分类： CD抗原CD Antigens

ProSpec,CD1A Human PRO-2427,CD1A人重组PRO-2427

ProSpec,CD1A Human PRO-2427,CD1A人重组PRO-2427,CD1a是一种跨膜糖蛋白，在结构上与主要的组织相容性复合物蛋白相关，并与β-2-微球蛋白形成异二聚体。 CD1a 主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。

  • CD1A Human

  • CD1A Human Recombinant
  • PRO-2427

Catalogue number

PRO-2427

Synonyms

T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, R4, T6; CD1, FCB6, HTA1, CD1A.

Introduction

CD1a is a transmembrane glycoproteins, which is structurally related to the major histocompatibility complex proteins and form heterodimers with beta-2-microglobulin. CD1a mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

CD1a是一种跨膜糖蛋白，在结构上与主要的组织相容性复合物蛋白相关，并与β-2-微球蛋白形成异二聚体。 CD1a 主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。 人类基因组包含五个 CD1 家族基因，这些基因在 1 号染色体上组成一个簇。CD1 家族成员被认为在其细胞定位和对特定脂质配体的特异性方面不同。 该基因编码的蛋白质定位于质膜和早期内吞系统的循环囊泡。 已观察到选择性剪接的转录变体，但尚未确定其生物学有效性。

Description

CD1A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 291 amino acids and having a molecular mass of 33.2kDa. . CD1A is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD1A 是单条糖基化多肽链，含有 291 个氨基酸，分子量为 33.2kDa。 . CD1A 在 C 末端用 9 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD1A protein solution containing Phosphate Buffered Saline , and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD1a Antibody

ProSpec PRO-1267,CD1B Human,CD1B人重组PRO-1267

ProSpec PRO-1267,CD1B Human,CD1B人重组PRO-1267,大肠杆菌产生的 CD1B Human Recombinant 是单条非糖基化多肽链，包含 310 个氨基酸，分子量为 34.2kDa

  • CD1B Human

  • CD1B Human Recombinant
  • PRO-1267

Catalogue number

PRO-1267

Synonyms

T-cell surface glycoprotein CD1b, CD1B, CD1, CD1A, R1.

Introduction

CD1B belongs to CD1 family of transmembrane glycoproteins, which are structurally associated with the MHC proteins and form heterodimers with the beta-2-microglobulin. CD1B includes one Ig-like domain. CD1B is an antigen-presenting protein which connects self and nonself lipid and glycolipid antigens and displays them to T-cell receptors on natural killer T-cells.

Description

CD1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 310 amino acids and having a molecular mass of 34.2kDa.CD1B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
大肠杆菌产生的 CD1B Human Recombinant 是单条非糖基化多肽链，包含 310 个氨基酸，分子量为 34.2kDa。CD1B 在 N 端与 24 个氨基酸的 His-tag 融合，并通过专有色谱纯化 技巧。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD1B protein solution containing 20mM Tris-HCl buffer , 0.2M NaCl, 20% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMSEHAFQ GPTSFHVIQT SSFTNSTWAQ TQGSGWLDDL QIHGWDG TAIFLKPWSK GNFSDKEVAE LEEIFRVYIF GFAREVQDFA GDFQMKYPFE IQGIAGCELH SGGAIVSFLR GALGGLDFLS VKNASCVPSP EGGSRAQKFC ALIIQYQGIM ETVRILLYET CPRYLLGVLN AGKADLQRQV KPEAWLSSGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ EQQGTQLGDI LPNANWTWYL RATLDVADGE AAGLSCRVKH SSLEGQDIIL YWRNPTSIGS.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec PRO-2491,CD1D Human,CD1D人重组PRO-2491

ProSpec PRO-2491,CD1D Human,CD1D人重组PRO-2491,CD1d 呈递的脂质抗原在与存在于 NKT 膜上的 T 细胞受体相互作用期间激活一类特殊的 T 细胞，即自然杀伤 T 细胞。

  • CD1D Human

  • CD1D Human Recombinant
  • PRO-2491

Catalogue number

PRO-2491

Synonyms

Antigen-presenting glycoprotein CD1d, R3G1, CD antigen: CD1d, Differentiation Antigen CD1-Alpha-3, T-Cell Surface Glycoprotein CD1d, Thymocyte Antigen CD1D, CD1A, R3, CD1d Molecule, CD1D Antigen, D Polypeptide, CD1d Antigen, R3G1, HMC Class I, Antigen-Like Glycoprotein CD1D, Antigen-Presenting Glycoprotein CD1d.

Introduction

CD1D, also known as antigen-presenting glycoprotein CD1d, is a transmembrane glycoprotein which belongs to the CD1 family of glycolipid antigen-presenting MHC-like molecules. CD1d-presented lipid antigens activate a special class of T cells, familiar as natural killer T cells, during the interaction with the T-cell receptor present on NKT membranes. Once activated, NKT cells rapidly produce Th1 &Th2 cytokines, usually represented by interleukin 4 production.

CD1D又称为抗原呈递糖蛋白CD1d，是一种跨膜糖蛋白，属于糖脂类抗原呈递MHC分子CD1家族。 CD1d 呈递的脂质抗原在与存在于 NKT 膜上的 T 细胞受体相互作用期间激活一类特殊的 T 细胞，即自然杀伤 T 细胞。 一旦被激活，NKT 细胞会迅速产生 Th1 和 Th2 细胞因子，通常以白细胞介素 4 的产生为代表。

Description

CD1D produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 290 amino acids and having a molecular mass of 32.9kDa .

CD1Dis expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD1D protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage, it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

EVPQRLFPLR CLQISSFANS SWTRTDGLAW LGELQTHSWS NDSDTVRSLK PWSQGTFSDQ QWETLQHIFR VYRSSFTRDV KEFAKMLRLS YPLELQVSAG CEVHPGNASN NFFHVAFQGK DILSFQGTSW EPTQEAPLWV NLAIQVLNQD KWTRETVQWL LNGTCPQFVS GLLESGKSEL
KKQVKPKAWL SRGPSPGPGR LLLVCHVSGF YPKPVWVKWM RGEQEQQGTQ PGDILPNADE TWYLRATLDV VAGEAAGLSC RVKHSSLEGQ DIVLYWGGSY TSLEHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD1E Human PRO-1907,CD1E人重组PRO-1907

CD1E 属于跨膜糖蛋白 CD1 家族，在结构上与主要 MHC 蛋白相关，并与 β-2-微球蛋白形成异二聚体。ProSpec,CD1E Human PRO-1907,CD1E人重组PRO-1907

  • CD1E Human

  • CD1E Human Recombinant
  • PRO-1907

Catalogue number

PRO-1907

Synonyms

CD1A, R2, T-cell surface glycoprotein CD1e, membrane-associated, R2G1, sCD1e.

Introduction

CD1E belongs to the CD1 family of transmembrane glycoproteins which are structurally associated to the main MHC proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome is comprised of 5 CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are belief to differ in their cellular localization and specificity for particular lipid ligands. CD1E localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a steady soluble form. The soluble form is necessary for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.
CD1E 属于跨膜糖蛋白 CD1 家族，在结构上与主要 MHC 蛋白相关，并与 β-2-微球蛋白形成异二聚体。 CD1 蛋白主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。 人类基因组由 1 号染色体上的 5 个 CD1 家族基因组成。CD1 家族成员相信其细胞定位和对特定脂质配体的特异性不同。 CD1E 定位在高尔基体、内体和溶酶体中，并被切割成稳定的可溶形式。 可溶形式对于将一些糖脂在细胞内加工成可由其他 CD1 家族成员呈递的形式是必需的。

Description

CD1E Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids and having a molecular mass of 33.1kDa.CD1E is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD1E protein solution contains 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSEEQLSFR MLQTSSFANH SWAHSEGSGW LGDLQTHGWD TVLGTIRFLK PWSHGNFSKQ ELKNLQSLFQ LYFHSFIQIV QASAGQFQLE YPFEIQILAG CRMNAPQIFL NMAYQGSDFL SFQGISWEPS PGAGIRAQNI CKVLNRYLDI KEILQSLLGH TCPRFLAGLM EAGESELKRK VKPEAWLSCG PSPGPGRLQL VCHVSGFYPK PVWVMWMRGE QEQRGTQRGD VLPNADETWY LRATLDVAAG EAAGLSCRVK HSSLGGHDLI IHWGGYS.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD14 Human,CD14人重组PRO-1975

ProSpec,CD14 Human,CD14人重组PRO-1975,CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。

    • CD14 Human

    • CD14 Human Recombinant
    • PRO-1975

Catalogue number

PRO-1975

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

CD14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids and having a molecular mass of 37.9kDa.
CD14is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD14 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 353 个氨基酸，分子量为 37.9kDa。
CD14 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD14 protein solution containing 20mM Tris-HCl buffer , 30% glycerol 0.15M NaCl and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSTTPEPCE LDDEDFRCVC NFSEPQPDWS EAFQCVSAVE VEIHAGGLNL EPFLKRVDAD ADPRQYADTV KALRVRRLTV GAAQVPAQLL VGALRVLAYS RLKELTLEDL KITGTMPPLP LEATGLALSS LRLRNVSWAT GRSWLAELQQ WLKPGLKVLS IAQAHSPAFS CEQVRAFPAL TSLDLSDNPG LGERGLMAAL CPHKFPAIQN LALRNTGMET PTGVCAALAA AGVQPHSLDL SHNSLRATVN PSAPRCMWSS ALNSLNLSFA GLEQVPKGLP AKLRVLDLSC NRLNRAPQPD ELPEVDNLTL DGNPFLVPGT ALPHEGSMNS GVV.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD14 Mouse, Sf9
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  • CD14 Human, CHO

ProSpec,CD14 Human HEK,CD14 人重组 HEK PRO-1642

ProSpec,CD14 Human HEK,CD14 人重组 HEK PRO-1642,CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用

