a protein solution containing 10mM Sodium Citrate buffer and 20% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQVCADPSEEWVQ KYVSDLELSA.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1a Mouse CHM-320,巨噬细胞炎症蛋白-1 Alpha 小鼠重组CHM-320

ProSpec,MIP 1a Mouse CHM-320,巨噬细胞炎症蛋白-1 Alpha 小鼠重组CHM-320,MIP-1a 和 MIP-1b，现在分别正式命名为 CCL3 和 CCL4。两者都是巨噬细胞受到细菌内毒素刺激后产生的主要因子。

MIP 1a Mouse
Macrophage Inflammatory Protein-1 Alpha Mouse Recombinant
CHM-320
2µg

10µg

1mg
Catalogue number

CHM-320

Synonyms

Introduction

Description

Macrophage Inflammatory Protein-1 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7820 Dalton.
The MIP-1a is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白-1 α 小鼠重组体是一种单一的、非糖基化的多肽链，包含 69 个氨基酸，分子量为 7820 道尔顿。
MIP-1a 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from 1mg/ml solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL3 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 99.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Pro-Tyr-Gly-Ala.

Biological Activity

The Activity is calculated by the ability to chemoattract of Balb3/C splenocytes using 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1a Mouse His,巨噬细胞炎症蛋白-1 Alpha 小鼠重组CHM-008

ProSpec,MIP 1a Mouse His,巨噬细胞炎症蛋白-1 Alpha 小鼠重组CHM-008,它们激活可导致急性中性粒细胞炎症的人类粒细胞。它们还诱导成纤维细胞和巨噬细胞合成和释放其他促炎细胞因子，例如白细胞介素1、IL-6和TNF-α。 CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

MIP 1a Mouse, His
Macrophage Inflammatory Protein-1 Alpha Mouse Recombinant , His Tag
CHM-008
2µg

10µg

1mg

Catalogue number

CHM-008

Synonyms

Introduction

Description

MIP-1a Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of 10.4kDa.
MIP-1a is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

MIP-1a protein solution containing 20mM Sodium citrate buffer and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMAPYGAD TPTACCFSYS RKIPRQFIVD YFETSSLCSQ PGVIFLTKRN RQICADSKET WVQEYITDLE LNA.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1a Rat CHM-343,巨噬细胞炎症蛋白-1 α 大鼠重组CHM-343

ProSpec,MIP 1a Rat CHM-343,巨噬细胞炎症蛋白-1 α 大鼠重组CHM-343,在人类中，有两种主要形式，MIP-1a 和 MIP-1b，现在分别正式命名为 CCL3 和 CCL4。

MIP 1a Rat
Macrophage Inflammatory Protein-1 Alpha Rat Recombinant
CHM-343
5µg

20µg

1mg

Catalogue number

CHM-343

Synonyms

Introduction

Description

Macrophage Inflammatory Protein-1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7853 Dalton.
The MIP-1a is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白-1 α 大鼠重组体是一种单一的、非糖基化的多肽链，包含 69 个氨基酸，分子量为 7853 道尔顿。
MIP-1a 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from 1 mg/ml solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 MIP-1a 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Pro-Tyr-Gly-Ala.

Biological Activity

The Activity is calculated by the ability to chemoattract of rat peritoneal macrophages using a conc. of 60 ng/ml corresponding to a Specific Activity of 16,667IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1b Human CHM-276,巨噬细胞炎症蛋白-1 Beta 人重组CHM-276

ProSpec,MIP 1b Human CHM-276,巨噬细胞炎症蛋白-1 Beta 人重组CHM-276,巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。在人类中，有两种主要形式，即 MIP-1a 和 MIP-1b，现在也被命名为 CCL3 和 CCL4。

MIP 1b Human
Macrophage Inflammatory Protein-1 Beta Human Recombinant
CHM-276
2µg

10µg

1mg

Catalogue number

CHM-276

Synonyms

Small inducible cytokine A4, CCL4, Macrophage inflammatory protein 1-beta, MIP-1- beta, MIP-1-beta, T-cell activation protein 2, ACT-2, PAT 744, H400, SIS-gamma, Lymphocyte activation gene 1 protein, LAG-1, HC21, G-26 T-lymphocyte-secreted protein, chemokine ligand 4, ACT2, G-26, LAG1, MIP1B, SCYA4, AT744.1, MGC104418, MGC126025, MGC126026.

Introduction

Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now also named CCL3 and CCL4. Both factors are produced by macrophages after they are stimulated with bacterial endotoxins. MIP-1a and MIP-1b activate human granulocytes which can lead to acute neutrophilic inflammation. MIP-1a and MIP-1b induce synthesis and release of other pro-inflammatory cytokines such as interleukin-1 , IL-6 and TNF-alpha from fibroblasts and macrophages. CCL3 and CCL4 genes are both located on human chromosome 17.

巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。在人类中，有两种主要形式，即 MIP-1a 和 MIP-1b，现在也被命名为 CCL3 和 CCL4。这两种因子都是巨噬细胞在受到细菌内毒素刺激后产生的。 MIP-1a 和 MIP-1b 激活可导致急性中性粒细胞炎症的人粒细胞。 MIP-1a和MIP-1b诱导成纤维细胞和巨噬细胞合成和释放其他促炎细胞因子，例如白细胞介素1、IL-6和TNF-α。 CCL3 和 CCL4 基因都位于人类第 17 号染色体上。

Description

Macrophage Inflammatory Protein-1 beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7620 Dalton.
The CCL4 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白-1 β 人重组体是一种单一的、非糖基化的多肽链，含有 69 个氨基酸，分子量为 7620 道尔顿。
CCL4 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 99.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Pro-Met-Gly-Ser.

Biological Activity

The Activity is calculated by the ability to chemoattract Human blood monocytes using a concentration of 5-20ng/ml corresponding to a Specific Activity of 50,000-200,000IU/mg.

References

Title: CONFUSION BETWEEN CCL4 AND CCL4L1: AN EXAMPLE TO
BEAR IN MIND WHEN USING THIRD-PARTY REAGENTS.

Publication: Inmunologia Vol. 26 / Num 1/ Enero-Marzo 2007: 51-54 .

