ProSpec-GRO g Mouse,GRO-伽玛小鼠重组CHM-255

ProSpec-GRO g Mouse,GRO-伽玛小鼠重组CHM-255,CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

GRO g Mouse
GRO-Gamma Mouse Recombinant
CHM-255
2µg

10µg

1mg

Catalogue number

CHM-255

Synonyms

C-X-C motif chemokine 3, Dendritic cell inflammatory protein 1, Cxcl3, Dcip1, Gm1960.

Introduction

趋化因子配体 3 是属于 CXC 趋化因子家族的小细胞因子，也称为 GRO3 癌基因、GRO 蛋白 γ 和巨噬细胞炎症蛋白-2-β。 CXCL3 控制单核细胞的迁移和粘附，并通过与称为 CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

Description

GRO-g Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7.7kDa.
The CXCL3 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The Mouse CXCL3 lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized GRO-gamma in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 GRO-γ 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重构后，CXCL3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SELRCQCLNT LPRVDFETIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QGPRLQIIIK KILKSGKSS.

Biological Activity

Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml, corresponding to a specific activity of 10,000-100,000 units/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO g Mouse His CHM-283,CXCL3 控制单核细胞的迁移和粘附

ProSpec-GRO g Mouse His CHM-283,CXCL3 控制单核细胞的迁移和粘附，并通过与称为 CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

GRO g Mouse, His
GRO-Gamma Mouse Recombinant , His Tag
CHM-283
2µg

10µg

1mg

Catalogue number

CHM-283

Synonyms

C-X-C motif chemokine 3, Dendritic cell inflammatory protein 1, Cxcl3, Dcip1, Gm1960, GRO-g.

Introduction

Description

GRO-g Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 98 amino acids and having a molecular mass of 10.6kDa.
CXCL3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

GRO-gamma protein solution containing 20mM Tris-HCl buffer , 50% glycerol, 0.15M NaCl and 5mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAVVAS ELRCQCLNTL PRVDFETIQS LTVTPPGPHC TQTEVIATLK DGQEVCLNPQ GPRLQIIIKK ILKSGKSS.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO g/CINC-2a Rat,GRO-γ大鼠重组体,CINC-2α CHM-258

ProSpec-GRO g/CINC-2a Rat,GRO-γ大鼠重组体,CINC-2α CHM-258,CXCL3 控制单核细胞的迁移和粘附，并通过与称为 CXCR2 的细胞表面趋化因子受体相互作用介导其对靶细胞的影响。 CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

GRO g/CINC-2a Rat
GRO-Gamma Rat Recombinant , CINC-2 alpha
CHM-258
2µg

10µg

1mg

Catalogue number

CHM-258

Synonyms

Cytokine-induced neutrophil chemoattractant 2, CINC2, CINC-2, Macrophage inflammatory protein 2-alpha.

Introduction

Chemokine ligand 3 is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene , GRO protein gamma and macrophage inflammatory protein-2-beta . CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.

Description

GRO-g Rat Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7.8kDa. The CXCL3 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The Rat CXCL3 lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized GRO-gamma in sterile 18Mcm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL3 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSDKSS.

Biological Activity

Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml, corresponding to a specific activity of 10,000-100,000 units/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO1/KC Mouse,GRO1/KC 小鼠重组 CHM-335

CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。ProSpec-GRO1/KC Mouse,GRO1/KC 小鼠重组 CHM-335

GRO1/KC Mouse
GRO1/KC Mouse Recombinant
CHM-335
5µg

20µg

1mg

Catalogue number

CHM-335

Synonyms

Growth-regulated alpha protein, CXCL1, Platelet-derived growth factor-inducible protein KC, Secretory protein N51, KC, Fsp, N51, gro, Gro1, Mgsa, Scyb1, chemokine ligand 1.

Introduction

趋化因子配体 1 是一种小细胞因子，属于 CXC 趋化因子家族，以前称为 GRO1 致癌基因、中性粒细胞激活蛋白 3 和黑色素瘤生长刺激活性α。它由人类黑色素瘤细胞分泌，具有促有丝分裂特性，并与黑色素瘤发病机制有关。 CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达，具有中性粒细胞趋化活性。 CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用，并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。 CXCL1 基因位于人类第 4 号染色体上，位于其他 CXC 趋化因子基因中。

Description

KC Mouse Recombinant 也称为 N51 和 GRO-1，在大肠杆菌中产生，是一种单一的、非糖基化的多肽链，包含 72 个氨基酸，分子量约为 7.8 kDa。

GRO-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein solution was lyophilized from 20mM phosphate buffer pH-7.4 and 0.1M NaCl.

Solubility

It is recommended to reconstitute the lyophilized GRO1 Recombinant in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 KC 小鼠虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重组后，CXCL1 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK.

Biological Activity

The biological activity was determined by measuring the ability to chemoattrat human neutrophilsat a concentration of 10ng/ml-100ng/ml.

Protein content

蛋白质定量通过两种独立的方法进行：
1. 280 nm 的紫外光谱，使用 0.03 的吸光度值作为 0.1% 溶液的消光系数。该值是由 PC GENE 计算机蛋白质序列分析程序计算得出的。
2. RP-HPLC 分析，使用 KC 标准溶液作为参考标准。

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO1/KC Mouse His CHM-002

ProSpec-GRO1/KC Mouse His CHM-002,这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。 CXCL1 基因位于人类第 4 号染色体上，位于其他 CXC 趋化因子基因中。

GRO1/KC Mouse, His
GRO/KC Mouse Recombinant, His Tag
CHM-002
5µg

20µg

1mg

Catalogue number

CHM-002

Synonyms

Growth-regulated alpha protein, CXCL1, Platelet-derived growth factor-inducible protein KC, Secretory protein N51, KC, Fsp, N51, gro, Gro1, Mgsa, Scyb1, chemokine ligand 1.

Introduction

Description

GRO1/KC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids and having a molecular mass of 10.5kDa.
GRO1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

GRO1 protein solution containing 20mM Tris-HCl buffer , 10% glycerol and 0.1M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAPIAN ELRCQCLQTM AGIHLKNIQS LKVLPSGPHC TQTEVIATLK NGREACLDPE APLVQKIVQK MLKGVPK.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-GRO-g/CINC-2b Rat,GRO-gamma CINC-2 beta 大鼠重组CHM-273

ProSpec-GRO-g/CINC-2b Rat,GRO-gamma CINC-2 beta 大鼠重组CHM-273,CXCL3 基因位于其他 CXC 趋化因子簇中的 4 号染色体上。

GRO-g/CINC-2b Rat
GRO-gamma, CINC-2 beta Rat Recombinant
CHM-273
2µg

10µg

1mg

Catalogue number

CHM-273

Synonyms

Macrophage inflammatory protein 2-beta, MIP2-beta, CXCL3, Growth-regulated protein gamma, GRO-gamma, GRO-gamma , GRO3, GROg, MIP2B, SCYB3, MIP-2b, CINC-2b, MGSA gamma.

Introduction

Description

GRO-g Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 68 amino acids and having a total molecular mass of 7.8kDa.
GRO-g is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized GRO-g in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GRO-g although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GRO-g should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 GRO-g 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，GRO-g 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSPSL.

Biological Activity

Determined by its ability to chemoattract human CXCR2 transfected 293 cells using a concentration range of 10-100ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-MIP2 Viral,MIP-2病毒重组 CHM-376

ProSpec-MIP2 Viral,MIP-2病毒重组 CHM-376,病毒 MIP-2 与 CCR3 趋化因子受体结合，趋化因子和其他 β 趋化因子通过该受体激活嗜酸性粒细胞。病毒 MIP-2 激活和化学吸引人类嗜酸性粒细胞。

MIP2 Viral
MIP-2 Viral Recombinant
CHM-376
10µg

50µg

1mg

Catalogue number

CHM-376

Synonyms

MIP-2 Viral, Viral MIP-2, MIP2 Viral, Viral MIP2, Viral Macrophage inflammatory Protein-2.

Introduction

Viral MIP-2 is closely related to MIP-1α, show amino acid sequence similarity of about 41%. At the amino acid sequence level, Viral MIP-1 and Viral MIP-2 share 48% similarity. Viral MIP-1 and Viral MIP-2 are more closely linked to one another phylogenetically than to other human chemokines, signifying that they have gene duplication within the virus rather than by two independent gene aquisitions. Viral MIP-2 binds to the CCR3 chemokine receptor through which eotaxin and other β chemokines activate eosinophils. Viral MIP-2 activates and chemoattract human eosinphils.