  • CD14 Human HEK

  • CD14 Human Recombinant HEK
  • PRO-1642

Catalogue number

PRO-1642

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

CD14 Human Recombinant produced by mammalian expression system in human cells is a single polypeptide chain containing 341 amino acids . CD14 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
CD14 Human Recombinant 由哺乳动物表达系统在人细胞中产生，是一条含有 341 个氨基酸的多肽链。 CD14 在 C 端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

HEK293 cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CD14 was lyophilized from a 0.2 µM filtered solution of 20mM PB and 150mM NaCl, PH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CD14 in 1xPBS to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD14 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

TTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVD
ADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKIT
GTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAF
SCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCA
ALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKL
RVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACVDHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD14 Human, CHO
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ProSpec-CD14 Human CHO,CD14 人重组CHO PRO-536

ProSpec-CD14 Human CHO,CD14 人重组CHO PRO-536,可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

  • CD14 Human, CHO

  • CD14 Human Recombinant, CHO
  • PRO-536

Catalogue number

PRO-536

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

The CD14 is produced from human CD14 transfected CHO-cells. Before transfection the complete human CD14-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR. The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wild type CD14 is the 50-kDa protein containing 335 amino acids and lacks the GPI-Anchor.
CD14 由人 CD14 转染的 CHO 细胞产生。 在转染之前，通过 PCR 扩增完整的人 CD14-cDNA 并克隆到表达载体 p-POL-DHFR 中。 骨髓分化抗原 CD14 是细菌 LPS 的主要受体。 重组野生型 CD14 的主要形式是含有 335 个氨基酸的 50-kDa 蛋白质，并且缺乏 GPI-Anchor。

Source

CHO-cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CD14 was lyophilized from a concentrated protein solution containing phosphate-buffered saline, pH 7.2.

Solubility

It is recommended to reconstitute the lyophilized CD14 in sterile 18MΩ-cm H2O not less than 100µg/ml. Further dilutions should be made with phosphate buffered saline .

Stability

Lyophilized CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD14 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Biological Activity

Up to 20 µg/ml CD14 inhibit binding of FITC-LPS to 600,000 CD14+CHO transfectants .

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec,CD14 Mouse,CD14 小鼠重组 PRO-537

ProSpec,CD14 Mouse,CD14 小鼠重组 PRO-537,CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。

  • CD14 Mouse

  • CD14 Mouse Recombinant
  • PRO-537

Catalogue number

PRO-537

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

The CD14 is produced from mouse CD14 transfected CHO-cells in serum free medium. Before transfection the complete mouse CD14-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR). The recombinant mouse CD-14 was purified by His-tag and controlled by page.
The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wildtype CD14 is the 50 kDa protein.

Source

CHO-cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CD14 was lyophilized from a concentrated protein solution containing phosphate-buffered saline, pH 7.2.

Solubility

It is recommended to reconstitute the lyophilized Mouse CD14 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Mouse CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CD14 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Applications

• ELISA.
• Inhibition Assays.
• Western Blotting.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD14 Human HEK
  • CD14 Human, CHO
  • CD14 Antibody
  • CD14 Mouse, Sf9
  • CD14 Human
  • CD14 Antibody, Biotin
  • CD14 Antibody, FITC
  • CD14 PAT87H7AT Antibody

ProSpec,CD14 Mouse Sf9,CD14 小鼠重组体Sf9 PRO-2233

ProSpec,CD14 Mouse Sf9,CD14 小鼠重组体Sf9 PRO-2233,在 Sf9 杆状病毒细胞中产生的 CD14 是单条糖基化多肽链，包含 357 个氨基酸，分子量为 38.3kDa。

  • CD14 Mouse, Sf9

  • CD14 Mouse Recombinant, Sf9
  • PRO-2233

Catalogue number

PRO-2233

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

CD14 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 357 amino acids and having a molecular mass of 38.3kDa.

CD14 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD14 是单条糖基化多肽链，包含 357 个氨基酸，分子量为 38.3kDa。

CD14 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD14 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

SPAPPEPCEL DEESCSCNFS DPKPDWSSAF NCLGAADVEL YGGGRSLEYL LKRVDTEADL GQFTDIIKSL SLKRLTVRAA RIPSRILFGA LRVLGISGLQ ELTLENLEVT GTAPPPLLEA TGPDLNILNL RNVSWATRDA WLAELQQWLK PGLKVLSIAQ AHSLNFSCEQ VRVFPALSTL DLSDNPELGE RGLISALCPL KFPTLQVLAL RNAGMETPSG VCSALAAARV QLQGLDLSHN SLRDAAGAPS CDWPSQLNSL NLSFTGLKQV PKGLPAKLSV LDLSYNRLDR NPSPDELPQV GNLSLKGNPF LDSESHSEKF NSGVVTAGAP SSQAVALSGT LALLLGDRLF VHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD14 Human, CHO
  • CD14 Human HEK
  • CD14 Human
  • CD14 Mouse

ProSpec-CD2 Human Sf9,CD2人重组sf9 PRO-2390

CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。ProSpec-CD2 Human Sf9,CD2人重组sf9 PRO-2390

  • CD2 Human, Sf9

  • CD2 Human Recombinant, sf9
  • PRO-2390
  • Catalogue number

PRO-2390

Synonyms

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

Introduction

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.

CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

Description

CD2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 194 amino acids and having a molecular mass of 22.3kDa .
CD2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD2 Human Recombinant 是单条糖基化多肽链，包含 194 个氨基酸，分子量为 22.3kDa。
CD2 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD2 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPKEITNAL ETWGALGQDI NLDIPSFQMS DDIDDIKWEK TSDKKKIAQF RKEKETFKEK DTYKLFKNGT LKIKHLKTDD QDIYKVSIYD TKGKNVLEKI FDLKIQERVS KPKISWTCIN TTLTCEVMNG TDPELNLYQD GKHLKLSQRV ITHKWTTSLS AKFKCTAGNK VSKESSVEPV
SCPEKGLDHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD2 Human
  • CD2 Human, GST

ProSpec,CD2 Human,CD2人重组PRO-1337

ProSpec,CD2 Human,CD2人重组PRO-1337,CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。

  • CD2 Human

  • CD2 Human Recombinant
  • PRO-1337

Catalogue number

PRO-1337

Synonyms

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

Introduction

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

Description

CD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids and having a molecular mass of 23.8kDa.
CD2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD2 protein solution containing 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL
SAKFKCTAGN KVSKESSVEP VSCPEKGLD.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD2 Human, GST
  • CD2 Human, Sf9

ProSpec-CD2 Human GST,CD2 人重组PRO-468

ProSpec-CD2 Human GST,CD2 人重组PRO-468,p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

  • CD2 Human, GST

  • CD2 Human Recombinant, GST Tag
  • PRO-468

Catalogue number

PRO-468

Synonyms

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

Introduction

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

Description

CD2 Human Recombinant expressed in E.coli, shows a 46 kDa band on -PAGE.
The CD2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD2 at 100µg/ml in 50mM Tris-HCl pH7.5 and 10Mm L-glutathione .

Stability

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Applications

• ELISA.
• Inhibition Assays.
• Western Blotting.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD2 FITC Antibody
  • CD2 Human
  • CD2 Antibody
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ProSpec-CD200 Human Sf9,CD200 人类重组sf9 PRO-2416

CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。ProSpec-CD200 Human Sf9,CD200 人类重组sf9 PRO-2416

  • CD200 Human, Sf9

  • CD200 Human Recombinant, sf9
  • PRO-2416

Catalogue number

PRO-2416

Synonyms

CD200, MOX1, MOX2, MRC, OX-2, CD200 Molecule, CD200 Antigen, Antigen Identified By Monoclonal Antibody MRC OX-2, OX-2 Membrane Glycoprotein.

Introduction

CD200 is a type-1 membrane glycoprotein which is a part of the immunoglobulin superfamily due to its 2 immunoglobulin domains. CD200 regulates myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in various tissues. CD200 is also Costimulates T-cell proliferation.

CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。 CD200 调节骨髓细胞活性并为各种组织中的巨噬细胞谱系提供抑制信号。 CD200 也是共刺激 T 细胞增殖。

Description

CD200 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 444 amino acids and having a molecular mass of 49.7kDa .
CD200 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD200 Human Recombinant 是单条糖基化多肽链，包含 444 个氨基酸，分子量为 49.7kDa。
CD200 在 C 末端用 242 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD200 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPQVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKGLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200 Human
  • CD200 Mouse

ProSpec,CD200 Human,CD200 人重组PRO-1974

CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。ProSpec,CD200 Human,CD200 人重组PRO-1974

  • CD200 Human

  • CD200 Human Recombinant
  • PRO-1974

Catalogue number

PRO-1974

Synonyms

MOX1, MOX2, MRC, OX-2, OX-2 membrane glycoprotein, CD_antigen, CD200.

Introduction

CD200 is a type-1 membrane glycoprotein which is a part of the immunoglobulin superfamily due to its 2 immunoglobulin domains. CD200 regulates myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in various tissues. CD200 is also Costimulates T-cell proliferation.
CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。 CD200 调节骨髓细胞活性并为各种组织中的巨噬细胞谱系提供抑制信号。 CD200 也是共刺激 T 细胞增殖。

Description

CD200 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids and having a molecular mass of 24.8kDa.
CD200 is fused to a 23 amino acid His-tag at N-terminus.
在大肠杆菌中产生的 CD200 Human Recombinant 是单条非糖基化多肽链，含有 225 个氨基酸，分子量为 24.8kDa。
CD200 在 N 端与 23 个氨基酸的 His 标签融合。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD200 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSQVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKG.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200R1 Mouse
  • CD200 Human, Sf9
  • CD200 Mouse

ProSpec,CD200 Mouse,CD200 小鼠重组PRO-2612

ProSpec,CD200 Mouse,CD200 小鼠重组,在杆状病毒中产生的 CD200 小鼠重组体是一条单条糖基化多肽链，包含 210 个氨基酸，分子量为 23.5kDa。

  • CD200 Mouse

  • CD200 Mouse Recombinant
  • PRO-2612

Catalogue number

PRO-2612

Synonyms

MOX1, MOX2, MRC, OX-2, OX-2 membrane glycoprotein, CD_antigen, CD200.

