分类： CD抗原CD Antigens

ProSpec-CD4 Human (203-317),CD-4人重组CYT-316

ProSpec-CD4 Human (203-317),CD-4人重组CYT-316,CD4 是一种单链跨膜糖蛋白，存在于代表 45% 外周血淋巴细胞的 T 细胞亚群上。 它也存在于 80% 的胸腺细胞上，而单核细胞上的水平较低。

  • CD4 Human

  • CD-4 Human Recombinant
  • CYT-316

Catalogue number

CYT-316

Synonyms

gp55, HLA-2, L3 / T4, Ly-4, T cell antigen T4/LEU3, T4, sCD4.

Introduction

CD4, a single chain transmembrane glycoprotein, is found on a T cell subset representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. Antibody to CD4 recognizes T-helper cells required for recognition of class II antigens. It reacts with ~60% of peripheral blood E rosette-positive cells while showing negligible reactivity with E- cells, monocytes, granulocytes, EBV-transformed B cell lines, and mouse splenocytes.
CD4 是一种单链跨膜糖蛋白，存在于代表 45% 外周血淋巴细胞的 T 细胞亚群上。 它也存在于 80% 的胸腺细胞上，而单核细胞上的水平较低。 它参与由 APC 识别与 MHC II 类一起呈递的抗原。 它作为 HIV 的受体。 CD4 抗体可识别识别 II 类抗原所需的 T 辅助细胞。 它与约 60% 的外周血 E 玫瑰花结阳性细胞发生反应，而与 E 细胞、单核细胞、粒细胞、EBV 转化的 B 细胞系和小鼠脾细胞的反应性可忽略不计。

Description

CD-4 Human Recombinant His Tag protein encoding 203-317 amino acids.

Source

Escherichia Coli.

Physical Appearance

Sterile lyophilized powder.

Formulation

Each mg contains 1X PBS, 0.1% and 1mM DTT.

Stability

Store vial at -20oC to -80oC. When stored at the recommended temperature, this protein is stable for 12 months.
Please avoid freeze-thaw cycles.

Applications

• Protein Assay.
• Antibody Production.
• Western Blotting.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Solubility

It is recommended to reconstitute the lyophilized CD-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

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  • CD4 Antibody

ProSpec,CD40 Human,CD40人重组PRO-1911

CD40 属于 TNF 受体超级家族。 已发现 CD40 在介导广泛的免疫和炎症反应中至关重要，包括 T 细胞依赖性免疫球蛋白类别转换、记忆 B 细胞发育和生发中心形成。ProSpec,CD40 Human,CD40人重组PRO-1911

  • CD40 Human

  • CD40 Human Recombinant
  • PRO-1911

Catalogue number

PRO-1911

Synonyms

CD40 Molecule, TNF Receptor Superfamily Member 5, TNFRSF5, Tumor Necrosis Factor Receptor Superfamily, Member 5, Bp50, B-Cell Surface Antigen CD40, CD40L Receptor, CDW40, B Cell Surface Antigen CD40, B Cell-Associated Molecule, CD40 Antigen , CD40 Type II Isoform, Nerve Growth Factor Receptor-Related B-Lymphocyte Activation Molecule, p50, Tumor Necrosis Factor Receptor Superfamily Member 5, CDw40, CD40 Antigen.

Introduction

CD40 belongs to the TNF-receptor super family. CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis.
CD40 属于 TNF 受体超级家族。 已发现 CD40 在介导广泛的免疫和炎症反应中至关重要，包括 T 细胞依赖性免疫球蛋白类别转换、记忆 B 细胞发育和生发中心形成。 AT-hook 转录因子 AKNA 可协调调节 CD40 及其配体的表达，这对同型细胞相互作用具有重要意义。 衔接蛋白 TNFR2 与 CD40 相互作用并充当信号转导的介质。 发现 CD40 与其配体的相互作用对于淀粉样蛋白-β 诱导的小胶质细胞活化至关重要，因此被认为是阿尔茨海默病发病机制的早期事件。

Description

CD40 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 196 amino acids and having a molecular mass of 21.6kDa.

CD40 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD40 protein solution containing 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSEPPTACR EKQYLINSQC CSLCQPGQKL VSDCTEFTET ECLPCGESEF LDTWNRETHC HQHKYCDPNL GLRVQQKGTS ETDTICTCEE GWHCTSEACE SCVLHRSCSP GFGVKQIATG VSDTICEPCP VGFFSNVSSA FEKCHPWTSC ETKDLVVQQA GTNKTDVVCG PQDRLR

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD40 Human, HEK

ProSpec,CD40 Mouse,CD40 小鼠重组PRO-2242

CD40 属于 TNF 受体超级家族。 已发现 CD40 在介导广泛的免疫和炎症反应中至关重要，包括 T 细胞依赖性免疫球蛋白类别转换、记忆 B 细胞发育和生发中心形成。ProSpec,CD40 Mouse,CD40 小鼠重组PRO-2242

  • CD40 Mouse

  • CD40 Mouse Recombinant
  • PRO-2242

Catalogue number

PRO-2242

Synonyms

Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40.

Introduction

CD40 belongs to the TNF-receptor super family. CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis.
CD40 属于 TNF 受体超级家族。 已发现 CD40 在介导广泛的免疫和炎症反应中至关重要，包括 T 细胞依赖性免疫球蛋白类别转换、记忆 B 细胞发育和生发中心形成。 AT-hook 转录因子 AKNA 可协调调节 CD40 及其配体的表达，这对同型细胞相互作用具有重要意义。 衔接蛋白 TNFR2 与 CD40 相互作用并充当信号转导的介质。 发现 CD40 与其配体的相互作用对于淀粉样蛋白-β 诱导的小胶质细胞活化至关重要，因此被认为是阿尔茨海默病发病机制的早期事件。

Description

CD40 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 180 amino acids and having a molecular mass of 20.1kDa .
CD40 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD40 是单条糖基化多肽链，含有 180 个氨基酸，分子量为 20.1kDa。
CD40 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD40 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。

对于长期储存，建议添加载体蛋白。

避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

LGQCVTCSDK QYLHDGQCCD LCQPGSRLTS HCTALEKTQC HPCDSGEFSA QWNREIRCHQ HRHCEPNQGL RVKKEGTAES DTVCTCKEGQ HCTSKDCEAC AQHTPCIPGF GVMEMATETT DTVCHPCPVG FFSNQSSLFE KCYPWTSCED KNLEVLQKGT SQTNVICGLK SRMRHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD40 Human

ProSpec-CD46 Human,CD46人重组PRO-1414

ProSpec-CD46 Human,CD46人重组PRO-1414,膜辅因子蛋白亚型 14 是一种 I 型膜蛋白，具有辅助因子活性，可通过血清因子 I 使补体成分 C3b 和 C4b 失活。此功能存在于补体控制蛋白重复序列中，CCP1-4 对调节至关重要。

  • CD46 Human

  • CD46 Human Recombinant
  • PRO-1414

Catalogue number

PRO-1414

Synonyms

AHUS2, MCP, MIC10, TLX, TRA2.10, Membrane cofactor protein, Trophoblast leukocyte common antigen, CD46.

Introduction

Membrane cofactor protein isoform 14 , is a type I membrane protein which has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats , with CCP1–4 vital for regulation. CD46 is also involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 is common in thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm.
膜辅因子蛋白亚型 14 是一种 I 型膜蛋白，具有辅助因子活性，可通过血清因子 I 使补体成分 C3b 和 C4b 失活。此功能存在于补体控制蛋白重复序列中，CCP1-4 对调节至关重要。 CD46 还参与受精过程中精子与卵母细胞的融合。 CD46常见于胸腺细胞、T细胞、B细胞、单核细胞、粒细胞、NK细胞、血小板、内皮细胞、上皮细胞、成纤维细胞、胎盘和精子中。

Description

CD46 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids and having a molecular mass of 33.8kDa. CD46 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD46 protein solution containing 20mM Tris-HCl buffer , 0.1M NaCl and 20% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LD.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD46 Antibody
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ProSpec,CD46 Human Sf9,CD46 人重组Sf9 PRO-2361

ProSpec,CD46 Human Sf9,CD46 人重组Sf9 PRO-2361,CD46 还参与受精过程中精子与卵母细胞的融合。 CD46常见于胸腺细胞、T细胞、B细胞、单核细胞、粒细胞、NK细胞、血小板、内皮细胞、上皮细胞、成纤维细胞、胎盘和精子中。

  • Description

  • CD46 Human, Sf9

  • CD46 Human Recombinant, Sf9
  • PRO-2361

Catalogue number

PRO-2361

Synonyms

AHUS2, MCP, MIC10, TLX, TRA2.10, Membrane cofactor protein, Trophoblast leukocyte common antigen, CD46.

Introduction

Membrane cofactor protein isoform 14 , is a type I membrane protein which has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats , with CCP1–4 vital for regulation. CD46 is also involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 is common in thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm.
膜辅因子蛋白亚型 14 是一种 I 型膜蛋白，具有辅助因子活性，可通过血清因子 I 使补体成分 C3b 和 C4b 失活。此功能存在于补体控制蛋白重复序列中，CCP1-4 对调节至关重要。 CD46 还参与受精过程中精子与卵母细胞的融合。 CD46常见于胸腺细胞、T细胞、B细胞、单核细胞、粒细胞、NK细胞、血小板、内皮细胞、上皮细胞、成纤维细胞、胎盘和精子中。

Description

CD46 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 268 amino acids and having a molecular mass of 32.5kDa .
CD46 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD46 protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADLCEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LDHHHHHH

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD46 Human

ProSpec,CD47 Human,CD47人重组PRO-2237

在 Sf9 杆状病毒细胞中产生的 CD47 是一条糖基化多肽链，在 C 端与一个 6 个氨基酸的 His 标签融合，共含有 129 个氨基酸，分子量为 14.7kDa。ProSpec,CD47 Human,CD47人重组PRO-2237

  • CD47 Human

  • CD47 Human Recombinant
  • PRO-2237

Catalogue number

PRO-2237

Synonyms

CD47 Molecule, Antigenic Surface Determinant Protein OA3, CD47 Antigen , Antigen Identified By Monoclonal Antibody 1D8, Integrin Associated Protein, Integrin-Associated Protein, Rh-Related Antigen, CD47 Glycoprotein, MER6, IAP, Integrin-Associated Signal Transducer, Leukocyte Surface Antigen CD47, CD47 Antigen, Protein MER6, OA3, CD47.
CD47 分子、抗原性表面决定蛋白 OA3、CD47 抗原、由单克隆抗体 1D8 鉴定的抗原、整合素相关蛋白、整合素相关蛋白、Rh 相关抗原、CD47 糖蛋白、MER6、IAP、整合素相关信号转导子、白细胞表面抗原 CD47 、CD47 抗原、蛋白 MER6、OA3、CD47。

Introduction

CD47, functions in cell adhesions by performing as an adhesion receptor for THBS1 on platelets, furthermore CD47 plays a role in the modulation of integrins. In addition, CD47 takes a vital part in memory formation as well as synaptic plasticity in the hippocampus. Receptor for SIRPA avoids maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 prevents premature elimination of red blood cells, and it is also implicated in membrane permeability changes induced following virus infection.
CD47 通过作为血小板上 THBS1 的粘附受体在细胞粘附中发挥作用，此外 CD47 在整联蛋白的调节中起作用。 此外，CD47 在海马的记忆形成和突触可塑性中起着至关重要的作用。 SIRPA 受体可避免未成熟树突细胞成熟并抑制成熟树突细胞产生细胞因子。 CD47 可防止红细胞过早消除，并且它还与病毒感染后诱导的膜通透性变化有关。

Description

CD47 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 6 aa His Tag at C-terminus containing a total of 129 amino acids and having a molecular mass of 14.7kDa.
CD47 shows multiple bands between 18-28kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD47 是一条糖基化多肽链，在 C 端与一个 6 个氨基酸的 His 标签融合，共含有 129 个氨基酸，分子量为 14.7kDa。
CD47 在 -PAGE、还原条件和专有色谱技术纯化后显示 18-28kDa 之间的多个条带。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD47 protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS PNEHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD47 Human, IgG-His

ProSpec,CD47 Human IgG-His,CD47人重组PRO-1767

ProSpec,CD47 Human IgG-His,CD47人重组PRO-1767,在 Sf9 昆虫细胞中产生的 CD47 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 362 个氨基酸，分子量为 40.9kDa。

  • CD47 Human, IgG-His

  • CD47 Human Recombinant, IgG-His Tag
  • PRO-1767

Catalogue number

PRO-1767

Synonyms

CD47 Molecule, Antigenic Surface Determinant Protein OA3, CD47 Antigen , Antigen Identified by Monoclonal, Antibody 1D8, Integrin Associated Protein, Integrin-Associated Protein, Rh-Related, Antigen, CD47 Glycoprotein, MER6, IAP, Integrin-Associated Signal Transducer, Leukocyte Surface Antigen CD47, CD47 Antigen, Protein MER6, OA3.

