分类： ProSpec

ProSpec,CD1A Human PRO-2427,CD1A人重组PRO-2427

ProSpec,CD1A Human PRO-2427,CD1A人重组PRO-2427,CD1a是一种跨膜糖蛋白，在结构上与主要的组织相容性复合物蛋白相关，并与β-2-微球蛋白形成异二聚体。 CD1a 主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。

  • CD1A Human

  • CD1A Human Recombinant
  • PRO-2427

Catalogue number

PRO-2427

Synonyms

T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, R4, T6; CD1, FCB6, HTA1, CD1A.

Introduction

CD1a is a transmembrane glycoproteins, which is structurally related to the major histocompatibility complex proteins and form heterodimers with beta-2-microglobulin. CD1a mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

CD1a是一种跨膜糖蛋白，在结构上与主要的组织相容性复合物蛋白相关，并与β-2-微球蛋白形成异二聚体。 CD1a 主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。 人类基因组包含五个 CD1 家族基因，这些基因在 1 号染色体上组成一个簇。CD1 家族成员被认为在其细胞定位和对特定脂质配体的特异性方面不同。 该基因编码的蛋白质定位于质膜和早期内吞系统的循环囊泡。 已观察到选择性剪接的转录变体，但尚未确定其生物学有效性。

Description

CD1A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 291 amino acids and having a molecular mass of 33.2kDa. . CD1A is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD1A 是单条糖基化多肽链，含有 291 个氨基酸，分子量为 33.2kDa。 . CD1A 在 C 末端用 9 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD1A protein solution containing Phosphate Buffered Saline , and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD1a Antibody

ProSpec-BCA-1 Human/CHM-348,BCA-1/BLC 人重组

BCA-1 Human
BCA-1/BLC Human Recombinant
CHM-348 5µg
CHM-348 20µg
CHM-348 1mg

Catalogue number

CHM-348

Synonyms

C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ANGIE2.

Introduction

BCA-1 is a CXC chemokine that is highly expressed in thesecondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer’s patches. CXCL13 promotes the migration of B lymphocytes , by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt’s lymphoma receptor 1 . BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 – 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR-1, now designated CXCR-5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.
BCA-1是一种CXC趋化因子，在次级淋巴器官中高度表达，例如脾脏、淋巴结和派尔氏斑的滤泡。 CXCL13 通过刺激钙流入并趋化表达伯基特淋巴瘤受体 1 的细胞，从而促进 B 淋巴细胞的迁移。 因此，BCA1 在 B 淋巴细胞归巢到滤泡中起作用。 人 BCA-1 与小鼠蛋白质具有 64% 的氨基酸序列相似性，与其他已知的 CXC 趋化因子具有 23-34% 的氨基酸序列同一性。 重组或化学合成的 BCA1 对 B 淋巴细胞是一种有效的化学引诱物，但对 T 淋巴细胞、单核细胞或中性粒细胞没有。 BLR1 是一种 G 蛋白偶联受体，最初是从 Burkitt 淋巴瘤细胞中分离出来的，现在已被证明是 BCA1 的特异性受体。 在造血谱系的细胞中，BLR-1（现在称为 CXCR-5）的表达仅限于 B 淋巴细胞和 T 辅助记忆细胞的一个亚群。

Description

在大肠杆菌中产生的 CXCL13 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 87 个氨基酸，分子量为 10.3 kDa。
BCA-1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The BCA-1 protein was lyophilized from a concentrated solution containing 20mM PBS & 150mM NaCl pH-7.4.

Solubility

It is recommended to reconstitute the lyophilized CXCL13 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BCA1 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNG CPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKR SSSTLPVPVFKRKIP.

Biological Activity

Determined by its ability to chemoattract human B cells using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BCA-1 Human, His
  • BCA-1 Mouse
  • BCA1 Macaque

ProSpec-BCA-1 Human, His/CHM-023,CHM-023 5µg

BCA-1 Human, His
BCA-1/ BLC Human Recombinant, His Tag

CHM-023 5µg
CHM-023 20µg
CHM-023 1mg

Catalogue number

CHM-023

Synonyms

C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ANGIE2.

Introduction

BCA-1是一种CXC趋化因子，在次级淋巴器官中高度表达，例如脾脏、淋巴结和派尔氏斑的滤泡。 CXCL13 通过刺激钙流入并趋化表达伯基特淋巴瘤受体 1 的细胞，从而促进 B 淋巴细胞的迁移。 因此，BCA1 在 B 淋巴细胞归巢到滤泡中起作用。 人 BCA-1 与小鼠蛋白质具有 64% 的氨基酸序列相似性，与其他已知的 CXC 趋化因子具有 23-34% 的氨基酸序列同一性。 重组或化学合成的 BCA1 对 B 淋巴细胞是一种有效的化学引诱物，但对 T 淋巴细胞、单核细胞或中性粒细胞没有。 BLR1 是一种 G 蛋白偶联受体，最初是从 Burkitt 淋巴瘤细胞中分离出来的，现在已被证明是 BCA1 的特异性受体。 在造血谱系的细胞中，BLR-1（现在称为 CXCR-5）的表达仅限于 B 淋巴细胞和 T 辅助记忆细胞的一个亚群。

Description

BCA 1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain topological domain containing 110 amino acids and having a molecular mass of 12.7kDa. BCA 1 is fused to a 23 amino acid His-tag at N-terminus.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

BCA 1 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSVLEVYYT SLRCRCVQES SVFIPRRFID RIQILPRGNG CPRKEIIVWK KNKSIVCVDP QAEWIQRMME VLRKRSSSTL PVPVFKRKIP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BCA-1 Mouse
  • BCA-1 Human
  • BCA1 Macaque

ProSpec PRO-1267,CD1B Human,CD1B人重组PRO-1267

ProSpec PRO-1267,CD1B Human,CD1B人重组PRO-1267,大肠杆菌产生的 CD1B Human Recombinant 是单条非糖基化多肽链，包含 310 个氨基酸，分子量为 34.2kDa

  • CD1B Human

  • CD1B Human Recombinant
  • PRO-1267

Catalogue number

PRO-1267

Synonyms

T-cell surface glycoprotein CD1b, CD1B, CD1, CD1A, R1.

Introduction

CD1B belongs to CD1 family of transmembrane glycoproteins, which are structurally associated with the MHC proteins and form heterodimers with the beta-2-microglobulin. CD1B includes one Ig-like domain. CD1B is an antigen-presenting protein which connects self and nonself lipid and glycolipid antigens and displays them to T-cell receptors on natural killer T-cells.

Description

CD1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 310 amino acids and having a molecular mass of 34.2kDa.CD1B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
大肠杆菌产生的 CD1B Human Recombinant 是单条非糖基化多肽链，包含 310 个氨基酸，分子量为 34.2kDa。CD1B 在 N 端与 24 个氨基酸的 His-tag 融合，并通过专有色谱纯化 技巧。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD1B protein solution containing 20mM Tris-HCl buffer , 0.2M NaCl, 20% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMSEHAFQ GPTSFHVIQT SSFTNSTWAQ TQGSGWLDDL QIHGWDG TAIFLKPWSK GNFSDKEVAE LEEIFRVYIF GFAREVQDFA GDFQMKYPFE IQGIAGCELH SGGAIVSFLR GALGGLDFLS VKNASCVPSP EGGSRAQKFC ALIIQYQGIM ETVRILLYET CPRYLLGVLN AGKADLQRQV KPEAWLSSGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ EQQGTQLGDI LPNANWTWYL RATLDVADGE AAGLSCRVKH SSLEGQDIIL YWRNPTSIGS.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec PRO-2491,CD1D Human,CD1D人重组PRO-2491

ProSpec PRO-2491,CD1D Human,CD1D人重组PRO-2491,CD1d 呈递的脂质抗原在与存在于 NKT 膜上的 T 细胞受体相互作用期间激活一类特殊的 T 细胞，即自然杀伤 T 细胞。

  • CD1D Human

  • CD1D Human Recombinant
  • PRO-2491

Catalogue number

PRO-2491

Synonyms

Antigen-presenting glycoprotein CD1d, R3G1, CD antigen: CD1d, Differentiation Antigen CD1-Alpha-3, T-Cell Surface Glycoprotein CD1d, Thymocyte Antigen CD1D, CD1A, R3, CD1d Molecule, CD1D Antigen, D Polypeptide, CD1d Antigen, R3G1, HMC Class I, Antigen-Like Glycoprotein CD1D, Antigen-Presenting Glycoprotein CD1d.