Introduction

CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 210 amino acids and having a molecular mass of 23.5kDa. CD200 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

在杆状病毒中产生的 CD200 小鼠重组体是一条单条糖基化多肽链，包含 210 个氨基酸，分子量为 23.5kDa。 CD200 在 C 端与 8 个氨基酸的 His-Tag 融合，并通过专有色谱技术进行纯化。

Description

CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 441 amino acids and having a molecular mass of 49.5kDa.
CD200 is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.

在杆状病毒中产生的 CD200 小鼠重组体是一条糖基化的单一多肽链，包含 441 个氨基酸，分子量为 49.5kDa。
CD200 在 C 末端与 239 个氨基酸的 hIgG-His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD200 solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

QVEVVTQDER KALHTTASLR CSLKTSQEPL IVTWQKKKAV SPENMVTYSK THGVVIQPAY KDRINVTELG LWNSSITFWN TTLEDEGCYM CLFNTFGSQK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGTGIE NSTESHFHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGLEHHHHHH.

Measured by its binding ability in a functional ELISA with pro-2363.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200 Human
  • CD200 Human, Sf9

ProSpec,CD200R1 Human,CD200 受体 1 人重组体PRO-2548

ProSpec,CD200R1 Human,CD200 受体 1 人重组体PRO-2548,在 Sf9 昆虫细胞中产生的 CD200R1 是单条糖基化多肽链，含有 462 个氨基酸，分子量为 51.9kDa。

  • CD200R1 Human

  • CD200 Receptor 1 Human Recombinant
  • PRO-2548

Catalogue number

PRO-2548

Synonyms

Cell surface glycoprotein CD200 receptor 1 isoform d, CD200R1, CD200R, HCRTR2, MOX2R, OX2R, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r.

Introduction

CD200R1, also known as cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 inhibitory signaling pathway has been involved in taking a prominent role in limiting inflammation in a broad range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, in addition to inducible nitric oxide synthase in response to selected stimuli.

CD200R1，也称为细胞表面糖蛋白 CD200 受体 1，是一种在髓系细胞上表达的 CD200 受体同种型。 CD200R1 抑制信号通路在广泛的炎症性疾病中在限制炎症方面发挥着重要作用。 CD200R1 信号传导抑制促炎分子的表达，包括肿瘤坏死因子、干扰素，以及响应选定刺激的诱导型一氧化氮合酶。

Description

CD200R1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 462 amino acids and having a molecular mass of 51.9kDa . CD200R1 is expressed with 242 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 昆虫细胞中产生的 CD200R1 是单条糖基化多肽链，含有 462 个氨基酸，分子量为 51.9kDa。 CD200R1 在 C 末端用 242 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD200R1 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADLSSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYKK ETNETKETNC TDERITWVSR PDQNSDLQIR TVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAHISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Related Products

  • CD200R1 Mouse

ProSpec,CD200R1 Mouse,CD200 受体 1 小鼠重组PRO-2363

ProSpec,CD200R1 Mouse,CD200 受体 1 小鼠重组PRO-2363,CD200R1，也称为细胞表面糖蛋白 CD200 受体 1，是一种在髓系细胞上表达的 CD200 受体同种型。 CD200R1 抑制信号通路在广泛的炎症性疾病中在限制炎症方面发挥着重要作用。

  • CD200R1 Mouse

  • CD200 Receptor 1 Mouse Recombinant
  • PRO-2363

Catalogue number

PRO-2363

Synonyms

Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r.

Introduction

CD200R1, also known as cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 inhibitory signaling pathway has been involved in taking a prominent role in limiting inflammation in a broad range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, in addition to inducible nitric oxide synthase in response to selected stimuli.

CD200R1，也称为细胞表面糖蛋白 CD200 受体 1，是一种在髓系细胞上表达的 CD200 受体同种型。 CD200R1 抑制信号通路在广泛的炎症性疾病中在限制炎症方面发挥着重要作用。 CD200R1 信号传导抑制促炎分子的表达，包括肿瘤坏死因子、干扰素，以及响应选定刺激的诱导型一氧化氮合酶。

Description

CD200R1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 455 amino acids and having a molecular mass of 50.4kDa. .
CD200R1 is expressed with a 239 amino acid hIgG His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 昆虫细胞中产生的 CD200R1 是单条糖基化多肽链，含有 455 个氨基酸，分子量为 50.4kDa。 .
CD200R1 在 C 末端用 239 个氨基酸的 hIgG His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD200R1 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPTDKNQTT QNNSSSPLTQ VNTTVSVQIG TKALLCCFSI PLTKAVLITW IIKLRGLPSC TIAYKVDTKT NETSCLGRNI TWASTPDHSP ELQISAVTLQ HEGTYTCETV TPEGNFEKNY DLQVLVPPEV TYFPEKNRSA VCEAMAGKPA AQISWSPDGD CVTTSESHSN GTVTVRSTCH WEQNNVSDVS CIVSHLTGNQ SLSIELSRGG NQSLRPLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200 Human
  • CD200R1 Human

ProSpec,MSR1 Human,巨噬细胞清道夫受体 1 人重组体PRO-2201

ProSpec,MSR1 Human,巨噬细胞清道夫受体 1 人重组体PRO-2201,巨噬细胞清道夫受体 1，也称为 MSR1，是 A 类巨噬细胞清道夫受体的成员

  • MSR1 Human

  • Macrophage Scavenger Receptor 1 Human Recombinant
  • PRO-2201

Catalogue number

PRO-2201

Synonyms

Macrophage Scavenger Receptor 1, SCARA1, Macrophage Acetylated LDL Receptor I And II, Scavenger Receptor Class A Member 1, SRA, Macrophage Scavenger Receptor Types I And II, Macrophage Scavenger Receptor Type III, Scavenger Receptor Class A, Member 1 CD204 Antigen, CD204, PhSR1, PhSR2, SR-A.

Introduction

Macrophage Scavenger Receptor 1, also known as MSR1 is a member of the class A macrophage scavenger receptors, which comprises three different types 1, 2 and 3 generated by alternative splicing. Furthermore, these receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological as well as pathological processes which include atherosclerosis, Alzheimer’s disease, and host defense.
巨噬细胞清道夫受体 1，也称为 MSR1，是 A 类巨噬细胞清道夫受体的成员，包括通过可变剪接产生的三种不同类型的 1、2 和 3。 此外，这些受体或同种型是巨噬细胞特异性三聚体整合膜糖蛋白，并且与许多巨噬细胞相关的生理和病理过程有关，包括动脉粥样硬化、阿尔茨海默病和宿主防御。

Description

MSR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 398 amino acids and having a molecular mass of 43.7kDa.
MSR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 MSR1 Human Recombinant 是单条非糖基化多肽链，包含 398 个氨基酸，分子量为 43.7kDa。
MSR1 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

MSR1 protein solution containing 20mM Tris-HCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSKWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ WGTRACSHSE DAGVTCTL

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • MSR1 Human, sf9

ProSpec,CD207 Human,CD207 人重组PRO-2204

CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。ProSpec,CD207 Human,CD207 人重组PRO-2204

  • CD207 Human

  • CD207 Human Recombinant
  • PRO-2204

Catalogue number

PRO-2204

Synonyms

C-type lectin domain family 4 member K, CLEC4K, Langerin, CD207.

Introduction

CD207 is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Moreover, CD207 is expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, the organelles present in the cytoplasm of Langerhans cells and comprised of superimposed and zippered membranes. CD207 is a C-type lectin with mannose binding specificity, and it has been suggested that mannose binding by the CD207 protein leads to internalization of antigen into Birbeck granules thus providing access to a nonclassical antigen-processing pathway.
CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。 Langerin 位于伯贝克颗粒中，该细胞器存在于朗格汉斯细胞的细胞质中，由重叠的拉链膜组成。 CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中，从而提供了进入非经典抗原加工途径的途径。

Description

CD207 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids and having a molecular mass of 32.2kDa.
CD207 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD207 Human Recombinant 是单条非糖基化多肽链，含有 287 个氨基酸，分子量为 32.2kDa。
CD207 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD207 protein solution containing 20mM Tris 8.0 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEP.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD207 Human, sf9

ProSpec-CD207 Human sf9,CD207 人类重组体sf9 PRO-2317

ProSpec-CD207 Human sf9,CD207 人类重组体sf9 PRO-2317,CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中

  • CD207 Human, sf9

  • CD207 Human Recombinant, sf9
  • PRO-2317

Catalogue number

PRO-2317

Synonyms

C-type lectin domain family 4 member K, Langerin, CD207, CD207 Molecule, CD207 Molecule, Langerin, CD207 Antigen, Langerin, CLEC4K, Langerhans Cell Specific C-Type Lectin, Langerin.

Introduction

CD207 is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Moreover, CD207 is expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, the organelles present in the cytoplasm of Langerhans cells and comprised of superimposed and zippered membranes. CD207 is a C-type lectin with mannose binding specificity, and it has been suggested that mannose binding by the CD207 protein leads to internalization of antigen into Birbeck granules thus providing access to a nonclassical antigen-processing pathway.
CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。 Langerin 位于伯贝克颗粒中，该细胞器存在于朗格汉斯细胞的细胞质中，由重叠的拉链膜组成。 CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中，从而提供了进入非经典抗原加工途径的途径。

Description

CD207 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 273 amino acids and having a molecular mass of 30.9kDa .
CD207 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD207 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEPHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD207 Human

ProSpec,CD226 Human,CD226 人重组PRO-1353

ProSpec,CD226 Human,CD226 人重组PRO-1353,CD226 属于 Ig 超家族，包含 V 组的 2 个 Ig 样结构域。 CD226 是一种 65kDa 糖蛋白，在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达。

  • CD226 Human

  • CD226 Human Recombinant
  • PRO-1353

Catalogue number

PRO-1353

Synonyms

DNAM-1, PTA1, TLiSA1, CD226 antigen, DNAX accessory molecule 1, DNAM1, Recombinant Human CD226.