Link: http://revista.inmunologia.org/Upload/Articles/7/5/756.pdf

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-MIP 1b Mouse CHM-321,巨噬细胞炎症蛋白 1 β 小鼠重组CHM-321

ProSpec-MIP 1b Mouse CHM-321,巨噬细胞炎症蛋白 1 β 小鼠重组CHM-321,它们激活可导致急性中性粒细胞炎症的人类粒细胞。它们还诱导其他促炎细胞因子如白细胞介素 1、IL-6 和 TNF-α 的合成和释放。来自成纤维细胞和巨噬细胞。

MIP 1b Mouse
Macrophage Inflammatory Protein-1 beta Mouse Recombinant
CHM-321
2µg

10µg

1mg

Catalogue number

CHM-321

Synonyms

Introduction

Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1? and MIP-1? that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 , IL-6 and TNF-? from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.

巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。在人类中，有两种主要形式，MIP-1？和 MIP-1？现在分别正式命名为 CCL3 和 CCL4。两者都是巨噬细胞受到细菌内毒素刺激后产生的主要因子。它们激活可导致急性中性粒细胞炎症的人类粒细胞。它们还诱导其他促炎细胞因子如白细胞介素 1、IL-6 和 TNF-α 的合成和释放。来自成纤维细胞和巨噬细胞。 CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

Description

Macrophage Inflammatory Protein-1 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7808 Dalton.
The MIP-1b is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白-1 β 小鼠重组体是一种单一的、非糖基化的多肽链，含有 69 个氨基酸，分子量为 7808 道尔顿。
MIP-1b 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Mouse MIP-1b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Mouse MIP-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干小鼠 MIP-1b 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重组后，小鼠 CCL4 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Biological Activity

Mouse MIP-1 beta activity is calculated by the ability to chemoattract Human blood monocytes at 20-100ng/ml corresponding to a Specific Activity of 10,000-50,000IU/mg.

Amino acid sequence

APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 1b Rat CHM-003,巨噬细胞炎症蛋白 1 β 大鼠重组CHM-003

ProSpec,MIP 1b Rat CHM-003,巨噬细胞炎症蛋白 1 β 大鼠重组CHM-003,CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

MIP 1b Rat
Macrophage Inflammatory Protein-1 beta Rat Recombinant
CHM-003
5µg

20µg

1mg

Catalogue number

CHM-003

Synonyms

C-C motif chemokine 4, Macrophage inflammatory protein 1-beta, MIP-1-beta, Small-inducible cytokine A4, Ccl4, Mip1b, Scya4.

Introduction

Description

MIP-1b Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 69 amino acids and having a molecular mass of 7.8 kDa.
The MIP-1b is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Filtered and lyophilized from a concentrated solution in 30% Acetonitrile and 0.1% TFA.

Solubility

It is recommended to reconstitute the lyophilized Mouse MIP-1b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Biological Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 µg/ml.

Amino acid sequence

APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 3 Human,巨噬细胞炎症蛋白 3 人重组CHM-358

ProSpec,MIP 3 Human,巨噬细胞炎症蛋白 3 人重组CHM-358,CCL23 是 CCR1 趋化因子受体的配体。 CCL23 是聚集在 17 号染色体 q 臂上的几个细胞因子基因之一，位于包含其他几个 CC 趋化因子的基因座中。

MIP 3 Human
Macrophage Inflammatory Protein-3 Human Recombinant
CHM-358
5µg

20µg

1mg

Catalogue number

CHM-358

Synonyms

C-C motif chemokine 23, Small-inducible cytokine A23, Macrophage inflammatory protein 3, Myeloid progenitor inhibitory factor 1, CK-beta-8, MIP-3, MPIF-1, CKB-8, CCL23, MIP3, MPIF1, SCYA23, CKb8, Ckb-8-1.

Introduction

CCL23 is a ligand for the CCR1chemokine receptor. CCL23 is one of several cytokine genes clustered on the q-arm of chromosome 17, in a locus containing several other CC chemokines. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but not activated lymphocytes. Furthermore, it was shown that MIP-3 inhibits colony formation of bone marrow myeloid immature progenitors. MIP-3 is mainly expressed in lung and liver tissue, but can be also found in bone marrow and placenta, as well as in some cell lines of myeloid origin.
Alternative splicing of the CCL23 gene produces 2 mRNAs which encode a short and a long isoform of the MIP-3. CK?8 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 a.a. residue signal peptide which is cleaved to generate a 99 a.a. residue mature CK?8 . Further N-terminal processing of the 99 a.a. residue variant can produce a 75 a.a. residue CK?8 which is considerably more active than the 99 a.a. residue variant.
MIP-3 may be involved in the malignant progression of certain human cancer cells which overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. MIP-3 may also be involved in angiogenesis via upregulation of matrix metalloproteinase MMP-2 expression.

CCL23 是 CCR1 趋化因子受体的配体。 CCL23 是聚集在 17 号染色体 q 臂上的几个细胞因子基因之一，位于包含其他几个 CC 趋化因子的基因座中。 MIP-3 趋化单核细胞、静息 T 淋巴细胞和中性粒细胞，但不吸引活化的淋巴细胞。此外，显示 MIP-3 抑制骨髓髓系未成熟祖细胞的集落形成。 MIP-3 主要在肺和肝组织中表达，但也可见于骨髓和胎盘，以及一些骨髓来源的细胞系。
CCL23 基因的可变剪接产生 2 个 mRNA，它们编码 MIP-3 的短同种型和长同种型。 CK?8 cDNA 编码一个 120 个氨基酸残基的前体蛋白，推定为 21 个氨基酸。残基信号肽被切割产生 99 a.a.残基成熟CK?8。 99 a.a. 的进一步 N 端处理残基变体可产生 75 a.a. CK?8 比 99 a.a. 活性更高。残基变体。
MIP-3 可能参与某些人类癌细胞的恶性进展，这些癌细胞通过 ErbB2 酪氨酸激酶的反式激活过度表达 ErbB2。 MIP-3 也可能通过上调基质金属蛋白酶 MMP-2 的表达而参与血管生成。

Description

MIP-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 99 amino acids and having a molecular mass of 11.3kDa.
The MIP-3 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MIP-3 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 99 个氨基酸，分子量为 11.3kDa。
MIP-3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Filtered and lyophilized from a concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MIP-3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL23 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 MIP-3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL23 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

RVTKDAETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR SIPCSLLESYFETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL DTRIKTRKN.

Biological Activity

Determined by its ability to chemoattract human T cell population using a concentration range of 10-50ng/ml corresponding to a Specific Activity of 20,000-100,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 3a Human,巨噬细胞炎症蛋白 3 α 人重组CHM-351

ProSpec,MIP 3a Human,巨噬细胞炎症蛋白 3 α 人重组CHM-351,CCL-20 是一种趋化因子，它比单核细胞更能吸引淋巴细胞和中性粒细胞。 MIP-3 α 在集落形成试验中抑制骨髓祖细胞的增殖。

MIP 3a Human
Macrophage Inflammatory Protein-3 alpha Human Recombinant
CHM-351
5µg

20µg

1mg

Catalogue number

CHM-351

Synonyms

S Small inducible cytokine A20 precursor, CCL20, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Liver and activation- regulated chemokine, CC chemokine LARC, Beta chemokine exodus-1, CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20.