病毒MIP-2与MIP-1α密切相关，显示氨基酸序列相似性约为41%。在氨基酸序列水平上，病毒 MIP-1 和病毒 MIP-2 具有 48% 的相似性。病毒 MIP-1 和病毒 MIP-2 在系统发育上比与其他人类趋化因子更密切相关，这表明它们在病毒内具有基因复制，而不是通过两个独立的基因获取。病毒 MIP-2 与 CCR3 趋化因子受体结合，趋化因子和其他 β 趋化因子通过该受体激活嗜酸性粒细胞。病毒 MIP-2 激活和化学吸引人类嗜酸性粒细胞。

Description

MIP-2 Viral Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa.
The MIP-2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from 1mg/ml solution containing 20mM Phospahte Buffer, pH 7.4 % 0.15M NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL2 Viral in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MIP-2 Viral protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 MIP-2 病毒蛋白虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CXCL2 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by RP-HPLC & -PAGE.

Amino acid sequence

LGASWHRPDK CCLGYQKRPL PQVLLSSWYP TSQLCSKPGV IFLTKRGRQV
CADKSKDWVK KLMQQLPVTA.

Biological Activity

Determined by the inhibitory effect on monocyte migration response to human MIP1A using a concentration range of 1µg-10µg/ml of viral MIP2 which will inhibit 25ng/ml of human MIP1A.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-HCC 1 Human,HCC-1人重组CHM-311

ProSpec-HCC 1 Human,HCC-1人重组CHM-311,CCL13 激活单核细胞，但不诱导其趋化性。人类 CCL13 位于属于 CC 家族的其他趋化因子簇内的 17 号染色体上。

HCC 1 Human
HCC-1 Human Recombinant
CHM-311
2µg

10µg

1mg

Catalogue number

CHM-311

Synonyms

Small inducible cytokine A14, CCL14, Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1, NCC-2, chemokine ligand 14, CC-1, CC-3, CKb1, MCIF, SY14, HCC-1, HCC-3, SCYL2, SCYA14.

Introduction

Chemokine ligand 14 is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is procesed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut. CCL13 activates monocytes, but does not induce their chemotaxis. Human CCL13 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.

趋化因子配体 14 是一种属于 CC 趋化因子家族的小细胞因子。它也通常称为HCC-1。它是作为一种蛋白质前体产生的，经过加工产生一种成熟的活性蛋白质，该蛋白质含有 74 个氨基酸，其氨基酸组成与 CCL3 和 CCL4 有 46% 的相同性。这种趋化因子在各种组织中表达，包括脾脏、骨髓、肝脏、肌肉和肠道。 CCL13 激活单核细胞，但不诱导其趋化性。人类 CCL13 位于属于 CC 家族的其他趋化因子簇内的 17 号染色体上。

Description

HCC-1 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 8411 Dalton.
The HCC-1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 HCC-1 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 72 个氨基酸，分子量为 8411 道尔顿。
HCC-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CCL14 protein was lyophilized with 20mM PBS pH-7.4 and 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized HCC-1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized HCC1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

TESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHS
VCTNPSDKWVQDYIKDMKEN.

Biological Activity

The Biological activity is calculated by its ability to chemoattract Human monocytes at 5-20ng/ml corresponding to a Specific Activity of 50,000-200,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-HCC 1 Human (66 a.a.) CHM-006,HCC-1人重组

人类 CCL13 位于属于 CC 家族的其他趋化因子簇内的 17 号染色体上。ProSpec-HCC 1 Human (66 a.a.) CHM-006,HCC-1人重组

HCC 1 Human
HCC-1 Human Recombinant
CHM-006
2µg

10µg

1mg

Catalogue number

CHM-006

Synonyms

Small inducible cytokine A14, CCL14, Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1, NCC-2, chemokine ligand 14, CC-1, CC-3, CKb1, MCIF, SY14, HCC-1, HCC-3, SCYL2, SCYA14.

Introduction

Description

HCC-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 66 amino acids and having a molecular mass of 7.8kDa.
The HCC-1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 HCC-1 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 66 个氨基酸，分子量为 7.8kDa。
HCC-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CCL14 protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4 and 5% trehalose.

Solubility

It is recommended to reconstitute the lyophilized HCC-1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 HCC1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL14 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPYHPSECCF TYTTYKIPRQ RIMDYYETNS QCSKPGIVFI TKRGHSVCTN PSDKWVQDYI KDMKEN.

Biological Activity

The Biological activity is determined by its ability to chemoattract human monocytes using a concentration range of 5.0-20.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-HCC 1 Human His,CHM-253

ProSpec-HCC 1 Human His,CHM-253,它也通常称为HCC-1。它是作为一种蛋白质前体产生的，经过加工产生一种成熟的活性蛋白质，该蛋白质含有 74 个氨基酸，其氨基酸组成与 CCL3 和 CCL4 有 46% 的相同性。

HCC 1 Human, His
HCC-1 Human Recombinant, His Tag
CHM-253
2µg

10µg

1mg

Catalogue number

CHM-253

Synonyms

Small inducible cytokine A14, CCL14, Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1, NCC-2, chemokine ligand 14, CC-1, CC-3, CKb1, MCIF, SY14, HCC-1, HCC-3, SCYL2, SCYA14.

Introduction

Description

HCC-1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 95 amino acids and having a molecular mass of 10.9kDa. The HCC-1 is purified by proprietary chromatographic techniques.

HCC-1 Human Recombinant 在 N 末端融合了 21 个氨基酸的 His 标签，在大肠杆菌中产生，是一条含有 95 个氨基酸且分子量为 10.9kDa 的单一非糖基化多肽链。 HCC-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The HCC-1 solution contains Phosphate Buffered Saline pH7.4 containing 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MTKTESSSRG PYHPSECCFT YTTYKIPRQR IMDYYETNSQ CSKPGIVFIT KRGHSVCTNP SDKWVQDYIK DMKEN.

Usage

ProSpec 的产品仅供实验室研究使用。该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-I 309 Human CHM-312,I-309 人类重组

ProSpec-I 309 Human CHM-312,I-309 人类重组,在大肠杆菌中产生的 I-309 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 74 个氨基酸，分子量为 8504 道尔顿。

Catalogue number

CHM-312

Synonyms

Small inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine ligand 1, P500, SISe, TCA3, I-309, SCYA1.

Introduction

Chemokine ligand 1 is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.

趋化因子配体 1 是一种由活化的 T 细胞分泌的小糖蛋白，属于称为趋化因子的炎性细胞因子家族。 CCL1 通过与称为 CCR8 的细胞表面趋化因子受体相互作用来吸引单核细胞、NK 细胞、未成熟 B 细胞和树突状细胞。这种趋化因子存在于人类 17 号染色体上的一大群 CC 趋化因子中。

Description

I-309 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8504 Dalton.
The I-309 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 I-309 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 74 个氨基酸，分子量为 8504 道尔顿。
I-309 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CCL1 protein was lyophilized with no additives.

Solubility

It is recommended to reconstitute the lyophilized I-309 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized I-309 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 99.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Ser-Met-Gln.

Biological Activity

The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-I 309 Human His CHM-254

Catalogue number

CHM-254

Synonyms

Small inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine ligand 1, P500, SISe, TCA3, I-309, SCYA1.

Introduction

Description

I-309 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids and having a molecular mass of 10.8kDa. The I-309 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The I-309 solution contains 20mM Tris-HCl buffer , 2mM DTT, 10% glycerol and 50mM NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL 8 Canine,白细胞介素8犬重组CHM-009

IL-8 就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也称为中性粒细胞趋化因子。ProSpec,IL 8 Canine,白细胞介素8犬重组CHM-009

IL 8 Canine
Interleukin-8 Canine Recombinant
CHM-009
5µg

20µg

1mg

Catalogue number

CHM-009

Synonyms

Interleukin-8, IL-8, C-X-C motif chemokine 8, IL8, CXCL8.

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies.When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。它也由内皮细胞合成，内皮细胞将 IL-8 储存在它们的储存囊泡 Weibel-Palade 体中。当第一次遇到抗原时，遇到它的原代细胞是吞噬颗粒的巨噬细胞。在处理后，它们会释放趋化因子以向其他免疫细胞发出信号，使其进入炎症部位。 IL-8 就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也称为中性粒细胞趋化因子。

Description

Interleukin-8 Canine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.
The IL8 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized IL-8 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IL-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 IL-8 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，IL8 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

AVLSRVSSEL RCQCIKTHST PFHPKYIKEL RVIDSGPHCE NSEIIVKLFN GNEVCLDPKE KWVQKVVQIF LKKAEKQDP.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected murine BaF3 cells is in a concentration range of 0.15-0.75 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL 8 Human (1-72),白细胞介素 8 人重组CHM-231

ProSpec,IL 8 Human (1-72),白细胞介素 8 人重组CHM-231,当第一次遇到抗原时，遇到它的原代细胞是吞噬颗粒的巨噬细胞。在处理后，它们会释放趋化因子以向其他免疫细胞发出信号，使其进入炎症部位。 IL-8 就是这样一种趋化因子。

IL 8 Human
Interleukin-8 Human Recombinant
CHM-231
5µg

25µg

1mg

Catalogue number

CHM-231

Synonyms

IL-8, CXCL8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil-activating peptide, MONAP, Emoctakin, K60, NAF, LECT, LUCT, 3-10C, LYNAP, SCYB8, TSG-1, AMCF-I, b-ENAP.