Introduction

CD226 belongs to the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 is a 65kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. CD226 facilitates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. CD226 also plays a role in megakaryocytic cell maturation.
CD226 属于 Ig 超家族，包含 V 组的 2 个 Ig 样结构域。 CD226 是一种 65kDa 糖蛋白，在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达。 CD226 促进血小板和巨核细胞与血管内皮细胞的细胞粘附。 CD226 还在巨核细胞成熟中起作用。

Description

CD226 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 259 amino acids and having a molecular mass of 29.4kDa.
CD226 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD226 protein solution containing 20mM Tris-HCl buffer , 0.4M UREA and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNQYTLFVA.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD226 Human, Sf9

ProSpec,CD226 Human Sf9,CD226 人重组体Sf9 PRO-2371

ProSpec,CD226 Human Sf9,CD226 人重组体Sf9 PRO-2371,在 Sf9 杆状病毒细胞中产生的 CD226 Human Recombinant 是单条糖基化多肽链，包含 471 个氨基酸，分子量为 53.2kDa。

  • Description

  • CD226 Human, Sf9

  • CD226 Human Recombinant, Sf9
  • PRO-2371

Catalogue number

PRO-2371

Synonyms

CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226 Molecule, CD226 Antigen, DNAX Accessory Molecule 1, DNAM-1, DNAM1, T Lineage-Specific Activation Antigen 1 Antigen, Platelet And T Cell Activation Antigen 1, DNAX Accessory Molecule-1, Adhesion Glycoprotein, TLiSA1, PTA1.

Introduction

CD226 belongs to the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 is a 65kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. CD226 facilitates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. CD226 also plays a role in megakaryocytic cell maturation.
CD226 属于 Ig 超家族，包含 V 组的 2 个 Ig 样结构域。 CD226 是一种 65kDa 糖蛋白，在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达。 CD226 促进血小板和巨核细胞与血管内皮细胞的细胞粘附。 CD226 还在巨核细胞成熟中起作用。

Description

CD226 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 471 amino acids and having a molecular mass of 53.2kDa .

CD226 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD226 Human Recombinant 是单条糖基化多肽链，包含 471 个氨基酸，分子量为 53.2kDa。

CD226 在 C 末端与 239 个氨基酸的 hIgG-His-tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD226 protein solution containing Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

ADPEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD226 Human

ProSpec,CD244 Human,CD244 人重组PRO-1173

ProSpec,CD244 Human,CD244 人重组PRO-1173,ProSpec,CD244 Human,CD244 人重组PRO-1173,NK 细胞和靶细胞通过 CD244 受体的相互作用被认为可以调节 NK 细胞的溶细胞活性。

  • CD244 Human

  • CD244 Human Recombinant
  • PRO-1173

Catalogue number

PRO-1173

Synonyms

Natural killer cell receptor 2B4, NK cell activation-inducing ligand, NAIL, NK cell type I receptor protein 2B4, NKR2B4, h2B4, CD244, 2B4, Nmrk, SLAMF4.

Introduction

Cluster of Differentiation 244 contains 2 Ig-like domains. CD244 is a cell surface receptor expressed on natural killer cells which mediate non-major histocompatibility complex restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis, and have a role in the pathophysiology of allergic rhinitis .
分化簇244包含2个Ig样结构域。 CD244 是一种在自然杀伤细胞上表达的细胞表面受体，可介导非主要组织相容性复合物限制性杀伤。 NK 细胞和靶细胞通过 CD244 受体的相互作用被认为可以调节 NK 细胞的溶细胞活性。 CD244分子在嗜酸性粒细胞粘附和趋化中起作用，并且在变应性鼻炎的病理生理学中起作用。

Description

CD244 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 230 amino acids and having a molecular mass of 25.5kDa.
CD244 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD244 protein solution containing 20mM Tris-HCl buffer, pH8.0 and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHGKGCQG SADHVVSISG VPLQLQPNSI QTKVDSIAWK KLLPSQNGFH HILKWENGSL PSNTSNDRFS FIVKNLSLLI KAAQQQDSGL YCLEVTSISG KVQTATFQVF VFDKVEKPRL QGQGKILDRG RCQVALSCLV SRDGNVSYAW YRGSKLIQTA GNLTYLDEEV DINGTHTYTC NVSNPVSWES HTLNLTQDCQ NAHQEFRFWP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD244 Human, Sf9

ProSpec-CD244 Human Sf9,CD244 人重组体Sf9 PRO-2413

在 Sf9 昆虫细胞中产生的 CD244 Human Recombinant 是单条糖基化多肽链，包含 448 个氨基酸，分子量为 50.2kDa。ProSpec-CD244 Human Sf9,CD244 人重组体Sf9 PRO-2413

  • CD244 Human, Sf9

  • CD244 Human Recombinant, Sf9
  • PRO-2413

Catalogue number

PRO-2413

Synonyms

Natural killer cell receptor 2B4, NK cell activation-inducing ligand, NAIL, NK cell type I receptor protein 2B4, NKR2B4, h2B4, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2B4.

Introduction

Cluster of Differentiation 244 contains 2 Ig-like domains. CD244 is a cell surface receptor expressed on natural killer cells which mediate non-major histocompatibility complex restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis, and have a role in the pathophysiology of allergic rhinitis .

分化簇244包含2个Ig样结构域。 CD244 是一种在自然杀伤细胞上表达的细胞表面受体，可介导非主要组织相容性复合物限制性杀伤。 NK 细胞和靶细胞通过 CD244 受体的相互作用被认为可以调节 NK 细胞的溶细胞活性。 CD244分子在嗜酸性粒细胞粘附和趋化中起作用，并且在变应性鼻炎的病理生理学中起作用。

Description

CD244 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 448 amino acids and having a molecular mass of 50.2kDa . CD244 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 昆虫细胞中产生的 CD244 Human Recombinant 是单条糖基化多肽链，包含 448 个氨基酸，分子量为 50.2kDa。 CD244 在 C 末端用 239 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD244 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

ADLGKGCQGS ADHVVSISGV PLQLQPNSIQ TKVDSIAWKK LLPSQNGFHH ILKWENGSLP SNTSNDRFSF IVKNLSLLIK AAQQQDSGLY CLEVTSISGK VQTATFQVFV FDKVEKPRLQ GQGKILDRGR CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN VSNPVSWESH TLNLTQDCQN AHQEFRFWPL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD244 Human

ProSpec,CD27 Human,CD27 人重组PRO-1213

ProSpec,CD27 Human,CD27 人重组PRO-1213,在大肠杆菌中产生的 CD27 Human Recombinant 是单条多肽链，包含 196 个氨基酸，分子量为 21.8 kDa。

  • CD27 Human

  • CD27 Human Recombinant
  • PRO-1213

Catalogue number

PRO-1213

Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 7,T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen,T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.

Introduction

CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.
CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。

Description

CD27 Human Recombinant produced in E. coli is a single polypeptide chain containing 196 amino acids and having a molecular mass of 21.8 kDa.
CD27 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD27 Human Recombinant 是单条多肽链，包含 196 个氨基酸，分子量为 21.8 kDa。
CD27 在 N 端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD27 solution contains 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTPAPK SCPERHYWAQ GKLCCQMCEP GTFLVKDCDQ HRKAAQCDPC IPGVSFSPDH HTRPHCESCR HCNSGLLVRN CTITANAECA CRNGWQCRDK ECTECDPLPN PSLTARSSQA LSPHPQPTHL PYVSEMLEAR TAGHMQTLAD FRQLPARTLS THWPPQRSLC SSDFIR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD27 Human, sf9
  • CD27 Human, HEK

ProSpec,CD27 Human HEK,CD27 人重组体HEK PRO-2751

CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。ProSpec,CD27 Human HEK,CD27 人重组体HEK PRO-2751

  • CD27 Human, HEK

  • CD27 Human Recombinant, HEK
  • PRO-2751

Catalogue number

PRO-2751

Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 7, T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen, T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.

Introduction

CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.

CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。

Description

CD27 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing a total of 411 amino acids, having a molecular mass of 46.2kDa.
CD27 is fused to a 239 amino acid hIgG-His-Tag at C-terminus,and is purified by proprietary chromatographic techniques.

Source

HEK293 Cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD27 solution contains 10% Glycerol and Phosphate-Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Biological Activity

ED50 range is ≤ 0.8 ug/ml. Defined by its binding ability in a functional ELISA with Human CD27 Ligand/TNFSF7 .

Amino acid sequence

ATPAPKSCPE RHYWAQGKLC CQMCEPGTFL VKDCDQHRKA AQCDPCIPGV SFSPDHHTRP HCESCRHCNS GLLVRNCTIT ANAECACRNG WQCRDKECTE CDPLPNPSLT ARSSQALSPH PQPTHLPYVS EMLEARTAGH MQTLADFRQL PARTLSTHWP PQRSLCSSDF IRLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD27 Human

ProSpecCD27 Human sf9,CD27 人重组sf9 PRO-2345

ProSpecCD27 Human sf9,CD27 人重组sf9 PRO-2345,CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。

  • CD27 Human, sf9

  • CD27 Human Recombinant, sf9
  • PRO-2345

Catalogue number

PRO-2345

Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 7, T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen, T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.