Introduction

CD1D, also known as antigen-presenting glycoprotein CD1d, is a transmembrane glycoprotein which belongs to the CD1 family of glycolipid antigen-presenting MHC-like molecules. CD1d-presented lipid antigens activate a special class of T cells, familiar as natural killer T cells, during the interaction with the T-cell receptor present on NKT membranes. Once activated, NKT cells rapidly produce Th1 &Th2 cytokines, usually represented by interleukin 4 production.

CD1D又称为抗原呈递糖蛋白CD1d，是一种跨膜糖蛋白，属于糖脂类抗原呈递MHC分子CD1家族。 CD1d 呈递的脂质抗原在与存在于 NKT 膜上的 T 细胞受体相互作用期间激活一类特殊的 T 细胞，即自然杀伤 T 细胞。 一旦被激活，NKT 细胞会迅速产生 Th1 和 Th2 细胞因子，通常以白细胞介素 4 的产生为代表。

Description

CD1D produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 290 amino acids and having a molecular mass of 32.9kDa .

CD1Dis expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD1D protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage, it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

EVPQRLFPLR CLQISSFANS SWTRTDGLAW LGELQTHSWS NDSDTVRSLK PWSQGTFSDQ QWETLQHIFR VYRSSFTRDV KEFAKMLRLS YPLELQVSAG CEVHPGNASN NFFHVAFQGK DILSFQGTSW EPTQEAPLWV NLAIQVLNQD KWTRETVQWL LNGTCPQFVS GLLESGKSEL
KKQVKPKAWL SRGPSPGPGR LLLVCHVSGF YPKPVWVKWM RGEQEQQGTQ PGDILPNADE TWYLRATLDV VAGEAAGLSC RVKHSSLEGQ DIVLYWGGSY TSLEHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-BCA1 Macaque,BCA1猕猴/CHM-035

ProSpec-BCA1 Macaque,BCA1猕猴/CHM-035,BCA-1是一种CXC趋化因子，在次级淋巴器官中高度表达，例如脾脏、淋巴结和派尔氏斑的滤泡。 CXCL13 通过刺激钙流入并趋化表达伯基特淋巴瘤受体 1 的细胞，从而促进 B 淋巴细胞的迁移。

BCA1 Macaque
BCA-1/ BLC Rhesus Macaque Recombinant
CHM-035
CHM-035 50µg
CHM-035 100µg
CHM-035 1mg

Catalogue number

CHM-035

Synonyms

C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ANGIE2.

Introduction

BCA-1是一种CXC趋化因子，在次级淋巴器官中高度表达，例如脾脏、淋巴结和派尔氏斑的滤泡。 CXCL13 通过刺激钙流入并趋化表达伯基特淋巴瘤受体 1 的细胞，从而促进 B 淋巴细胞的迁移。 因此，BCA1 在 B 淋巴细胞归巢到滤泡中起作用。 人 BCA-1 与小鼠蛋白质具有 64% 的氨基酸序列相似性，与其他已知的 CXC 趋化因子具有 23-34% 的氨基酸序列同一性。 重组或化学合成的 BCA1 对 B 淋巴细胞是一种有效的化学引诱物，但对 T 淋巴细胞、单核细胞或中性粒细胞没有。 BLR1 是一种 G 蛋白偶联受体，最初是从 Burkitt 淋巴瘤细胞中分离出来的，现在已被证明是 BCA1 的特异性受体。 在造血谱系的细胞中，BLR-1（现在称为 CXCR-5）的表达仅限于 B 淋巴细胞和 T 辅助记忆细胞的一个亚群。

Description

BCA-1/ BLC Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 87 amino acid and having a molecular mass of approximately 10.3kDa.
BCA1 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM Tris-HCl, pH 8.0 and 300mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized BCA-1/ BLC Rhesus Macaque in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BCA-1/ BLC Rhesus Macaque should be stored at 4°C between 2-7 days and for future use below -18°C.

Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VLEVYYTHLR CRCVQESSVF IPRRFIDRIQ ISPRGNGCPR KEIIVWKKNK SVVCVDPQAE WIQRIMEMLR KKSSSTPPVP VFKRKIP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BCA-1 Human
  • BCA-1 Human, His
  • BCA-1 Mouse

ProSpec,CD1E Human PRO-1907,CD1E人重组PRO-1907

CD1E 属于跨膜糖蛋白 CD1 家族，在结构上与主要 MHC 蛋白相关，并与 β-2-微球蛋白形成异二聚体。ProSpec,CD1E Human PRO-1907,CD1E人重组PRO-1907

  • CD1E Human

  • CD1E Human Recombinant
  • PRO-1907

Catalogue number

PRO-1907

Synonyms

CD1A, R2, T-cell surface glycoprotein CD1e, membrane-associated, R2G1, sCD1e.

Introduction

CD1E belongs to the CD1 family of transmembrane glycoproteins which are structurally associated to the main MHC proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome is comprised of 5 CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are belief to differ in their cellular localization and specificity for particular lipid ligands. CD1E localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a steady soluble form. The soluble form is necessary for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.
CD1E 属于跨膜糖蛋白 CD1 家族，在结构上与主要 MHC 蛋白相关，并与 β-2-微球蛋白形成异二聚体。 CD1 蛋白主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。 人类基因组由 1 号染色体上的 5 个 CD1 家族基因组成。CD1 家族成员相信其细胞定位和对特定脂质配体的特异性不同。 CD1E 定位在高尔基体、内体和溶酶体中，并被切割成稳定的可溶形式。 可溶形式对于将一些糖脂在细胞内加工成可由其他 CD1 家族成员呈递的形式是必需的。

Description

CD1E Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids and having a molecular mass of 33.1kDa.CD1E is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD1E protein solution contains 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSEEQLSFR MLQTSSFANH SWAHSEGSGW LGDLQTHGWD TVLGTIRFLK PWSHGNFSKQ ELKNLQSLFQ LYFHSFIQIV QASAGQFQLE YPFEIQILAG CRMNAPQIFL NMAYQGSDFL SFQGISWEPS PGAGIRAQNI CKVLNRYLDI KEILQSLLGH TCPRFLAGLM EAGESELKRK VKPEAWLSCG PSPGPGRLQL VCHVSGFYPK PVWVMWMRGE QEQRGTQRGD VLPNADETWY LRATLDVAAG EAAGLSCRVK HSSLGGHDLI IHWGGYS.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-BCA-1 Mouse/CHM-030,CHM-030,BCA-1/BLC Mouse Recombinant

BCA-1 Mouse
BCA-1/BLC Mouse Recombinant
CHM-030 5µg
CHM-030 20µg
CHM-030 1mg

Catalogue number

CHM-030

Synonyms

C-X-C motif chemokine 13, B lymphocyte chemoattractant, CXC chemokine BLC, Small-inducible cytokine B13, Cxcl13, Blc, Scyb13.