Introduction

CCL-20 is a chemotactic factor that draws lymphocytes & neutrophils, rathar than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL-20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL-20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria.
MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.

CCL-20 是一种趋化因子，它比单核细胞更能吸引淋巴细胞和中性粒细胞。 MIP-3 α 在集落形成试验中抑制骨髓祖细胞的增殖。 MIP3A 通过将淋巴细胞和树突状细胞吸引到上皮细胞，在黏膜淋巴组织的形成和功能中发挥作用。 C-末端加工形式已被证明对白细胞具有同样的趋化活性。 CCL-20 具有抗菌活性 e.coli atcc 25922 和 s.aureus atcc 29213。CCL-20 基因转录由幽门螺杆菌激活，幽门螺杆菌通过涉及 IkappaB 激酶和 NF-kappaB 诱导激酶的细胞内信号通路激活 NF-kappaB . MIP-3 α 在幽门螺杆菌感染的胃炎症期间参与趋化因子介导的淋巴细胞运输。 CCL-20 表达参与将 CD45R0 阳性 T 细胞亚群募集到肠固有层中。
MIP-3A 负责通过募集 C-C 基序受体 6 表达淋巴细胞来促进牙髓炎症阴道上皮细胞通过分泌 MIP-3 α 对精液中存在的因子作出反应，这增加了 HIV 传播过程中朗格汉斯细胞的募集。

Description

MIP-3 Alpha Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 8 kDa.
The MIP-3a is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MIP-3 Alpha in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-3a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL20 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM.

Biological Activity

Determined by its ability to chemoattract human T lymphocytes using a concentration range of 10.0 -50.0 ng/ml, corresponding to a specific activity of 20,000-100,000units/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-MIP 3a Human His,巨噬细胞炎症蛋白 3 α 人重组CHM-252

ProSpec-MIP 3a Human His,巨噬细胞炎症蛋白 3 α 人重组CHM-252,CCL-20 具有抗菌活性 e.coli atcc 25922 和 s.aureus atcc 29213。CCL-20 基因转录由幽门螺杆菌激活，幽门螺杆菌通过涉及 IkappaB 激酶和 NF-kappaB 诱导激酶的细胞内信号通路激活 NF-kappaB .

MIP 3a Human, His
Macrophage Inflammatory protein-3 alpha Human Recombinant, His Tag
CHM-252
2µg

10µg

1mg

Catalogue number

CHM-252

Synonyms

Introduction

CCL-20 is a chemotactic factor that draws lymphocytes & neutrophils, rathar than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL-20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL-20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria. MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.

CCL-20 是一种趋化因子，它比单核细胞更能吸引淋巴细胞和中性粒细胞。 MIP-3 α 在集落形成试验中抑制骨髓祖细胞的增殖。 MIP3A 通过将淋巴细胞和树突状细胞吸引到上皮细胞，在黏膜淋巴组织的形成和功能中发挥作用。 C-末端加工形式已被证明对白细胞具有同样的趋化活性。 CCL-20 具有抗菌活性 e.coli atcc 25922 和 s.aureus atcc 29213。CCL-20 基因转录由幽门螺杆菌激活，幽门螺杆菌通过涉及 IkappaB 激酶和 NF-kappaB 诱导激酶的细胞内信号通路激活 NF-kappaB . MIP-3 α 在幽门螺杆菌感染的胃炎症期间参与趋化因子介导的淋巴细胞运输。 CCL-20 表达参与将 CD45R0 阳性 T 细胞亚群募集到肠固有层中。 MIP-3A 负责通过募集 C-C 基序受体 6 表达淋巴细胞来促进牙髓炎症阴道上皮细胞通过分泌 MIP-3 α 对精液中存在的因子作出反应，这增加了 HIV 传播过程中朗格汉斯细胞的募集。

Description

MIP 3a Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 91 amino acids and having a molecular mass of 10.3kDa. The MIP 3a is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The MIP 3a solution contains Phosphate Buffered Saline pH7.4 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MASNFDCCLG YTDRILHPKF IVGFTRQLAN EGCDINAIIF HTKKKLSVCA NPKQTWVKYI VRLLSKKVKN M.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 3a Mouse,巨噬细胞炎症蛋白 3 α 小鼠重组CHM-236

ProSpec,MIP 3a Mouse,巨噬细胞炎症蛋白 3 α 小鼠重组CHM-236,MIP-3 α 在幽门螺杆菌感染的胃炎症期间参与趋化因子介导的淋巴细胞运输。 CCL20 表达参与将 CD45R0 阳性 T 细胞亚群募集到肠固有层中。

MIP 3a Mouse
Macrophage Inflammatory Protein-3 alpha Mouse Recombinant
CHM-236
5µg

20µg

1mg

Catalogue number

CHM-236

Synonyms

Small inducible cytokine A20 precursor, CCL20, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Liver and activation- regulated chemokine, CC chemokine LARC, Beta chemokine exodus-1, CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20, C-C motif chemokine 20, CC chemokine ST38, exodus-1.

Introduction

CCL20 is a chemotactic factor that draws lymphocytes & neutrophils, rather than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria.
MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.

CCL20 是一种趋化因子，可吸引淋巴细胞和中性粒细胞，而不是单核细胞。 MIP-3 α 在集落形成试验中抑制骨髓祖细胞的增殖。 MIP3A 通过将淋巴细胞和树突状细胞吸引到上皮细胞，在黏膜淋巴组织的形成和功能中发挥作用。 C-末端加工形式已被证明对白细胞具有同样的趋化活性。 CCL20 具有抗菌活性 e.coli atcc 25922 和 s.aureus atcc 29213。CCL20 基因转录由幽门螺杆菌激活，幽门螺杆菌通过涉及 IkappaB 激酶和 NF-kappaB 诱导激酶的细胞内信号通路激活 NF-kappaB。 MIP-3 α 在幽门螺杆菌感染的胃炎症期间参与趋化因子介导的淋巴细胞运输。 CCL20 表达参与将 CD45R0 阳性 T 细胞亚群募集到肠固有层中。
MIP-3A 负责通过募集 C-C 基序受体 6 表达淋巴细胞来促进牙髓炎症阴道上皮细胞通过分泌 MIP-3 α 对精液中存在的因子作出反应，这增加了 HIV 传播过程中朗格汉斯细胞的募集。

Description

Macrophage Inflammatory Protein-3 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa.
The MIP-3a is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized MIP-3a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-3a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL-20 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

ASNYDCCLSY IQTPLPSRAI VGFTRQMADE ACDINAIIFH TKKRKSVCAD PKQNWVKRAV NLLSLRVKKM.