Introduction

CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.
CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。

Description

CD27 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 413 amino acids and having a molecular mass of 46.4kDa .
CD27 is fused with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD27 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

ADPTPAPKSC PERHYWAQGK LCCQMCEPGT FLVKDCDQHR KAAQCDPCIP GVSFSPDHHT RPHCESCRHC NSGLLVRNCT ITANAECACR NGWQCRDKEC TECDPLPNPS LTARSSQALS PHPQPTHLPY VSEMLEARTA GHMQTLADFR QLPARTLSTH WPPQRSLCSS DFIRLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD27 Human

ProSpec,CD23 Human Sf9,CD23 人重组体Sf9 PRO-2499

ProSpec,CD23 Human Sf9,CD23 人重组体Sf9 PRO-2499,FCER2 是一种 C 型凝集素，与许多抗体受体相反。 FCER2 位于活化的巨噬细胞、成熟 B 细胞、滤泡树突细胞、血小板和嗜酸性粒细胞上。

  • CD23 Human, Sf9

  • CD23 Human Recombinant, Sf9
  • PRO-2499

Catalogue number

PRO-2499

Synonyms

Low affinity immunoglobulin epsilon Fc receptor isoform a, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, C-type lectin domain family 4 member J, Immunoglobulin E-binding factor, Lymphocyte IgE receptor.

Introduction

FCER2, or Fc epsilon RII, is a receptor for IgE with low affinity, which is critical to regulation of IgE levels. IgE is an antibody isotype that attached to allergy and resistance to parasites. FCER2 is a C-type lectin, contrary to many of the receptors for antibodies. FCER2 is located on activated macrophages, mature B cells, follicular dendritic cells, platelets and eosinophils.

FCER2 或 Fc epsilon RII 是一种低亲和力的 IgE 受体，对 IgE 水平的调节至关重要。 IgE 是一种抗体同种型，与过敏和对寄生虫的抵抗力有关。 FCER2 是一种 C 型凝集素，与许多抗体受体相反。 FCER2 位于活化的巨噬细胞、成熟 B 细胞、滤泡树突细胞、血小板和嗜酸性粒细胞上。

Description

CD23 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 283 amino acids and having a molecular mass of 32.0kDa.
CD23 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD23 是单条糖基化多肽链，包含 283 个氨基酸，分子量为 32.0kDa。
CD23 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD23 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPDTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR
NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT
PSAPLHSHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • sCD23 Human

ProSpec,sCD23 Human,可溶性 CD23 人重组体PRO-1789

CD23 是一种 45kDa 糖蛋白，存在于新鲜分离的外周血和扁桃体 B 细胞亚群中，并在 EBV 转化的 B 淋巴母细胞上强烈表达。 CD23 分子与 B 细胞上发现的低亲和力 IgE 受体相同,ProSpec,sCD23 Human,可溶性 CD23 人重组体PRO-1789

  • sCD23 Human

  • Soluble CD23 Human Recombinant
  • PRO-1789

Catalogue number

PRO-1789

Synonyms

Low affinity immunoglobulin epsilon Fc receptor, Lymphocyte IgE receptor, Fc-epsilon-RII, BLAST-2, Immunoglobulin E-binding factor, CD23 antigen, FCER2, CD23, FCE2, CD23A, IGEBF, CLEC4J.

Introduction

CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma.
CD23 是一种 45kDa 糖蛋白，存在于新鲜分离的外周血和扁桃体 B 细胞亚群中，并在 EBV 转化的 B 淋巴母细胞上强烈表达。 CD23 分子与 B 细胞上发现的低亲和力 IgE 受体相同。 已在 B 细胞慢性淋巴细胞白血病病例和一些中心母细胞/中心细胞淋巴瘤病例的肿瘤细胞中检测到 CD23 的表达。

Description

sCD23 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.2kDa.
The sCD23 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Amino acid sequence

MELQVSSGFV CNTCPEKWIN FQRKCYYFGK GTKQWVHARY ACDDMEGQLV SIHSPEEQDF LTKHASHTGS WIGLRNLDLK GEFIWVDGSH VDYSNWAPGE PTSRSQGEDC VMMRGSGRWN DAFCDRKLGA WVCDRLATCT PPASEGSAES MGPDSRPDPD GRLPTPSAPL HS

Solubility

It is recommended to reconstitute the lyophilized sCD23 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Stability

Lyophilized sCD23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sCD23 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein . Please prevent freeze-thaw cycles.

Biological Activity

The ED50 is determined by its ability to induce TNF-alpha production by human PBMCs.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD23 Human, Sf9

ProSpec,CD274 Human,CD274 人重组PRO-1103

ProSpec,CD274 Human,CD274 人重组PRO-1103,在大肠杆菌中产生的 CD274 Human Recombinant 是单条多肽链，含有 245 个氨基酸，分子量为 27.9kDa。

  • CD274 Human

  • CD274 Human Recombinant
  • PRO-1103

Catalogue number

PRO-1103

Synonyms

CD274 molecule, CD274 antigen, programmed cell death 1 ligand 1, PD-L1, PDCD1L1, PDCD1LG1, PDCD1 ligand 1, B7 homolog 1, B7H1.

Introduction

CD274 takes part in the costimulatory signal, vital for T-cell proliferation and creation of IL10 and IFNG, in a PDCD1-independent and an IL2-dependent manner. CD274 collaboration with PDCD1 inhibits cytokine production and T-cell proliferation.
CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

Description

CD274 Human Recombinant produced in E. coli is a single polypeptide chain containing 245 amino acids and having a molecular mass of 27.9kDa .
CD274 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD274 Human Recombinant 是单条多肽链，含有 245 个氨基酸，分子量为 27.9kDa。
CD274 在 N 末端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD274 solution contains 20mM Tris-HCl buffer , 1mM DTT and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMFTVTV PKDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNER.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD274 Mouse
  • CD274 Human, Sf9

ProSpec-CD274 Human Sf9,CD274 人重组体Sf9 PRO-2453

ProSpec-CD274 Human Sf9,CD274 人重组体Sf9 PRO-2453,CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

  • CD274 Human, Sf9

  • CD274 Human Recombinant, Sf9
  • PRO-2453

Catalogue number

PRO-2453

Synonyms

CD274 molecule, CD274 antigen, programmed cell death 1 ligand 1, PD-L1, PDCD1L1, PDCD1LG1, PDCD1 ligand 1, B7 homolog 1, B7H1.

Introduction

CD274 takes part in the costimulatory signal, vital for T-cell proliferation and creation of IL10 and IFNG, in a PDCD1-independent and an IL2-dependent manner. CD274 collaboration with PDCD1 inhibits cytokine production and T-cell proliferation.

CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

Description

CD274 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 462 amino acids and having a molecular mass of 52.5kDa . CD274 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD274 Human Recombinant 是单条糖基化多肽链，包含 462 个氨基酸，分子量为 52.5kDa。 CD274 在 C 末端用 239 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD274 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

ADLFTVTVPK DLYVVEYGSN MTIECKFPVE KQLDLAALIV YWEMEDKNII QFVHGEEDLK VQHSSYRQRA RLLKDQLSLG NAALQITDVK LQDAGVYRCM ISYGGADYKR ITVKVNAPYN KINQRILVVD PVTSEHELTC QAEGYPKAEV IWTSSDHQVL SGKTTTTNSK REEKLFNVTS TLRINTTTNE IFYCTFRRLD PEENHTAELV IPELPLAHPP NERLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD274 Human
  • CD274 Mouse

ProSpec,CD274 Mouse,CD274 小鼠重组PRO-1164

ProSpec,CD274 Mouse,CD274 小鼠重组PRO-1164,CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

  • CD274 Mouse

  • CD274 Mouse Recombinant
  • PRO-1164

Catalogue number

PRO-1164

Synonyms

Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, A530045L16Rik.

Introduction

CD274 takes part in the costimulatory signal, vital for T-cell proliferation and creation of IL10 and IFNG, in a PDCD1-independent and an IL2-dependent manner. CD274 collaboration with PDCD1 inhibits cytokine production and T-cell proliferation.
CD274 以不依赖 PDCD1 和依赖 IL2 的方式参与共刺激信号，这对 T 细胞增殖和 IL10 和 IFNG 的产生至关重要。 CD274 与 PDCD1 协作抑制细胞因子产生和 T 细胞增殖。

Description

CD274 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 246 amino acids and having a molecular mass of 27.6kDa .
CD274 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD274 protein solution containing 20mM Tris-HCl buffer , 10% glycerol and 0.15M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMFTITA PKDLYVVEYG SNVTMECRFP VERELDLLAL VVYWEKEDEQ VIQFVAGEED LKPQHSNFRG RASLPKDQLL KGNAALQITD VKLQDAGVYC CIISYGGADY KRITLKVNAP YRKINQRISV DPATSEHELI CQAEGYPEAE VIWTNSDHQP
VSGKRSVTTS RTEGMLLNVT SSLRVNATAN DVFYCTFWRS QPGQNHTAEL IIPELPATHP PQNRTH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD274 Human
  • CD274 Human, Sf9

ProSpec,CD247 Human,CD247 人重组PRO-1335

T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。ProSpec,CD247 Human,CD247 人重组PRO-1335

  • CD247 Human

  • CD247 Human Recombinant
  • PRO-1335

Catalogue number

PRO-1335

Synonyms

T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD3Z, T3Z, TCRZ, CD3H, CD3Q, CD3-ZETA.