Introduction

BCA-1是一种CXC趋化因子，在次级淋巴器官中高度表达，例如脾脏、淋巴结和派尔氏斑的滤泡。 CXCL13 通过刺激钙流入并趋化表达伯基特淋巴瘤受体 1 的细胞，从而促进 B 淋巴细胞的迁移。 因此，BCA1 在 B 淋巴细胞归巢到滤泡中起作用。 人 BCA-1 与小鼠蛋白质具有 64% 的氨基酸序列相似性，与其他已知的 CXC 趋化因子具有 23-34% 的氨基酸序列同一性。 重组或化学合成的 BCA1 对 B 淋巴细胞是一种有效的化学引诱物，但对 T 淋巴细胞、单核细胞或中性粒细胞没有。 BLR1 是一种 G 蛋白偶联受体，最初是从 Burkitt 淋巴瘤细胞中分离出来的，现在已被证明是 BCA1 的特异性受体。 在造血谱系的细胞中，BLR-1（现在称为 CXCR-5）的表达仅限于 B 淋巴细胞和 T 辅助记忆细胞的一个亚群。

Description

CXCL13 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10kDa.
The BCA-1 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The BCA1 protein was lyophilized from a 0.2µm filtered solution in Acetonitrile and TFA.

Solubility

It is recommended to reconstitute the lyophilized CXCL13 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BCA1 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by -PAGE.

Amino acid sequence

ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA.

Biological Activity

The ED50, as measured by its ability to chemoattract human CXCR5-transfected mouse BaF3 cells, is less than 2µg/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BCA-1 Human, His
  • BCA-1 Human
  • BCA1 Macaque

ProSpec,CD14 Human,CD14人重组PRO-1975

ProSpec,CD14 Human,CD14人重组PRO-1975,CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。

    • CD14 Human

    • CD14 Human Recombinant
    • PRO-1975

Catalogue number

PRO-1975

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

CD14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids and having a molecular mass of 37.9kDa.
CD14is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD14 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 353 个氨基酸，分子量为 37.9kDa。
CD14 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD14 protein solution containing 20mM Tris-HCl buffer , 30% glycerol 0.15M NaCl and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSTTPEPCE LDDEDFRCVC NFSEPQPDWS EAFQCVSAVE VEIHAGGLNL EPFLKRVDAD ADPRQYADTV KALRVRRLTV GAAQVPAQLL VGALRVLAYS RLKELTLEDL KITGTMPPLP LEATGLALSS LRLRNVSWAT GRSWLAELQQ WLKPGLKVLS IAQAHSPAFS CEQVRAFPAL TSLDLSDNPG LGERGLMAAL CPHKFPAIQN LALRNTGMET PTGVCAALAA AGVQPHSLDL SHNSLRATVN PSAPRCMWSS ALNSLNLSFA GLEQVPKGLP AKLRVLDLSC NRLNRAPQPD ELPEVDNLTL DGNPFLVPGT ALPHEGSMNS GVV.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD14 Mouse, Sf9
  • CD14 PAT87H7AT Antibody
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  • CD14 Antibody
  • CD14 Human, CHO

ProSpec-BRAK Human/CHM-001,BRAK人重组,CHM-001

ProSpec-BRAK Human/CHM-001,BRAK人重组,CHM-001

  • BRAK Human

  • BRAK Human Recombinant
  • CHM-001

Catalogue number

CHM-001

Synonyms

C-X-C motif chemokine 14, Small-inducible cytokine B14, Chemokine BRAK, Bolekine, NJAC, KS1, Kec, BMAC, MIP-2g, SCYB14, CXCL14, BRAK, MGC10687.

Introduction

CXCL14 is involved in immunoregulatory and inflammatory processes. BRAK protein is structurally related to the CXC subfamily of cytokines. CXCL14 displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. CXCL14 is involved in the homeostasis of monocyte-derived macrophages.

Description

CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.
The CXCL14 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CXCL14 was lyophilized after extensive dialysis against 20mM Tris-HCl, pH 8.5 and 1M NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL14 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Cys-Lys-Cys.

Biological Activity

The ED50 of CXCL14 as determined by its ability to induce calcium flux of prostaglandin E2 treated THP1 human acute monocytic leukemia cells was 1.0-10.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BRAK Human, His
  • BRAK Mouse
  • BRAK Rat

ProSpec CHM-239,BRAK Human, His,BRAK人重组体,CHM-239

ProSpec CHM-239,BRAK Human, His,BRAK人重组体,CHM-239,在大肠杆菌中产生的 CXCL14 Human Recombinant 是一种单一的、非糖基化的多肽链，包含 88 个氨基酸，分子量为 10.66 kDa。

BRAK Human, His

BRAK Human Recombinant , His-Tag
CHM-239

Catalogue number

CHM-239

Synonyms

C-X-C motif chemokine 14, Small-inducible cytokine B14, Chemokine BRAK, Bolekine, NJAC, KS1, Kec, BMAC, MIP-2g, SCYB14, CXCL14, BRAK, MGC10687.

Introduction

CXCL14 is involved in immunoregulatory and inflammatory processes. BRAK protein is structurally related to the CXC subfamily of cytokines. CXCL14 displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. CXCL14 is involved in the homeostasis of monocyte-derived macrophages.
CXCL14 参与免疫调节和炎症过程。 BRAK 蛋白在结构上与细胞因子的 CXC 亚家族相关。 CXCL14 对单核细胞显示趋化活性，但对淋巴细胞、树突细胞、中性粒细胞或巨噬细胞没有趋化活性。 CXCL14 参与单核细胞衍生巨噬细胞的稳态。

Description

CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa.
The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus.
The BRAK is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CXCL14 Human Recombinant 是一种单一的、非糖基化的多肽链，包含 88 个氨基酸，分子量为 10.66 kDa。
Human BRAK 包含一个 10 a.a. 在 N 末端融合 His 标签。
BRAK 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized powder.

Formulation

CXCL14 filtered and lyophilized from a concentrated solution containing 20mM Tris buffer & 20mM NaCl pH-7.5.

Solubility

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干的 CXCL14，然后可以进一步稀释成其他水溶液。 产品不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Stability

Lyophilized BRAK although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BRAK should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 BRAK 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，BRAK 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

MKHHHHHHAS SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BRAK Mouse
  • BRAK Human
  • BRAK Rat

ProSpec,CD14 Human HEK,CD14 人重组 HEK PRO-1642

ProSpec,CD14 Human HEK,CD14 人重组 HEK PRO-1642,CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用

  • CD14 Human HEK

  • CD14 Human Recombinant HEK
  • PRO-1642

Catalogue number

PRO-1642

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

CD14 Human Recombinant produced by mammalian expression system in human cells is a single polypeptide chain containing 341 amino acids . CD14 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
CD14 Human Recombinant 由哺乳动物表达系统在人细胞中产生，是一条含有 341 个氨基酸的多肽链。 CD14 在 C 端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

HEK293 cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CD14 was lyophilized from a 0.2 µM filtered solution of 20mM PB and 150mM NaCl, PH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CD14 in 1xPBS to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD14 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

TTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVD
ADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKIT
GTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAF
SCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCA
ALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKL
RVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACVDHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec CHM-007,BRAK Mouse,BRAK 小鼠重组,CHM-007

  • BRAK Mouse

  • BRAK Mouse Recombinant
  • CHM-007

Catalogue number

CHM-007

Synonyms

C-X-C motif chemokine 14, B-cell and monocyte-activating chemokine, Chemokine BRAK, Kidney-expressed chemokine CXC, MIP-2G, Small-inducible cytokine B14, Cxcl14, Bmac, Kec, Ks1, Mip2g, Scyb14, BRAK, NJAC, AI414372, bolekine, MIP2gamma, 1110031L23Rik, 1200006I23Rik.