Introduction

CD47, functions in cell adhesions by performing as an adhesion receptor for THBS1 on platelets, furthermore CD47 plays a role in the modulation of integrins. In addition, CD47 takes a vital part in memory formation as well as synaptic plasticity in the hippocampus. Receptor for SIRPA avoids maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 prevents premature elimination of red blood cells, and it is also implicated in membrane permeability changes induced following virus infection.
CD47 通过作为血小板上 THBS1 的粘附受体在细胞粘附中发挥作用，此外 CD47 在整联蛋白的调节中起作用。 此外，CD47 在海马的记忆形成和突触可塑性中起着至关重要的作用。 SIRPA 受体可避免未成熟树突细胞成熟并抑制成熟树突细胞产生细胞因子。 CD47 可防止红细胞过早消除，并且它还与病毒感染后诱导的膜通透性变化有关。

Description

CD47 Human Recombinant produced in Sf9 Insect cell is a single, non-glycosylated polypeptide chain containing 362 amino acids and having a molecular mass of 40.9kDa .
CD47 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.
在 Sf9 昆虫细胞中产生的 CD47 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 362 个氨基酸，分子量为 40.9kDa。
CD47 在 C 末端与 239 个氨基酸的 hIgG-His-tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD47 protein solution containing Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS PNELEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP
EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD47 Human

ProSpec,CD5 Human,CD5人重组PRO-1939

CD5 通常在皮肤 T 细胞淋巴瘤中丢失，其缺乏可作为这种情况下恶性肿瘤的指标。 CD5 在 T 细胞急性淋巴细胞白血病中的缺失虽然相对罕见，但与预后不良有关。 CD5 作为调节 T 细胞增殖的受体。ProSpec,CD5 Human,CD5人重组PRO-1939

  • CD5 Human

  • CD5 Human Recombinant
  • PRO-1939

Catalogue number

PRO-1939

Synonyms

CD5 Molecule, CD5, LEU1, CD5 Antigen , Lymphocyte Antigen T1/Leu-1, T1, T-Cell Surface Glycoprotein CD5, CD5 Antigen.

Introduction

CD5 is a suitable immunohistochemical marker for T-cells, though not as sensitive as CD3. Approximately 76% of T-cell neoplasms are reported to express CD5, and it is also observed in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. CD5 is commonly lost in cutaneous T-cell lymphoma, and its deficiency can be used as an indicator of malignancy in this condition. CD5’s absence in T cell acute lymphoblastic leukemia, though relatively rare, is linked with a poor prognosis. CD5 serves as a receptor in regulating T-cell proliferation.
CD5 是一种合适的 T 细胞免疫组织化学标记物，但不如 CD3 敏感。 据报道，大约 76% 的 T 细胞肿瘤表达 CD5，并且在慢性淋巴细胞白血病、毛细胞白血病和套细胞淋巴瘤细胞中也观察到。 CD5 通常在皮肤 T 细胞淋巴瘤中丢失，其缺乏可作为这种情况下恶性肿瘤的指标。 CD5 在 T 细胞急性淋巴细胞白血病中的缺失虽然相对罕见，但与预后不良有关。 CD5 作为调节 T 细胞增殖的受体。

Description

CD5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 371 amino acids and having a molecular mass of 41.0 kDa.
CD5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD5 solution contains 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 80% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSRLSWYDP DFQARLTRSN SKCQGQLEVY LKDGWHMVCS QSWGRSSKQW EDPSQASKVC QRLNCGVPLS LGPFLVTYTP QSSIICYGQL GSFSNCSHSR NDMCHSLGLT CLEPQKTTPP TTRPPPTTTP EPTAPPRLQL VAQSGGQHCA GVVEFYSGSL GGTISYEAQD KTQDLENFLC NNLQCGSFLK HLPETEAGRA QDPGEPREHQ PLPIQWKIQN SSCTSLEHCF RKIKPQKSGR VLALLCSGFQ PKVQSRLVGG SSICEGTVEV RQGAQWAALC DSSSARSSLR WEEVCREQQC GSVNSYRVLD AGDPTSRGLF CPHQKLSQCH ELWERNSYCK KVFVTCQDPN P.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD5 Antibody
  • CD5 Human, Sf9

ProSpec,CD5 Human Sf9,CD5 人重组体Sf9 PRO-2400

ProSpec,CD5 Human Sf9,CD5 人重组体Sf9 PRO-2400,CD5 通常在皮肤 T 细胞淋巴瘤中丢失，其缺乏可作为这种情况下恶性肿瘤的指标。 CD5 在 T 细胞急性淋巴细胞白血病中的缺失虽然相对罕见，但与预后不良有关。 CD5 作为调节 T 细胞增殖的受体。

  • CD5 Human, Sf9

  • CD5 Human Recombinant, Sf9
  • PRO-2400

Catalogue number

PRO-2400

Synonyms

CD5 Molecule, Lymphocyte Antigen T1/Leu-1, CD5 Antigen , LEU1, T-Cell Surface Glycoprotein CD5, CD5 Antigen, T1.

Introduction

CD5 is a suitable immunohistochemical marker for T-cells, though not as sensitive as CD3. Approximately 76% of T-cell neoplasms are reported to express CD5, and it is also observed in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. CD5 is commonly lost in cutaneous T-cell lymphoma, and its deficiency can be used as an indicator of malignancy in this condition. CD5’s absence in T cell acute lymphoblastic leukemia, though relatively rare, is linked with a poor prognosis. CD5 serves as a receptor in regulating T-cell proliferation.

CD5 是一种合适的 T 细胞免疫组织化学标记物，但不如 CD3 敏感。 据报道，大约 76% 的 T 细胞肿瘤表达 CD5，并且在慢性淋巴细胞白血病、毛细胞白血病和套细胞淋巴瘤细胞中也观察到。 CD5 通常在皮肤 T 细胞淋巴瘤中丢失，其缺乏可作为这种情况下恶性肿瘤的指标。 CD5 在 T 细胞急性淋巴细胞白血病中的缺失虽然相对罕见，但与预后不良有关。 CD5 作为调节 T 细胞增殖的受体。

Description

CD5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 359 amino acids and having a molecular mass of 40kDa . CD5 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD5 protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPEFRLSWY DPDFQARLTR SNSKCQGQLE VYLKDGWHMV CSQSWGRSSK QWEDPSQASK VCQRLNCGVP LSLGPFLVTY TPQSSIICYG QLGSFSNCSH SRNDMCHSLG LTCLEPQKTT PPTTRPPPTT TPEPTAPPRL QLVAQSGGQH CAGVVEFYSG SLGGTISYEA QDKTQDLENF LCNNLQCGSF LKHLPETEAG RAQDPGEPRE HQPLPIQWKI QNSSCTSLEH CFRKIKPQKS GRVLALLCSG FQPKVQSRLV GGSSICEGTV EVRQGAQWAA LCDSSSARSS LRWEEVCREQ QCGSVNSYRV LDAGDPTSRG LFCPHQKLSQ CHELWERNSY CKKVFVTCQD PNPHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD5 Human
  • CD5 Antibody

ProSpec,CD8B Human,CD8B人重组PRO-1843

ProSpec,CD8B Human,CD8B人重组PRO-1843,CD8B 编码 CD8 抗原的 CD8 β 链异构体。 CD8 是一种细胞表面糖蛋白，可促进免疫系统内有效的细胞间相互作用，位于大多数细胞毒性 T 淋巴细胞上。

  • CD8B Human

  • CD8B Human Recombinant
  • PRO-1843

Catalogue number

PRO-1843

Synonyms

T Lymphocyte Surface Glycoprotein Beta Chain, CD8 Antigen, Beta Polypeptide 1 , CD8b Molecule, CD8b Antigen, T-Cell Surface Glycoprotein CD8 Beta Chain, CD8B1, LYT3, LY3, LEU2, P37.

Introduction

CD8B encodes the CD8 beta chain isoforms of the CD8 antigen. CD8 is a cell surface glycoprotein which facilitates efficient cell-cell interactions within the immune system and is located on most cytotoxic T lymphocytes. The T-cell receptor on the T lymphocyte and the co-receptor CD8 antigen identify antigens exposed by an antigen presenting cell in the context of class I MHC molecules. The functional co-receptor is either a heterodimer composed of one alpha and one beta chain or a homodimer composed of two alpha chains. Both alpha and beta chains share substantial homology to immunoglobulin variable light chains.
CD8B 编码 CD8 抗原的 CD8 β 链异构体。 CD8 是一种细胞表面糖蛋白，可促进免疫系统内有效的细胞间相互作用，位于大多数细胞毒性 T 淋巴细胞上。 T 淋巴细胞上的 T 细胞受体和辅助受体 CD8 抗原识别在 I 类 MHC 分子的情况下由抗原呈递细胞暴露的抗原。 功能性共受体是由一条α链和一条β链组成的异二聚体或由两条α链组成的同源二聚体。 α 和 β 链都与免疫球蛋白可变轻链具有实质性的同源性。

Description

CD8B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 172 amino acids and having a molecular mass of 19.2 kDa. CD8B is fused to a 23 amino acid His-tag at N-terminus.
在大肠杆菌中产生的 CD8B Human Recombinant 是一个单一的、非糖基化的多肽链，包含 172 个氨基酸，分子量为 19.2 kDa。 CD8B 在 N 端与 23 个氨基酸的 His 标签融合。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The CD8B solution contains 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 80% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD8B Human, Sf9

ProSpec-CD8B Human Sf9,CD8B人重组PRO-2508

CD8B 编码 CD8 抗原的 CD8 β 链异构体。 CD8 是一种细胞表面糖蛋白，可促进免疫系统内有效的细胞间相互作用，位于大多数细胞毒性 T 淋巴细胞上。ProSpec-CD8B Human Sf9,CD8B人重组PRO-2508

  • CD8B Human, Sf9

  • CD8B Human Recombinant, Sf9
  • PRO-2508

Catalogue number

PRO-2508

Synonyms

CD8b Molecule, CD8 Antigen, Beta Polypeptide 1 , CD8B1, T Lymphocyte Surface Glycoprotein Beta Chain, T-Cell Surface Glycoprotein CD8 Beta Chain, CD8b Antigen, Leu2, LYT3, P37, LY3, T-cell surface glycoprotein CD8 beta chain.

Introduction

CD8B encodes the CD8 beta chain isoforms of the CD8 antigen. CD8 is a cell surface glycoprotein which facilitates efficient cell-cell interactions within the immune system and is located on most cytotoxic T lymphocytes. The T-cell receptor on the T lymphocyte and the co-receptor CD8 antigen identify antigens exposed by an antigen presenting cell in the context of class I MHC molecules. The functional co-receptor is either a heterodimer composed of one alpha and one beta chain or a homodimer composed of two alpha chains. Both alpha and beta chains share substantial homology to immunoglobulin variable light chains.

CD8B 编码 CD8 抗原的 CD8 β 链异构体。 CD8 是一种细胞表面糖蛋白，可促进免疫系统内有效的细胞间相互作用，位于大多数细胞毒性 T 淋巴细胞上。 T 淋巴细胞上的 T 细胞受体和辅助受体 CD8 抗原识别在 I 类 MHC 分子的情况下由抗原呈递细胞暴露的抗原。 功能性共受体是由一条α链和一条β链组成的异二聚体或由两条α链组成的同源二聚体。 α 和 β 链都与免疫球蛋白可变轻链具有实质性的同源性。

Description

CD8B produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 158 amino acids and having a molecular mass of 17.8kDa. .
CD8B is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD8B protein solution contains 10% glycerol & Phosphate Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

ADPLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SPHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD8B Human

ProSpec,CD5L Human,CD5分子样人重组PRO-1578

ProSpec,CD5L Human,CD5分子样人重组PRO-1578,CD5抗原样参与免疫系统的调节。 CD5L 起凋亡抑制剂的作用。 CD5L 在脾脏、淋巴结、胸腺和骨髓中表达。

  • CD5L Human

  • CD5 Molecule-Like Human Recombinant
  • PRO-1578

Catalogue number

PRO-1578

Synonyms

CD5 antigen-like, CT-2, IgM-associated peptide, SP-alpha, CD5L, API6, AIM, API6, PRO229, Spalpha.

Introduction

CD5 antigen-like participates in the regulation of the immune system. CD5L functions as an inhibitor of apoptosis. CD5L is expressed in the spleen, lymph node, thymus and bone marrow.
CD5抗原样参与免疫系统的调节。 CD5L 起凋亡抑制剂的作用。 CD5L 在脾脏、淋巴结、胸腺和骨髓中表达。

Description

CD5L Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 337 amino acids including a 9 a.a N-terminal His tag. The total molecular mass is 37.2kDa .
在大肠杆菌中产生的 CD5L Human Recombinant 是一个单一的、非糖基化的多肽链，包含 337 个氨基酸，包括一个 9 个氨基酸的 N 端 His 标签。 总分子量为37.2kDa。

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized powder.

Formulation

CD5L filtered and lyophilized from 0.5mg/ml in 50mM Tris buffer, pH 8.6.

Solubility

It is recommended to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. CD5L is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MKHHHHHHAS PSGVRLVGGL HRCEGRVEVE QKGQWGTVCD DGWDIKDVAV LCRELGCGAA SGTPSGILYE PPAEKEQKVL IQSVSCTGTE DTLAQCEQEE VYDCSHDEDA GASCENPESS FSPVPEGVRL ADGPGHCKGR VEVKHQNQWY TVCQTGWSLR AAKVVCRQLG CGRAVLTQKR CNKHAYGRKP IWLSQMSCSG REATLQDCPS GPWGKNTCNH DEDTWVECED PFDLRLVGGD NLCSGRLEVL HKGVWGSVCD DNWGEKEDQV VCKQLGCGKS LSPSFRDRKC YGPGVGRIWL DNVRCSGEEQ SLEQCQHRFW GFHDCTHQED VAVICSG.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD5L Human, HEK
  • CD5L Mouse

ProSpec,CD5L Human HEK,CD5分子样人重组PRO-2025

ProSpec,CD5L Human HEK,CD5分子样人重组PRO-2025,在 HEK 细胞中产生的 CD5L Human Recombinant 是单条糖基化多肽链，总共包含 334 个氨基酸，计算出的分子量为 36.9kDa，并在 C 末端与 6aa His 标签融合。

  • CD5L Human, HEK

  • CD5 Molecule-Like Human Recombinant, HEK
  • PRO-2025

Catalogue number

PRO-2025

Synonyms

CD5 antigen-like, CT-2, IgM-associated peptide, SP-alpha, CD5L, API6, AIM, API6, PRO229, Spalpha.