Introduction

T-cell surface glycoprotein CD3 zeta chain is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.
T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。 zeta 链在将抗原识别与几种细胞内信号转导途径偶联方面具有核心作用。 CD247 抗原的低表达导致免疫反应受损。

Description

CD247 Human Recombinant produced in E. coli is a single polypeptide chain containing 136 amino acids and having a molecular mass of 15.4kDa.
CD247 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD247 solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD247 Human, Sf9

ProSpec,CD247 Human Sf9,CD247 人重组体Sf9 PRO-2529

ProSpec,CD247 Human Sf9,CD247 人重组体Sf9 PRO-2529,T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。

    • CD247 Human, Sf9

    • CD247 Human Recombinant, Sf9
    • PRO-2529

Catalogue number

PRO-2529

Synonyms

CD247 Molecule, T-Cell Surface Glycoprotein CD3 Zeta Chain, T-Cell Receptor T3 Zeta Chain, CD247 Antigen, CD3Z, TCRZ, T3Z, T-Cell Antigen Receptor Complex, Zeta Subunit Of CD3, CD3Z Antigen, Zeta Polypeptide , CD3z Antigen, Zeta Polypeptide , CD247 Antigen, Zeta Subunit , TCR Zeta Chain, CD3zeta Chain, CD3-ZETA, IMD25, CD3H, CD3Q.

Introduction

T-cell surface glycoprotein CD3 zeta chain is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.

T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta，它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。 zeta 链在将抗原识别与几种细胞内信号转导途径偶联方面具有核心作用。 CD247 抗原的低表达导致免疫反应受损。

Description

CD247 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 122 amino acids and having a molecular mass of 14.1kDa. . CD247 is expressed with an 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD247 protein solution contains 20mM Tris-HCl buffer , 50% glycerol, 1mM DTT, 1mM EDTA and  0.1M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPRHHHH HH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD247 Human

ProSpec,CD3e Human,CD3e人重组PRO-1317

ProSpec,CD3e Human,CD3e人重组PRO-1317,CD3-ε 多肽与 CD3-γ、-δ 和 -zeta 以及 T 细胞受体 α/β 和 γ/δ 异二聚体一起产生 T 细胞受体-CD3 复合物。 这种复合物在将抗原识别与许多细胞内信号转导途径耦合方面具有重要作用。

  • CD3e Human

  • CD3e Human Recombinant
  • PRO-1317

Catalogue number

PRO-1317

Synonyms

T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E, TCRE.

Introduction

CD3-epsilonpolypeptide along with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, creates the T-cell receptor-CD3 complex. This complex has an imperative role in coupling antigen recognition to a number of intracellular signal-transduction pathways. The genes encoding the epsilon, gamma delta polypeptides are found in the same cluster on chromosome 11. The epsilon polypeptide plays a vital role in T-cell development. CD3E gene defects cause immunodeficiency. CD3E is also linked to a susceptibility to type I diabetes in women.
CD3-ε 多肽与 CD3-γ、-δ 和 -zeta 以及 T 细胞受体 α/β 和 γ/δ 异二聚体一起产生 T 细胞受体-CD3 复合物。 这种复合物在将抗原识别与许多细胞内信号转导途径耦合方面具有重要作用。 在 11 号染色体上的同一簇中发现了编码 epsilon、gamma delta 多肽的基因。epsilon 多肽在 T 细胞发育中起着至关重要的作用。 CD3E基因缺陷导致免疫缺陷。 CD3E 还与女性对 I 型糖尿病的易感性有关。

Description

CD3e Human Recombinant produced in E. coli is a single polypeptide chain containing 127 amino acids and having a molecular mass of 14.1kDa.
CD3e is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD3e Human Recombinant 是单条多肽链，含有 127 个氨基酸，分子量为 14.1kDa。
CD3e 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD3e solution contains 20mM Tris-HCl buffer , 0.2M NaCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMD.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD3E Antibody

ProSpec PRO-2412,CD3G Human,CD3G人重组PRO-2412

ProSpec PRO-2412,CD3G Human,CD3G人重组PRO-2412,CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。 T 细胞受体-CD3 复合物参与将抗原识别与许多细胞内信号转导途径偶联

  • CD3G Human

  • CD3G Human Recombinant
  • PRO-2412

Catalogue number

PRO-2412

Synonyms

T-cell surface glycoprotein CD3 gamma chain, CD3-GAMMA, T3G, CD3G

Introduction

CD3-gamma polypeptide is encoded by CD3 Gamma which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, configures the T-cell receptor-CD3 complex. The T-cell receptor-CD3 complex takes part in coupling antigen recognition to numerous intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Deficiencies in this gene are associated with T cell immunodeficiency.
CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。 T 细胞受体-CD3 复合物参与将抗原识别与许多细胞内信号转导途径偶联。 编码ε、γ和δ多肽的基因位于11号染色体上的同一簇中。该基因的缺陷与T细胞免疫缺陷有关。

Description

CD3G Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.8kDa .
CD3G is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Insect cells.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD3G protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

ADPQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATISHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD3G Protein

ProSpec,CD3G Protein PRO-1392,CD3 Gamma 人类重组PRO-1392

ProSpec,CD3G Protein PRO-1392,CD3 Gamma 人类重组PRO-1392,CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。

  • CD3G Protein

  • CD3 Gamma Human Recombinant
  • PRO-1392

Catalogue number

PRO-1392

Synonyms

T-cell surface glycoprotein CD3 gamma chain, CD3-GAMMA, T3G, CD3G.

Introduction

CD3-gamma polypeptide is encoded by CD3 Gamma which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, configures the T-cell receptor-CD3 complex. The T-cell receptor-CD3 complex takes part in coupling antigen recognition to numerous intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Deficiencies in this gene are associated with T cell immunodeficiency.
CD3-γ多肽由CD3 Gamma编码，CD3 Gamma与CD3-ε、-δ和-zeta以及T细胞受体α/β和γ/δ异二聚体一起构成T细胞受体-CD3复合物。 T 细胞受体-CD3 复合物参与将抗原识别与许多细胞内信号转导途径偶联。 编码ε、γ和δ多肽的基因位于11号染色体上的同一簇中。该基因的缺陷与T细胞免疫缺陷有关。

Description

CD3G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids and having a molecular mass of 13.1kDa. CD3G is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD3G protein solution containing 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSQSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATIS.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD3G Human

ProSpec,CD33 Human,CD33 人重组PRO-1887

ProSpec,CD33 Human,CD33 人重组PRO-1887,在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。

  • CD33 Human

  • CD33 Human Recombinant
  • PRO-1887

Catalogue number

PRO-1887

Synonyms

CD33Molecule, CD33Antigen , Sialic Acid Binding Ig-Like Lectin 3, Sialic Acid-Binding Ig-Like Lectin 3, SIGLEC3, gp67, SIGLEC-3, Myeloid Cell Surface AntigenCD33, p67, Siglec-3, CD33Antigen.

Introduction

CD33 is putative adhesion molecule of myelomonocytic-derived cells which mediates sialic-acid dependent binding to cells. CD33 prefers to bind to alpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 perform as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases through their SH2 domains which block signal transduction through dephosphorylation of signaling molecules. In addition, CD33 induces apoptosis in acute myeloid leukemia.
CD33 是骨髓单核细胞衍生细胞的推定粘附分子，它介导唾液酸依赖性与细胞的结合。 CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。 在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。 此外，CD33 在急性髓性白血病中诱导细胞凋亡。

Description

CD33 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids and having a molecular mass of 29.1kDa.

CD33 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD33 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea, and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD33 Human, Sf9

ProSpec,CD33 Human Sf9,CD33 人重组体Sf9 PRO-2492

在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。ProSpec,CD33 Human Sf9,CD33 人重组体Sf9 PRO-2492

  • CD33 Human, Sf9

  • CD33 Human Recombinant, Sf9
  • PRO-2492

Catalogue number

PRO-2492

Synonyms

Myeloid cell surface antigen CD33 isoform 1, CD33, FLJ00391, p67, SIGLEC-3, SIGLEC3, gp67.

Introduction

CD33 is putative adhesion molecule of myelomonocytic-derived cells which mediates sialic-acid dependent binding to cells. CD33 prefers to bind to alpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 perform as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases through their SH2 domains which block signal transduction through dephosphorylation of signaling molecules. In addition, CD33 induces apoptosis in acute myeloid leukemia.

CD33 是骨髓单核细胞衍生细胞的推定粘附分子，它介导唾液酸依赖性与细胞的结合。 CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。 在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。 此外，CD33 在急性髓性白血病中诱导细胞凋亡。

Description

CD33 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 239 aa hIgG-His Tag at C-terminus containing a total of 484 amino acids and having a molecular mass of 54kDa. CD33 shows multiple bands between 50-70kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD33 protein solution contains Phosphate buffered saline & 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADLDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVHLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD33 Human

ProSpec,CD300A Human,CD300A 人重组PRO-1618

CD300A 属于 CD300 家族，包含 1 个 Ig 样 V 型结构域。 该蛋白质不仅由自然杀伤细胞表达，而且由 T 细胞亚群、B 细胞、树突细胞、肥大细胞、粒细胞和单核细胞表达。ProSpec,CD300A Human,CD300A 人重组PRO-1618

  • CD300A Human

  • CD300A Human Recombinant
  • PRO-1618

Catalogue number

PRO-1618

Synonyms

CD300a Molecule, CD300a Antigen, IRp60, CD300 Antigen-Like Family Member A, NK Inhibitory Receptor, Immunoglobulin Superfamily Member 12, CMRF35-Like Molecule 8, CMRF35-H, Inhibitory Receptor Protein 60, CMRF-35-H9, CMRF-35H, CLM-8, IRC1, IRC2, CMRF35H Leukocyte Immunoglobulin-Like Receptor, Leukocyte Membrane Antigen, IgSF12.
CD300a 分子、CD300a 抗原、IRp60、CD300 抗原样家族成员 A、NK 抑制性受体、免疫球蛋白超家族成员 12、CMRF35 样分子 8、CMRF35-H、抑制性受体蛋白 60、CMRF-35-H9、CMRF-35H、 CLM-8、IRC1、IRC2、CMRF35H 白细胞免疫球蛋白样受体、白细胞膜抗原、IgSF12。