Introduction

CXCL14 参与免疫调节和炎症过程。 BRAK 蛋白在结构上与细胞因子的 CXC 亚家族相关。 CXCL14 对单核细胞显示趋化活性，但对淋巴细胞、树突细胞、中性粒细胞或巨噬细胞没有趋化活性。 CXCL14 参与单核细胞衍生巨噬细胞的稳态。

Description

在大肠杆菌中产生的 CXCL14 Mouse Recombinant 是一种单一的、非糖基化的多肽链，含有 77 个氨基酸，分子量为 9.4kDa。
CXCL14 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CXCL14 was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4 and 500mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL14 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE.

Biological Activity

The ED50 of CXCL14 as determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BRAK Human
  • BRAK Rat
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ProSpec-CD14 Human CHO,CD14 人重组CHO PRO-536

ProSpec-CD14 Human CHO,CD14 人重组CHO PRO-536,可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

  • CD14 Human, CHO

  • CD14 Human Recombinant, CHO
  • PRO-536

Catalogue number

PRO-536

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

The CD14 is produced from human CD14 transfected CHO-cells. Before transfection the complete human CD14-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR. The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wild type CD14 is the 50-kDa protein containing 335 amino acids and lacks the GPI-Anchor.
CD14 由人 CD14 转染的 CHO 细胞产生。 在转染之前，通过 PCR 扩增完整的人 CD14-cDNA 并克隆到表达载体 p-POL-DHFR 中。 骨髓分化抗原 CD14 是细菌 LPS 的主要受体。 重组野生型 CD14 的主要形式是含有 335 个氨基酸的 50-kDa 蛋白质，并且缺乏 GPI-Anchor。

Source

CHO-cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CD14 was lyophilized from a concentrated protein solution containing phosphate-buffered saline, pH 7.2.

Solubility

It is recommended to reconstitute the lyophilized CD14 in sterile 18MΩ-cm H2O not less than 100µg/ml. Further dilutions should be made with phosphate buffered saline .

Stability

Lyophilized CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD14 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Biological Activity

Up to 20 µg/ml CD14 inhibit binding of FITC-LPS to 600,000 CD14+CHO transfectants .

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec CHM-021,BRAK Rat,BRAK 大鼠重组/CHM-021

ProSpec CHM-021,BRAK Rat,BRAK 大鼠重组/CHM-021,CXCL14 参与免疫调节和炎症过程。 BRAK 蛋白在结构上与细胞因子的 CXC 亚家族相关。 CXCL14 对单核细胞显示趋化活性，但对淋巴细胞、树突细胞、中性粒细胞或巨噬细胞没有趋化活性。 CXCL14 参与单核细胞衍生巨噬细胞的稳态。

  • BRAK Rat

  • BRAK Rat Recombinant
  • CHM-021

Catalogue number

CHM-021

Synonyms

C-X-C motif chemokine 14, B-cell and monocyte-activating chemokine, Chemokine BRAK, Kidney-expressed chemokine CXC, MIP-2G, Small-inducible cytokine B14, Cxcl14, Bmac, Kec, Ks1, Mip2g, Scyb14, BRAK, NJAC, AI414372, bolekine, MIP2gamma, 1110031L23Rik, 1200006I23Rik.

Introduction

CXCL14 参与免疫调节和炎症过程。 BRAK 蛋白在结构上与细胞因子的 CXC 亚家族相关。 CXCL14 对单核细胞显示趋化活性，但对淋巴细胞、树突细胞、中性粒细胞或巨噬细胞没有趋化活性。 CXCL14 参与单核细胞衍生巨噬细胞的稳态。

Description

CXCL14 Rat Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.
The CXCL14 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CXCL14 was lyophilized from a 0.2µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.

Solubility

It is recommended to reconstitute the lyophilized CXCL14 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE.

Biological Activity

Determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BRAK Human, His
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  • BRAK Human

ProSpec,CD14 Mouse,CD14 小鼠重组 PRO-537

ProSpec,CD14 Mouse,CD14 小鼠重组 PRO-537,CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。

  • CD14 Mouse

  • CD14 Mouse Recombinant
  • PRO-537

Catalogue number

PRO-537

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

The CD14 is produced from mouse CD14 transfected CHO-cells in serum free medium. Before transfection the complete mouse CD14-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR). The recombinant mouse CD-14 was purified by His-tag and controlled by page.
The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wildtype CD14 is the 50 kDa protein.

Source

CHO-cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CD14 was lyophilized from a concentrated protein solution containing phosphate-buffered saline, pH 7.2.

Solubility

It is recommended to reconstitute the lyophilized Mouse CD14 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Mouse CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CD14 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Applications

• ELISA.
• Inhibition Assays.
• Western Blotting.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD14 Human HEK
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ProSpec-C-10 Mouse/CHM-307,C-10 小鼠重组/CHM-307

ProSpec-C-10 Mouse/CHM-307,C-10 小鼠重组/CHM-307,CCL6 也可以在小鼠肺中由细胞因子白介素 13 诱导。小鼠 CCL6 位于 11 号染色体上。CCL6 的细胞表面受体被认为是趋化因子受体 CCR1。

  • C-10 Mouse

  • C-10 Mouse Recombinant
  • CHM-307

Catalogue number

CHM-307

Synonyms

Small inducible cytokine A6, CCL6, C10 protein, c10, MRP-1, Scya6, chemokine ligand 6.

Introduction

Chemokine ligand 6 is a small cytokine belonging to the CC chemokine family that has only been identified in rodents.
In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in bone marrow cultures that have been stimulated with the cytokine GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced. CCL6 can also be induced in the mouse lung by the cytokine interleukin 13. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.
趋化因子配体 6 是一种小细胞因子，属于 CC 趋化因子家族，仅在啮齿动物中发现。
在小鼠中，CCL6 在来自嗜中性粒细胞和巨噬细胞谱系的细胞中表达，并且可以在适合骨髓细胞分化的条件下被大量诱导。 它在用细胞因子 GM-CSF 刺激的骨髓培养物中高度表达。 某些低水平的基因表达也出现在某些骨髓来源的细胞系中，这些细胞系也可以在 GM-CSF 培养中被大大诱导。 然而，在活化的 T 细胞系中，CCL6 的表达大大降低。 CCL6 也可以在小鼠肺中由细胞因子白介素 13 诱导。小鼠 CCL6 位于 11 号染色体上。CCL6 的细胞表面受体被认为是趋化因子受体 CCR1。

Description

C-10 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 95 amino acids and having a molecular mass of 10.7kDa.
The CCL6 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CCL6 Mouse was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized C10 protein in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized C10 protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL6 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA.

Biological Activity

The Biological activity was determined by its ability to chemoattract human CCR1 transfected BaF3 mouse proB cells using a concentration range of 0.05-0.25µg/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • C-10 Rat

ProSpec,CD14 Mouse Sf9,CD14 小鼠重组体Sf9 PRO-2233

ProSpec,CD14 Mouse Sf9,CD14 小鼠重组体Sf9 PRO-2233,在 Sf9 杆状病毒细胞中产生的 CD14 是单条糖基化多肽链，包含 357 个氨基酸，分子量为 38.3kDa。

  • CD14 Mouse, Sf9

  • CD14 Mouse Recombinant, Sf9
  • PRO-2233

Catalogue number

PRO-2233

Synonyms

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

Introduction

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

Description

CD14 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 357 amino acids and having a molecular mass of 38.3kDa.