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Description

Interleukin-8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8452 Dalton.
The IL-8 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的白细胞介素 8 人重组体是一种单一的、非糖基化的多肽链，包含 72 个氨基酸，分子量为 8452 道尔顿。
IL-8 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The IL-8 was lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Interleukin-8 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ala-Lys-Glu-Leu.

Biological Activity

Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 10-100 ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL 8 Human (1-77),白细胞介素 8 人重组CHM-327

ProSpec,IL 8 Human (1-77),白细胞介素 8 人重组CHM-327,在大肠杆菌中产生的 IL-8 Human Recombinant 是一种单一的、非糖基化的多肽链，包含 77 个氨基酸，分子量为 8904 道尔顿。

IL 8 Human
Interleukin-8 Human Recombinant
CHM-327
5µg

25µg

1mg

Catalogue number

CHM-327

Synonyms

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Description

Interleukin-8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8904 Dalton.
The IL-8 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 IL-8 Human Recombinant 是一种单一的、非糖基化的多肽链，包含 77 个氨基酸，分子量为 8904 道尔顿。
IL-8 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的白细胞介素 8 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CXCL8 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS.

Biological Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25-150 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-IL 8 Human (1-77) His,CHM-345

ProSpec-IL 8 Human (1-77) His,CHM-345,白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。它也由内皮细胞合成，内皮细胞将 IL-8 储存在它们的储存囊泡 Weibel-Palade 体中。

IL 8 Human , His
Interleukin-8 Human Recombinant , His Tag
CHM-345
10µg

50µg

1mg

Catalogue number

CHM-345

Synonyms

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Description

Interleukin-8 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment and having a total molecular mass of 13.7kDa with an amino-terminal hexahistidine tag.
The IL-8 His is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的白细胞介素 8 人重组体是单一的、非糖基化的多肽链，包含 77 个氨基酸片段，总分子量为 13.7kDa，带有氨基末端六组氨酸标签。
IL-8 His 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

IL8 His is supplied in 10mM Tris-HCl pH 8, 250mM NaCl and 50% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL 8 Human Pichia CHM-349

ProSpec,IL 8 Human Pichia CHM-349,白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。它也由内皮细胞合成，内皮细胞将 IL-8 储存在它们的储存囊泡 Weibel-Palade 体中。

IL 8 Human, Pichia
Interleukin-8 Human Recombinant, Pichia
CHM-349
5µg

25µg

1mg

Catalogue number

CHM-349

Synonyms

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies.
When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。它也由内皮细胞合成，内皮细胞将 IL-8 储存在它们的储存囊泡 Weibel-Palade 体中。
当第一次遇到抗原时，遇到它的原代细胞是吞噬颗粒的巨噬细胞。在处理后，它们会释放趋化因子以向其他免疫细胞发出信号，使其进入炎症部位。 IL-8 就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也称为中性粒细胞趋化因子。

Description

Interleukin-8 Human Recombinant produced in Yeast is a single, glycosylated polypeptide chain containing 79 amino acids and having a molecular mass of 9 kDa.
The IL-8 is purified by proprietary chromatographic techniques.

Source

Pichia Pastoris.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing 20mM sodium phosphate buffer pH-8.

Solubility

It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的白细胞介素 8 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CXCL8 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by -PAGE.

Biological Activity

Chemotactic activity was reached at 25ng/ml on human neutrophils.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL 8 Porcine CHM-340,白细胞介素8猪重组CHM-340

ProSpec,IL 8 Porcine CHM-340,白细胞介素8猪重组CHM-340,冻干的白细胞介素 8 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CXCL8 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。

IL 8 Porcine
Interleukin-8 Porcine Recombinant
CHM-340
5µg

20µg

1mg

Catalogue number

CHM-340

Synonyms

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Description

Interleukin-8 Porcine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 78 amino acids and having a molecular mass of 9.1kDa.
The IL8 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Biological Activity

The biological activity was determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 20-200 ng/ml.

Amino acid sequence

ARVSAELRCQ CINTHSTPFH PKFIKELRVI ESGPHCENSE IIVKLVNGKE VCLDPKEKWV QKVVQIFLKR TEKQQQQQ.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL 8 Rhesus Macaque CHM-004,白细胞介素8恒河猴重组

ProSpec,IL 8 Rhesus Macaque CHM-004,白细胞介素8恒河猴重组,白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。它也由内皮细胞合成，内皮细胞将 IL-8 储存在它们的储存囊泡 Weibel-Palade 体中。

IL 8 Rhesus Macaque
Interleukin-8 Rhesus Macaque Recombinant
CHM-004
5µg

25µg

1mg

Catalogue number

CHM-004

Synonyms

Introduction

Description

IL 8 Rhesus Macaque Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.
The IL 8 Rhesus Macaque is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 IL 8 Rhesus Macaque Recombinant 是一种单一的、非糖基化的多肽链，包含 79 个氨基酸，分子量为 9.1kDa。
IL 8 Rhesus Macaque 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized IL-8 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IL-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-8 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by -PAGE.

Amino acid sequence

AVLPRSAKEL RCECIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE PWVQRVVEKF VKRAENQNP

Biological Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 50-150ng/ml, corresponding to a Specific Activity of 6,667-20,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-IL8 Canine HEK CHM-045,白细胞介素8，HEK犬重组CHM-045

ProSpec-IL8 Canine HEK CHM-045,白细胞介素8，HEK犬重组CHM-045,IL-8 就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也称为中性粒细胞趋化因子。

Description

Catalogue number

CHM-045

Synonyms

Interleukin-8, IL-8, C-X-C motif chemokine 8, IL8, CXCL8

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. IL8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies.When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。 IL8 也由内皮细胞合成，内皮细胞将 IL-8 储存在其储存囊泡 Weibel-Palade 体中。当第一次遇到抗原时，遇到它的原代细胞是吞噬颗粒的巨噬细胞。在处理后，它们会释放趋化因子以向其他免疫细胞发出信号，使其进入炎症部位。 IL-8 就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也称为中性粒细胞趋化因子。

Description

IL8 Canine, HEK Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 80 amino acids and having a molecular mass of 9.4 kDa.
IL8 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

HEK293 Cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The IL8 solution contains phosphate buffered saline and 20% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

VSSELRCQCI KTHSTPFHPK YIKELRVIDS GPHCENSEII VKLFNGNEVC LDPKEKWVQK VVQIFLKKAE KQDPHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IL8 GST,CHM-047

ProSpec,IL8 GST,CHM-047,白细胞介素 8 是一种由巨噬细胞和其他细胞类型（如上皮细胞）产生的趋化因子。它也由内皮细胞合成，内皮细胞将 IL-8 储存在它们的储存囊泡 Weibel-Palade 体中。

IL8 GST
Interleukin-8 Human Recombinant, GST Tag
CHM-047
100µg

0.5mg

1mg

Catalogue number

CHM-047

Synonyms

Interleukin-8, IL-8, C-X-C motif chemokine 8, IL8, CXCL8

Introduction

Interleukin-8 is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Description

Recombinant Human Interleukin-8 produced in E. coli containing 72 amino acids.
Recombinant Human Interleukin-8 is fused to GST tag at its N-terminus and purified by proprietary chromatographic technique.

在大肠杆菌中产生的重组人白介素 8，含有 72 个氨基酸。
重组人白介素 8 在其 N 端与 GST 标签融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

IL8 GST solution contains 25mM Tris-Base/ 25mM K₂CO_3.

Stability

Purity

Protein is >95% pure as determined by 10% PAGE .

Applications

Immunoassay.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec CHM-330,IP 10 Human,IP-10 人类重组CHM-330

ProSpec CHM-330,IP 10 Human,IP-10 人类重组CHM-330,CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。

IP 10 Human
IP-10 Human Recombinant
CHM-330
5µg

25µg

1mg

Catalogue number

CHM-330

Synonyms

Small inducible cytokine B10, CXCL10, 10 kDa, Gamma-IP10, IP-10, chemokine ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10.

Introduction

Chemokine ligand 10 is a small cytokine belonging to the CXC chemokine family. CXCL10 is secreted by several cell types in response to IFN. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

趋化因子配体 10 是属于 CXC 趋化因子家族的小细胞因子。 CXCL10 由几种细胞类型响应 IFN 分泌。这些细胞类型包括单核细胞、内皮细胞和成纤维细胞。 CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。 CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。该趋化因子的三维晶体结构已在 3 种不同条件下确定，分辨率高达 1.92A。

Description

IP-10 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.6kDa.
The IP-10 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 IP-10 人重组体是一条单一的、非糖基化的多肽链，包含 77 个氨基酸，分子量为 8.6kDa。
IP-10 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid .

Solubility

It is recommended to reconstitute the lyophilized IP-10 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 IP-10 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重构后，CXCL10 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKA IKNLLKAVSKERSKRSP.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IP 10 Human His,CHM-346

ProSpec,IP 10 Human His,CHM-346,趋化因子配体 10 是一种小细胞因子，属于 CXC 趋化因子家族，也称为 10 kDa 干扰素-γ 诱导蛋白。 CXCL10 由几种细胞类型响应 IFN-α 分泌。

Description

Catalogue number

CHM-346

Synonyms

Small inducible cytokine B10, CXCL10, 10 kDa interferon-gamma-induced protein, Gamma-IP10, IP-10, chemokine ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10.

Introduction

Chemokine ligand 10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein . CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cellsand fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytesand T cells, promotion of T cell adhesion to endothelial cells, anti tumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

趋化因子配体 10 是一种小细胞因子，属于 CXC 趋化因子家族，也称为 10 kDa 干扰素-γ 诱导蛋白。 CXCL10 由几种细胞类型响应 IFN-α 分泌。这些细胞类型包括单核细胞、内皮细胞和成纤维细胞。 CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。 CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。该趋化因子的三维晶体结构已在 3 种不同条件下确定，分辨率高达 1.92A。

Description

IP-10 His Tag Human Recombinant ?produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment and having a total molecular mass of 8.5 kDa with an amino-terminal hexahistidine tag.
The IP-10 His is purified by proprietary chromatographic techniques.

IP-10 His Tag Human Recombinant ?在大肠杆菌中产生是单一的、非糖基化的多肽链，包含 77 个氨基酸片段，总分子量为 8.5 kDa，带有氨基末端的六组氨酸标签。
IP-10 His 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

IP-10 His is supplied in 10mM Tris HCl pH8, 1mM EDTA and 50% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Purity

Greater than 95.0% as determined by Analysis by RP-HPLC.
Analysis by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IP 10 Mouse,IP-10 小鼠重组CHM-336

ProSpec,IP 10 Mouse,IP-10 小鼠重组CHM-336,趋化因子配体 10 是属于 CXC 趋化因子家族的小细胞因子。 CXCL10 由几种细胞类型分泌。这些细胞类型包括单核细胞、内皮细胞和成纤维细胞

IP 10 Mouse
IP-10 Mouse Recombinant
CHM-336
5µg

25µg

1mg

Catalogue number

CHM-336

Synonyms

Small inducible cytokine B10, CXCL10, 10 kDa, Gamma-IP10, IP-10, chemokine ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10.

Introduction

Chemokine ligand 10 is a small cytokine belonging to the CXC chemokine family. CXCL10 is secreted by several cell types. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

趋化因子配体 10 是属于 CXC 趋化因子家族的小细胞因子。 CXCL10 由几种细胞类型分泌。这些细胞类型包括单核细胞、内皮细胞和成纤维细胞。 CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。 CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。该趋化因子的三维晶体结构已在 3 种不同条件下确定，分辨率高达 1.92A。

Description

IP-10 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8701 Dalton.
The IP-10 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

IP-10 was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized IP-10 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 IP-10 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重构后，CXCL10 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP.

Biological Activity

Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 100.0-500.0 ng/ml.

Protein content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 0.02 as the extinction coefficient for a 0.1% solution. This value is calculated by the PC GENE computer analysis program of protein sequences .
2. Analysis by RP-HPLC, using a standard solution of IP-10 as a Reference Standard.

蛋白质定量通过两种独立的方法进行：
1. 280 nm 的紫外光谱，使用 0.02 的吸光度值作为 0.1% 溶液的消光系数。该值是由 PC GENE 计算机蛋白质序列分析程序计算得出的。
2. RP-HPLC分析，使用IP-10的标准溶液作为参考标准。

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IP 10 Rat,CHM-264,IP-10 大鼠重组CHM-264

ProSpec,IP 10 Rat,CHM-264,IP-10 大鼠重组CHM-264,CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。

IP 10 Rat

IP-10 Rat Recombinant
CHM-264
5µg

25µg

1mg

Catalogue number

CHM-264

Synonyms

C-X-C motif chemokine 10, Gamma-IP10, IP-10, Protein Mob-1, Small-inducible cytokine B10, Cxcl10, Inp10, Mob1, Scyb10.

Introduction

Chemokine ligand 10 is a small cytokine belonging to the CXC chemokine family. CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

趋化因子配体 10 是属于 CXC 趋化因子家族的小细胞因子。 CXCL10 由几种细胞类型响应 IFN-α 分泌。这些细胞类型包括单核细胞、内皮细胞和成纤维细胞。 CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。 CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。该趋化因子的三维晶体结构已在 3 种不同条件下确定，分辨率高达 1.92A。

Description

IP-10 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.6kDa.
The IP-10 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized IP-10 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP.

Biological Activity

Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-IP 10 Rhesus macaque,IP-10 恒河猴重组体CHM-010

ProSpec-IP 10 Rhesus macaque,IP-10 恒河猴重组体CHM-010,CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。

IP 10 Rhesus macaque
IP-10 Rhesus macaque Recombinant
CHM-010
5µg

25µg

1mg

Catalogue number

CHM-010

Synonyms

C-X-C motif chemokine 10, 10 kDa, Gamma-IP10, IP-10, Small-inducible cytokine B10, CXCL10, SCYB10.

Introduction

Chemokine ligand 10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa IP-10. CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

趋化因子配体 10 是一种小细胞因子，属于 CXC 趋化因子家族，也称为 10 kDa IP-10。 CXCL10 由几种细胞类型响应 IFN-α 分泌。这些细胞类型包括单核细胞、内皮细胞和成纤维细胞。 CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。 CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。该趋化因子的三维晶体结构已在 3 种不同条件下确定，分辨率高达 1.92A。

Description

IP-10 Rhesus macaque Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.7kDa.
The IP-10 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 IP-10 Rhesus macaque Recombinant 是一种单一的、非糖基化的多肽链，包含 77 个氨基酸，分子量为 8.7kDa。
IP-10 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized IP-10 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

IPLSRTVRCT CISISNQPVN PRSLEKLEII PPSQFCPHVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP.

Biological Activity

Determined by its ability to chemoattract human peripheral blood T-Lymphocytes using a concentration range of 10.0-100.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,IP10 Guinea Pig,IP-10 豚鼠重组CHM-046

CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。ProSpec,IP10 Guinea Pig,IP-10 豚鼠重组CHM-046

IP10 Guinea Pig
IP-10 Guinea Pig Recombinant
CHM-046
10µg

50µg

100µg

Catalogue number

CHM-046

Synonyms

CXCL10, CRG-2.

Introduction

Description

IP10 Guinea Pig Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids and having a total molecular mass of 8.7kDa.
The IP10 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a sterile filtered aqueous solution containing 10 mM Sodium Phosphate, pH 7.5.

Solubility

It is recommended to reconstitute the lyophilized IP10 in sterile water at a concentration of 0.1 mg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized IP10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IP10 Human should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

IPHSRTIRCT CIETSTQPVN PKSFKKLEII PASQSCPRVE IIATMKMNGE KRCLDPESKV IKNLLKAVRK ERSKRS

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec CHM-334,I TAC Human,I-TAC 人重组CHM-334

ProSpec CHM-334,I TAC Human,I-TAC 人重组CHM-334,趋化因子配体 11 是属于 CXC 趋化因子家族的一种小细胞因子，也称为诱导型 T 细胞 α 趋化因子和 . I-TAC在外周血白细胞、胰腺和肝脏中高表达，在胸腺、脾脏和肺中表达中等，在小肠、胎盘和前列腺中低表达

I TAC Human
I-TAC Human Recombinant
CHM-334
5µg

20µg

1mg

Catalogue number

CHM-334

Synonyms

Small inducible cytokine B11, CXCL11, I-TAC, IP-9, H174, Beta-R1, chemokine ligand 11, IP9, b-R1, SCYB11, SCYB9B, MGC102770.

Introduction

Chemokine ligand 11 is a small cytokine belonging to the CXC chemokinen family that is also called inducible T-cell alpha chemoattractant and . I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells. The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

趋化因子配体 11 是属于 CXC 趋化因子家族的一种小细胞因子，也称为诱导型 T 细胞 α 趋化因子和 . I-TAC在外周血白细胞、胰腺和肝脏中高表达，在胸腺、脾脏和肺中表达中等，在小肠、胎盘和前列腺中低表达。 CXCL11的基因表达受IFN-g和IFN-b强烈诱导，而受IFN-a弱诱导。 I-TAC 趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用，引发其对靶细胞的影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 I-TAC 对活化的 T 细胞具有趋化性。 CXCL11 基因与 CXC 趋化因子家族的许多其他成员一起位于人类 4 号染色体上。

Description

I-TAC Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 8300 Dalton.
The I-TAC is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2?m filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized I-TAC in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized I-TAC although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution I-TAC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 I-TAC 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重构后，I-TAC 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF.