Introduction

CD5 antigen-like participates in the regulation of the immune system. CD5L functions as an inhibitor of apoptosis. CD5L is expressed in the spleen, lymph node, thymus and bone marrow.
CD5抗原样参与免疫系统的调节。 CD5L 起凋亡抑制剂的作用。 CD5L 在脾脏、淋巴结、胸腺和骨髓中表达。

Description

CD5L Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing a total of 334 amino acids, having a calculated molecular mass of 36.9kDa and fused to a 6 aa His tag at C-Terminus.
在 HEK 细胞中产生的 CD5L Human Recombinant 是单条糖基化多肽链，总共包含 334 个氨基酸，计算出的分子量为 36.9kDa，并在 C 末端与 6aa His 标签融合。

Source

HEK 293.

Physical Appearance

Filtered White lyophilized powder.

Formulation

CD5L was filtered and lyophilized from 0.5mg/ml solution in phosphate buffered saline pH 7.5.

Solubility

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. CD5L is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.

Amino acid sequence

SPSGVRLVGG LHRCEGRVEV EQKGQWGTVC DDGWDIKDVA VLCRELGCGA ASGTPSGILY EPPAEKEQKV LIQSVSCTGT EDTLAQCEQE EVYDCSHDED AGASCENPES SFSPVPEGVR LADGPGHCKG RVEVKHQNQW YTVCQTGWSL RAAKVVCRQL GCGRAVLTQK RCNKHAYGRK PIWLSQMSCS GREATLQDCP SGPWGKNTCN HDEDTWVECE DPFDLRLVGG DNLCSGRLEV LHKGVWGSVC DDNWGEKEDQ VVCKQLGCGK SLSPSFRDRK CYGPGVGRIW LDNVRCSGEE QSLEQCQHRF WGFHDCTHQE DVAVICSGHH HHHH.

Purity

Greater than 95.0% as determined by -PAGE.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD5L Mouse
  • CD5L Human

ProSpec,CD5L Mouse,CD5 分子样小鼠重组PRO-2243

ProSpec,CD5L Mouse,CD5 分子样小鼠重组PRO-2243,在 Sf9 昆虫细胞中产生的 CD5L 是一条糖基化多肽链，包含 339 个氨基酸，分子量为 37.6 kDa。 .

  • CD5L Mouse

  • CD5 Molecule-Like Mouse Recombinant
  • PRO-2243

Catalogue number

PRO-2243

Synonyms

CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, Apoptosis inhibitory 6 CT-2, SP-alpha, Cd5l’ Aim, Api6.

Introduction

CD5 antigen-like participates in the regulation of the immune system. CD5L functions as an inhibitor of apoptosis. CD5L is expressed in the spleen, lymph node, thymus and bone marrow.
CD5抗原样参与免疫系统的调节。 CD5L 起凋亡抑制剂的作用。 CD5L 在脾脏、淋巴结、胸腺和骨髓中表达。

Description

CD5L produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 339 amino acids and having a molecular mass of 37.6 kDa. .
CD5L is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 昆虫细胞中产生的 CD5L 是一条糖基化多肽链，包含 339 个氨基酸，分子量为 37.6 kDa。 .
CD5L 在 C 末端用 8 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD5L protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ESPTKVQLVG GAHRCEGRVE VEHNGQWGTV CDDGWDRRDV AVVCRELNCG AVIQTPRGAS YQPPASEQRV LIQGVDCNGT EDTLAQCELN YDVFDCSHEE DAGAQCENPD SDLLFIPEDV RLVDGPGHCQ GRVEVLHQSQ WSTVCKAGWN LQVSKVVCRQ LGCGRALLTY GSCNKSTQGK GPIWMGKMSC SGQEANLRSC LLSRLENNCT HGEDTWMECE DPFELKLVGG DTPCSGRLEV LHKGSWGSVC DDNWGEKEDQ VVCKQLGCGK SLHPSPKTRK IYGPGAGRIW LDDVNCSGKE QSLEFCRHRL WGYHDCTHKE DVEVICTDFD VLEHHHHHH.

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD5L Human, HEK
  • CD5L Human

ProSpec,CD68 Human,CD68 人重组PRO-1209

ProSpec,CD68 Human,CD68 人重组PRO-1209,它是一种 I 型整合膜蛋白，具有高度糖基化的细胞外结构域，可与组织和器官特异性凝集素或选择素结合。 该蛋白质也是清道夫受体家族的成员。

  • CD68 Human

  • CD68 Human Recombinant
  • PRO-1209

Catalogue number

PRO-1209

Synonyms

Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236.

Introduction

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
CD68 编码一种 110-kD 的跨膜糖蛋白，在人类单核细胞和组织巨噬细胞中高度表达。 它是溶酶体/内体相关膜糖蛋白家族的成员。 该蛋白质主要定位于溶酶体和内体，其中一小部分循环到细胞表面。 它是一种 I 型整合膜蛋白，具有高度糖基化的细胞外结构域，可与组织和器官特异性凝集素或选择素结合。 该蛋白质也是清道夫受体家族的成员。 清道夫受体通常起到清除细胞碎片、促进吞噬作用和介导巨噬细胞募集和活化的作用。 选择性剪接导致多个转录本编码不同的亚型。

Description

CD68 Human Recombinant produced in E. coli is a single polypeptide chain containing 323 amino acids and having a molecular mass of 34.1 kDa.
CD68 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD68 solution contains 20mM Tris-HCl buffer , 0.1M NaCl, 1M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHPLHHH SSGLVPRGSH MGSHMNDCPH KKSATLLPSF TVTPTVTEST GTTSHRTTKS HKTTTHRTTT TGTTSHGPTT ATHNPTTTSH GNVTVHPTSN STATSQGPST ATHSPATTSH GNATVHPTSN STATSPGFTS SAHPEPPPPS PSPSPTSKET IGDYTWTNGS QPCVHLQAQI QIRVMYTTQG GGEAWGISVL NPNKTKVQGS CEGAHPHLLL SFPYGHLSFG FMQDLQQKVV YLSYMAVEYN VSFPHAAQWT FSAQNASLRD LQAPLGQSFS CSNSSIILSP AVHLDLLSLR LQAAQLPHTG VFGQSFSCPS DRS

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD68 Human, 38kDa
  • CD68 Human, sf9

ProSpec,CD68 Human 38kDa,CD68 人重组PRO-293

ProSpec,CD68 Human 38kDa,CD68 人重组PRO-293,CD68 编码一种 110-kD 的跨膜糖蛋白，在人类单核细胞和组织巨噬细胞中高度表达。 它是溶酶体/内体相关膜糖蛋白家族的成员。 该蛋白质主要定位于溶酶体和内体，其中一小部分循环到细胞表面。

  • CD68 Human, 38kDa

  • CD68 Human Recombinant, 38kDa
  • PRO-293

Catalogue number

PRO-293

Synonyms

Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236.

Introduction

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
CD68 编码一种 110-kD 的跨膜糖蛋白，在人类单核细胞和组织巨噬细胞中高度表达。 它是溶酶体/内体相关膜糖蛋白家族的成员。 该蛋白质主要定位于溶酶体和内体，其中一小部分循环到细胞表面。 它是一种 I 型整合膜蛋白，具有高度糖基化的细胞外结构域，可与组织和器官特异性凝集素或选择素结合。 该蛋白质也是清道夫受体家族的成员。 清道夫受体通常起到清除细胞碎片、促进吞噬作用和介导巨噬细胞募集和活化的作用。 选择性剪接导致多个转录本编码不同的亚型。

Description

CD68 Human Recombinant full length expressed in E.coli, shows a 38 kDa band on -PAGE.
CD68 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD68 at 100µg/1ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol.

Stability

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD68 Human, sf9
  • CD68 Human

ProSpec-CD68 Human sf9,CD68 人重组PRO-2375

CD68 编码一种 110-kD 的跨膜糖蛋白，在人类单核细胞和组织巨噬细胞中高度表达。 它是溶酶体/内体相关膜糖蛋白家族的成员。ProSpec-CD68 Human sf9,CD68 人重组PRO-2375

  • CD68 Human, sf9

  • CD68 Human Recombinant, sf9
  • PRO-2375

Catalogue number

PRO-2375

Synonyms

Macrosialin, CD68, Gp110, Macrosialin isoform A, GP110, LAMP4, SCARD1.

Introduction

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
CD68 编码一种 110-kD 的跨膜糖蛋白，在人类单核细胞和组织巨噬细胞中高度表达。 它是溶酶体/内体相关膜糖蛋白家族的成员。 该蛋白质主要定位于溶酶体和内体，其中一小部分循环到细胞表面。 它是一种 I 型整合膜蛋白，具有高度糖基化的细胞外结构域，可与组织和器官特异性凝集素或选择素结合。 该蛋白质也是清道夫受体家族的成员。 清道夫受体通常起到清除细胞碎片、促进吞噬作用和介导巨噬细胞募集和活化的作用。 选择性剪接导致多个转录本编码不同的亚型。

Description

CD68 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 307 amino acids and having a molecular mass of 32.6kDa .
CD68 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD68 Human Recombinant 是单条糖基化多肽链，包含 307 个氨基酸，分子量为 32.6kDa。
CD68 在 C 末端与 6 个氨基酸 His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD68 protein solution containing Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by analysis by -PAGE.

Amino acid sequence

ADPNDCPHKK SATLLPSFTV TPTVTESTGT TSHRTTKSHK TTTHRTTTTG TTSHGPTTAT HNPTTTSHGN VTVHPTSNST ATSQGPSTAT HSPATTSHGN ATVHPTSNST ATSPGFTSSA HPEPPPPSPS PSPTSKETIG DYTWTNGSQP CVHLQAQIQI RVMYTTQGGG EAWGISVLNP NKTKVQGSCE GAHPHLLLSF PYGHLSFGFM QDLQQKVVYL SYMAVEYNVS FPHAAQWTFS AQNASLRDLQ APLGQSFSCS NSSIILSPAV HLDLLSLRLQ AAQLPHTGVF GQSFSCPSDR SHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD68 Human, 38kDa
  • CD68 Human

ProSpec,CD55 Human,CD55人重组PRO-2514

ProSpec,CD55 Human,CD55人重组PRO-2514,CD55 广泛分布于造血和非造血细胞中。 CD55 在肿瘤发生、细胞拯救和逃避细胞凋亡的自分泌环、细胞运动、侵袭性等方面具有关键作用。

  • CD55 Human

  • CD55 Human Recombinant
  • PRO-2514

Catalogue number

PRO-2514

Synonyms

CD55 Antigen, DAF, CD55 Molecule, CHAPLE, Cromer Blood Group Antigen, Complement Decay-Accelerating Factor, CROM.

Introduction

Decay-Accelerating Factor Isoform 1 or CD55, is a protein that attached to the cell membrane through glycophosphatidylinositol anchor. CD55 regulates the complement system in the outer membrane. The protein is a receptor to many types of enteroviruses such as coxsackieviruses. CD55 is widely scattered amidst hematopoietic & non-hematopoietic cells. The CD55 has a crucial part in tumorigenesis, autocrine loops for cell rescue and evasion of apoptosis, cell motility, invasiveness etc.

衰变加速因子 Isoform 1 或 CD55，是一种通过糖磷脂酰肌醇锚附着在细胞膜上的蛋白质。 CD55 调节外膜中的补体系统。 该蛋白是多种肠道病毒如柯萨奇病毒的受体。 CD55 广泛分布于造血和非造血细胞中。 CD55 在肿瘤发生、细胞拯救和逃避细胞凋亡的自分泌环、细胞运动、侵袭性等方面具有关键作用。

Description

CD55 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 9 aa His Tag at C-terminus containing a total of 328 amino acids and having a molecular mass of 36kDa. CD55 shows multiple bands between 40-57kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD55 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPDCGLPPD VPNAQPALEG RTSFPEDTVI TYKCEESFVK IPGEKDSVIC LKGSQWSDIE EFCNRSCEVP TRLNSASLKQ PYITQNYFPV GTVVEYECRP GYRREPSLSP KLTCLQNLKW STAVEFCKKK SCPNPGEIRN GQIDVPGGIL FGATISFSCN TGYKLFGSTS SFCLISGSSV QWSDPLPECR EIYCPAPPQI DNGIIQGERD HYGYRQSVTY ACNKGFTMIG EHSIYCTVNN DEGEWSGPPP ECRGKSLTSK VPPTVQKPTT VNVPTTEVSP TSQKTTTKTT TPNAQATRST PVSRTTKHFH ETTPNKGSGT TSHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD55 Mouse

ProSpec,CD55 Mouse,CD55 小鼠重组PRO-2319

ProSpec,CD55 Mouse,CD55 小鼠重组PRO-2319,在 Sf9 杆状病毒细胞中产生的 CD55 是单条糖基化多肽链，包含 336 个氨基酸，分子量为 36.8kDa。

  • CD55 Mouse

  • CD55 Mouse Recombinant
  • PRO-2319

Catalogue number

PRO-2319

Synonyms

Complement decay-accelerating factor, GPI-anchored, DAF-GPI, CD_antigen: CD55.