CD14 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD14 是单条糖基化多肽链，包含 357 个氨基酸，分子量为 38.3kDa。

CD14 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD14 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

SPAPPEPCEL DEESCSCNFS DPKPDWSSAF NCLGAADVEL YGGGRSLEYL LKRVDTEADL GQFTDIIKSL SLKRLTVRAA RIPSRILFGA LRVLGISGLQ ELTLENLEVT GTAPPPLLEA TGPDLNILNL RNVSWATRDA WLAELQQWLK PGLKVLSIAQ AHSLNFSCEQ VRVFPALSTL DLSDNPELGE RGLISALCPL KFPTLQVLAL RNAGMETPSG VCSALAAARV QLQGLDLSHN SLRDAAGAPS CDWPSQLNSL NLSFTGLKQV PKGLPAKLSV LDLSYNRLDR NPSPDELPQV GNLSLKGNPF LDSESHSEKF NSGVVTAGAP SSQAVALSGT LALLLGDRLF VHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD14 Human, CHO
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  • CD14 Human
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ProSpec-C-10 Rat/CHM-268,C-10 大鼠重组/CHM-268

ProSpec-C-10 Rat/CHM-268,C-10 大鼠重组/CHM-268,Lyophilized C-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution C-10 should be stored at 4C between 2-7 days and for future use below -18C.

  • C-10 Rat

  • C-10 Rat Recombinant
  • CHM-268

Catalogue number

CHM-268

Synonyms

Small inducible cytokine A6, CCL6, C10 protein, c10, MRP-1, Scya6, chemokine ligand 6.

Introduction

Chemokine ligand 6 is a small cytokine belonging to the CC chemokine family that has only been identified in rodents.
In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in bone marrow cultures that have been stimulated with the cytokine GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced. CCL6 can also be induced in the mouse lung by the cytokine interleukin 13. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.
趋化因子配体 6 是一种小细胞因子，属于 CC 趋化因子家族，仅在啮齿动物中发现。
在小鼠中，CCL6 在来自嗜中性粒细胞和巨噬细胞谱系的细胞中表达，并且可以在适合骨髓细胞分化的条件下被大量诱导。 它在用细胞因子 GM-CSF 刺激的骨髓培养物中高度表达。 某些低水平的基因表达也出现在某些骨髓来源的细胞系中，这些细胞系也可以在 GM-CSF 培养中被大大诱导。 然而，在活化的 T 细胞系中，CCL6 的表达大大降低。 CCL6 也可以在小鼠肺中由细胞因子白介素 13 诱导。小鼠 CCL6 位于 11 号染色体上。CCL6 的细胞表面受体被认为是趋化因子受体 CCR1。

Description

C-10 Rat Recombinant produced in E.Coli is a signle, non-glycosylated, polypeptide chain containing 94 amino acids and having a total molecular mass of 10.4kDa.
C-10 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized C-10 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized C-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution C-10 should be stored at 4C between 2-7 days and for future use below -18C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GLIQDTVKED RPFNPTIIHQ GFQDSSDCCF SYASQIPCSR FIYYFPTSGG CTKPGIIFVT RKRKRVCANP SDQRVQTCIS TLKLGPRSGN SAIA.

Biological Activity

Determined by its ability to chemoattract human CCR1 transfected BaF3 mouse proB cells using a concentration range of 0.05-0.25 ug/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • C-10 Mouse

ProSpec-CD2 Human Sf9,CD2人重组sf9 PRO-2390

CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。ProSpec-CD2 Human Sf9,CD2人重组sf9 PRO-2390

  • CD2 Human, Sf9

  • CD2 Human Recombinant, sf9
  • PRO-2390
  • Catalogue number

PRO-2390

Synonyms

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

Introduction

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.

CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

Description

CD2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 194 amino acids and having a molecular mass of 22.3kDa .
CD2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD2 Human Recombinant 是单条糖基化多肽链，包含 194 个氨基酸，分子量为 22.3kDa。
CD2 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD2 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPKEITNAL ETWGALGQDI NLDIPSFQMS DDIDDIKWEK TSDKKKIAQF RKEKETFKEK DTYKLFKNGT LKIKHLKTDD QDIYKVSIYD TKGKNVLEKI FDLKIQERVS KPKISWTCIN TTLTCEVMNG TDPELNLYQD GKHLKLSQRV ITHKWTTSLS AKFKCTAGNK VSKESSVEPV
SCPEKGLDHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec-CTACK Human/CHM-373,CTACK 人重组/CHM-373

ProSpec-CTACK Human/CHM-373,CTACK 人重组/CHM-373,ALP, CTACK, ESKINE, ILC, PESKY, SCYA27, CCL27, C-C motif chemokine 27, Small-inducible cytokine A27, IL-11 R-alpha-locus chemokine, Skinkine, ESkine, Cutaneous T-cell-attracting chemokine.

  • CTACK Human

  • CTACK Human Recombinant
  • CHM-373

Catalogue number

CHM-373

Synonyms

ALP, CTACK, ESKINE, ILC, PESKY, SCYA27, CCL27, C-C motif chemokine 27, Small-inducible cytokine A27, IL-11 R-alpha-locus chemokine, Skinkine, ESkine, Cutaneous T-cell-attracting chemokine.

Introduction

CTACK is a chemotactic factor that attracts skin-associated memory T-lymphocytes. CTACK is involved in mediating homing of lymphocytes to cutaneous sites. CTACK Binds to CCR10.

Description

在大肠杆菌中产生的 CTACK Human Recombinant 是一种单一的、非糖基化的多肽链，包含 89 个氨基酸，分子量为 10.3kDa。 CTACK 蛋白通过标准色谱法纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CTACK Human solution containing 10mM sodium citrate pH-3.5 & 10% glycerol.

Stability

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Amino acid sequence

MFLLPPSTAC CTQLYRKPLS DKLLRKVIQV ELQEADGDCH LQAFVLHLAQ RSICIHPQNP SLSQWFEHQE RKLHGTLPKL NFGMLRKMG.

Purity

Greater than 95% as determined by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CTACK Mouse

ProSpec-CTACK Mouse/CHM-013,CTACK 小鼠重组/CHM-013

ProSpec-CTACK Mouse/CHM-013,CTACK 小鼠重组/CHM-013,CTACK 是一种趋化因子，可吸引与皮肤相关的记忆 T 淋巴细胞。 CTACK 参与介导淋巴细胞向皮肤部位的归巢。 CTACK 与 CCR10 结合。

  • CTACK Mouse

  • CTACK Mouse Recombinant
  • CHM-013

Catalogue number

CHM-013

Synonyms

C-C motif chemokine 27, CC chemokine ILC, Cutaneous T-cell-attracting chemokine, CTACK, ESkine, IL-11 R-alpha-locus chemokine, ALP, mILC, Skinkine, Small-inducible cytokine A27, Ccl27, Ilc, Scya27.

Introduction

CTACK 是一种趋化因子，可吸引与皮肤相关的记忆 T 淋巴细胞。 CTACK 参与介导淋巴细胞向皮肤部位的归巢。 CTACK 与 CCR10 结合。

Description

CTACK Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 95 amino acids and having a molecular mass of 10.9kDa.
The CTACK is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH7.4 and 300mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CTACK in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 CTACK 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CTACK 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

LPLPSSTSCC TQLYRQPLPS RLLRRIVHME LQEADGDCHL QAVVLHLARR SVCVHPQNRS LARWLERQGK RLQGTVPSLN LVLQKKMYSN PQQQN.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of 10-100 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec,CD2 Human,CD2人重组PRO-1337

ProSpec,CD2 Human,CD2人重组PRO-1337,CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。

  • CD2 Human

  • CD2 Human Recombinant
  • PRO-1337

Catalogue number

PRO-1337

Synonyms

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

Introduction

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

Description

CD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids and having a molecular mass of 23.8kDa.
CD2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD2 protein solution containing 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSMKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL
SAKFKCTAGN KVSKESSVEP VSCPEKGLD.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec-CD2 Human GST,CD2 人重组PRO-468

ProSpec-CD2 Human GST,CD2 人重组PRO-468,p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

  • CD2 Human, GST

  • CD2 Human Recombinant, GST Tag
  • PRO-468

Catalogue number

PRO-468

Synonyms

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

Introduction

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

Description

CD2 Human Recombinant expressed in E.coli, shows a 46 kDa band on -PAGE.
The CD2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD2 at 100µg/ml in 50mM Tris-HCl pH7.5 and 10Mm L-glutathione .