Biological Activity

The Activity is calculated by its ability to chemoattract primary human T cells at 2-20ng/ml, corresponding to a specific activity of 50,000-500,000 units/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 3b Human CHM-287,巨噬细胞炎症蛋白 3 Beta 人重组CHM-287

ProSpec,MIP 3b Human CHM-287,巨噬细胞炎症蛋白 3 Beta 人重组CHM-287,CCL19 的基因位于人类第 9 号染色体上。该趋化因子通过与趋化因子受体趋化因子受体 CCR7 结合而对其靶细胞产生影响。

MIP 3b Human
Macrophage Inflammatory Protein-3 Beta Human Recombinant
CHM-287
5µg

20µg

1mg

Catalogue number

CHM-287

Synonyms

Small inducible cytokine A19, CCL19, Macrophage inflammatory protein 3 beta, MIP-3- beta, EBI1-ligand chemokine, ELC, Beta chemokine exodus-3, CK beta-11, chemokine ligand 19, CKb11, MIP3B, MIP-3b, SCYA19, MGC34433.

Introduction

Chemokine ligand 19 is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine and macrophage inflammatory protein-3-beta . CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen. The gene for CCL19 is located on human chromosome 9. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells.

趋化因子配体 19 是一种小细胞因子，属于 CC 趋化因子家族，也称为 EBI1 配体趋化因子和巨噬细胞炎症蛋白-3-β。 CCL19 在胸腺和淋巴结中大量表达，在气管和结肠中表达水平适中，在胃、小肠、肺、肾和脾脏中表达水平较低。 CCL19 的基因位于人类第 9 号染色体上。该趋化因子通过与趋化因子受体趋化因子受体 CCR7 结合而对其靶细胞产生影响。它吸引免疫系统的某些细胞，包括树突状细胞和抗原结合的 B 细胞。

Description

Macrophage Inflammatory Protein-3 beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.8kDa.
The MIP-3b is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized without any additives.

Solubility

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-3b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-3b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL19 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS.

Biological Activity

The Activity of CCL19 is calculated by the ability to chemoattract Human T cells using a concentration of 7-40ng/ml corresponding to a Specific Activity of 25,000-143,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 3b Human T7 CHM-374,巨噬细胞炎症蛋白 3 人重组体T7 CHM-374

ProSpec,MIP 3b Human T7 CHM-374,巨噬细胞炎症蛋白 3 人重组体T7 CHM-374,趋化因子配体 19 是一种小细胞因子，属于 CC 趋化因子家族，也称为 EBI1 配体趋化因子和巨噬细胞炎症蛋白-3-β。

MIP 3b Human, T7
Macrophage Inflammatory protein-3 Human Recombinant, T7 Tag
CHM-374
5µg

20µg

1mg

Catalogue number

CHM-374

Synonyms

Introduction

Description

MIP3b Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of 10.4kDa.
MIP3b is fused to a 16 amino acid T7-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MIP3b Human Recombinant 是一条单一的、非糖基化的多肽链，含有 93 个氨基酸，分子量为 10.4kDa。
MIP3b 在 N 末端与 16 个氨基酸的 T7 标签融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

MIP3b protein solution containing Phosphate Buffered Saline pH7.4 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MASMTGGQQM GRGSHMGTND AEDCCLSVTQ KPIPGYIVRN FHYLLIKDGC RVPAVVFTTL RGRQLCAPPD QPWVERIIQR LQRTSAKMKR RSS.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 3b Mouse CHM-341,巨噬细胞炎症蛋白 3 Beta 小鼠重组CHM-341

ProSpec,MIP 3b Mouse CHM-341,巨噬细胞炎症蛋白 3 Beta 小鼠重组CHM-341,CCL19 的基因位于人类第 9 号染色体上。该趋化因子通过与趋化因子受体趋化因子受体 CCR7 结合而对其靶细胞产生影响。

MIP 3b Mouse
Macrophage Inflammatory Protein-3 Beta Mouse Recombinant
CHM-341
5µg

20µg

1mg

Catalogue number

CHM-341

Synonyms

Introduction

Description

Macrophage Inflammatory Protein-3 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9216 Dalton.
The MIP-3b is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CCL19 was lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-3b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的巨噬细胞炎症蛋白-3b 用不低于 100µg/ml 的无菌 18MΩ-cm H2O 复溶，然后可以进一步稀释成其他水溶液。

Stability

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Gly-Ala-Asn-Asp-Ala.

Biological Activity

The Activity is calculated by the ability to chemoattract Human mature dendritic cells using a concentration range of 8-80 ng/ml.

Protein content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 0.91 as the extinction coefficient for a 0.1% solution. This value is calculated by the PC GENE computer analysis program of protein sequences .
2. Analysis by RP-HPLC, using a calibrated solution of MIP-3b as a Reference Standard.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 4 Human CHM-322,巨噬细胞炎症蛋白 4 人重组CHM-322

趋化因子配体 18 是一种小细胞因子，属于 CC 趋化因子家族，以前称为 PARC,ProSpec,MIP 4 Human CHM-322,巨噬细胞炎症蛋白 4 人重组CHM-322

MIP 4 Human
Macrophage Inflammatory Protein-4 Human Recombinant
CHM-322
2µg

10µg

1mg

Catalogue number

CHM-322

Synonyms

Small inducible cytokine A18, CCL18, Macrophage inflammatory protein 4, MIP-4, Pulmonary and activation-regulated chemokine, CC chemokine PARC, Alternative macrophage activation-associated CC chemokine 1, AMAC-1, Dendritic cell chemokine 1, DC-CK1, chemokine ligand 18, CKb7, PARC, AMAC1, DCCK1, SCYA18.

Introduction

Chemokine ligand 18 is a small cytokine belonging to the CC chemokine family that was previously called PARC . MIP-4 is approximately 60% identical in amino acid sequence to CCL3. MIP-4 is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and non activated lymphocytes. The gene for human CCL18 contains three exons and is located on chromosome 17.