Introduction

CD55 belongs to the RCA family characterized by 4-30 SCRs in their plasma-exposed regions. CD55 is widely expressed in malignant tumors and nevertheless functions as an inhibitor of the complement system.

Description

CD55 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 336 amino acids and having a molecular mass of 36.8kDa .
CD55 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD55 是单条糖基化多肽链，包含 336 个氨基酸，分子量为 36.8kDa。
CD55 在 C 末端用 8 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD55 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

DCGPPPDIPN ARPILGRHSK FAEQSKVAYS CNNGFKQVPD KSNIVVCLEN GQWSSHETFC EKSCVAPERL SFASLKKEYL NMNFFPVGTI VEYECRPGFR KQPPLPGKAT CLEDLVWSPV AQFCKKKSCP NPKDLDNGHI NIPTGILFGS EINFSCNPGY RLVGVSSTFC SVTGNTVDWD DEFPVCTEIH CPEPPKINNG IMRGEYT YSQVVTYSCD KGFILVGNAS IYCTVSKSDV GQWSSPPPRC IEKSKVPTKK PTINVPSTGT PSTPQKPTTE SVPNPGDQPT PQKPSTVKVS ATQHVPVTKT TVRHPIRTST DKGEPNTGLE HHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD55 Human

ProSpec,CD7 Human,CD7人重组PRO-1673

T细胞抗原CD7是一种I型跨膜糖蛋白，表达于多能造血细胞、几乎所有人类胸腺细胞和一些外周血T细胞上。 在某些生理条件下，人类 T 细胞亚群中缺少 CD7 分子。ProSpec,CD7 Human,CD7人重组PRO-1673

  • CD7 Human

  • CD7 Human Recombinant
  • PRO-1673

Catalogue number

PRO-1673

Synonyms

T-cell antigen CD7, GP40, LEU-9, Tp40, TP41, CD7, T-cell leukemia antigen, T-cell surface antigen Leu-9.

Introduction

T-cell antigen CD7 is a type I transmembrane glycoprotein which is expressed on pluripotential hemapoietic cells, nearly all human thymocytes and some peripheral blood T cells. The CD7 molecule is missing in a subset of human T cells under some physiologic conditions. An increase in CD7 negative T cells can be observed in a number of inflammatory skin diseases.
T细胞抗原CD7是一种I型跨膜糖蛋白，表达于多能造血细胞、几乎所有人类胸腺细胞和一些外周血T细胞上。 在某些生理条件下，人类 T 细胞亚群中缺少 CD7 分子。 在许多炎症性皮肤病中可以观察到 CD7 阴性 T 细胞的增加。

Description

CD7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 178 amino acids and having a molecular mass of 18.8 kDa.
CD7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD7 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSAQEVQQS PHCTTVPVGA SVNITCSTSG GLRGIYLRQL GPQPQDIIYY EDGVVPTTDR RFRGRIDFSG SQDNLTITMH RLQLSDTGTY TCQAITEVNV YGSGTLVLVT EEQSQGWHRC SDAPPRASAL PAPPTGSALP DPQTASALPD PPAASALP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD7 Antibody
  • CD7 Human, Sf9

ProSpec-CD7 Human Sf9,CD7人重组PRO-2420

T细胞抗原CD7是一种I型跨膜糖蛋白，表达于多能造血细胞、几乎所有人类胸腺细胞和一些外周血T细胞上。 在某些生理条件下，人类 T 细胞亚群中缺少 CD7 分子。ProSpec-CD7 Human Sf9,CD7人重组PRO-2420

  • CD7 Human, Sf9

  • CD7 Human Recombinant, Sf9
  • PRO-2420

Catalogue number

PRO-2420

Synonyms

T-cell antigen CD7, GP40, LEU-9, Tp40, TP41, CD7, T-cell leukemia antigen, T-cell surface antigen Leu-9.

Introduction

T-cell antigen CD7 is a type I transmembrane glycoprotein which is expressed on pluripotential hemapoietic cells, nearly all human thymocytes and some peripheral blood T cells. The CD7 molecule is missing in a subset of human T cells under some physiologic conditions. An increase in CD7 negative T cells can be observed in a number of inflammatory skin diseases.

T细胞抗原CD7是一种I型跨膜糖蛋白，表达于多能造血细胞、几乎所有人类胸腺细胞和一些外周血T细胞上。 在某些生理条件下，人类 T 细胞亚群中缺少 CD7 分子。 在许多炎症性皮肤病中可以观察到 CD7 阴性 T 细胞的增加。

Description

CD7 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 164 amino acids and having a molecular mass of 17.5kDa . CD7 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD7 Human Recombinant 是单条糖基化多肽链，包含 164 个氨基酸，分子量为 17.5kDa。 CD7 在 C 末端用 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD7 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADLAQEVQQS PHCTTVPVGA SVNITCSTSG GLRGIYLRQL GPQPQDIIYY EDGVVPTTDR RFRGRIDFSG SQDNLTITMH RLQLSDTGTY TCQAITEVNV YGSGTLVLVT EEQSQGWHRC SDAPPRASAL PAPPTGSALP DPQTASALPD PPAASALPHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD7 Human
  • CD7 Antibody

ProSpec,NT5E (CD73) Human,5′-核苷酸酶体外人重组PRO-1853

ProSpec,NT5E (CD73) Human,5′-核苷酸酶体外人重组PRO-1853,NT5E，也称为 CD73，是一种质膜蛋白，可催化细胞外核苷酸转化为可透过膜的核苷。 NT5E 是淋巴细胞分化的决定因素。

  • NT5E Human

  • 5′-Nucleotidase Ecto Human Recombinant
  • PRO-1853

Catalogue number

PRO-1853

Synonyms

NT, eN, NT5, NTE, eNT, CD73, E5NT, 5′-nucleotidase, 5′-NT, Ecto-5′-nucleotidase, NT5E.

Introduction

NT5E, also known as CD73, is a plasma membrane protein which catalyzes the conversion of extracellular nucleotides into membrane-permeable nucleosides. NT5E is functions as a determinant of lymphocyte differentiation. Defects in NT5E can cause the calcification of joints and arteries.
NT5E，也称为 CD73，是一种质膜蛋白，可催化细胞外核苷酸转化为可透过膜的核苷。 NT5E 是淋巴细胞分化的决定因素。 NT5E 的缺陷会导致关节和动脉的钙化。

Description

NT5E Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 247amino acids and having a molecular mass of 27kDa. NT5E is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

NT5E protein solution containing 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MWELTILHTN DVHSRLEQTS EDSSKCVNAS RCMGGVARLF TKVQQIRRAE PNVLLLDAGD QYQGTIWFTV YKGAEVAHFM NALRYDAMAL GNHEFDNGVE GLIEPLLKEA KFPILSANIK AKGPLASQIS GLYLPYKVLP VGDEVVGIVG YTSKETPFLS NPGTNLVFED EITALQPEVD KLKTLNVNKI IALGHSGFEM DKLIAQKVRG VDVVVGGHSN TFLYTGN.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD73 Antibody
  • NT5E Mouse

ProSpec,NT5E (CD73) Mouse,5′-核苷酸酶体外小鼠重组PRO-2386

ProSpec,NT5E (CD73) Mouse,5′-核苷酸酶体外小鼠重组PRO-2386,在 Sf9 杆状病毒细胞中产生的 NT5E 小鼠重组体是单条糖基化多肽链，含有 531 个氨基酸，分子量为 59.1kDa。

  • NT5E Mouse

  • 5′-Nucleotidase Ecto Mouse Recombinant
  • PRO-2386

Catalogue number

PRO-2386

Synonyms

5′-nucleotidase , 5′-NT, Ecto-5′-nucleotidase, CD73, Nt5e, Nt5, Nte.

Introduction

NT5E, also known as CD73, is a plasma membrane protein which catalyzes the conversion of extracellular nucleotides into membrane-permeable nucleosides. NT5E is functions as a determinant of lymphocyte differentiation. Defects in NT5E can cause the calcification of joints and arteries.
NT5E，也称为 CD73，是一种质膜蛋白，可催化细胞外核苷酸转化为可透过膜的核苷。 NT5E 是淋巴细胞分化的决定因素。 NT5E 的缺陷会导致关节和动脉的钙化。

Description

NT5E Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 531 amino acids and having a molecular mass of 59.1kDa .
NT5E is expressed with an 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 NT5E 小鼠重组体是单条糖基化多肽链，含有 531 个氨基酸，分子量为 59.1kDa。
NT5E 在 C 末端用 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

NT5E protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Biological Activity

Specific activity is > 8,000 pmol/min/ug, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of Adenosine 5-monophosphate to phosphate per minute per minute at pH 7.5 at 25°C.

Amino acid sequence

WELTILHTND VHSRLEQTSD DSTKCLNASL CVGGVARLFT KVQQIRKEEP NVLFLDAGDQ YQGTIWFTVY KGLEVAHFMN ILGYDAMALG NHEFDNGVEG LIDPLLRNVK FPILSANIKA RGPLAHQISG LFLPSKVLSV GGEVVGIVGY TSKETPFLSN PGTNLVFEDE ISALQPEVDK LKTLNVNKII ALGHSGFEMD KLIAQKVRGV DIVVGGHSNT FLYTGNPPSK EVPAGKYPFI VTADDGRQVP VVQAYAFGKY LGYLKVEFDD KGNVITSYGN PILLNSSIPE DATIKADINQ WRIKLDNYST QELGRTIVYL DGSTQTCRFR ECNMGNLICD AMINNNLRHP DEMFWNHVSM CIVNGGGIRS PIDEKNNGTI TWENLAAVLP FGGTFDLVQL KGSTLKKAFE HSVHRYGQST GEFLQVGGIH VVYDINRKPW NRVVQLEVLC TKCRVPIYEP LEMDKVYKVT LPSYLANGGD GFQMIKDELL KHDSGDQDIS VVSEYISKMK VVYPAVEGRI KFSLEHHHHH H.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD73 Antibody
  • NT5E Human

ProSpec,CD58 Human,CD58人重组PRO-2138

CD58 是免疫球蛋白超家族的一部分。 CD58是T淋巴细胞CD2蛋白的配体，参与T淋巴细胞的粘附和活化。 CD58 定位于质膜。ProSpec,CD58 Human,CD58人重组PRO-2138

  • CD58 Human

  • CD58 Human Recombinant
  • PRO-2138

Catalogue number

PRO-2138

Synonyms

ag3, LFA-3, LFA3, CD58 molecule, Lymphocyte function-associated antigen 3, Ag3, Surface glycoprotein LFA-3.

Introduction

CD58 is part of the immunoglobulin superfamily. CD58 is a ligand of the T lymphocyte CD2 protein, and is invloved in adhesion and activation of T lymphocytes. CD58 is localized to the plasma membrane.
CD58 是免疫球蛋白超家族的一部分。 CD58是T淋巴细胞CD2蛋白的配体，参与T淋巴细胞的粘附和活化。 CD58 定位于质膜。

Description

CD58 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids and having a molecular mass of 23.8kDa.
CD58 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques
在大肠杆菌中产生的 CD58 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 210 个氨基酸，分子量为 23.8kDa。
CD58 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术纯化

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD58 protein solution containing 20mM Phosphate buffer and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSFSQQIYG VVYGNVTFHV PSNVPLKEVL WKKQKDKVAE LENSEFRAFS SFKNRVYLDT VSGSLTIYNL TSSDEDEYEM ESPNITDTMK FFLYVLESLP SPTLTCALTN GSIEVQCMIP EHYNSHRGLI MYSWDCPMEQ CKRNSTSIYF KMENDLPQKI QCTLSNPLFN TTSSIILTTC IPSSGHSRHR.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD58 Antibody
  • CD58 Antibody, Biotin
  • CD58 Antibody, FITC
  • CD58 Human, Sf9

ProSpec,CD58 Human Sf9,CD58人重组PRO-2493

ProSpec,CD58 Human Sf9,CD58人重组PRO-2493,CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。

  • CD58 Human, Sf9

  • CD58 Human Recombinant, Sf9
  • PRO-2493

Catalogue number

PRO-2493

Synonyms

Lymphocyte function-associated antigen 3 isoform 1, CD58, ag3, LFA-3, LFA3, Surface glycoprotein LFA-3.

Introduction

CD33 is putative adhesion molecule of myelomonocytic-derived cells which mediates sialic-acid dependent binding to cells. CD33 prefers to bind to alpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 perform as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases through their SH2 domains which block signal transduction through dephosphorylation of signaling molecules. In addition, CD33 induces apoptosis in acute myeloid leukemia.