Stability

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Applications

• ELISA.
• Inhibition Assays.
• Western Blotting.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD2 FITC Antibody
  • CD2 Human
  • CD2 Antibody
  • CD2 Human, Sf9

ProSpec-CXCL16 Human/CHM-029,CXCL16 人重组/CHM-029

CXC 趋化因子配体 16 是一种 I 型膜蛋白，在其细胞外区域包含一个不含 ELR 基序的 CXC 趋化因子结构域。 人和小鼠 CXCL16 共享 70% a.a. 其趋化因子结构域内的序列相似性和 49% 的总体 a.a. 序列同一性。

  • CXCL16 Human

  • CXCL16 Human Recombinant
  • CHM-029

Catalogue number

CHM-029

Synonyms

Chemokine Ligand 16, Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein, Transmembrane Chemokine CXCL16, Small-Inducible Cytokine B16, CXC Chemokine Ligand 16, SR-PSOX, SRPSOX, C-X-C Motif Chemokine 16, CXCLG16, SCYB16, CXCL16.

Introduction

CXC 趋化因子配体 16 是一种 I 型膜蛋白，在其细胞外区域包含一个不含 ELR 基序的 CXC 趋化因子结构域。 人和小鼠 CXCL16 共享 70% a.a. 其趋化因子结构域内的序列相似性和 49% 的总体 a.a. 序列同一性。 功能性 CXCL16 可以作为大约 35kDa 可溶性蛋白从细胞表面脱落。 CXCR6 是 CXCL16 的功能性受体。 CXCL16 充当巨噬细胞上的清道夫受体，与 OxLDL 特异性结合，提示 CXCL16 可能参与动脉粥样硬化等病理生理学。 此外，CXCL16 诱导强烈的趋化反应和钙动员。 CXCL16 与 CXCR6/Bonzo 结合。

Description

CXCL16 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 89 amino acids and having a molecular mass of 10kDa.
The CXCL16 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CXCL16 protein was lyophilized from a 0.2µm filtered solution in PBS.

Solubility

It is recommended to reconstitute the lyophilized CXCL16 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 CXCL16 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，CXCL16 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by -PAGE.

Amino acid sequence

NEGSVTGSCY CGKRISP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP.

Biological Activity

The ED50, as measured by its ability to chemoattract mouse CXCR6-transfected mouse BaF3 cells, is less than 12ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CXCL16 Mouse

ProSpec-CD200 Human Sf9,CD200 人类重组sf9 PRO-2416

CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。ProSpec-CD200 Human Sf9,CD200 人类重组sf9 PRO-2416

  • CD200 Human, Sf9

  • CD200 Human Recombinant, sf9
  • PRO-2416

Catalogue number

PRO-2416

Synonyms

CD200, MOX1, MOX2, MRC, OX-2, CD200 Molecule, CD200 Antigen, Antigen Identified By Monoclonal Antibody MRC OX-2, OX-2 Membrane Glycoprotein.

Introduction

CD200 is a type-1 membrane glycoprotein which is a part of the immunoglobulin superfamily due to its 2 immunoglobulin domains. CD200 regulates myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in various tissues. CD200 is also Costimulates T-cell proliferation.

CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。 CD200 调节骨髓细胞活性并为各种组织中的巨噬细胞谱系提供抑制信号。 CD200 也是共刺激 T 细胞增殖。

Description

CD200 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 444 amino acids and having a molecular mass of 49.7kDa .
CD200 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD200 Human Recombinant 是单条糖基化多肽链，包含 444 个氨基酸，分子量为 49.7kDa。
CD200 在 C 末端用 242 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD200 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPQVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKGLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200 Human
  • CD200 Mouse

ProSpec-CXCL16 Mouse/CHM-363,CXCL16 小鼠重组/CHM-363

ProSpec-CXCL16 Mouse/CHM-363,CXCL16 小鼠重组/CHM-363,在大肠杆菌中产生的 CXCL16 Mouse Recombinant 是一条单一的、非糖基化的多肽链，包含 88 个氨基酸，分子量为 9.9kDa。

  • CXCL16 Mouse

  • CXCL16 Mouse Recombinant
  • CHM-363

Catalogue number

CHM-363

Synonyms

C-X-C motif chemokine 16, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SR-PSOX, Cxcl16, Srpsox, Zmynd15, AV290116, BB024863, 0910001K24Rik.

Introduction

小鼠 CXCL16 是一种非 ELR 基序，包括具有跨膜结构域的 CXC 趋化因子。小鼠 CXCL16 cDNA 编码一个 246 a.a.具有假定 26 a.a. 的前体蛋白。残基信号肽，一个 88 a.a.残留趋化因子结构域，一个 87 a.a.残留粘蛋白样间隔区，a 22 a.a.残基跨膜结构域和一个 23 a.a.残基胞质尾。
CXCL16 诱导强烈的趋化反应和钙动员。此外，CXCL16 可作为巨噬细胞上的清道夫受体，与 OxLDL 特异性结合，这表明它可能与动脉粥样硬化等病理生理学有关。
小鼠 CXCL16 由淋巴器官 T 细胞区域中的树突状细胞以及脾红髓中的细胞以膜结合和可溶形式产生。 CXCR6/Bonzo 是 CXCL16 的受体。 CXCL16 在脾脏、淋巴结和 Peyer 斑块中表达。它还在肺、肾、小肠和胸腺等非淋巴组织中表达，在心脏和肝脏中表达较弱，在脑和纯化的 B 细胞和 T 细胞中不表达。
CXCL16 缺乏与乳腺癌进展有关。此外，CXCL16 通过调节肝组织中 T 淋巴细胞浸润参与免疫性肝损伤。此外，CXCL16 在维持由自然杀伤 T 细胞介导的心脏同种异体移植物耐受性方面具有独特的作用。此外，CXCL16 不仅在 NKT 细胞产生 IFN-γ 方面具有重要作用，而且在促进由 NKT 细胞介导的 Th1 倾向的免疫反应中也具有重要作用。

Description

在大肠杆菌中产生的 CXCL16 Mouse Recombinant 是一条单一的、非糖基化的多肽链，包含 88 个氨基酸，分子量为 9.9kDa。
CXCL16 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a concentrated solution in 20mM PB, pH 7.4, 50mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized CXCL16 Mouse in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL16 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP.

Biological Activity

Determined by its ability to chemoattract murine lymphocytes using a concentration range of 100-1000ng/ml corresponding to a Specific Activity of 1,000-10,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CXCL16 Human

ProSpec,CD200 Human,CD200 人重组PRO-1974

CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。ProSpec,CD200 Human,CD200 人重组PRO-1974

  • CD200 Human

  • CD200 Human Recombinant
  • PRO-1974

Catalogue number

PRO-1974

Synonyms

MOX1, MOX2, MRC, OX-2, OX-2 membrane glycoprotein, CD_antigen, CD200.