趋化因子配体 18 是一种小细胞因子，属于 CC 趋化因子家族，以前称为 PARC。 MIP-4 在氨基酸序列上与 CCL3 的相同性约为 60%。 MIP-4 在肺中以高水平表达，而在某些淋巴组织（例如淋巴结）中表达水平较低，并且对活化的 T 细胞和未活化的淋巴细胞具有趋化性。人类 CCL18 的基因包含三个外显子，位于第 17 号染色体上。

Description

Macrophage Inflammatory Protein-4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7813 Dalton.
The MIP-4 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白 4 人重组体是一种单一的、非糖基化的多肽链，包含 69 个氨基酸，分子量为 7813 道尔顿。
MIP-4 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

MIP-4 protein is lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MIP-4 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIP-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids of MIP-4 was determined and found to be Ala-Gln-Val-Gly-Thr.

Biological Activity

The Activity MIP-4 is calculated by the ability to chemoattract Human T lymphocytes at 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-MIP 4 Human His CHM-339,巨噬细胞炎症蛋白 4 人重组体CHM-339

ProSpec-MIP 4 Human His CHM-339,巨噬细胞炎症蛋白 4 人重组体CHM-339,趋化因子配体 18 是一种小细胞因子，属于 CC 趋化因子家族，以前称为 PARC。 CCL18 在氨基酸序列上与 CCL3 有大约 60% 的相同性。

MIP 4 Human, His
Macrophage Inflammatory protein-4 Human Recombinant, His-Tag
CHM-339
1µg

5µg

50µg

Catalogue number

CHM-339

Synonyms

Introduction

Chemokine ligand 18 is a small cytokine belonging to the CC chemokine family that was previously called PARC . CCL18 is approximately 60% identical in amino acid sequence to CCL3. It is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and non activated lymphocytes. The gene for human CCL18 contains three exons and is located on chromosome 17.

趋化因子配体 18 是一种小细胞因子，属于 CC 趋化因子家族，以前称为 PARC。 CCL18 在氨基酸序列上与 CCL3 有大约 60% 的相同性。它在肺中以高水平表达，而在某些淋巴组织（如淋巴结）中表达水平较低，并且对活化的 T 细胞和未活化的淋巴细胞具有趋化性。人类 CCL18 的基因包含三个外显子，位于第 17 号染色体上。

Description

MIP-4 Human Recombinant fused with a 25 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 93 amino acids and having a molecular mass of 10.4kDa. The MIP-4 is purified by proprietary chromatographic techniques.

MIP-4 Human Recombinant 在 N 末端融合了 25 个氨基酸的 His 标签，在大肠杆菌中产生，是一条含有 93 个氨基酸且分子量为 10.4kDa 的单一非糖基化多肽链。 MIP-4 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The MIP-4 solution contains 10mM Sodium Citrate pH3.5 and 10% Glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMQVGTN KELCCLVYTS WQIPQKFIVD YSETSPQCPK PGVILLTKRG RQICADPNKK WVQKYISDLK LNA.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-MIP 5 (68 a.a) Human CHM-011,巨噬细胞炎症蛋白 5 人重组CHM-011

ProSpec-MIP 5 (68 a.a) Human CHM-011,巨噬细胞炎症蛋白 5 人重组CHM-011,CCL15 cDNA 编码一个预测的 113 个氨基酸的蛋白质，该蛋白质含有一个推定的 21 个氨基酸的信号肽，该信号肽被切割以产生一个 92 个氨基酸残基的成熟蛋白质。

MIP 5 Human
Macrophage Inflammatory Protein-5 Human Recombinant
CHM-011
5µg

25µg

1mg

Catalogue number

CHM-011

Synonyms

Small inducible cytokine A15 precursor, CCL15, Macrophage inflammatory protein 5, MIP-5, MIP5, Chemokine CC-2, HCC-2, NCC-3, MIP- 1 delta, Leukotactin-1, LKN-1, Mrp-2b, C-C motif chemokine 15.

Introduction

CCL15, a new human CC chemokine, was isolated from a human fetal spleen cDNA library. CCL15 cDNA encodes a predicted 113 amino acid protein containing a putative signal peptide of 21 amino acids that is cleaved to generate a 92 aa residue mature protein. Within the CC family members, human CCL15 shares 45%, 44%, 35%, and 30% aa homology with mouse C10, human MPIF-1, human HCC-1, and mouse MIP-1?, respectively. The gene for MIP-5 is found on chromosome 17 where the genes for most of the human CC chemokines are located. Human CCL15 is expressed in T and B lymphocytes, NK cells, monocytes and monocyte-derived dendritic cells. Human MIP-5 is chemotactic for T cells and monocytes and has been shown to induce calcium flux in human CCR-1-transfected cells.

CCL15 是一种新的人类 CC 趋化因子，是从人类胎儿脾脏 cDNA 文库中分离出来的。 CCL15 cDNA 编码一个预测的 113 个氨基酸的蛋白质，该蛋白质含有一个推定的 21 个氨基酸的信号肽，该信号肽被切割以产生一个 92 个氨基酸残基的成熟蛋白质。在 CC 家族成员中，人 CCL15 分别与小鼠 C10、人 MPIF-1、人 HCC-1 和小鼠 MIP-1? 具有 45%、44%、35% 和 30% 的 aa 同源性。 MIP-5 的基因位于 17 号染色体上，大多数人类 CC 趋化因子的基因都位于该处。人 CCL15 在 T 和 B 淋巴细胞、NK 细胞、单核细胞和单核细胞衍生的树突细胞中表达。人 MIP-5 对 T 细胞和单核细胞具有趋化性，并且已显示在人 CCR-1 转染的细胞中诱导钙通量。

Description

Macrophage Inflammatory Protein-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 68 amino acids and having a molecular mass of 7.4kDa. The MIP5 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

MIP5 was lyophilized from a 0.2µm filtered concentrated solution containing PBS, pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized MIP5 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL15 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 MIP-5 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL15 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SFHFAADCCT SYISQSIPCS LMKSYFETSS ECSKPGVIFL TKKGRQVCAK PSGPGVQDCM KKLKPYSI.

Biological Activity

Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED₅₀ for this effect is typically 2-4ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP 5 Human CHM-230,巨噬细胞炎症蛋白 5 人重组CHM-230

ProSpec,MIP 5 Human CHM-230,巨噬细胞炎症蛋白 5 人重组CHM-230,CCL15 cDNA 编码一个预测的 113 个氨基酸的蛋白质，该蛋白质含有一个推定的 21 个氨基酸的信号肽，该信号肽被切割以产生一个 92 个氨基酸残基的成熟蛋白质。

MIP 5 Human
Macrophage Inflammatory Protein-5 Human Recombinant
CHM-230
5µg

25µg

1mg

Catalogue number

CHM-230

Synonyms

Small inducible cytokine A15 precursor, CCL15, Macrophage inflammatory protein 5, MIP-5, MIP5, Chemokine CC-2, HCC-2, NCC-3, MIP- 1 delta, Leukotactin-1, LKN-1, Mrp-2b, C-C motif chemokine 15.