Biological Activity

Determined by its ability to chemoattract human IL-2 activated T-Lymphocytes using a concentration range of 0.1-10.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec I TAC Human His,CHM-232

ProSpec I TAC Human His,CHM-232,这种趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用而对其靶细胞产生影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 CXCL11 对活化的 T 细胞具有趋化性。

I TAC Human, His
I-TAC Human Recombinant , His Tag
CHM-232
5µg

20µg

1mg

Catalogue number

CHM-232

Synonyms

Small inducible cytokine B11, CXCL11, Interferon-inducible T-cell alpha chemoattractant, I-TAC, Interferon-gamma-inducible protein 9, IP-9, H174, Beta-R1, chemokine ligand 11, IP9, b-R1, SCYB11, SCYB9B, MGC102770.

Introduction

Chemokine ligand 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant and Interferon-gamma-inducible protein 9 . It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

趋化因子配体 11 是一种小细胞因子，属于 CXC 趋化因子家族，也称为干扰素诱导型 T 细胞 α 趋化因子和干扰素-γ 诱导蛋白 9。它在外周血白细胞、胰腺和肝脏中高表达，在胸腺、脾脏和肺中表达中等，在小肠、胎盘和前列腺中低表达。 CXCL11的基因表达受IFN-g和IFN-b强烈诱导，而受IFN-a弱诱导。这种趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用而对其靶细胞产生影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 CXCL11 对活化的 T 细胞具有趋化性。它的基因与 CXC 趋化因子家族的许多其他成员一起位于人类第 4 号染色体上。

Description

I-TAC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 94 amino acids and having a molecular mass of 10.6kDa.
I-TAC is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 I-TAC Human Recombinant 是单一的非糖基化多肽链，含有 94 个氨基酸，分子量为 10.6kDa。
I-TAC 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The I-TAC solution contains 10mM sodium citrate, 20% glycerol and 2mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-I TAC Mouse,I-TAC 小鼠重组CHM-026

ProSpec-I TAC Mouse,I-TAC 小鼠重组CHM-026,I-TAC趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用，引发其对靶细胞的影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 I-TAC 对活化的 T 细胞具有趋化性。CXCL11 基因与 CXC 趋化因子家族的许多其他成员一起位于人类第 4 号染色体上。

I TAC Mouse
I-TAC Mouse Recombinant
CHM-026
5µg

20µg

1mg

Catalogue number

CHM-026

Synonyms

C-X-C motif chemokine 11, I-TAC, Small-inducible cytokine B11, Cxcl11, Scyb11.

Introduction

Chemokine ligand 11 is a small cytokine belonging to the CXC chemokinen family. I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TACchemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells.The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

趋化因子配体 11 是属于 CXC 趋化因子家族的小细胞因子。 I-TAC在外周血白细胞、胰腺和肝脏中高表达，在胸腺、脾脏和肺中表达中等，在小肠、胎盘和前列腺中低表达。 CXCL11的基因表达受IFN-g和IFN-b强烈诱导，而受IFN-a弱诱导。 I-TAC趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用，引发其对靶细胞的影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 I-TAC 对活化的 T 细胞具有趋化性。CXCL11 基因与 CXC 趋化因子家族的许多其他成员一起位于人类第 4 号染色体上。

Description

I TAC Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

I TAC protein was lyophilized from a 0.2 µm filtered concentrated solution in 10 mM Sodium Citrate, pH 4.0, with 600 mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized I TAC in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized I TAC although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution I TAC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 I TAC 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。重组后，I TAC 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine CXCR3 transfected 293 cells is in a concentration of 10-100 ng/ml corresponding to a specific activity of 10,000-100,000 IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CCL3L1 Human,LD78-beta 人重组CHM-263

ProSpec,CCL3L1 Human,LD78-beta 人重组CHM-263,CCL3L1 是一种属于 CC 趋化因子的小细胞因子。 CCL3L1 基因是聚集在 17 号染色体 q 臂上的几个细胞因子基因之一。CCL3L1 参与免疫调节和炎症过程。

CCL3L1 Human
LD78-beta Human Recombinant
CHM-263
5µg

20µg

1mg

Catalogue number

CHM-263

Synonyms

C-C motif chemokine 3-like 1, G0/G1 switch regulatory protein 19-2, LD78-beta, PAT 464.2, Small-inducible cytokine A3-like 1, Tonsillar lymphocyte LD78 beta protein, CCL3L1, D17S1718, G0S19-2, SCYA3L1, LD78, 464.2, SCYA3L, LD78BETA, MGC12815.

Introduction

CCL3L1 is a small cytokine that belongs to the CC chemokines. The CCL3L1 gene is one of several cytokine genes clustered on the q-arm of chromosome 17. CCL3L1 is involved in immunoregulatory and inflammatory processes. CCL3L1 binds to several chemokine receptors including CCBP2 and CCR5. CCR5 is a co-receptor for HIV, and binding of the CCL3L1 protein to CCR5 inhibits HIV entry.

CCL3L1 是一种属于 CC 趋化因子的小细胞因子。 CCL3L1 基因是聚集在 17 号染色体 q 臂上的几个细胞因子基因之一。CCL3L1 参与免疫调节和炎症过程。 CCL3L1 与几种趋化因子受体结合，包括 CCBP2 和 CCR5。 CCR5 是 HIV 的共受体，CCL3L1 蛋白与 CCR5 的结合可抑制 HIV 进入。

Description

CCL3L1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.7kDa. The CCL3L1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CCL3L1 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 70 个氨基酸，分子量为 7.7kDa。 CCL3L1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1xPBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CCL3L1 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CCL3L1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL3L1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA.

Biological Activity

The biological activity was determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CCL3L1 Human His,CHM-251

ProSpec,CCL3L1 Human His,CHM-251,CCL3L1 Human Recombinant 在 N 末端融合了 22 个氨基酸的 His 标签，在大肠杆菌中产生，是一条含有 90 个氨基酸且分子量为 10kDa 的单一非糖基化多肽链。

CCL3L1 Human, His
LD78-beta Human Recombinant, His Tag
CHM-251
5µg

20µg

1mg

Catalogue number

CHM-251

Synonyms

Introduction

Description

CCL3L1 Human Recombinant fused with a 22 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 90 amino acids and having a molecular mass of 10kDa. The CCL3L1 is purified by proprietary chromatographic techniques.

CCL3L1 Human Recombinant 在 N 末端融合了 22 个氨基酸的 His 标签，在大肠杆菌中产生，是一条含有 90 个氨基酸且分子量为 10kDa 的单一非糖基化多肽链。 CCL3L1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CCL3L1 solution contains Phosphate Buffered Saline pH7.4 containing 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,Lymphotactin Human,Lymhotactin 人重组CHM-314

ProSpec,Lymphotactin Human,Lymhotactin 人重组CHM-314,XCL1 的细胞来源包括活化的胸腺和外周血 CD8+ T 细胞。这种趋化因子会吸引 T 细胞。在人类中，XCL1 与另一种称为 XCL2 的趋化因子密切相关，后者的基因位于 1 号染色体的同一位点。

Lymphotactin Human
Lymphotactin Human Recombinant
CHM-314
3×2µg

2×10µg

1mg

Catalogue number

CHM-314

Synonyms

XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.

Introduction

Chemokine ligand is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose geneis found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.

趋化因子配体是一种属于 XC 趋化因子家族的小细胞因子，也称为淋巴趋化素。它在脾脏、胸腺、肠和外周血白细胞中含量较高，在肺、前列腺和卵巢中含量较低。 XCL1 的细胞来源包括活化的胸腺和外周血 CD8+ T 细胞。这种趋化因子会吸引 T 细胞。在人类中，XCL1 与另一种称为 XCL2 的趋化因子密切相关，后者的基因位于 1 号染色体的同一位点。XCL1 通过与称为 XCR1 的趋化因子受体结合来诱导其趋化功能。

Description

Lymphotactin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 92 amino acids and having a molecular mass of 10007 Dalton.
The Lymphotactin is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Lymphotactin Human Recombinant 是一种单一的、非糖基化的多肽链，含有 92 个氨基酸，分子量为 10007 道尔顿。
Lymphotactin 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The XCL1 was lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Lymphotactin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution XCL1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please avoid freeze-thaw cycles.

Purity

Greater than 99.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Ser-Glu-Val-Ser.

Biological Activity

The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,Lymphotactin Human His,CHM-357

ProSpec-Lymphotactin Human His,CHM-357,XCL1 是属于 XC 趋化因子家族的一种小细胞因子，也称为淋巴趋化素。它在脾脏、胸腺、肠和外周血白细胞中含量较高，在肺、前列腺和卵巢中含量较低。

Lymphotactin Human, His
Lymphotactin Human Recombinant , His Tag
CHM-357
2µg

10µg

1mg

Catalogue number

CHM-357

Synonyms

XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.