CD33 是骨髓单核细胞衍生细胞的推定粘附分子，它介导唾液酸依赖性与细胞的结合。 CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。 在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。 此外，CD33 在急性髓性白血病中诱导细胞凋亡。

Description

CD58 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 196 amino acids and having a molecular mass of 22.5kDa. .
CD58 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD58 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPFSQQIYG VVYGNVTFHV PSNVPLKEVL WKKQKDKVAE LENSEFRAFS SFKNRVYLDT VSGSLTIYNL TSSDEDEYEM ESPNITDTMK FFLYVLESLP SPTLTCALTN GSIEVQCMIP EHYNSHRGLI MYSWDCPMEQ CKRNSTSIYF KMENDLPQKI QCTLSNPLFN TTSSIILTTC IPSSGHSRHR HHHHHH

Related Products

  • CD58 Antibody
  • CD58 Antibody, Biotin
  • CD58 Antibody, FITC
  • CD58 Human

ProSpec,CD74 Human,CD74人重组PRO-1467

ProSpec,CD74 Human,CD74人重组PRO-1467,CD74 是一种跨膜蛋白，它是陪伴 MHC II 类二聚体从内质网到细胞表面的不变链。 CD74 由 T 淋巴细胞和 B 淋巴细胞谱系的细胞表达。 CD74 在几种癌症中上调，并且在炎症期间也由非免疫细胞表达。

  • CD74 Human

  • CD74 Human Recombinant
  • PRO-1467

Catalogue number

PRO-1467

Synonyms

DHLAG, HLADG, Ia-GAMMA, li, HLA-DR antigens-associated invariant chain, p33, Ia antigen-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, Gamma Chain Of Class II Antigens, MHC HLA-DR Gamma Chain.

Introduction

CD74 , is a transmembrane protein which is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. CD74 upregulated in several cancers and is also expressed by non immune cells during inflammation. Diseases related with CD74 include thymic epithelial neoplasm and gastroduodenitis. Among its related super-pathways are Immune System and Immune response Antigen presentation by MHC class II. In addition CD74 functions as cell surface receptor for the cytokine MIF.
CD74 是一种跨膜蛋白，它是陪伴 MHC II 类二聚体从内质网到细胞表面的不变链。 CD74 由 T 淋巴细胞和 B 淋巴细胞谱系的细胞表达。 CD74 在几种癌症中上调，并且在炎症期间也由非免疫细胞表达。 与 CD74 相关的疾病包括胸腺上皮肿瘤和胃十二指肠炎。 其相关的超级途径包括 MHC II 类的免疫系统和免疫反应抗原呈递。 此外，CD74 作为细胞因子 MIF 的细胞表面受体发挥作用。

Description

CD74 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 183 amino acids and having a molecular mass of 20.6kDa.
CD74 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD74 protein solution containing 20mM Tris-HCl buffer , 0.1M NaCl, 30% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSQQQGRLD KLTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP MGALPQGPMQ NATKYGNMTE DHVMHLLQNA DPLKVYPPLK GSFPENLRHL KNTMETIDWK VFESWMHHWL LFEMSRHSLE QKPTDAPPKE SLELEDPSSG LGVTKQDLGP VPM

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD74 Human, Sf9

ProSpec,CD74 Human Sf9,CD74人重组PRO-2225

ProSpec,CD74 Human Sf9,CD74人重组PRO-2225,CD74 由 T 淋巴细胞和 B 淋巴细胞谱系的细胞表达。 CD74 在几种癌症中上调，并且在炎症期间也由非免疫细胞表达。

  • CD74 Human, Sf9

  • CD74 Human Recombinant, Sf9
  • PRO-2225

Catalogue number

PRO-2225

Synonyms

DHLAG, HLADG, Ia-GAMMA, li, HLA-DR antigens-associated invariant chain, p33, Ia antigen-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, Gamma Chain Of Class II Antigens, MHC HLA-DR Gamma Chain.

Introduction

CD74 , is a transmembrane protein which is the invariant chain that chaperones MHC class IIdimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and Blymphocyte lineages. CD74 upregulated in several cancers and is also expressed by non immune cells during inflammation. Diseases related with CD74 include thymic epithelial neoplasm and gastroduodenitis. Among its related super-pathways are Immune System and Immune response Antigen presentation by MHC class II. In addition CD74 functions as cell surface receptor for the cytokine MIF.
CD74 是一种跨膜蛋白，它是陪伴 MHC II 类二聚体从内质网到细胞表面的不变链。 CD74 由 T 淋巴细胞和 B 淋巴细胞谱系的细胞表达。 CD74 在几种癌症中上调，并且在炎症期间也由非免疫细胞表达。 与 CD74 相关的疾病包括胸腺上皮肿瘤和胃十二指肠炎。 其相关的超级途径包括 MHC II 类的免疫系统和免疫反应抗原呈递。 此外，CD74 作为细胞因子 MIF 的细胞表面受体发挥作用。

Description

CD74 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 19.05kDa . CD74 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD74 是单条糖基化多肽链，包含 166 个氨基酸，分子量为 19.05kDa。 CD74 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD74 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

QQQGRLDKLT VTSQNLQLEN LRMKLPKPPK PVSKMRMATP LLMQALPMGA LPQGPMQNAT KYGNMTEDHV MHLLQNADPL KVYPPLKGSF PENLRHLKNT METIDWKVFE SWMHHWLLFE MSRHSLEQKP TDAPPKESLE LEDPSSGLGV TKQDLGPVPM HHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD74 Human

ProSpec,CD80 Human,CD80人重组

ProSpec,CD80 Human,CD80人重组,在 Sf9 昆虫细胞中产生的 CD80 Human Recombinant 是单条糖基化多肽链，含有 216 个氨基酸，分子量为 24.9kDa。

  • CD80 Human

  • CD80 Human Recombinant
  • PRO-2473

Catalogue number

PRO-2473

Synonyms

CD80 Molecule, CD80 Antigen , B-Lymphocyte Activation Antigen B7, CTLA-4 Counter-Receptor B7.1, Activation B7-1 Antigen, CD28LG1, CD28LG, LAB7, BB1, B7, Costimulatory Molecule Variant IgV-CD80, T-Lymphocyte Activation Antigen CD80, Costimulatory Factor CD80, CD80 Antigen, B7-1, B7.1.

Introduction

CD80 which is a member of cell surface immunoglobulin superfamily takes part in the costimulatory signal essential for T-lymphocyte activation. CD80 binds to either human or mouse CD28 and CTLA-4 – binding to CD28 induces T-cell proliferation and cytokine production while binding to CTLA-4 inhibits T-cell activation. CD80 is expressed on activated B cells, activated T cells, and macrophages.

CD80 是细胞表面免疫球蛋白超家族的成员，参与 T 淋巴细胞活化所必需的共刺激信号。 CD80 与人类或小鼠 CD28 和 CTLA-4 结合——与 CD28 结合可诱导 T 细胞增殖和细胞因子产生，而与 CTLA-4 结合可抑制 T 细胞活化。 CD80 在活化的 B 细胞、活化的 T 细胞和巨噬细胞上表达。

Description

CD80 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 216 amino acids and having a molecular mass of 24.9kDa .
CD80 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 昆虫细胞中产生的 CD80 Human Recombinant 是单条糖基化多肽链，含有 216 个氨基酸，分子量为 24.9kDa。
CD80 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Purity

Greater than 95.0% as determined by -PAGE.

Formulation

CD80 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Amino acid sequence

VIHVTKEVKE VATLSCGHNV SVEELAQTRI YWQKEKKMVL TMMSGDMNIW PEYKNRTIFD ITNNLSIVIL ALRPSDEGTY ECVVLKYEKD AFKREHLAEV TLSVKADFPT PSISDFEIPT SNIRRIICST SGGFPEPHLS WLENGEELNA INTTVSQDPE TELYAVSSKL DFNMTTNHSF MCLIKYGHLR VNQTFNWNTT KQEHFPDNLE HHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD80 Mouse,CD80 小鼠重组PRO-2326

ProSpec,CD80 Mouse,CD80 小鼠重组PRO-2326,由于与 T 细胞的 CD28 和 CTLA4 配体结合，B 淋巴细胞活化抗原 B7-1 为 T 淋巴细胞提供调节信号 CD-80 参与 T 淋巴细胞活化所必需的共刺激信号。

  • CD80 Mouse

  • CD80 Mouse Recombinant
  • PRO-2326

Catalogue number

PRO-2326

Synonyms

LAB7, CD28LG, CD28LG1, CD28LG1, B71.

Introduction

The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells CD-80 is involved in the costimulatory signal essential for t- lymphocyte activation. t-cell proliferation and cytokine production is induced by the binding of cd28 or ctla-4 to this receptor.
由于与 T 细胞的 CD28 和 CTLA4 配体结合，B 淋巴细胞活化抗原 B7-1 为 T 淋巴细胞提供调节信号 CD-80 参与 T 淋巴细胞活化所必需的共刺激信号。 cd28 或 ctla-4 与该受体结合可诱导 t 细胞增殖和细胞因子产生。

Description

CD80 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 216 amino acids and having a molecular mass of 24.7kDa . CD80 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD80 是单条糖基化多肽链，含有 216 个氨基酸，分子量为 24.7kDa。 CD80 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD80 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

DVDEQLSKSV KDKVLLPCRY NSPHEDESED RIYWQKHDKV VLSVIAGKLK VWPEYKNRTL YDNTTYSLII LGLVLSDRGT YSCVVQKKER GTYEVKHLAL VKLSIKADFS TPNITESGNP SADTKRITCF ASGGFPKPRF SWLENGRELP GINTTISQDP ESELYTISSQ LDFNTTRNHT IKCLIKYGDA HVSEDFTWEK PPEDPPDSKN HHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD80 Antibody

ProSpec,CD79A Human,CD79A 人重组CD79A 人重组

CD79A 是 B 细胞受体的信号转导部分，在 B 细胞发育和功能中发挥各种作用。 BCR 表面表达和前 B 细胞和前 B 细胞的有效分化也需要 CD79A。ProSpec,CD79A Human,CD79A 人重组CD79A 人重组

  • CD79A Human

  • CD79A Human Recombinant
  • PRO-2468

Catalogue number

PRO-2468

Synonyms

CD79a Molecule, Membrane-Bound Immunoglobulin-Associated Protein, CD79A Antigen , CD79a Molecule, Immunoglobulin-Associated Alpha, Surface IgM-Associated Protein, MB-1 Membrane Glycoprotein, Ig-Alpha, IGA, B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain, CD79a Antigen, MB-1, MB1.

CD79a 分子、膜结合免疫球蛋白相关蛋白、CD79A 抗原、CD79a 分子、免疫球蛋白相关 α、表面 IgM 相关蛋白、MB-1 膜糖蛋白、Ig-α、IGA、B 细胞抗原受体复合物相关蛋白 α 链，CD79a 抗原，MB-1，MB1。

Introduction

CD79A is a signal-transducing part of the B-cell receptor which plays various roles in B cell development and function. CD79A is also needed for BCR surface expression and for efficient differentiation of pro-B and pre-B-cells. CD79A plays an important role in the tumor promoting effects of myeloid cells, and is a novel target for cancer therapy.

CD79A 是 B 细胞受体的信号转导部分，在 B 细胞发育和功能中发挥各种作用。 BCR 表面表达和前 B 细胞和前 B 细胞的有效分化也需要 CD79A。 CD79A在骨髓细胞的促肿瘤作用中起重要作用，是癌症治疗的新靶点。

Description

CD79A Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa .
CD79A is expressed with a 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Insect cells.

Purity

Greater than 95.0% as determined by -PAGE.

Formulation

CD79A protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Amino acid sequence

LWMHKVPASL MVSLGEDAHF QCPHNSSNNA NVTWWRVLHG NYTWPPEFLG PGEDPNGTLI IQNVNKSHGG IYVCRVQEGN ESYQQSCGTY LRVRQPPPRP FLDMGEGTKN RLEHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD79B Human,CD79B 人重组PRO-1304

CD79B 是一种 36 kDa 跨膜糖蛋白，属于免疫球蛋白超家族。 CD79A 和 CD79B 的异二聚体与 B 细胞表面的膜附着免疫球蛋白连接，形成 B 细胞抗原受体复合物。

  • CD79B Human

  • CD79B Human Recombinant
  • PRO-1304

Catalogue number

PRO-1304

Synonyms

AGM6, B29, IGB, B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, B-cell-specific glycoprotein B29, Immunoglobulin-associated B29 protein, CD79b, CD antigen, CD79b.

Introduction

CD79B is a 36 kDa trans membrane glycoprotein belonging to the immunoglobulin superfamily. Heterodimers of CD79A and CD79B connect with a membrane attached immunoglobulin on the B cell surface to create the B cell antigen receptor complex . CD79A and CD79B are essential for BCR-mediated signaling and subsequently for the development and activation of B lineage cells.
CD79B 是一种 36 kDa 跨膜糖蛋白，属于免疫球蛋白超家族。 CD79A 和 CD79B 的异二聚体与 B 细胞表面的膜附着免疫球蛋白连接，形成 B 细胞抗原受体复合物。 CD79A 和 CD79B 对于 BCR 介导的信号传导以及随后对于 B 系细胞的发育和激活至关重要。

Description

CD79B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17.7kDa.
CD79B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD79B Human Recombinant 是一条单一的、非糖基化的多肽链，包含 155 个氨基酸，分子量为 17.7kDa。
CD79B 在 N 末端与 24 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD79B protein solution contains 20mM Tris-HCl buffer , 2M UREA and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMARSEDR YRNPKGSACS RIWQSPRFIA RKRGFTVKMH CYMNSASGNV SWLWKQEMDE NPQQLKLEKG RMEESQNESL ATLTIQGIRF EDNGIYFCQQ KCNNTSEVYQ GCGTELRVMG FSTLAQLKQR NTLKD.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD79B Human, Sf9

ProSpec-CD79B Human Sf9,CD79B 人重组PRO-2404

ProSpec-CD79B Human Sf9,CD79B 人重组PRO-2404,CD79B 是一种 36 kDa 跨膜糖蛋白，属于免疫球蛋白超家族。 CD79A 和 CD79B 的异二聚体与 B 细胞表面的膜附着免疫球蛋白连接，形成 B 细胞抗原受体复合物。

  • CD79B Human, Sf9

  • CD79B Human Recombinant, Sf9
  • PRO-2404
  • Catalogue number

PRO-2404

Synonyms

CD79b Molecule, CD79B Antigen , CD79b Molecule, Immunoglobulin-Associated Beta, Immunoglobulin-Associated B29 Protein, B-Cell-Specific Glycoprotein B29, Ig-Beta, IGB, B29, B-Cell Antigen Receptor Complex-Associated Protein Beta Chain, CD79b Antigen, CD79B, AGM6.