Introduction

Description

Macrophage Inflammatory Protein-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 92 amino acids and having a molecular mass of 10.1 kDa.
The MIP5 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的巨噬细胞炎症蛋白 5 人重组体是一种单一的、非糖基化的多肽链，含有 92 个氨基酸，分子量为 10.1 kDa。
MIP5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

MIP5 was lyophilized from a concentrated solution containing 20mM PBS pH-7.4 and 100mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MIP5 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QFINDAETELMMSKLPLENPVVLNSFHFAADCCTSYISQSIPCSLMKSYFETSSECSKP GVIFLTKKGRQVCAKPSGPGVQDCMKKLKPYSI.

Biological Activity

Determined by its ability to chemoattract human T-lymphocytes using a concentration range of 1-10 ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MIP-1 Gamma Mouse CHM-257,巨噬细胞炎症蛋白-1 γ 小鼠重组CHM-257

ProSpec,MIP-1 Gamma Mouse CHM-257,巨噬细胞炎症蛋白-1 γ 小鼠重组CHM-257,在大肠杆菌中产生的 MIP-1 gamma Mouse Recombinant 是一种单一的、非糖基化的多肽链，含有 101 个氨基酸，分子量为 11.6 kDa。 MIP-1 gamma 采用专有色谱技术进行纯化。

MIP-1 Gamma Mouse
Macrophage Inflammatory Protein-1 Gamma Mouse Recombinant
CHM-257
5µg

20µg

1mg

Catalogue number

CHM-257

Synonyms

CCL9/10, MRP2, CCF18.

Introduction

Mouse MIP-1 gamma is 75% identical in its amino acid compostion as compared to the rat specie. MIP-1 gamma is a CC chemokine localized in murine blood and a widespread range of murine tissues, without having an identified human homolog. MIP-1 gamma signals through the CCR1 receptor. MIP-1 gamma chemoattracts neutrophils and also inhibits colony formation of bone marrow myeloid immature progenitors. MIP-1 gamma has six cysteines including the four highly conserved cysteine residues present in CC chemokines.

与大鼠相比，小鼠 MIP-1 γ 的氨基酸组成有 75% 相同。 MIP-1 γ 是一种 CC 趋化因子，位于鼠血和广泛的鼠组织中，但没有确定的人类同源物。 MIP-1 伽马信号通过 CCR1 受体。 MIP-1 γ 趋化嗜中性粒细胞并且还抑制骨髓髓系未成熟祖细胞的集落形成。 MIP-1 γ 具有六个半胱氨酸，包括存在于 CC 趋化因子中的四个高度保守的半胱氨酸残基。

Description

MIP-1 gamma Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 101 amino acids and having a molecular mass of 11.6 kDa. The MIP-1 gamma is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MIP-1 gamma Mouse Recombinant 是一种单一的、非糖基化的多肽链，含有 101 个氨基酸，分子量为 11.6 kDa。 MIP-1 gamma 采用专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The MIP-1 gamma was lyophilized from 1xPBS solution pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized MIP-1 gamma in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-1 gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL9/10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Biological Activity

Defined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10 ng/ml, corresponding to a Specific Activity of 10,000-100,000IU/mg.

Amino acid sequence

QITHATETKE VQSSLKAQQG LEIEMFHMGF QDSSDCCLSY NSRIQCSRFI GYFPTSGGCT RPGIIFISKR GFQVCANPSD RRVQRCIERL EQNSQPRTYK Q.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-NAP 2 95 a.a. Human,中性粒细胞活化蛋白 2 人重组体CHM-277

ProSpec-NAP 2 95 a.a. Human,中性粒细胞活化蛋白 2 人重组体CHM-277,趋化因子配体是属于 CXC 趋化因子家族的小细胞因子。它是一种在血小板活化后从血小板中大量释放的蛋白质。

NAP 2 95 a.a. Human
Neutrophil Activating Protein-2 Human Recombinant, 95 a.a.
CHM-277
2µg

10µg

1mg
Catalogue number

CHM-277

Synonyms

Platelet basic protein, PBP, Small inducible cytokine B7, CXCL7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, pro-platelet basic protein ligand 7), TC1, TC2, TGB, TGB1, B-TG1, CTAP3, NAP-2, SCYB7, THBGB, LA-PF4, THBGB1, Beta-TG, CTAPIII, CTAP-III.

Introduction

Chemokine ligand is a small cytokine belonging to the CXC chemokine family. It is a protein that is released in large amounts from platelets following their activation. It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.

趋化因子配体是属于 CXC 趋化因子家族的小细胞因子。它是一种在血小板活化后从血小板中大量释放的蛋白质。它刺激各种过程，包括有丝分裂、细胞外基质的合成、葡萄糖代谢和纤溶酶原激活剂的合成。

Description

NAP 2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 95 amino acids and having a molecular mass of 10.3 kDa.
The NAP 2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

NAP 2 is supplied as a sterile filtered clear solution.

Formulation

NAP 2 protein 1mg/ml is supplied in 20mM Tris-HCL, pH-7.5, 1mM DTT and 10% Glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MSSTKGQTKR NLAKGKEESL DSDLYAELRC MCIKTTSGIH PKNIQSLEVI GKGTHCNQVE VIATLKDGRK ICLDPDAPRI KKIVQKKLAG DESAD

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,NAP 2 Human CHM-274,中性粒细胞活化蛋白 2 人重组体CHM-274

ProSpec,NAP 2 Human CHM-274,中性粒细胞活化蛋白 2 人重组体CHM-274,Neutrophil Activating Protein-2 Human Recombinant 在大肠杆菌中产生，是一种非糖基化的多肽链，含有 70 个氨基酸，分子量为 7609 道尔顿。

NAP 2 Human
Neutrophil Activating Protein-2 Human Recombinant
CHM-274
2µg

10µg

1mg
Catalogue number

CHM-274

Synonyms

Introduction

Description

Neutrophil Activating Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 70 amino acids and having a molecular mass of 7609 Dalton.
The NAP-2 is purified by proprietary chromatographic techniques.