Introduction

CD300A belongs to the CD300 family and contains 1 Ig-like V-type domain. The protein is expressed not only by natural killer cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer cells, and to the down-regulation of mast cell degranulation.
CD300A 属于 CD300 家族，包含 1 个 Ig 样 V 型结构域。 该蛋白质不仅由自然杀伤细胞表达，而且由 T 细胞亚群、B 细胞、树突细胞、肥大细胞、粒细胞和单核细胞表达。 CD300A 是抑制性受体，可能有助于下调自然杀伤细胞的溶细胞活性，并有助于下调肥大细胞脱粒。

Description

CD300A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 14.7kDa.
CD300A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD300A 人重组体是一条单一的、非糖基化的多肽链，含有 134 个氨基酸，分子量为 14.7kDa。
CD300A 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The CD300A solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 1mM DTT and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSLSKCRTV AGPVGGSLSV QCPYEKEHRT LNKYWCRPPQ IFLCDKIVET KGSAGKRNGR VSIRDSPANL SFTVTLENLT EEDAGTYWCG VDTPWLRDFH DPVVEVEVSV FPAS

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD300C Human,CD300C 人重组PRO-273

ProSpec,CD300C Human,CD300C 人重组PRO-273,CMRF35 样分子 6 ，是 CD300 家族的成员。 CMRF35 抗原通过与单克隆抗体的反应性进行鉴定，并存在于单核细胞、中性粒细胞和一些 T 和 B 淋巴细胞上。

  • CD300C Human

  • CD300C Human Recombinant
  • PRO-273

Catalogue number

PRO-273

Synonyms

CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR, CMRF35-like molecule 6, CD300 antigen-like family member C, Immunoglobulin superfamily member 16.

Introduction

CMRF35-like molecule 6 , is a member of the CD300 family. The CMRF35 antigen was identified by reactivity with a monoclonal antibody and present on monocytes, neutrophils, and some T and B lymphocytes.
CMRF35 样分子 6 ，是 CD300 家族的成员。 CMRF35 抗原通过与单克隆抗体的反应性进行鉴定，并存在于单核细胞、中性粒细胞和一些 T 和 B 淋巴细胞上。

Description

CD300C Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 186 amino acids and having a molecular mass of 20.2kDa. CD300C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD300C Human Recombinant 是一条单一的、非糖基化的多肽链，包含 186 个氨基酸，分子量为 20.2kDa。 CD300C 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD300C protein solution containing 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSGYFPLSH PMTVAGPVGG SLSVQCRYEK EHRTLNKFWC RPPQILRCDK IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT YWCGVDTPWL RDFHDPIVEV EVSVFPAGTT TASSPQSSMG TSGPPTKLPV HTWPSVTRKD SPEPSPHPGS
LFSNVR.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD300C Human, Sf9

ProSpec-CD300C Human Sf9,CD300C 人重组体PRO-2401

ProSpec-CD300C Human Sf9,CD300C 人重组体PRO-2401,在 Sf9 杆状病毒细胞中产生的 CD300C Human Recombinant 是单条糖基化多肽链，包含 163 个氨基酸，分子量为 18kDa。 CD300C 在 C 末端带有 8 个氨基酸的 His 标签，并通过专有色谱技术进行纯化。

  • CD300C Human, Sf9

  • CD300C Human Recombinant, Sf9
  • PRO-2401

Catalogue number

PRO-2401

Synonyms

CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR, CMRF35-like molecule 6, CD300 antigen-like family member C, Immunoglobulin superfamily member, CD300C.

Introduction

CMRF35-like molecule 6 , is a member of the CD300 family. The CMRF35 antigen was identified by reactivity with a monoclonal antibody and present on monocytes, neutrophils, and some T and B lymphocytes.

Description

CD300C Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 163 amino acids and having a molecular mass of 18kDa . CD300C is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD300C Human Recombinant 是单条糖基化多肽链，包含 163 个氨基酸，分子量为 18kDa。 CD300C 在 C 末端带有 8 个氨基酸的 His 标签，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD300C protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MTVAGPVGGS LSVQCRYEKE HRTLNKFWCR PPQILRCDKI VETKGSAGKR NGRVSIRDSP ANLSFTVTLE NLTEEDAGTY WCGVDTPWLR DFHDPIVEVE VSVFPAGTTT ASSPQSSMGT SGPPTKLPVH TWPSVTRKDS PEPSPHPGSL FSNVRLEHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD300C Human

ProSpec,CD300E Human,CD300E 人重组PRO-2114

ProSpec,CD300E Human,CD300E 人重组PRO-2114,CMRF35 样分子 2 前体是 CD300 家族的成员。 CD300E 是一种 205 个氨基酸的单通道 I 型膜蛋白，包含一个 Ig 样 V 型结构域。 在与 DAP12 相互作用时，CD300E 可能作为一种激活受体发挥作用。

  • CD300E Human

  • CD300E Human Recombinant
  • PRO-2114

Catalogue number

PRO-2114

Synonyms

CD300e Molecule, CD300e Antigen, CD300LE, IREM2, CLM2, Immune Receptor Expressed On Myeloid Cells 2, Polymeric Immunoglobulin Receptor 2,CD300 Antigen Like Family Member E, CD300 Antigen-Like Family Member E,Poly-Ig Receptor 2, CMRF35-A5, PIgR2, CMRF35-Like Molecule 2, CMRF35A5, CD300E.

Introduction

CMRF35-like molecule 2 precursor is a member of the CD300 family. CD300E is a 205 amino acid single-pass type I membrane protein which contains one Ig-like V-type domain. While interacting with DAP12, CD300E probably performs as an activating receptor. CD300E is present on the surface of mature hematopoietic cells of the monocyte & myeloid lineages.
CMRF35 样分子 2 前体是 CD300 家族的成员。 CD300E 是一种 205 个氨基酸的单通道 I 型膜蛋白，包含一个 Ig 样 V 型结构域。 在与 DAP12 相互作用时，CD300E 可能作为一种激活受体发挥作用。 CD300E 存在于单核细胞和骨髓谱系的成熟造血细胞表面。

Description

CD300E Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.9kDa.
CD300E is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD300E protein solution containing 20mM Tris-HCl buffer .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSLKGPGSV TGTAGDSLTV WCQYESMYKG YNKYWCRGQY DTSCESIVET KGEEKVERNG RVSIRDHPEA LAFTVTMQNL NEDDAGSYWC KIQTVWVLDS WSRDPSDLVR VYVSPAITTP RRTTHPATPP IFLVVNPGRN LSTGEVLTQN SGFRLSSPH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec,CD34 Human,CD34人重组PRO-1363

ProSpec,CD34 Human,CD34人重组PRO-1363,在大肠杆菌中产生的 CD34 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 280 个氨基酸，分子量为 29.7kDa。 CD34 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

  • CD34 Human

  • CD34 Human Recombinant
  • PRO-1363

Catalogue number

PRO-1363

Synonyms

CD34 molecule, Hematopoietic progenitor cell antigen CD34, CD34 Antigen, CD34.

Introduction

CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells.
CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Description

CD34 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 280 amino acids and having a molecular mass of 29.7kDa. CD34 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD34 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 280 个氨基酸，分子量为 29.7kDa。 CD34 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD34 protein solution containing 20mM Tris-HCl buffer , 0.1M NaCl, 20% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSLDNNGTAT PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD34 Antibody
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ProSpec,CD34 Human GST,CD34 人重组PRO-292

CD34 是一种单链跨膜糖蛋白，在人淋巴和骨髓造血祖细胞上选择性表达。ProSpec,CD34 Human GST,CD34 人重组PRO-292

  • CD34 Human, GST

  • CD34 Human Recombinant, GST Tag
  • PRO-292

Catalogue number

PRO-292

Synonyms

Hematopoietic progenitor cell antigen CD34, CD34.

Introduction

CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells.
CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
CD34 是一种单链跨膜糖蛋白，在人淋巴和骨髓造血祖细胞上选择性表达。
CD34 已被用于测量血管生成，据报道可预测肿瘤复发。

Description

CD34 Human Recombinant full length expressed in E.coli, CD34 is antibody reactive.
The CD34 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD34 in 50mM Tris-HCl, pH7.5, 10mM L-glutathione .

Stability

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD34 Human, Sf9
  • CD34 Human
  • CD34 Antibody
  • CD34 PAT3B6AT Antibody

ProSpec,CD34 Human Sf9,CD34人重组PRO-2358

ProSpec,CD34 Human Sf9,CD34人重组PRO-2358,在 Sf9 杆状病毒细胞中产生的 CD34 Human Recombinant 是单条糖基化多肽链，包含 268 个氨基酸，分子量为 28.6kDa。

  • CD34 Human, Sf9

  • CD34 Human Recombinant, Sf9
  • PRO-2358

Catalogue number

PRO-2358

Synonyms

CD34 molecule, Hematopoietic progenitor cell antigen CD34, CD34 Antigen, CD34.