Introduction

CD79B is a 36 kDa trans membrane glycoprotein belonging to the immunoglobulin superfamily. Heterodimers of CD79A and CD79B connect with a membrane attached immunoglobulin on the B cell surface to create the B cell antigen receptor complex . CD79A and CD79B are essential for BCR-mediated signaling and subsequently for the development and activation of B lineage cells.

CD79B 是一种 36 kDa 跨膜糖蛋白，属于免疫球蛋白超家族。 CD79A 和 CD79B 的异二聚体与 B 细胞表面的膜附着免疫球蛋白连接，形成 B 细胞抗原受体复合物。 CD79A 和 CD79B 对于 BCR 介导的信号传导以及随后对于 B 系细胞的发育和激活至关重要。

Description

CD79B Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 140 amino acids and having a molecular mass of 16.3kDa .
CD79B is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD79B Human Recombinant 是单条糖基化多肽链，包含 140 个氨基酸，分子量为 16.3kDa。
CD79B 在 C 末端用 9 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD79B protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPARSEDRY RNPKGSACSR IWQSPRFIAR KRGFTVKMHC YMNSASGNVS WLWKQEMDEN PQQLKLEKGR MEESQNESLA TLTIQGIRFE DNGIYFCQQK CNNTSEVYQG CGTELRVMGF STLAQLKQRN TLKDHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD79B Human

ProSpec,CD84 Human,CD84人重组PRO-1229

ProSpec,CD84 Human,CD84人重组PRO-1229,CD84 属于信号淋巴细胞活化分子家族，其形成较大的 CD2 细胞表面受体 Ig 超家族的一个子集。

  • CD84 Human

  • CD84 Human Recombinant
  • PRO-1229

Catalogue number

PRO-1229

Synonyms

CD84 Molecule, CD84 Antigen , Cell Surface Antigen MAX.3, Leukocyte Differentiation Antigen CD84, Signaling Lymphocytic Activation Molecule 5, Leukocyte Antigen CD84, SLAM Family Member 5, SLAMF5, Hly9-Beta, LY9B, HCD84, MCD84.

Introduction

CD84 belongs to the signaling lymphocyte activation molecule family which forms a subset of the greater CD2 cell-surface receptor Ig superfamily. CD84, a membrane glycoprotein, is a homophilic adhesion molecule found in various immune cells types and takes part in regulating receptor-mediated signaling in those cells.
CD84 属于信号淋巴细胞活化分子家族，其形成较大的 CD2 细胞表面受体 Ig 超家族的一个子集。 CD84 是一种膜糖蛋白，是一种在各种免疫细胞类型中发现的同源性粘附分子，并参与调节这些细胞中受体介导的信号传导。

Description

CD84 Human Recombinant produced in E. coli is a single polypeptide chain containing 229 amino acids and having a molecular mass of 25.4 kDa.
CD84 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD84 solution contains 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 80% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMKDSEI FTVNGILGES VTFPVNIQEP RQVKIIAWTS KTSVAYVTPG DSETAPVVTV THRNYYERIH ALGPNYNLVI SDLRMEDAGD YKADINTQAD PYTTTKRYNL QIYRRLGKPK ITQSLMASVN STCNVTLTCS VEKEEKNVTY NWSPLGEEGN VLQIFQTPED QELTYTCTAQ NPVSNNI SARQLCADIA MGFRTHHTG.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD84 Human, Sf9

ProSpec-CD84 Human Sf9,CD84 人重组体Sf9 PRO-2409

ProSpec-CD84 Human Sf9,CD84 人重组体Sf9 PRO-2409,CD84 属于信号淋巴细胞活化分子家族，其形成较大的 CD2 细胞表面受体 Ig 超家族的一个子集。

  • CD84 Human, Sf9

  • CD84 Human Recombinant, Sf9
  • PRO-2409

Catalogue number

PRO-2409

Synonyms

CD84 Molecule, Signaling Lymphocytic Activation Molecule 5, Leukocyte Differentiation Antigen CD84, CD84 Antigen , Cell Surface Antigen MAX.3, Hly9-Beta, SLAMF5, Leucocyte Differentiation Antigen CD84, Leukocyte Antigen CD84, SLAM Family Member 5, CD84 Antigen, HCD84, MCD84, LY9B, SLAM family member 5, Cell surface antigen MAX.3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5.

Introduction

CD84 belongs to the signaling lymphocyte activation molecule family which forms a subset of the greater CD2 cell-surface receptor Ig superfamily. CD84, a membrane glycoprotein, is a homophilic adhesion molecule found in various immune cells types and takes part in regulating receptor-mediated signaling in those cells.

CD84 属于信号淋巴细胞活化分子家族，其形成较大的 CD2 细胞表面受体 Ig 超家族的一个子集。 CD84 是一种膜糖蛋白，是一种在各种免疫细胞类型中发现的同源性粘附分子，并参与调节这些细胞中受体介导的信号传导。

Description

CD84 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 213 amino acids and having a molecular mass of 23.8kDa .
CD84 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD84 Human Recombinant 是单条糖基化多肽链，包含 213 个氨基酸，分子量为 23.8kDa。
CD84 在 C 末端用 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD84 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

ADPKDSEIFT VNGILGESVT FPVNIQEPRQ VKIIAWTSKT SVAYVTPGDS ETAPVVTVTH RNYYERIHAL GPNYNLVISD LRMEDAGDYK ADINTQADPY TTTKRYNLQI YRRLGKPKIT QSLMASVNST CNVTLTCSVE KEEKNVTYNW SPLGEEGNVL QIFQTPEDQE LTYTCTAQNP
VSNNISA RQLCADIAMG FRTHHTGHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD84 Human

ProSpec,CD93 Human,CD93 人重组PRO-2336

ProSpec,CD93 Human,CD93 人重组PRO-2336,在 Sf9 杆状病毒细胞中产生的 CD93 Human Recombinant 是单条糖基化多肽链，包含 567 个氨基酸，分子量为 59.3kDa。

  • CD93 Human

  • CD93 Human Recombinant
  • PRO-2336

Catalogue number

PRO-2336

Synonyms

CD93 Molecule, CD93 Antigen, Complement Component 1, Q Subcomponent, Receptor 1, Complement Component 1 Q Subcomponent Receptor 1, Matrix-Remodeling-Associated Protein 4, Matrix-Remodelling Associated 4, C1q/MBL/SPA Receptor, C1qR, C1Qrp, C1QR1, MXRA4, CDw93, C1qR, C1q Receptor 1, DJ737E23.1, ECSM3.

Introduction

CD93, is a receptor or else an element of a larger receptor complex for C1q, MBL2-mannose-binding lectin and SPA-pulmonary surfactant protein A. CD93 mediates the enhancement of phagocytosis in monocytes as well as macrophages upon interaction with soluble defense collagens. CD93 takes part in the intercellular adhesion. Furthermore, CD93 was expressed on plasmablasts/plasma cells, including long-lived plasma cells which demonstrated decreased cell cycle activity, high levels of isotype-switched Ig secretion, as well as modification of the transcriptional network. CD93 is vital for the maintenance of plasma cells in bone marrow niches.

CD93 是 C1q、MBL2-甘露糖结合凝集素和 SPA-肺表面活性蛋白 A 的受体或更大受体复合物的元素。CD93 在与可溶性防御胶原相互作用时介导单核细胞和巨噬细胞吞噬作用的增强。 CD93参与细胞间粘附。 此外，CD93 在浆母细胞/浆细胞上表达，包括长寿浆细胞，其表现出细胞周期活性降低、同种型转换 Ig 分泌水平高以及转录网络的修饰。 CD93 对于维持骨髓壁龛中的浆细胞至关重要。

Description

CD93 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 567 amino acids and having a molecular mass of 59.3kDa .
CD93 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD93 Human Recombinant 是单条糖基化多肽链，包含 567 个氨基酸，分子量为 59.3kDa。
CD93 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD93 protein solution containing Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

TGADTEAVVC VGTACYTAHS GKLSAAEAQN HCNQNGGNLA TVKSKEEAQH VQRVLAQLLR REAALTARMS KFWIGLQREK GKCLDPSLPL KGFSWVGGGE DTPYSNWHKE LRNSCISKRC VSLLLDLSQP LLPSRLPKWS EGPCGSPGSP GSNIEGFVCK FSFKGMCRPL ALGGPGQVTY TTPFQTTSSS LEAVPFASAA NVACGEGDKD ETQSHYFLCK EKAPDVFDWG SSGPLCVSPK YGCNFNNGGC HQDCFEGGDG SFLCGCRPGF RLLDDLVTCA SRNPCSSSPC RGGATCVLGP HGKNYTCRCP QGYQLDSSQL DCVDVDECQD SPCAQECVNT PGGFRCECWV GYEPGGPGEG ACQDVDECAL GRSPCAQGCT NTDGSFHCSC EEGYVLAGED GTQCQDVDEC VGPGGPLCDS LCFNTQGSFH CGCLPGWVLA PNGVSCTMGP VSLGPPSGPP DEEDKGEKEG STVPRAATAS PTRGPEGTPK ATPTTSRPSL SSDAPITSAP LKMLAPSGSP GVWREPSIHH ATAASGPQEP AGGDSSVATQ NNDGTDGQKV EHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD93 Mouse

ProSpec,CD93 Mouse,CD93 小鼠重组PRO-2255

ProSpec,CD93 Mouse,CD93 小鼠重组PRO-2255,CD93 是 C1q、MBL2-甘露糖结合凝集素和 SPA-肺表面活性蛋白 A 的受体或更大受体复合物的元素。CD93 在与可溶性防御胶原相互作用时介导单核细胞和巨噬细胞吞噬作用的增强。

  • CD93 Mouse

  • CD93 Mouse Recombinant
  • PRO-2255

Catalogue number

PRO-2255

Synonyms

C1q/MBL/SPA receptor, C1qR, C1qRp, Cell surface antigen AA4, Complement, component 1 q subcomponent receptor 1, Lymphocyte antigen 68, Ly-68, CD93, Cd93.

Introduction

CD93, is a receptor or else an element of a larger receptor complex for C1q, MBL2-mannose-binding lectin and SPA-pulmonary surfactant protein A. CD93 mediates the enhancement of phagocytosis in monocytes as well as macrophages upon interaction with soluble defense collagens. CD93 takes part in the intercellular adhesion. Furthermore, CD93 was expressed on plasmablasts/plasma cells, including long-lived plasma cells which demonstrated decreased cell cycle activity, high levels of isotype-switched Ig secretion, as well as modification of the transcriptional network. CD93 is vital for the maintenance of plasma cells in bone marrow niches.
CD93 是 C1q、MBL2-甘露糖结合凝集素和 SPA-肺表面活性蛋白 A 的受体或更大受体复合物的元素。CD93 在与可溶性防御胶原相互作用时介导单核细胞和巨噬细胞吞噬作用的增强。 CD93参与细胞间粘附。 此外，CD93 在浆母细胞/浆细胞上表达，包括长寿浆细胞，其表现出细胞周期活性降低、同种型转换 Ig 分泌水平高以及转录网络的修饰。 CD93 对于维持骨髓壁龛中的浆细胞至关重要。

Description

CD93 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 558 amino acids and having a molecular mass of 60.1kDa. . CD93 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9 昆虫细胞中产生的 CD93 是单条糖基化多肽链，含有 558 个氨基酸，分子量为 60.1kDa。 . CD93 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD93 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADSQAVVCEG TACYTAHWGK LSAAEAQHRC NENGGNLATV KSEEEARHVQ QALTQLLKTK APLEAKMGKF WIGLQREKGN CTYHDLPMRG FSWVGGGEDT AYSNWYKASK SSCIFKRCVS LILDLSLTPH PSHLPKWHES PCGTPEAPGN SIEGFLCKFN FKGMCRPLAL GGPGRVTYTT PFQATTSSLE AVPFASVANV ACGDEAKSET HYFLCNEKTP GIFHWGSSGP LCVSPKFGCS FNNGGCQQDC FEGGDGSFRC GCRPGFRLLD DLVTCASRNP CSSNPCTGGG MCHSVPLSEN YTCRCPSGYQ LDSSQVHCVD IDECQDSPCA QDCVNTLGSF HCECWVGYQP SGPKEEACED VDECAAANSP CAQGCINTDG SFYCSCKEGY IVSGEDSTQC EDIDECSDAR GNPCDSLCFN TDGSFRCGCP PGWELAPNGV FCSRGTVFSE LPARPPQKED NDDRKESTMP PTEMPSSPSG SKDVSNRAQT TGLFVQSDIP TASVPLEIEI PSEVSDVWFE LGTYLPTTSG HSKPTHEDSV SAHSDTDGQN LEHHHHHH.