Neutrophil Activating Protein-2 Human Recombinant 在大肠杆菌中产生，是一种非糖基化的多肽链，含有 70 个氨基酸，分子量为 7609 道尔顿。
NAP-2 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CXCL7 protein was lyophilized from a concentrated sterile solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Neutrophil Activating Protein-2in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized NAP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL7should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Glu-Leu-Arg-Cys.

Biological Activity

The specific activity as determined by the ability of NAP2 to chemoattract human neurotrophils using a concentration of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,NAP 2 Rat CHM-269,中性粒细胞活化蛋白 2 大鼠重组CHM-269

ProSpec,NAP 2 Rat CHM-269,中性粒细胞活化蛋白 2 大鼠重组CHM-269,ProSpec,NAP 2 Rat CHM-269,中性粒细胞活化蛋白 2 大鼠重组CHM-269

Description

Catalogue number

CHM-269

Synonyms

Introduction

Description

NAP-2 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 62 amino acids and having a molecular mass of 6.8kDa.
The NAP 2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

NAP-2 protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized NAP-2 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized NAP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 NAP-2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重构后，CXCL7 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

IELRCRCTNT LSGIPLNSIS RVNVFRPGAH CDNVEVIATL KNGKEVCLDP TAPMIKKIVK KI.

Biological Activity

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED₅₀ for this effect is less than 10ng/ml, corresponding to a specific activity of 100,000units/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CXCL4 Variant 1 Human,血小板因子 4 变体 1 人类重组CHM-243

ProSpec,CXCL4 Variant 1 Human,血小板因子 4 变体 1 人类重组CHM-243,血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血。

CXCL4 Variant 1 Human
Platelet Factor-4 Variant 1 Human Recombinant
CHM-243
1µg

5µg

50µg

Catalogue number

CHM-243

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets . Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血。作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化素家族的成员。人 PF4 用于证明诱导的血小板减少症。此外，它还用作肿瘤治疗期间血管生成的抑制剂。

Description

CXCL4 Variant-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa.
The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus and purified by standard chromatography techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered white lyophilized powder.

Formulation

The protein was lyophilized without additives.

Solubility

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MHHHHHHEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.

ProSpec,PF 4 Human,血小板因子 4 人重组CHM-350

ProSpec,PF 4 Human,血小板因子 4 人重组CHM-350,血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血。

PF 4 Human
Platelet Factor-4 Human Recombinant
CHM-350
5µg

20µg

1mg

Catalogue number

CHM-350

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets. Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血。作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。此外，它还用作肿瘤治疗期间血管生成的抑制剂。

Description

CXCL4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 70 amino acids and having a molecular mass of 7.8 kDa.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered white lyophilized powder.

Formulation

The CXCL4 protein was filtered and lyophilized from a concentrated solution containing 20mM PB and 1.5M NaCl, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 CXCL4 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CXCL4 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY

Biological Activity

The biological activity determined by a chemotaxis bioassay using human fibroblasts is in a concentration of 1.0-10 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.

ProSpec,PF 4 Mouse CHM-245,血小板因子 4 小鼠重组CHM-245

ProSpec,PF 4 Mouse CHM-245,血小板因子 4 小鼠重组CHM-245,冻干的 CXCL4 小鼠重组体虽然在室温下稳定 3 周，但应在 -18°C 以下干燥储存。重组后，小鼠 CXCL4 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

PF 4 Mouse
Platelet Factor-4 Mouse Recombinant
CHM-245
5µg

20µg

1mg

Catalogue number

CHM-245

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets. Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily.

血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部活性并促进凝血。作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化素家族的成员。

Description

CXCL4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.2kDa.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered white lyophilized powder.

Formulation

The Mouse CXCL4 protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4 and 1.5M NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL4 Mouse Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CXCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 CXCL4 小鼠重组体虽然在室温下稳定 3 周，但应在 -18°C 以下干燥储存。重组后，小鼠 CXCL4 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES.

Biological Activity

Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-PF 4 Protein,人类血小板因子4 CHM-234

PF 4 Protein
Platelet Factor-4 Human
CHM-234
5µg

20µg

1mg

Catalogue number

CHM-234

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，它从活化的血小板的 α 颗粒中释放出来，并以高亲和力与肝素结合。它的主要生理作用似乎是中和血管内皮表面的肝素样分子，从而抑制局部抗凝血酶 III 活性并促进凝血。作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。人 PF4 用于证明肝素诱导的血小板减少症。此外，它还用作肿瘤治疗期间血管生成的抑制剂。

Description

Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.

Source

Human Platelets.

Physical Appearance

Sterile Filtered white lyophilized powder.

Formulation

The CXCL4 protein was lyophilized in PBS buffer pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.

Activity Control

Binding of HIT-antibodies.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,PF4 Bovine,血小板因子 4 牛重组CHM-039

ProSpec,PF4 Bovine,血小板因子 4 牛重组CHM-039,作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。

Description

Catalogue number

CHM-039

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets.PF4’s major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Furthermore, it is used as an inhibitor in the angiogenesis during tumor therapy.

血小板因子 4 是一种 70 个氨基酸的蛋白质，从活化的血小板的 α 颗粒中释放出来。PF4 的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血 . 作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。此外，它还用作肿瘤治疗期间血管生成的抑制剂。

Description

Platelet Factor-4 Bovine Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 88 amino acid and having a molecular mass of approximately 9.5kDa.
PF4 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0.

Solubility

It is recommended to reconstitute the lyophilized Platelet Factor-4 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Platelet Factor-4 should be stored at 4°C between 2-7 days and for future use below -18°C.

Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH CPSPQLLATK KTGRKICLDQ QRPLYKKILK KLLDGDES.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human neutrophils is 10-100ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-PF4 Human His CHM-015,血小板因子 4 人重组CHM-015

ProSpec-PF4 Human His CHM-015,血小板因子 4 人重组CHM-015,Oncostatin-A 是 CXC 趋化因子家族的成员。人 PF4 用于证明肝素诱导的血小板减少症。此外，它还用作肿瘤治疗期间血管生成的抑制剂。

PF4 Human, His
Platelet Factor-4 Human Recombinant , His Tag
CHM-015
2µg

10µg

100µg

Catalogue number

CHM-015

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Description

PF4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 91 amino acids and having a molecular mass of 10kDa.
PF4 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless clear solution.