Introduction

XCL1 is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is located in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.

XCL1 是属于 XC 趋化因子家族的一种小细胞因子，也称为淋巴趋化素。它在脾脏、胸腺、肠和外周血白细胞中含量较高，在肺、前列腺和卵巢中含量较低。 XCL1 的细胞来源包括活化的胸腺和外周血 CD8+ T 细胞。这种趋化因子会吸引 T 细胞。在人类中，XCL1 与另一种称为 XCL2 的趋化因子密切相关，后者的基因位于 1 号染色体的同一位点。XCL1 通过与称为 XCR1 的趋化因子受体结合来诱导其趋化功能。

Description

XCL1 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 114 amino acids and having a molecular mass of 12.5 kDa. The XCL1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 XCL1 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 114 个氨基酸，分子量为 12.5 kDa。 XCL1 在 N 端与 20 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

Recombinant XCL1 contains 20mM Tris buffer pH-8, 200mM NaCl, 2mM DTT and 30% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MVGSEVSDKR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,Lymphotactin Mouse,淋巴细胞趋化素小鼠重组CHM-037

ProSpec,Lymphotactin Mouse,淋巴细胞趋化素小鼠重组CHM-037,XCL1 是一种小细胞因子，属于 XC 趋化因子家族，也称为淋巴趋化素。 XCL1 在脾脏、胸腺、肠和外周血白细胞中含量较高，而在肺、前列腺和卵巢中含量较低。

Lymphotactin Mouse
Lymphotactin Mouse Recombinant
CHM-037
50µg

100µg

1mg

Catalogue number

CHM-037

Synonyms

XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.

Introduction

XCL1 is a small cytokine belongs to the XC chemokine family that is also known as lymphotactin. XCL1 is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to XCL2, whose gene is found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.

XCL1 是一种小细胞因子，属于 XC 趋化因子家族，也称为淋巴趋化素。 XCL1 在脾脏、胸腺、肠和外周血白细胞中含量较高，而在肺、前列腺和卵巢中含量较低。 XCL1 的细胞来源包括活化的胸腺和外周血 CD8+ T 细胞。这种趋化因子会吸引 T 细胞。在人类中，XCL1 与 XCL2 密切相关，后者的基因位于 1 号染色体的同一位点。XCL1 通过与称为 XCR1 的趋化因子受体结合来诱导其趋化功能。

Description

Lymphotactin Mouse Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of approximately 10.1kDa.
Lymphotactin is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Lymphotactin Mouse Recombinant 是一种非糖基化多肽链，含有 93 个氨基酸，分子量约为 10.1kDa。
Lymphotactin 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized XCL1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Lymphotactin should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

reater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VGTEVLEESS CVNLQTQRLP VQKIKTYIIW EGAMRAVIFV TKRGLKICAD PEAKWVKAAI KTVDGRASTR KNMAETVPTG AQRSTSTAIT LTG.

Biological Activity

The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells is < 100 ng/ml, corresponding to a specific activity of > 1.0 × 104 IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec CHM-038,Lymphotactin Rat,淋巴细胞趋化素大鼠重组CHM-038

ProSpec CHM-038,Lymphotactin Rat,淋巴细胞趋化素大鼠重组CHM-038,XCL1 是一种小细胞因子，属于 XC 趋化因子家族，也称为淋巴趋化素。 XCL1 在脾脏、胸腺、肠和外周血白细胞中含量较高，而在肺、前列腺和卵巢中含量较低。

Lymphotactin Rat
Lymphotactin Rat Recombinant
CHM-038
50µg

100µg

1mg

Catalogue number

CHM-038

Synonyms

XCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.

Introduction

Description

Lymphotactin Rat Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of approximately 10.0kDa.
Lymphotactin is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VGTEVLQESI CVSLRTQRLP VQKIKTYTIK EGAMRAVIFV TKRGLRICAD PQAKWVKTAI KTVDGRASAS KSKAETIPTQ AQRSASTAVT LTG.

Biological Activity

The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells < 100 ng/ml, corresponding to a specific activity of > 1.0 × 10⁴ IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 1 Human,单核细胞趋化蛋白-1人重组CHM-271

ProSpec,MCP 1 Human,单核细胞趋化蛋白-1人重组CHM-271,它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP 1 Human
Monocyte Chemotactic Protein-1 Human Recombinant
CHM-271
5µg

20µg

1mg

Catalogue number

CHM-271

Synonyms

Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11.

Introduction

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B . CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。它存在于牙齿萌出和骨骼退化的部位。在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 βB 的控制。 CCL2 将免疫细胞（例如单核细胞）募集到组织损伤和感染部位。这种趋化因子作为蛋白质前体产生，含有 23 个氨基酸的信号肽和 76 个氨基酸的成熟肽。它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

Description

Monocyte Chemotactic Protein-1 Human Recombinant also known as Monocyte Chemotactic and Activating Factor produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8.6kDa.
The MCP-1 is purified by proprietary chromatographic techniques.

单核细胞趋化蛋白-1 人重组体也称为大肠杆菌中产生的单核细胞趋化和激活因子，是一种非糖基化的多肽链，含有 76 个氨基酸，分子量为 8.6kDa。
MCP-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CCL2 was lyophilized from a concentrated sterile solution without any additives.

Solubility

It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-1in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 MCP-1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL2 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by RP-HPLC and -PAGE.

Amino acid sequence

QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT.

Biological Activity

The specific activity as determined by the ability of MCP-1 to chemoattract human THP-1 cells is detectable starting at 1ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 1 Human His,CHM-246

ProSpec,MCP 1 Human His,CHM-246,它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP 1 Human, His
Monocyte Chemotactic Protein-1 Human Recombinant , His Tag
CHM-246
10µg

50µg

1mg

Catalogue number

CHM-246

Synonyms

Introduction

Description

MCP-1 Human Recombinant also known as Monocyte Chemotactic and Activating Factor produced in E.Coli is a non-glycosylated, Polypeptide chain containing 97 amino acids and having a molecular mass of 10.9 kDa.
The MCP-1 is fused to 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless clear solution.

Formulation

The His Tag MCP-1 protein solution contains 20mM Tris-HCL pH-8.0, 1mM DTT and 20% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MQPDAINAPV TCCYNFTNRK ISVQRLASYR RITSSKCPKE AVIFKTIVAK EICADPKQKW VQDSMDHLDK QTQTPKT.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 1 Mouse,单核细胞趋化蛋白-1小鼠重组CHM-313

ProSpec,MCP 1 Mouse,单核细胞趋化蛋白-1小鼠重组CHM-313,它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP 1 Mouse
Monocyte Chemotactic Protein-1 Mouse Recombinant
CHM-313
2µg

10µg

1mg

Catalogue number

CHM-313

Synonyms

Introduction

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B . CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acidsand a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。它存在于牙齿萌出和骨骼退化的部位。在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 βB 的控制。 CCL2 将免疫细胞（例如单核细胞）募集到组织损伤和感染部位。该趋化因子作为蛋白质前体产生，含有23个氨基酸的信号肽和76个氨基酸的成熟肽。它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

Description

Monocyte Chemotactic Protein-1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa.
The MCP-1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 1 小鼠重组体是一种单一的、非糖基化的多肽链，含有 125 个氨基酸，分子量为 14 kDa。
MCP-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized with no additives.

Solubility

It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 90.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Pro-Asp-Ala-Val.

Biological Activity

The biological activity was determined by calculating its ability to chemoattract Balb/C mouse spleen MNCs at 1.0-20.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 1 Mouse His,CHM-014

ProSpec,MCP 1 Mouse His,CHM-014,它是一种单体多肽，分子量约为 13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP 1 Mouse, His
Monocyte Chemotactic Protein-1 Mouse Recombinant , His Tag
CHM-014
5µg

20µg

1mg

Catalogue number

CHM-014

Synonyms

Introduction

Description

MCP-1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 146 amino acids and having a molecular mass of 16kDa.
MCP-1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MCP-1 Mouse Recombinant 是一条单一的、非糖基化的多肽链，含有 146 个氨基酸，分子量为 16kDa。
MCP-1 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless clear solution.

Formulation

MCP-1 protein solution containing PBS and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MQPDAVNAPL TCCYSFTSKM IPMSRLESYK RITSSRCPKE AVVFVTKLKR EVCADPKKEW VQTYIKNLDR NQMRSEPTTL FKTASALRSS APLNVKLTRK SEANASTTFS TTTSSTSVGV TSVTVN.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 1 Rat,单核细胞趋化蛋白-1大鼠重组CHM-315

ProSpec,MCP 1 Rat,单核细胞趋化蛋白-1大鼠重组CHM-315,它是一种单体多肽，分子量约为13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP 1 Rat
Monocyte Chemotactic Protein-1 Rat Recombinant
CHM-315
2µg

10µg

1mg

Catalogue number

CHM-315

Synonyms

Introduction

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B . CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weightof approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。它存在于牙齿萌出和骨骼退化的部位。在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 βB 的控制。 CCL2 将免疫细胞（例如单核细胞）募集到组织损伤和感染部位。这种趋化因子作为蛋白质前体产生，含有 23 个氨基酸的信号肽和 76 个氨基酸的成熟肽。它是一种单体多肽，分子量约为13kDa。与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

Description

Monocyte Chemotactic Protein-1 Rat Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 125 amino acids and having a molecular mass of 14.1 kDa.
The MCP-1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 1 大鼠重组体是一种非糖基化的多肽链，含有 125 个氨基酸，分子量为 14.1 kDa。
MCP-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated sterile solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL2 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by -PAGE.