Introduction

CD34 is a single chain transmembrane glycoprotein which is selectively expressed on human lymphoid and myeloid hemapoietic progenitor cells. CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Description

CD34 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 268 amino acids and having a molecular mass of 28.6kDa .
CD34 is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD34 Human Recombinant 是单条糖基化多肽链，包含 268 个氨基酸，分子量为 28.6kDa。
CD34 在 C 末端与 6 个氨基酸 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD34 protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADLSLDNNGT ATPELPTQGT FSNVSTNVSY QETTTPSTLG STSLHPVSQH GNEATTNITE TTVKFTSTSV ITSVYGNTNS SVQSQTSVIS TVFTTPANVS TPETTLKPSL SPGNVSDLST TSTSLATSPT KPYTSSSPIL SDIKAEIKCS GIREVKLTQG ICLEQNKTSS CAEFKKDRGE GLARVLCGEE QADADAGAQV CSLLLAQSEV RPQCLLLVLA NRTEISSKLQ LMKKHQSDLK KLGILDFTEQ DVASHQSYSQ KTHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD34 Human
  • CD34 Human, GST
  • CD34 Antibody
  • CD34 PAT3B6AT Antibody

ProSpec,CD36 Human,CD36 人重组PRO-2533

CD36 是在多种哺乳动物细胞类型中发现的完整膜蛋白，它是 B 类清道夫受体家族的一部分。 在人类中，它由 CD36 基因编码。ProSpec,CD36 Human,CD36 人重组PRO-2533

  • CD36 Human

  • CD36 Human Recombinant
  • PRO-2533

Catalogue number

PRO-2533

Synonyms

Platelet glycoprotein 4 isoform 1, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, Glycoprotein IIIb, GPIIIB, Leukocyte differentiation antigen CD36, PAS-4, Platelet collagen receptor, Platelet glycoprotein IV, Thrombospondin receptor.

Introduction

CD36 is an integral membrane protein found in a variety cell types of mammals, it is part of the class B scavenger receptor family. In humans it is encoded by the CD36 gene. The protein binds to ligands such as native lipoproteins, collagen, long-chain fatty acids, thrombospondin etc. CD36 plays a crucial role in transporting fatty acids into the cell.

CD36 是在多种哺乳动物细胞类型中发现的完整膜蛋白，它是 B 类清道夫受体家族的一部分。 在人类中，它由 CD36 基因编码。 该蛋白质与天然脂蛋白、胶原蛋白、长链脂肪酸、血小板反应蛋白等配体结合。CD36 在将脂肪酸转运到细胞中起关键作用。

Description

CD36 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 652 amino acids and having a molecular mass of 73.9kDa. .
CD36 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD36 是单条糖基化多肽链，包含 652 个氨基酸，分子量为 73.9kDa。 .
CD36 在 C 末端用 242 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD36 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

 

Amino acid sequence

ADLGDLLIQK TIKKQVVLEE GTIAFKNWVK TGTEVYRQFW IFDVQNPQEV MMNSSNIQVK QRGPYTYRVR FLAKENVTQD AEDNTVSFLQ PNGAIFEPSL SVGTEADNFT VLNLAVAAAS HIYQNQFVQM ILNSLINKSK SSMFQVRTLR ELLWGYRDPF LSLVPYPVTT TVGLFYPYNN
TADGVYKVFN GKDNISKVAI IDTYKGKRNL SYWESHCDMI NGTDAASFPP FVEKSQVLQF FSSDICRSIY AVFESDVNLK GIPVYRFVLP SKAFASPVEN PDNYCFCTEK IISKNCTSYG VLDISKCKEG RPVYISLPHF LYASPDVSEP IDGLNPNEEE HRTYLDIEPI TGFTLQFAKR
LQVNLLVKPS EKIQVLKNLK RNYIVPILWL NETGTIGDEK ANMFRSQVTG KINLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD36 Mouse

ProSpec,CD4 (26-396) Human,CD4人重组CYT-885

在大肠杆菌中产生的 CD4 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 396 个氨基酸，分子量为 44kDa。ProSpec,CD4 (26-396) Human,CD4人重组CYT-885

  • CD4 Human

  • CD4 Human Recombinant
  • CYT-885

Catalogue number

CYT-885

Synonyms

CD4 Molecule, T-Cell Surface Glycoprotein CD4, T-Cell Surface Antigen T4/Leu-3, CD4 Antigen , CD4 Receptor, CD4 Antigen, CD4mut, T-cell surface glycoprotein CD4.

Introduction

CD4 is a cell-surface glycoprotein found on the mature helper T cells and immature thymocytes, as well as on monocytes and macrophages. Normally, about 65% of T cells in the blood are CD4+ . A mature T cell with either have CD4 or CD8, but not both. During one stage of development T cells develop CD4 and CD8 receptors, but they eventually are differentiated in the thymus and become more specialized.

CD4 是一种细胞表面糖蛋白，存在于成熟的辅助 T 细胞和未成熟的胸腺细胞以及单核细胞和巨噬细胞上。 正常情况下，血液中约 65% 的 T 细胞是 CD4+。 具有 CD4 或 CD8 的成熟 T 细胞，但不是两者兼有。 在发育的一个阶段，T 细胞会产生 CD4 和 CD8 受体，但它们最终会在胸腺中分化并变得更加特化。

Description

CD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 396 amino acids and having a molecular mass of 44kDa.

CD4 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CD4 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 396 个氨基酸，分子量为 44kDa。

CD4 在 N 末端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD4 protein solution containing 20mM Tris Hcl, PH8.0 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHMKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV LNPEAGMWQC LLGQVLL ESNIKVLPTW STPVQP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD4 Human
  • CD4 Human
  • CD4 Human, Sf9

ProSpec-CD4 (26-396) Human Sf9,CD4人重组CYT-978

ProSpec-CD4 (26-396) Human Sf9,CD4人重组CYT-978,Sf9 昆虫细胞中产生的 CD4 是单条糖基化多肽链，含有 377 个氨基酸，分子量为 42.1kDa。

  • CD4 Human, Sf9

  • CD4 Human Recombinant, Sf9
  • CYT-978

Catalogue number

CYT-978

Synonyms

CD4 Molecule, T-Cell Surface Antigen T4/Leu-3, CD4 Antigen , T-Cell Surface Glycoprotein CD4, CD4 Receptor, CD4 Antigen, CD4mut.

Introduction

CD4 is a cell-surface glycoprotein found on the mature helper T cells and immature thymocytes, as well as on monocytes and macrophages. Normally, about 65% of T cells in the blood are CD4+ . A mature T cell with either have CD4 or CD8, but not both. During one stage of development T cells develop CD4 and CD8 receptors, but they eventually are differentiated in the thymus and become more specialized.
CD4 是一种细胞表面糖蛋白，存在于成熟的辅助 T 细胞和未成熟的胸腺细胞以及单核细胞和巨噬细胞上。 正常情况下，血液中约 65% 的 T 细胞是 CD4+。 具有 CD4 或 CD8 的成熟 T 细胞，但不是两者兼有。 在发育的一个阶段，T 细胞会产生 CD4 和 CD8 受体，但它们最终会在胸腺中分化并变得更加特化。

Description

CD4 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 377 amino acids and having a molecular mass of 42.1kDa .
CD4 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9 昆虫细胞中产生的 CD4 是单条糖基化多肽链，含有 377 个氨基酸，分子量为 42.1kDa。
CD4 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD4 a protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

KKVVLGKKGD TVELTCTASQ KKSIQFHWKN SNQIKILGNQ GSFLTKGPSK LNDRADSRRS LWDQGNFPLI IKNLKIEDSD TYICEVEDQK EEVQLLVFGL TANSDTHLLQ GQSLTLTLES PPGSSPSVQC RSPRGKNIQG GKTLSVSQLE LQDSGTWTCT VLQNQKKVEF KIDIVVLAFQ KASSIVYKKE GEQVEFSFPL AFTVEKLTGS GELWWQAERA SSSKSWITFD LKNKEVSVKR VTQDPKLQMG KKLPLHLTLP QALPQYAGSG NLTLALEAKT GKLHQEVNLV VMRATQLQKN LTCEVWGPTS PKLMLSLKLE NKEAKVSKRE KAVWVLNPEA GMWQCLL GQVLLESNIK VLPTWSTPVQ PHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD4 Human

ProSpec-CD4 Human (125-202),CD-4人重组CYT-315

ProSpec-CD4 Human (125-202),CD-4人重组CYT-315,CD4 是一种单链跨膜糖蛋白，存在于代表 45% 外周血淋巴细胞的 T 细胞亚群上。 它也存在于 80% 的胸腺细胞上，而单核细胞上的水平较低。

  • CD4 Human

  • CD-4 Human Recombinant
  • CYT-315

Catalogue number

CYT-315

Synonyms

gp55, HLA-2, L3 / T4, Ly-4, T cell antigen T4/LEU3, T4, sCD4.

Introduction

CD4, a single chain transmembrane glycoprotein, is found on a T cell subset representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. Antibody to CD4 recognizes T-helper cells required for recognition of class II antigens. It reacts with ~60% of peripheral blood E rosette-positive cells while showing negligible reactivity with E- cells, monocytes, granulocytes, EBV-transformed B cell lines, and mouse splenocytes.
CD4 是一种单链跨膜糖蛋白，存在于代表 45% 外周血淋巴细胞的 T 细胞亚群上。 它也存在于 80% 的胸腺细胞上，而单核细胞上的水平较低。 它参与由 APC 识别与 MHC II 类一起呈递的抗原。 它作为 HIV 的受体。 CD4 抗体可识别识别 II 类抗原所需的 T 辅助细胞。 它与约 60% 的外周血 E 玫瑰花结阳性细胞发生反应，而与 E 细胞、单核细胞、粒细胞、EBV 转化的 B 细胞系和小鼠脾细胞的反应性可忽略不计。

Description

CD-4 Human Recombinant is fused with a 4kDa His Tag and encoding amino acids 125-202, having a total molecular weight of 19 kDa.

Source

Escherichia Coli.

Physical Appearance

Sterile lyophilized powder.

Formulation

Each mg contains 1X PBS.

Solubility

It is recommended to reconstitute the lyophilized CD-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Store vial at -20oC to -80oC. When stored at the recommended temperature, this protein is stable for 12 months.
Please avoid freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Applications

• Protein Assay.
• Antibody Production.
• Western Blotting.

References

Title:Reduced Monomeric CD4 Is the Preferred Receptor for HIV.
Publication: 10.1074/jbc.M110.190579 December 24, 2010 The Journal of Biological Chemistry, 285, 40793-40799.
Link:http://www.jbc.org/content/285/52/40793.full#fn-1

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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