Introduction

CD200 is a type-1 membrane glycoprotein which is a part of the immunoglobulin superfamily due to its 2 immunoglobulin domains. CD200 regulates myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in various tissues. CD200 is also Costimulates T-cell proliferation.
CD200 是一种 1 型膜糖蛋白，由于其 2 个免疫球蛋白结构域，它是免疫球蛋白超家族的一部分。 CD200 调节骨髓细胞活性并为各种组织中的巨噬细胞谱系提供抑制信号。 CD200 也是共刺激 T 细胞增殖。

Description

CD200 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids and having a molecular mass of 24.8kDa.
CD200 is fused to a 23 amino acid His-tag at N-terminus.
在大肠杆菌中产生的 CD200 Human Recombinant 是单条非糖基化多肽链，含有 225 个氨基酸，分子量为 24.8kDa。
CD200 在 N 端与 23 个氨基酸的 His 标签融合。

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD200 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSQVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKG.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200R1 Mouse
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ProSpec-CXCL17 Human/CHM-019,VEGF 共调节趋化因子 1 人重组/CHM-019

ProSpec-CXCL17 Human/CHM-019,VEGF 共调节趋化因子 1 人重组/CHM-019,树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。

  • CXCL17 Human

  • VEGF Co-regulated Chemokine 1 Human Recombinant
  • CHM-019

Catalogue number

CHM-019

Synonyms

VEGF coregulated chemokine 1, C-X-C motif chemokine 17, Dendritic cell and monocyte chemokine-like protein, DMC, CXCL17, VCC1, Dcip1, VCC-1, UNQ473.

Introduction

树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。 CXCL17 诱导静止的、但不是 LPS 激活的外周血单核细胞和树突状细胞的趋化性，并且它还特异性地结合这些细胞。 当体外诱导形成管时，内皮细胞中CXCL17的表达增加。 在血管生成中起作用的CXCL17、CXCL1/GRO和CXCL8/IL8在原发性肺、乳腺和食管肿瘤中与VEGF的表达显着相关。 因此，CXCL17被认为在肿瘤血管生成中起作用。 成熟的大鼠 CXCL17 分别与小鼠、人 CXCL17 共享 82%、71% 的氨基酸序列同一性。

Description

CXCL17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 98 amino acids and having a molecular mass of 11.5kDa.
The CXCL17 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CXCL17 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4, containing 3% Trehalose.

Solubility

It is recommended to reconstitute the lyophilized CXCL17 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 CXCL17 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，CXCL17 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL.

Biological Activity

The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0µg/ml, corresponding to a specific activity of > 200IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CXCL17 Human, His
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ProSpec,CD200 Mouse,CD200 小鼠重组PRO-2612

ProSpec,CD200 Mouse,CD200 小鼠重组,在杆状病毒中产生的 CD200 小鼠重组体是一条单条糖基化多肽链，包含 210 个氨基酸，分子量为 23.5kDa。

  • CD200 Mouse

  • CD200 Mouse Recombinant
  • PRO-2612

Catalogue number

PRO-2612

Synonyms

MOX1, MOX2, MRC, OX-2, OX-2 membrane glycoprotein, CD_antigen, CD200.

Introduction

CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 210 amino acids and having a molecular mass of 23.5kDa. CD200 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

在杆状病毒中产生的 CD200 小鼠重组体是一条单条糖基化多肽链，包含 210 个氨基酸，分子量为 23.5kDa。 CD200 在 C 端与 8 个氨基酸的 His-Tag 融合，并通过专有色谱技术进行纯化。

Description

CD200 Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 441 amino acids and having a molecular mass of 49.5kDa.
CD200 is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.

在杆状病毒中产生的 CD200 小鼠重组体是一条糖基化的单一多肽链，包含 441 个氨基酸，分子量为 49.5kDa。
CD200 在 C 末端与 239 个氨基酸的 hIgG-His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD200 solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

QVEVVTQDER KALHTTASLR CSLKTSQEPL IVTWQKKKAV SPENMVTYSK THGVVIQPAY KDRINVTELG LWNSSITFWN TTLEDEGCYM CLFNTFGSQK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGTGIE NSTESHFHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGLEHHHHHH.

Measured by its binding ability in a functional ELISA with pro-2363.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200 Human
  • CD200 Human, Sf9

ProSpec-CXCL17 Human, His/CHM-024

ProSpec-CXCL17 Human, His/CHM-024,树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。

  • CXCL17 Human, His

  • VEGF Co-regulated Chemokine 1, His Tag Human Recombinant
  • VEGF 共调节趋化因子 1，His 标签人重组
  • CHM-024

Catalogue number

CHM-024

Synonyms

Dcip1, DMC, MGC138300, UNQ473, VCC-1, VCC1, VEGF coregulated chemokine 1, C-X-C motif chemokine 17, Dendritic cell and monocyte chemokine-like protein.

Introduction

树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。 CXCL17 诱导静止的、但不是 LPS 激活的外周血单核细胞和树突状细胞的趋化性，并且它还特异性地结合这些细胞。 当体外诱导形成管时，内皮细胞中CXCL17的表达增加。 在血管生成中起作用的CXCL17、CXCL1/GRO和CXCL8/IL8在原发性肺、乳腺和食管肿瘤中与VEGF的表达显着相关。 因此，CXCL17被认为在肿瘤血管生成中起作用。 成熟的大鼠 CXCL17 分别与小鼠、人 CXCL17 共享 82%、71% 的氨基酸序列同一性。

Description

CXCL17 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.7kDa.CXCL17 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CXCL17 protein solution contains 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CXCL17 Rat
  • CXCL17 Human

ProSpec,CD200R1 Human,CD200 受体 1 人重组体PRO-2548

ProSpec,CD200R1 Human,CD200 受体 1 人重组体PRO-2548,在 Sf9 昆虫细胞中产生的 CD200R1 是单条糖基化多肽链，含有 462 个氨基酸，分子量为 51.9kDa。

  • CD200R1 Human

  • CD200 Receptor 1 Human Recombinant
  • PRO-2548

Catalogue number

PRO-2548

Synonyms

Cell surface glycoprotein CD200 receptor 1 isoform d, CD200R1, CD200R, HCRTR2, MOX2R, OX2R, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r.

Introduction

CD200R1, also known as cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 inhibitory signaling pathway has been involved in taking a prominent role in limiting inflammation in a broad range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, in addition to inducible nitric oxide synthase in response to selected stimuli.

CD200R1，也称为细胞表面糖蛋白 CD200 受体 1，是一种在髓系细胞上表达的 CD200 受体同种型。 CD200R1 抑制信号通路在广泛的炎症性疾病中在限制炎症方面发挥着重要作用。 CD200R1 信号传导抑制促炎分子的表达，包括肿瘤坏死因子、干扰素，以及响应选定刺激的诱导型一氧化氮合酶。

Description

CD200R1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 462 amino acids and having a molecular mass of 51.9kDa . CD200R1 is expressed with 242 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 昆虫细胞中产生的 CD200R1 是单条糖基化多肽链，含有 462 个氨基酸，分子量为 51.9kDa。 CD200R1 在 C 末端用 242 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD200R1 protein solution contains phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADLSSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYKK ETNETKETNC TDERITWVSR PDQNSDLQIR TVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAHISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.

Related Products

  • CD200R1 Mouse

ProSpec-CXCL17 Rat/CHM-281,VEGF 共调节趋化因子 1 大鼠重组/CHM-281

ProSpec-CXCL17 Rat/CHM-281,VEGF 共调节趋化因子 1 大鼠重组/CHM-281,树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。

  • CXCL17 Rat

  • VEGF Co-regulated Chemokine 1 Rat Recombinant
  • CHM-281

Catalogue number

CHM-281

Synonyms

Protein Cxcl17, Cxcl17, RGD1304717, C-X-C motif chemokine 17, VEGF co-regulated chemokine 1, Vcc1, VCC-1.