Amino acid sequence

QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN.

Biological Activity

ED50 =1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg. The biological activity was determined by measuring the dose dependent chemotaxis with human THP-1 cells. The optimal concentration should be determined for each specific application by an initial dose-response assay.

References

Title: Adiponectin Reduces Hepatic Stellate Cell Migration by Promoting Tissue Inhibitor of Metalloproteinase-1 Secretion
Publications: Journal of Biological Chemistry : jbc-M114.
Link: http://www.jbc.org/content/early/2015/01/09/jbc.M114.598011.full.pdf

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 2 Canine,单核细胞趋化蛋白-2犬重组

ProSpec,MCP 2 Canine,单核细胞趋化蛋白-2犬重组,在大肠杆菌中产生的 MCP2 Canine Recombinant 是一条单一的、非糖基化的多肽链，包含 76 个氨基酸，分子量为 8.8kDa。

MCP 2 Canine
Monocyte Chemotactic Protein-2 Canine Recombinant
CHM-285
2µg

10µg

1mg

Catalogue number

CHM-285

Synonyms

C-C motif chemokine 8, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, MCP-2, Small-inducible cytokine A8, CCL8, MCP2.

Introduction

Chemokine ligand 8 is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 . The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, , and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.

趋化因子配体 8 是一种小细胞因子，属于 CC 趋化因子家族，曾被称为单核细胞趋化蛋白 2。 CCL8 蛋白作为含有 109 个氨基酸的前体产生，其被切割产生含有 75 个氨基酸的成熟 CCL8。 CCL8 基因由 3 个外显子编码，位于人类染色体 17q11.2 上的一大簇 CC 趋化因子中。 MCP-2 趋化并激活许多不同的免疫细胞，包括肥大细胞、嗜酸性粒细胞和嗜碱性粒细胞，以及参与炎症反应的单核细胞、T 细胞和 NK 细胞。 CCL8 通过与几种不同的细胞表面受体（称为趋化因子受体）结合来引发其作用。这些受体包括 CCR1、CCR2B 和 CCR5。

Description

MCP2 Canine Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids and having a molecular mass of 8.8kDa.
The CCL8 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MCP2 Canine Recombinant 是一条单一的、非糖基化的多肽链，包含 76 个氨基酸，分子量为 8.8kDa。
CCL8 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

MCP-2 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH7.4.

Solubility

It is recommended to reconstitute the lyophilized MCP2 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL8 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QPDSVSIPIT CCFSMVKRKI PMQKLESYMR ITNSQCPQEA VIFKTKASRE ICADPKQKWV QDYMNHLDQK SQAQKP.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 2 Human,单核细胞趋化蛋白2人重组CHM-316

ProSpec,MCP 2 Human,单核细胞趋化蛋白2人重组CHM-316,趋化因子配体 8 是一种小细胞因子，属于 CC 趋化因子家族，曾被称为单核细胞趋化蛋白 2。 CCL8 蛋白作为含有 109 个氨基酸的前体产生，其被切割产生含有 75 个氨基酸的成熟 CCL8。

MCP 2 Human
Monocyte Chemotactic Protein-2 Human Recombinant
CHM-316
2µg

10µg

1mg

Catalogue number

CHM-316

Synonyms

Small inducible cytokine A8, CCL8, Monocyte chemotactic protein 2, MCP-2, Monocyte chemoattractant protein 2, HC14, chemokine ligand 8, MCP2, SCYA8, SCYA10.

Introduction

Description

Monocyte Chemotactic Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8904 Dalton.
The MCP2 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 2 人重组体是一种非糖基化的多肽链，含有 76 个氨基酸，分子量为 8904 道尔顿。
MCP2 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated sterile solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-2in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL8should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Pro-Asp-Ser-Val.

Biological Activity

The biological activity was determined by measuring the dose dependent mobilization of intracellular calcium with human THP-1 cells. Significant calcium mobilization is observed with 500ng/mL of recombinant human MCP-2. Human MCP-2 also induces dose dependent chemotaxis of human THP-1 cells with an ED50=30-100 ng/mL corresponding to a Specific Activity of 10,000-33,334IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 2 Mouse,单核细胞趋化蛋白2小鼠重组CHM-355

CCL8 通过与几种不同的细胞表面受体（称为趋化因子受体）结合来引发其作用。这些受体包括 CCR1、CCR2B 和 CCR5。ProSpec,MCP 2 Mouse,单核细胞趋化蛋白2小鼠重组CHM-355

MCP 2 Mouse
Monocyte Chemotactic Protein-2 Mouse Recombinant
CHM-355
2µg

10µg

1mg

Catalogue number

CHM-355

Synonyms

Small inducible cytokine A8, CCL8, Monocyte chemotactic protein 2, MCP-2, Monocyte chemoattractant protein 2, HC14, chemokine ligand 8, MCP2, SCYA8, SCYA10, AB023418, 1810063B20Rik.

Introduction

Description

Monocyte Chemotactic Protein-2 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 74 amino acids and having a molecular mass of 8507 Dalton.
The MCP-2 is purified by proprietary chromatographic techniques.

大肠杆菌中产生的单核细胞趋化蛋白 2 小鼠重组体是一种非糖基化的多肽链，含有 74 个氨基酸，分子量为 8507 道尔顿。
MCP-2 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CCL8in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 MCP-2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL8 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP.

Biological Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 3 Human,单核细胞趋化蛋白3人重组体CHM-317

ProSpec,MCP 3 Human,单核细胞趋化蛋白3人重组体CHM-317,这种趋化因子位于人类的第 17 号染色体上，位于一个包含许多其他 CC 趋化因子的大簇中，并且与 CCL2 关系最密切。

MCP 3 Human
Monocyte Chemotactic Protein-3 Human Recombinant
CHM-317
2µg

10µg

1mg

Catalogue number

CHM-317

Synonyms

Small inducible cytokine A7, CCL7, Monocyte chemotactic protein 3, MCP-3, Monocyte chemoattractant protein 3, NC28, chemokine ligand 7, FIC, MARC, MCP3, SCYA6, SCYA7, MGC138463, MGC138465.

Introduction

Chemokine ligand 7 is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 . Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2.

趋化因子配体 7 是一种称为趋化因子的小细胞因子，以前称为单核细胞特异性趋化因子 3。由于 CCL7 在其成熟蛋白中具有两个相邻的 N 末端半胱氨酸残基，因此它被归类为称为 CC 趋化因子的趋化因子亚家族。 CCL7 特异性吸引单核细胞，并调节巨噬细胞功能。它由某些肿瘤细胞系和巨噬细胞产生。这种趋化因子位于人类的第 17 号染色体上，位于一个包含许多其他 CC 趋化因子的大簇中，并且与 CCL2 关系最密切。

Description

Monocyte Chemotactic Protein-3 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 9011 Dalton.
The MCP-3 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 3 人重组体是一种非糖基化的多肽链，含有 76 个氨基酸，分子量为 9011 道尔顿。
MCP-3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated sterile solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-3in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 MCP-3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，CCL7 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Pro-Val-Gly-Ile.

Biological Activity

The specific activity as determined by the ability of MCP-3 to chemoattract human peripheral blood at 8 – 80ng/ml corresponding to a Specific Activity of 12,500-125,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 3 Mouse,单核细胞趋化蛋白3小鼠重组CHM-318

ProSpec,MCP 3 Mouse,单核细胞趋化蛋白3小鼠重组CHM-318,趋化因子配体 7 是一种称为趋化因子的小细胞因子，以前称为单核细胞特异性趋化因子 3。由于 CCL7 在其成熟蛋白中具有两个相邻的 N 末端半胱氨酸残基，因此它被归类为称为 CC 趋化因子的趋化因子亚家族。

MCP 3 Mouse
Monocyte Chemotactic Protein-3 Mouse Recombinant
CHM-318
2µg

10µg

1mg

Catalogue number

CHM-318

Synonyms

Small inducible cytokine A7, CCL7, Monocyte chemotactic protein 3, MCP-3, Monocyte chemoattractant protein 3, NC28, chemokine ligand 7, FIC, MARC, MCP3, SCYA6, SCYA7, MGC138463, MGC138465.