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD93 Human

ProSpec,CD99 Human,CD99 人重组PRO-2444

ProSpec,CD99 Human,CD99 人重组PRO-2444,CD99或MIC2基因产物或E2抗原在卵巢的一些淋巴细胞、皮质胸腺细胞和颗粒细胞的细胞膜上表达。

  • CD99 Human

  • CD99 Human Recombinant
  • PRO-2444

Catalogue number

PRO-2444

Synonyms

CD99 antigen, T-cell surface glycoprotein E2, E2 antigen, Protein MIC2, 12E7, CD99, MIC2, MIC2X, MIC2Y.

Introduction

CD99, or MIC2 gene product, or E2 antigen is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. The antigen is also expressed by most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing’s sarcoma cells and primitive peripheral neuroectodermal tumors.

CD99或MIC2基因产物或E2抗原在卵巢的一些淋巴细胞、皮质胸腺细胞和颗粒细胞的细胞膜上表达。 大多数胰岛细胞、睾丸支持细胞和一些内皮细胞也表达该抗原。 成熟的粒细胞表达很少或不表达 CD99。 MIC2 在尤文氏肉瘤细胞和原始外周神经外胚层肿瘤中强烈表达。

Description

CD99 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 342 amino acids and having a molecular mass of 37.3kDa .
CD99 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD99 Human Recombinant 是单条糖基化多肽链，含有 342 个氨基酸，分子量为 37.3kDa。
CD99 在 C 末端用 239 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD99 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPDGGFDLS DALPDNENKK PTAIPKKPSA GDDFDLGDAV VDGENDDPRP PNPPKPMPNP NPNHPSSSGS FSDADLADGV SGGEGKGGSD GGGSHRKEGE EADLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,FCGR2A Human,CD32a 人重组PRO-029

ProSpec,FCGR2A Human,CD32a 人重组PRO-029,CD32a，又称FCGR2A，属于免疫球蛋白Fc受体基因家族，位于各种免疫反应细胞表面。 FCGR2A 是一种在巨噬细胞和中性粒细胞等吞噬细胞上发现的细胞表面受体，参与吞噬和清除免疫复合物的过程。

  • FCGR2A Human

  • CD32a Human Recombinant
  • PRO-029

Catalogue number

PRO-029

Synonyms

CD32, CD32A, CDw32, FcGR, IGFR2, MGC23887, MGC30032, Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, Fc-gamma-RIIa, FcRII-a, FCG2, FCGR2A1.

Introduction

CD32a, also known as FCGR2A, belongs to a family of immunoglobulin Fc receptor genes located on the surface of various immune response cells. FCGR2A which is a cell surface receptor found on phagocytic cells like macrophages and neutrophils, takes part in the process of phagocytosis and clearing of immune complexes. FCGR2A initiates cellular responses against pathogens and soluble antigens by binding to IgG. FCGR2A, which is a low affinity receptor, binds to the Fc region of immunoglobulins gamma.
CD32a，又称FCGR2A，属于免疫球蛋白Fc受体基因家族，位于各种免疫反应细胞表面。 FCGR2A 是一种在巨噬细胞和中性粒细胞等吞噬细胞上发现的细胞表面受体，参与吞噬和清除免疫复合物的过程。 FCGR2A 通过与 IgG 结合启动针对病原体和可溶性抗原的细胞反应。 FCGR2A 是一种低亲和力受体，与免疫球蛋白 γ 的 Fc 区结合。

Description

FCGR2A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids and having a molecular mass of 23.0kDa. FCGR2A is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 FCGR2A 人重组体是一条单一的、非糖基化的多肽链，包含 208 个氨基酸，分子量为 23.0kDa。 FCGR2A 在 N 端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

FCGR2A protein solution containing 20mM Tris-HCl buffer , 0.1M NaCl, 50% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMQAAPP KAVLKLEPPW INVLQEDSVT LTCQGARSPE IQWFHNG NLIPTHTQPS YRFKANNNDS GEYTCQTGQT SLSDPVHLTV LSEWLVLQTP HLEFQEGETI MLRCHSWKDK PLVKVTFFQN GKSQKFSRLD PTFSIPQANH SHSGDYHCTG NIGYTLFSSK PVTITVQVPS MGSSSPMG.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,FCGR2B Human,CD32 人重组PRO-1295

ProSpec,FCGR2B Human,CD32 人重组PRO-1295,在大肠杆菌中产生的 FCGR2B Human Recombinant 是一条单一的、非糖基化的多肽链，包含 197 个氨基酸，分子量为 22.0kDa。

  • FCGR2B Human

  • CD32 Human Recombinant
  • PRO-1295

Catalogue number

PRO-1295

Synonyms

CD32, CD32B, FCG2, FCGR2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc-gamma-RIIb, FcRII-b.

Introduction

FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. FCGR2B Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta . Variants in FCGR2B may increase susceptibilty to systemic lupus erythematosus .
FCGR2B 是免疫球蛋白 γ 复合物 Fc 区的低亲和力受体。 FCGR2B 参与免疫复合物的吞噬作用和 B 细胞产生抗体的调节。 FCGR2B 在单核细胞、中性粒细胞、巨噬细胞、嗜碱性粒细胞、嗜酸性粒细胞、朗格汉斯细胞、B 细胞、血小板细胞和胎盘中表达。 FCGR2B 的变异体可能会增加对系统性红斑狼疮的易感性。

Description

FCGR2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids and having a molecular mass of 22.0kDa. FCGR2Bis fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 FCGR2B Human Recombinant 是一条单一的、非糖基化的多肽链，包含 197 个氨基酸，分子量为 22.0kDa。 FCGR2Bis 在 N 末端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

FCGR2B protein solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 30% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAP.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,FCGR3A Human,CD16a 人重组PRO-1150

ProSpec,FCGR3A Human,CD16a 人重组PRO-1150,低亲和力免疫球蛋白 γ Fc 区受体 III-A 是免疫球蛋白 G 的 Fc 部分的受体，参与从循环中消除抗原-抗体复合物以及其他抗体依赖性反应。 FCGR3A 需要与 Fc epsilon 的 γ 亚基结合。

  • FCGR3A Human

  • CD16a Human Recombinant
  • PRO-1150

Catalogue number

PRO-1150

Synonyms

Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma, RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, FCG3, FCGR3, IGFR3, CD16, FCGRIII.

Introduction

Low affinity immunoglobulin gamma Fc region receptor III-A is a receptor for the Fc portion of immunoglobulin G, and is involved in the elimination of antigen-antibody complexes from the circulation, as well as other antibody-dependent responses. FCGR3A needs to associate with the gamma subunit of Fc epsilon. The FCGR3A receptor is expressed on natural killer cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils where the receptor is anchored through a phosphatidylinositol linkage. In addition, FCGR3A is expressed on macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. FCGR3A mediates antibody-dependent cellular cytotoxicity and other antibody-dependent responses, such as phagocytosis. FCGR3A gene mutations are linked with susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia.
低亲和力免疫球蛋白 γ Fc 区受体 III-A 是免疫球蛋白 G 的 Fc 部分的受体，参与从循环中消除抗原-抗体复合物以及其他抗体依赖性反应。 FCGR3A 需要与 Fc epsilon 的 γ 亚基结合。 FCGR3A 受体作为通过跨膜肽锚定的完整膜糖蛋白在自然杀伤细胞上表达，而 FCGR3B 在多形核中性粒细胞上表达，其中受体通过磷脂酰肌醇键锚定。 此外，FCGR3A 在巨噬细胞、T 细胞亚群、未成熟胸腺细胞和胎盘滋养细胞上表达。 FCGR3A 介导抗体依赖性细胞毒性和其他抗体依赖性反应，例如吞噬作用。 FCGR3A 基因突变与对复发性病毒感染的易感性、对系统性红斑狼疮的易感性和同种免疫新生儿中性粒细胞减少症有关。

Description

FCGR3A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 228 amino acids and having a molecular mass of 26kDa.
FCGR3A is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 FCGR3A 人重组体是一条单一的、非糖基化的多肽链，包含 228 个氨基酸，分子量为 26kDa。
FCGR3A 在 N 末端与 37 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

FCGR3A protein solution containing 20mM Tris-HCl buffer , 1M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQ.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • FCGR3A Human, Sf9

ProSpec-FCGR3A Human Sf9,CD16a 人重组

ProSpec-FCGR3A Human Sf9,CD16a 人重组,FCGR3A 受体作为通过跨膜肽锚定的完整膜糖蛋白在自然杀伤细胞上表达，而 FCGR3B 在多形核中性粒细胞上表达，其中受体通过磷脂酰肌醇键锚定。

  • FCGR3A Human, Sf9

  • CD16a Human Recombinant, Sf9
  • PRO-2360

Catalogue number

PRO-2360

Synonyms

Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma, RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, FCG3, FCGR3, IGFR3, CD16, FCGRIII.

Introduction

Low affinity immunoglobulin gamma Fc region receptor III-A is a receptor for the Fc portion of immunoglobulin G, and is involved in the elimination of antigen-antibody complexes from the circulation, as well as other antibody-dependent responses. FCGR3A needs to associate with the gamma subunit of Fc epsilon. The FCGR3A receptor is expressed on natural killer cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils where the receptor is anchored through a phosphatidylinositol linkage. In addition, FCGR3A is expressed on macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. FCGR3A mediates antibody-dependent cellular cytotoxicity and other antibody-dependent responses, such as phagocytosis. FCGR3A gene mutations are linked with susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia.
低亲和力免疫球蛋白 γ Fc 区受体 III-A 是免疫球蛋白 G 的 Fc 部分的受体，参与从循环中消除抗原-抗体复合物以及其他抗体依赖性反应。 FCGR3A 需要与 Fc epsilon 的 γ 亚基结合。 FCGR3A 受体作为通过跨膜肽锚定的完整膜糖蛋白在自然杀伤细胞上表达，而 FCGR3B 在多形核中性粒细胞上表达，其中受体通过磷脂酰肌醇键锚定。 此外，FCGR3A 在巨噬细胞、T 细胞亚群、未成熟胸腺细胞和胎盘滋养细胞上表达。 FCGR3A 介导抗体依赖性细胞毒性和其他抗体依赖性反应，例如吞噬作用。 FCGR3A 基因突变与对复发性病毒感染的易感性、对系统性红斑狼疮的易感性和同种免疫新生儿中性粒细胞减少症有关。

Description

FCGR3A Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22.8kDa .
FCGR3A is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 FCGR3A Human Recombinant 是单条糖基化多肽链，包含 200 个氨基酸，分子量为 22.8kDa。
FCGR3A 在 C 末端与 6 个氨基酸 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

FCGR3A protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPMRTEDLP KAVVFLEPQW YRVLEKDSVT LKCQGAYSPE DNSTQWFHNE SLISSQASSY FIDAATVDDS GEYRCQTNLS TLSDPVQLEV HIGWLLLQAP RWVFKEEDPI HLRCHSWKNT ALHKVTYLQN GKGRKYFHHN SDFYIPKATL KDSGSYFCRG LFGSKNVSSE TVNITITQGL AVSTISSFFP PGYQHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • FCGR3A Human

ProSpec,FCGR3B Human,CD16b 人重组PRO-2486

ProSpec,FCGR3B Human,CD16b 人重组PRO-2486,在 Sf9 杆状病毒细胞中产生的 FCGR3B 是单条糖基化多肽链，包含 188 个氨基酸，分子量为 21.4kDa。

  • FCGR3B Human

  • CD16b Human Recombinant
  • PRO-2486

Catalogue number

PRO-2486

Synonyms

Fc Fragment Of IgG Receptor IIIb, Fc Fragment Of IgG, Low Affinity IIIb, Receptor , Fc Gamma Receptor IIIb, IgG Fc Receptor III-1, Fc-Gamma RIII-Beta, Fc-Gamma RIIIb, FCRIIIb, FCR-10, FCRIII, FCGR3, CD16b, FCG3, Fc Fragment Of IgG, Low Affinity IIIb, Receptor For , Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B, Fc-Gamma Receptor IIIb , Fc-Gamma RIII, CD16b Antigen, IGFR3, CD16.

IgG受体IIIb的Fc片段，IgG的Fc片段，低亲和力IIIb，受体，Fcγ受体IIIb，IgG Fc受体III-1，Fc-γRIII-β，Fc-γRIIIb，FCRIIIb，FCR-10，FCRIII， FCGR3、CD16b、FCG3、IgG 的 Fc 片段、低亲和力 IIIb、受体 For 、低亲和力免疫球蛋白 γ Fc 区受体 III-B、Fc-γ 受体 IIIb、Fc-γ RIII、CD16b 抗原、IGFR3、CD16。

Introduction

FCGR3B, also known as CD16b belongs to the Ig super family. FCGR3B encodes a glycosylphosphatidylinositol -anchored protein which is expressed constitutively by neutrophils. FCGR3B binds to complex or aggregated IgG and monomeric IgG. Different from III-A, FCGR3B cannot arbitrate antibody-dependent cytotoxicity and phagocytosis. FCGR3B operate to capture immune complexes in peripheral blood circulation that does not activate neutrophils.