Formulation

PF4 protein solution contains 20mM Tris-HCl buffer , 0.2M NaCl, 50% glycerol and 2mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
请避免冻融循环。

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MEAEEDGDLQ CLCVKTTSQV RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQAPL YKKIIKKLLE S.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,PF4V1 Human,血小板因子 4 变体 1 人类重组CHM-027

ProSpec,PF4V1 Human,血小板因子 4 变体 1 人类重组CHM-027,在大肠杆菌中产生的 PF4V1 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 97 个氨基酸，分子量为 10.6kDa。

PF4V1 Human
Platelet Factor 4 Variant 1 Human Recombinant
CHM-027
2µg

10µg

1mg

Catalogue number

CHM-027

Synonyms

PF4V1, Platelet Factor 4 Variant 1, CXCL4L1, CXCL4V1, PF4alt, PF4var1, SCYB4V1, PF4-ALT, PF4A, C-X-C Motif Chemokine 4, Platelet Factor 4 Variant, Platelet Factor 4, Variant 1 , C-X-C Motif Chemokine 4 Variant.

Introduction

Platelet Factor 4 Variant 1 is a member of the intercrine alpha family. PF4V1 is an inhibitor of angiogenesis and inhibitor of endothelial cell chemotaxis .

Description

PF4V1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids and having a molecular mass of 10.6kDa.
PF4V1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 PF4V1 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 97 个氨基酸，分子量为 10.6kDa。
PF4V1 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless clear solution.

Formulation

PF4V1 protein solution contains 20mM Tris-HCl buffer , 0.2M NaCl, 50% glycerol and 1mM DTT.

Stability

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
请避免冻融循环。

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSFARAEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,Rantes Human,Rantes人类重组CHM-328

在 T 细胞释放的特定细胞因子的帮助下，RANTES 还诱导某些自然杀伤细胞的增殖和活化，形成 CHAK 细胞。 Rantes 也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。 Rantes 趋化因子已定位于人类的 17 号染色体。ProSpec,Rantes Human,Rantes人类重组CHM-328

Rantes Human
Rantes Human Recombinant
CHM-328
5µg

20µg

1mg

Catalogue number

CHM-328

Synonyms

Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.

Introduction

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. Rantes has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer cells to form CHAK cells. Rantes is also an HIV-suppressive factor released from CD8+ T cells. The Rantes chemokine has been localized to chromosome 17 in humans.

受激活、正常 T 细胞表达和分泌或 RANTES 的调节是一种 8 kDa 蛋白质，归类为趋化细胞因子或趋化因子。 Rantes 最近更名为 CCL5。 RANTES 对 T 细胞、嗜酸性粒细胞和嗜碱性粒细胞具有趋化作用，并在将白细胞募集到炎症部位方面发挥积极作用。在 T 细胞释放的特定细胞因子的帮助下，RANTES 还诱导某些自然杀伤细胞的增殖和活化，形成 CHAK 细胞。 Rantes 也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。 Rantes 趋化因子已定位于人类的 17 号染色体。

Description

Rantes Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7809.2 Dalton.
The Rantes is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Rantes Human Recombinant 是一种单一的非糖基化多肽链，含有 68 个氨基酸，分子量为 7809.2 道尔顿。
Rantes 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 50mM NaAc, pH 5.0, 100mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rantes should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS.

Biological Activity

The Rantes activity is determined by the chemoattract of human blood monocytes at a concentration between 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-Rantes Human His,Rantes人类重组CHM-361

ProSpec-Rantes Human His,Rantes人类重组CHM-361,在大肠杆菌中产生的 Rantes Human Recombinant 是单一的、非糖基化的多肽链，包含 68 个氨基酸片段，总分子量为 17.5kDa，并与 4.5kDa 的氨基末端六组氨酸标签融合。

Rantes Human, His
Rantes Human Recombinant , His Tag
CHM-361
2µg

10µg

1mg

Catalogue number

CHM-361

Synonyms

Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.

Introduction

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer cells to form CHAK cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.

受激活、正常 T 细胞表达和分泌或 RANTES 的调节是一种 8 kDa 蛋白质，归类为趋化细胞因子或趋化因子。它最近已更名为 CCL5。 RANTES 对 T 细胞、嗜酸性粒细胞和嗜碱性粒细胞具有趋化作用，并在将白细胞募集到炎症部位方面发挥积极作用。在 T 细胞释放的特定细胞因子的帮助下，RANTES 还诱导某些自然杀伤细胞的增殖和活化，形成 CHAK 细胞。它也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。这种趋化因子已定位于人类的第 17 号染色体。

Description

Rantes Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 68 amino acids fragment having a total molecular mass of 17.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag.
The Rantes His is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Rantes Human Recombinant 是单一的、非糖基化的多肽链，包含 68 个氨基酸片段，总分子量为 17.5kDa，并与 4.5kDa 的氨基末端六组氨酸标签融合。
Rantes His 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

Rantes His-Tag protein is supplied in 1x PBS and 50% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,Rantes Mouse CHM-342,Rantes 小鼠重组CHM-342

ProSpec,Rantes Mouse CHM-342,Rantes 小鼠重组CHM-342,在 T 细胞释放的特定细胞因子的帮助下，RANTES 还诱导某些自然杀伤细胞的增殖和活化，形成 CHAK 细胞。它也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。

Rantes Mouse
Rantes Mouse Recombinant
CHM-342
5µg

20µg

1mg

Catalogue number

CHM-342

Synonyms

Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.

Introduction

Description

Rantes Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton.

The Mouse Rantes is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Rantes Mouse Recombinant 是一个单一的、非糖基化的多肽链，含有 68 个氨基酸，分子量为 7876 道尔顿。

Mouse Rantes 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Mouse Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 Mouse Rantes 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重组后，小鼠 CCL5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS.

Biological Activity

The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,Rantes Rat,Rantes 大鼠重组CHM-352

ProSpec,Rantes Rat,Rantes 大鼠重组CHM-352,冻干的大鼠 Rantes 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重组后，大鼠 CCL5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

Rantes Rat
Rantes Rat Recombinant
CHM-352
5µg

20µg

1mg

Catalogue number

CHM-352

Synonyms

Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.

Introduction

Description

Rantes Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton.
The Rat Rantes is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Rat Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rat CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的大鼠 Rantes 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重组后，大鼠 CCL5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS.

Biological Activity

The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

MCP1 Human, HEK

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Stability

Purity

Biological Activity

Amino acid sequence

Usage

Related Products

MCP1 Rat, Sf9

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Stability

Purity

Amino acid sequence

Usage

Related Products

MDC Human

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Solubility

Stability

Biological Activity

Purity

Amino acid sequence

Usage

Related Products

MDC Human, His

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Stability

Purity

Amino acid sequence

Usage

Related Products

MDC Mouse

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Solubility

Stability

Biological Activity

Purity

Amino acid sequence

Usage

Related Products

MDC Rat

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Solubility

Stability