Introduction

Description

Monocyte Chemotactic Protein-3 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 74 amino acids and having a molecular mass of 8510 Dalton.
The MCP-3 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 3 小鼠重组体是一种非糖基化的多肽链，含有 74 个氨基酸，分子量为 8510 道尔顿。
MCP-3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated sterile solution containing no additives.

Solubility

It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QPDGPNASTC CYVKKQKIPK RNLKSYRRIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTP TPKP.

Biological Activity

The specific activity as determined by the ability of Mouse MCP-3 to chemoattract Balb/C mouse spleen MNCs at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-MCP 3 Rat,单核细胞趋化蛋白3大鼠重组体CHM-280

ProSpec-MCP 3 Rat,单核细胞趋化蛋白3大鼠重组体CHM-280,CCL7 特异性吸引单核细胞，并调节巨噬细胞功能。它由某些肿瘤细胞系和巨噬细胞产生。

MCP 3 Rat
Monocyte Chemotactic Protein-3 Rat Recombinant
CHM-280
2µg

10µg

1mg

Catalogue number

CHM-280

Synonyms

C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, MCP-3, Small-inducible cytokine A7, Ccl7, Mcp3, Scya7.

Introduction

Description

MCP-3 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8.5kDa.
The MCP-3 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

MCP-3 protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, 300mM NaCl, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized MCP-3 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCP3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 MCP-3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，MCP3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QPDGTNSSTC CYVKKQKIPK RNLKSYRKIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTS TPKP.

Biological Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-300.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 4 Human,单核细胞趋化蛋白4人重组体CHM-319

ProSpec,MCP 4 Human,单核细胞趋化蛋白4人重组体CHM-319,MCP-4 通过结合细胞表面 G 蛋白连接的趋化因子受体（如 CCR2、CCR3 和 CCR5）在单核细胞、嗜酸性粒细胞、T 淋巴细胞和嗜碱性粒细胞中诱导趋化性。 MCP-4 趋化因子的活性与哮喘等过敏反应有关。

MCP 4 Human
Monocyte Chemotactic Protein-4 Human Recombinant
CHM-319
2µg

10µg

1mg

Catalogue number

CHM-319

Synonyms

Small inducible cytokine A13, CCL13, Monocyte chemotactic protein 4, MCP-4, Monocyte chemoattractant protein 4, CK-beta-10, NCC-1, chemokine ligand 13, NCC1, CKb10, SCYL1, SCYA13, MGC17134.

Introduction

Chemokine ligand 13 is a small cytokine belonging to the CC chemokine family. The MCP-4 gene is located on human chromosome 17 within a large cluster of other CC chemokines. MCP-4 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. Activity of the MCP-4 chemokine has been implicated in allergic reactions such as asthma. MCP-4 can be induced by the inflammatory cytokines interleukin-1 and TNF-a.

趋化因子配体 13 是属于 CC 趋化因子家族的小细胞因子。 MCP-4 基因位于一大群其他 CC 趋化因子内的人类 17 号染色体上。 MCP-4 通过结合细胞表面 G 蛋白连接的趋化因子受体（如 CCR2、CCR3 和 CCR5）在单核细胞、嗜酸性粒细胞、T 淋巴细胞和嗜碱性粒细胞中诱导趋化性。 MCP-4 趋化因子的活性与哮喘等过敏反应有关。 MCP-4 可被炎症细胞因子 IL-1 和 TNF-a 诱导。

Description

Monocyte Chemotactic Protein-4 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 75 amino acids and having a molecular mass of 8.6 kDa. The MCP-4 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 4 人重组体是一种非糖基化的多肽链，含有 75 个氨基酸，分子量为 8.6 kDa。 MCP-4 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated sterile solution in 20mM PB, pH 7.4, 130mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized MCP-4 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized MCP-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCP-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 96.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

QPDALNVPSTCCFTFSSKKISLQRLKSYVITTSRCPQKAV
IFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT.

Biological Activity

The specific activity as determined by the ability of MCP-4 to chemoattaract human monocytes at 10-100ng/ml, corresponding to a Specific Activity of 10,000-100,000 units/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec CHM-275,MCP 4 Human His,CHM-275

ProSpec CHM-275,MCP 4 Human His,CHM-275,CCL13 蛋白通过结合细胞表面 G 蛋白连接的趋化因子受体（如 CCR2、CCR3 和 CCR5）在单核细胞、嗜酸性粒细胞、T 淋巴细胞和嗜碱性粒细胞中诱导趋化性。 CCL13 由炎性细胞因子 IL1 和 TNFA 诱导。

MCP 4 Human, His
Monocyte Chemotactic Protein-4 Human Recombinant , His-Tag
CHM-275
1µg

5µg

50µg

Catalogue number

CHM-275

Synonyms

CKb10, MCP-4, NCC-1, NCC1, SCYA1, SCYL1, CK-beta-10, Small-inducible cytokine A13.

Introduction

CCL13 chemokine is part of the CC chemokine family . CCL13 protein induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. CCL13 is induced by the inflammatory cytokines IL1 & TNFA.

CCL13趋化因子是CC趋化因子家族的一部分。 CCL13 蛋白通过结合细胞表面 G 蛋白连接的趋化因子受体（如 CCR2、CCR3 和 CCR5）在单核细胞、嗜酸性粒细胞、T 淋巴细胞和嗜碱性粒细胞中诱导趋化性。 CCL13 由炎性细胞因子 IL1 和 TNFA 诱导。

Description

MCP4 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 96 amino acids and having a molecular mass of 10.8 kDa.
The MCP-4 is fused to 21 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless clear solution.

Formulation

The His Tag 0.25mg/ml MCP4 protein solution contains PBS pH-7.4, 1mM DTT, 0.1M NaCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MQPDALNVPS TCCFTFSSKK ISLQRLKSYV ITTSRCPQKA VIFRTKLGKE ICADPKEKWV QNYMKHLGRK
.AHTLKT

Usage

Prospecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,MCP 5 Mouse,单核细胞趋化蛋白5小鼠重组CHM-266

ProSpec,MCP 5 Mouse,单核细胞趋化蛋白5小鼠重组CHM-266,MCP-5 是与人类 MCP1 最密切相关的克隆小鼠 CC 趋化因子。 MCP5 在胸腺和淋巴结中组成型表达。此外，在炎症条件下，CCL12 表达在活化的巨噬细胞和肥大细胞中被诱导。

MCP 5 Mouse
Monocyte Chemotactic Protein-5 Mouse Recombinant
CHM-266
5µg

20µg

1mg

Catalogue number

CHM-266

Synonyms

C-C motif chemokine 12, MCP-1-related chemokine, Monocyte chemoattractant protein 5, Monocyte chemotactic protein 5, MCP-5, Small-inducible cytokine A12, Ccl12, Mcp5, Scya12.

Introduction

MCP-5 is a cloned mouse CC chemokine most closely related to human MCP1 . MCP5 is expressed constitutively in the thymus and the lymph nodes. Under inflammatory conditions, moreover CCL12 expression is induced in activated macrophages and mast cells. The mouse MCP1 gene is mapped to the CC chemokine cluster on chromosome 11. Recombinant CCL12 is a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, MCP-5 also chemoattracts eosinophils. CCL12 is a functional ligand for CCR2.

MCP-5 是与人类 MCP1 最密切相关的克隆小鼠 CC 趋化因子。 MCP5 在胸腺和淋巴结中组成型表达。此外，在炎症条件下，CCL12 表达在活化的巨噬细胞和肥大细胞中被诱导。小鼠 MCP1 基因映射到 11 号染色体上的 CC 趋化因子簇。重组 CCL12 是单核细胞和淋巴细胞的有效趋化因子，但对中性粒细胞无效。在高浓度时，MCP-5 也会化学吸引嗜酸性粒细胞。 CCL12 是 CCR2 的功能性配体。

Description

MCP-5 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 82 amino acids and having a molecular mass of 9.3kDa.
The MCP5 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MCP-5 Mouse Recombinant 是一种单一的、非糖基化的多肽链，含有 82 个氨基酸，分子量为 9.3kDa。
MCP5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized MCP5 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CCL12 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCP5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 CCL12 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。复溶后，MCP5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTILDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG.

Biological Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

GRO g Mouse

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Solubility

Stability

Purity

Amino acid sequence

Biological Activity

Usage

Related Products

GRO g Mouse, His

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Stability

Purity

Amino acid sequence

Usage

Related Products

GRO g/CINC-2a Rat

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Solubility

Stability

Purity

Amino acid sequence

Biological Activity

Usage

Related Products

GRO1/KC Mouse

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Solubility

Stability

Purity

Amino acid sequence

Biological Activity

Protein content

Usage

Related Products

GRO1/KC Mouse, His

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation

Stability

Purity

Amino acid sequence

Usage

Related Products

GRO-g/CINC-2b Rat

Catalogue number

Synonyms

Introduction

Description

Source

Physical Appearance

Formulation