FCGR3B，也称为CD16b，属于Ig超家族。 FCGR3B 编码由中性粒细胞组成型表达的糖基磷脂酰肌醇锚定蛋白。 FCGR3B 与复杂或聚集的 IgG 和单体 IgG 结合。 与 III-A 不同，FCGR3B 不能仲裁抗体依赖性细胞毒性和吞噬作用。 FCGR3B 用于捕获外周血循环中不激活中性粒细胞的免疫复合物。

Description

FCGR3B produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 188 amino acids and having a molecular mass of 21.4kDa. .
FCGR3B is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 FCGR3B 是单条糖基化多肽链，包含 188 个氨基酸，分子量为 21.4kDa。 .
FCGR3B 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

FCGR3B protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA YSPEDNSTQW FHNENLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKDRKY FHHNSDFHIP KATLKDSGSY FCRGLVGSKN VSSETVNITI TQGLAVSTIS VEHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD164 Human,CD164 人重组PRO-2502

ProSpec,CD164 Human,CD164 人重组PRO-2502,在 Sf9 杆状病毒细胞中产生的 CD164 是一条糖基化多肽链，在 C 端与一个 6 个氨基酸的 His 标签融合，共含有 148 个氨基酸，分子量为 15.6kDa。

  • CD164 Human

  • CD164 Human Recombinant
  • PRO-2502

Catalogue number

PRO-2502

Synonyms

CD164 Molecule, Multi-Glycosylated Core Protein 24, CD164 Antigen, Sialomucin, Endolyn MGC-24v, MGC-24, MUC-24, Deafness, Autosomal Dominant 66, Sialomucin Core Protein 24, DFNA66, CD164.

Introduction

CD164, also known as Multi-Glycosylated Core Protein 24 is amember of the CD164 family.

Description

CD164 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 6 aa His Tag at C-terminus containing a total of 148 amino acids and having a molecular mass of 15.6kDa.
CD164 shows multiple bands between 28-57kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD164 是一条糖基化多肽链，在 C 端与一个 6 个氨基酸的 His 标签融合，共含有 148 个氨基酸，分子量为 15.6kDa。
CD164 在 -PAGE 上显示 28-57kDa 之间的多个条带，还原条件并通过专有色谱技术纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD164 protein solution contains 10% glycerol & Phosphate buffered saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

ADPDKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD164L2 Human

ProSpec,sCD40L Human,可溶性 CD-40 配体/TRAP 人重组体CYT-245

ProSpec,sCD40L Human,可溶性 CD-40 配体/TRAP 人重组体CYT-245,CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。

  • sCD40L Human

  • Soluble CD-40 Ligand/TRAP Human Recombinant
  • CYT-245

Catalogue number

CYT-245

Synonyms

CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L.

Introduction

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2 .
CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。 CD40 配体已显示在外周血单核细胞中诱导细胞因子产生和杀肿瘤活性。 它还共同刺激活化 T 细胞的增殖，并伴随着 IFN-γ、TNF-α 和 IL2 的产生。

Description

sCD40L Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 149 amino acids and having a molecular mass of 16308 Dalton.
The sCD40L is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 sCD40L 人重组体是一种非糖基化的多肽链，含有 149 个氨基酸，分子量为 16308 道尔顿。
sCD40L 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.0.

Solubility

It is recommended to reconstitute the lyophilized sCD40L in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized sCD40L although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD154 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 sCD40L 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，CD154 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Biological Activity

The ED50 as determined by the dose-dependant stimulation of IL-12 induction & IL-8 production by human PBMC was found to be 5-10 ng/ml.

Protein content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 1.1 as the extinction coefficient for a 0.1% solution. This value is calculated by the PC GENE computer analysis program of protein sequences .
2. Analysis by RP-HPLC, using a standard solution of CD40 as a Reference Standard.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • sCD40L Mouse
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  • CD40 Human
  • CD40 Antibody
  • sCD40L Human, His
  • CD40 Antibody, Biotin
  • sCD40L Human, His Active

ProSpec,sCD40L Human His,可溶性 CD40 配体/TRAP 人重组CYT-670

CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。ProSpec,sCD40L Human His,可溶性 CD40 配体/TRAP 人重组CYT-670

  • sCD40L Human, His

  • soluble CD40 Ligand/TRAP Human Recombinant, His Tag
  • CYT-670

Catalogue number

CYT-670

Synonyms

CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L, CD40LG.

Introduction

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2.
CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。 CD40 配体已显示在外周血单核细胞中诱导细胞因子产生和杀肿瘤活性。 它还共同刺激活化 T 细胞的增殖，并伴随着 IFN-γ、TNF-α 和 IL2 的产生。

Description

CD40LG Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 169 amino acids and having a molecular mass of 18.3kDa.
The CD40LG is purified by proprietary chromatographic techniques.

CD40LG Human Recombinant 在 N 末端融合了 20 个氨基酸的 His 标签，在大肠杆菌中产生，是一条含有 169 个氨基酸的单一非糖基化多肽链，分子量为 18.3kDa。
CD40LG 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The CD40LG solution 20mM Tris-HCl buffer , 1mM DTT, 40% glycerol and 0.2M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LCLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • sCD40L Human, His Active

ProSpec,sCD40L Human His Active,可溶性 CD40 配体/TRAP His 标签活性人重组CYT-1190

ProSpec,sCD40L Human His Active,可溶性 CD40 配体/TRAP His 标签活性人重组CYT-1190,CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。

  • sCD40L Human, His Active

  • soluble CD40 Ligand/TRAP His Tag Active Human Recombinant
  • CYT-1190

Catalogue number

CYT-1190

Synonyms

CD40 ligand, CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP.

Introduction

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2.

CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。 CD40 配体已显示在外周血单核细胞中诱导细胞因子产生和杀肿瘤活性。 它还共同刺激活化 T 细胞的增殖，并伴随着 IFN-γ、TNF-α 和 IL2 的产生。

Description

sCD40L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids and having a molecular mass of 18.3kDa.
sCD40L is fused to a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

sCD40L protein contains 20mM Tris-HCl buffer , 0.2M NaCl, 1mM DTT and 40% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Biological Activity

Measured by its binding ability in a functional ELISA with Human CD40/TNFRSF5.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LCLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • sCD40L Human, His
  • sCD40L Human

ProSpec,sCD40L Mouse,可溶性 CD-40 配体/TRAP 小鼠重组体CYT-472

ProSpec,sCD40L Mouse,可溶性 CD-40 配体/TRAP 小鼠重组体CYT-472,CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。

  • sCD40L Mouse

  • Soluble CD-40 Ligand/TRAP Mouse Recombinant
  • CYT-472

Catalogue number

CYT-472

Synonyms

CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L.

Introduction

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2 .
CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。 CD40 配体已显示在外周血单核细胞中诱导细胞因子产生和杀肿瘤活性。 它还共同刺激活化 T 细胞的增殖，并伴随着 IFN-γ、TNF-α 和 IL2 的产生。

Description

sCD40 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 149 amino acids and having a molecular mass of 16409 Dalton.
The sCD40 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 sCD40 Mouse Recombinant 是一种非糖基化的多肽链，含有 149 个氨基酸，分子量为 16409 道尔顿。
sCD40 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a sterile concentrated solution with 10mM Sodium Phosphate pH=7.5.

Solubility

It is recommended to reconstitute the lyophilized sCD40 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized sCD40 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD154 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 sCD40 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，CD154 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Gln-Arg-Gly-Asp.

Biological Activity

The ED50 as determined by its ability to induce MIP-1 alpha & TNF-alpha from mouse splenocytes was found to be 0.1µg/ml corresponding to a Specific Activity of 10,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.

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  • sCD40L Human, His
  • CD40 Antibody
  • sCD40L Human
  • CD40 Antibody, Biotin
  • CD40 Human
  • CD40 Antibody, FITC
  • sCD40L Mouse, sf9

ProSpec,sCD40L Mouse sf9,可溶性 CD40 配体/TRAPMouse 重组体CYT-917

ProSpec,sCD40L Mouse sf9,可溶性 CD40 配体/TRAPMouse 重组体CYT-917,在 Sf9 杆状病毒细胞中产生的 sCD40 Mouse Recombinant 是单条糖基化多肽链，包含 155 个氨基酸，分子量为 17.2kDa。

  • sCD40L Mouse, sf9

  • soluble CD40 Ligand/TRAPMouse Recombinant, sf9
  • CYT-917

Catalogue number

CYT-917

Synonyms

CD40 ligand, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD154, CD40lg, CD154, CD40-L, Cd40l, gp39, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, Tnfsf5.

Introduction

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2.
CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。 CD40 配体已显示在外周血单核细胞中诱导细胞因子产生和杀肿瘤活性。 它还共同刺激活化 T 细胞的增殖，并伴随着 IFN-γ、TNF-α 和 IL2 的产生。

Description

sCD40 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17.2kDa .
sCD40 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 sCD40 Mouse Recombinant 是单条糖基化多肽链，包含 155 个氨基酸，分子量为 17.2kDa。
sCD40 在 C 末端用 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

sCD40 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。

对于长期储存，建议添加载体蛋白。

避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENGKQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE RILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIHRVG FSSFGLLKLH HHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • sCD40L Human
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ProSpec,CD276 Mouse,CD276 小鼠重组PRO-2616

ProSpec,CD276 Mouse,CD276 小鼠重组PRO-2616,CD276 是除了 IFN-γ 产生之外的 T 细胞活化的共刺激分子。 此外，CD276 上调 BRCC3 表达，防止由 5-Fu 引起的 DNA 缺陷。

  • CD276 Mouse

  • CD276 Mouse Recombinant
  • PRO-2616

Catalogue number

PRO-2616

Synonyms

CD276 antigen, Cd276, 6030411F23Rik, AU016588, B7h3, B7RP-2, B7 homolog 3, B7-H3.

Introduction

CD276, belongs to the B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. CD276 is a costimulatory molecule for T cell activation in addition to IFN-gamma production. Furthermore, CD276 upregulates BRCC3 expression, preventing DNA defects caused by 5-Fu. CD276 is correlated with TNM stage of NSCLC and act as a potential biomarker for NSCLC-derived MPEs. CD276 inhibits natural-killer mediated cell lysis in tumor cells, and act as a marker for detection of neuroblastoma cells. CD276 is implicated in the development of acute as well as chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. In addition, CD276 provides the placenta & fetus a proper immunological environment during the course of pregnancy.

CD276，属于 T 细胞表达的免疫调节性跨膜糖蛋白 B7 家族。 CD276 是除了 IFN-γ 产生之外的 T 细胞活化的共刺激分子。 此外，CD276 上调 BRCC3 表达，防止由 5-Fu 引起的 DNA 缺陷。 CD276 与 NSCLC 的 TNM 分期相关，可作为 NSCLC 衍生 MPE 的潜在生物标志物。 CD276 抑制肿瘤细胞中自然杀伤剂介导的细胞裂解，并作为检测神经母细胞瘤细胞的标志物。 CD276 与急性和慢性移植排斥的发展以及黏膜表面淋巴细胞活性的调节有关。 此外，CD276 在怀孕期间为胎盘和胎儿提供了适当的免疫环境。

Description

CD276 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 226 amino acids and having a molecular mass of 24.7kDa.
CD276 is fused to a 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD276 protein solution contains Phosphate Buffered Saline containing 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

VEVQVSEDPV VALVDTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA
YSNRTALFPD LLVQGNASLR LQRVRVTDEG SYTCFVSIQD FDSAAVSLQV AAPYSKPSMT
LEPNKDLRPG NMVTITCSSY QGYPEAEVFW KDGQGVPLTG NVTTSQMANE RGLFDVHSVL
RVVLGANGTY SCLVRNPVLQ QDAHGSVTIT GQPLTFPPEA HHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD276 Human

ProSpec,CD3D Human,CD3D 人重组PRO-2539

CD3D，也称为 Delta 多肽，是一种单通道 1 型膜蛋白。 CD3D 与 CD3-zeta、CD3-γ、CD3-ε 和 T 细胞受体 α/β 和 γ/δ 异二聚体共同产生 T 细胞受体-CD3 复合物。ProSpec,CD3D Human,CD3D 人重组PRO-2539

  • CD3D Human

  • CD3D Human Recombinant
  • PRO-2539

Catalogue number

PRO-2539

Synonyms

CD3d Molecule, CD3d Antigen, Delta Polypeptide , CD3d Molecule, Delta , T-Cell Receptor T3 Delta Chain, T3D, T-Cell Surface Glycoprotein CD3 Delta Chain, CD3 Antigen, Delta Subunit, OKT3, Delta Chain, CD3d Antigen, CD3 Delta, CD3-DELTA, IMD19, CD3D.

Introduction

CD3D, also known as Delta Polypeptide , is a single-pass type 1 membrane protein. CD3D jointly with CD3-zeta, CD3-gamma, CD3-epsilon and the T-cell receptor alpha/beta and gamma/delta heterodimers, creates the T-cell receptor-CD3 complex. Once antigen presenting cells activate T-cell receptor , TCR-mediated signals are transferred through the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. Likewise, CD3D takes an important part in adaptive immune response and participates in thymocyte differentiation.

CD3D，也称为 Delta 多肽，是一种单通道 1 型膜蛋白。 CD3D 与 CD3-zeta、CD3-γ、CD3-ε 和 T 细胞受体 α/β 和 γ/δ 异二聚体共同产生 T 细胞受体-CD3 复合物。 一旦抗原呈递细胞激活 T 细胞受体，TCR 介导的信号就会通过 CD3 链 CD3D、CD3E、CD3G 和 CD3Z 传递通过细胞膜。 同样，CD3D 在适应性免疫反应中发挥重要作用并参与胸腺细胞分化。

Description

CD3D produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 239 aa hIgG-His-tag at C-terminus containing a total of 323 amino acids and having a molecular mass of 36.5kDa.
CD3D shows multiple bands between 40-57kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD3D protein solution contains 10% glycerol & Phosphate buffered saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

FKIPIEELED RVFVNCNTSI TWVEGTVGTL LSDITRLDLG KRILDPRGIY RCNGTDIYKD KESTVQVHYR MCQSCVELDP ATVALEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.