Introduction

树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。 CXCL17 诱导静止的、但不是 LPS 激活的外周血单核细胞和树突状细胞的趋化性，并且它还特异性地结合这些细胞。 当体外诱导形成管时，内皮细胞中CXCL17的表达增加。 在血管生成中起作用的CXCL17、CXCL1/GRO和CXCL8/IL8在原发性肺、乳腺和食管肿瘤中与VEGF的表达显着相关。 因此，CXCL17被认为在肿瘤血管生成中起作用。 成熟的大鼠 CXCL17 分别与小鼠、人 CXCL17 共享 82%、71% 的氨基酸序列同一性。

Description

CXCL17 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 97 amino acids and having a molecular mass of 11.5kDa.
The CXCL17 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CXCL17 protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, 300mM NaCl, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CXCL17 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized CXCL17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPNQEVARHH GDQHQAPRRW LWEGGQECDC KDWSLRVSKR KTTAVLEPPR KQCPCDHVKG SEKKNRRQKH HRKSQRPSRT CQQFLKRCQL ASFTLPL.

Biological Activity

Measured by its ability to induce VEGF expression in mouse endothelial cells. The ED50 for this effect is typically 1-5 µg/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CXCL17 Human
  • CXCL17 Human, His

ProSpec,CD200R1 Mouse,CD200 受体 1 小鼠重组PRO-2363

ProSpec,CD200R1 Mouse,CD200 受体 1 小鼠重组PRO-2363,CD200R1，也称为细胞表面糖蛋白 CD200 受体 1，是一种在髓系细胞上表达的 CD200 受体同种型。 CD200R1 抑制信号通路在广泛的炎症性疾病中在限制炎症方面发挥着重要作用。

  • CD200R1 Mouse

  • CD200 Receptor 1 Mouse Recombinant
  • PRO-2363

Catalogue number

PRO-2363

Synonyms

Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r.

Introduction

CD200R1, also known as cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 inhibitory signaling pathway has been involved in taking a prominent role in limiting inflammation in a broad range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, in addition to inducible nitric oxide synthase in response to selected stimuli.

CD200R1，也称为细胞表面糖蛋白 CD200 受体 1，是一种在髓系细胞上表达的 CD200 受体同种型。 CD200R1 抑制信号通路在广泛的炎症性疾病中在限制炎症方面发挥着重要作用。 CD200R1 信号传导抑制促炎分子的表达，包括肿瘤坏死因子、干扰素，以及响应选定刺激的诱导型一氧化氮合酶。

Description

CD200R1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 455 amino acids and having a molecular mass of 50.4kDa. .
CD200R1 is expressed with a 239 amino acid hIgG His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 昆虫细胞中产生的 CD200R1 是单条糖基化多肽链，含有 455 个氨基酸，分子量为 50.4kDa。 .
CD200R1 在 C 末端用 239 个氨基酸的 hIgG His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD200R1 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ADPTDKNQTT QNNSSSPLTQ VNTTVSVQIG TKALLCCFSI PLTKAVLITW IIKLRGLPSC TIAYKVDTKT NETSCLGRNI TWASTPDHSP ELQISAVTLQ HEGTYTCETV TPEGNFEKNY DLQVLVPPEV TYFPEKNRSA VCEAMAGKPA AQISWSPDGD CVTTSESHSN GTVTVRSTCH WEQNNVSDVS CIVSHLTGNQ SLSIELSRGG NQSLRPLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD200 Human
  • CD200R1 Human

ProSpec-GCP2 Bovine/CHM-040,粒细胞趋化蛋白2牛重组/CHM-040

ProSpec-GCP2 Bovine/CHM-040,粒细胞趋化蛋白2牛重组/CHM-040,粒细胞趋化蛋白 2，也称为 GCP-2，是一种中性粒细胞趋化蛋白。 GCP-2 通过其受体的结合和激活发出信号。

  • GCP2 Bovine

  • Granulocyte Chemotactic Protein 2 Bovine Recombinant
  • CHM-040

Catalogue number

CHM-040

Synonyms

C-X-C motif chemokine 6, Chemokine alpha 3, CKA-3, Granulocyte chemotactic protein 2, GCP-2, Small-inducible cytokine B6.

Introduction

粒细胞趋化蛋白 2，也称为 GCP-2，是一种中性粒细胞趋化蛋白。 GCP-2 通过其受体的结合和激活发出信号。 GCP-2除了具有趋化性和血管生成特性外，对革兰氏阳性菌和革兰氏阴性菌具有很强的抗菌活性。

Description

在大肠杆菌中产生的粒细胞趋化蛋白 2 牛重组体是一种非糖基化多肽链，含有 76 个氨基酸，分子量约为 8.0kDa。
GCP2 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0.

Solubility

It is recommended to reconstitute the lyophilized Granulocyte Chemotactic Protein 2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 GCP2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，粒细胞趋化蛋白 2 应在 4°C 下储存 2-7 天，以备将来在低于 -18°C 的温度下使用。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

GPVAAVVREL RCVCLTTTPG IHPKTVSDLQ VIAAGPQCSK VEVIATLKNG REVCLDPEAP LIKKIVQKIL DSGKNN.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human neutrophils is 10-50 ng/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • GCP-2 Human

ProSpec,MSR1 Human,巨噬细胞清道夫受体 1 人重组体PRO-2201

ProSpec,MSR1 Human,巨噬细胞清道夫受体 1 人重组体PRO-2201,巨噬细胞清道夫受体 1，也称为 MSR1，是 A 类巨噬细胞清道夫受体的成员

  • MSR1 Human

  • Macrophage Scavenger Receptor 1 Human Recombinant
  • PRO-2201

Catalogue number

PRO-2201

Synonyms

Macrophage Scavenger Receptor 1, SCARA1, Macrophage Acetylated LDL Receptor I And II, Scavenger Receptor Class A Member 1, SRA, Macrophage Scavenger Receptor Types I And II, Macrophage Scavenger Receptor Type III, Scavenger Receptor Class A, Member 1 CD204 Antigen, CD204, PhSR1, PhSR2, SR-A.

Introduction

Macrophage Scavenger Receptor 1, also known as MSR1 is a member of the class A macrophage scavenger receptors, which comprises three different types 1, 2 and 3 generated by alternative splicing. Furthermore, these receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological as well as pathological processes which include atherosclerosis, Alzheimer’s disease, and host defense.
巨噬细胞清道夫受体 1，也称为 MSR1，是 A 类巨噬细胞清道夫受体的成员，包括通过可变剪接产生的三种不同类型的 1、2 和 3。 此外，这些受体或同种型是巨噬细胞特异性三聚体整合膜糖蛋白，并且与许多巨噬细胞相关的生理和病理过程有关，包括动脉粥样硬化、阿尔茨海默病和宿主防御。

Description

MSR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 398 amino acids and having a molecular mass of 43.7kDa.
MSR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 MSR1 Human Recombinant 是单条非糖基化多肽链，包含 398 个氨基酸，分子量为 43.7kDa。
MSR1 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

MSR1 protein solution containing 20mM Tris-HCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSKWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ WGTRACSHSE DAGVTCTL

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • MSR1 Human, sf9

ProSpec-GCP-2 Human/CHM-025,粒细胞趋化蛋白2人重组/CHM-025

ProSpec-GCP-2 Human/CHM-025,粒细胞趋化蛋白2人重组/CHM-025,粒细胞趋化蛋白 2，也称为 GCP-2，是一种中性粒细胞趋化蛋白。

  • GCP-2 Human

  • Granulocyte Chemotactic Protein 2 Human Recombinant
  • CHM-025

Catalogue number

CHM-025

Synonyms

C-X-C motif chemokine 6, Chemokine alpha 3, CKA-3, Granulocyte chemotactic protein 2, GCP-2, Small-inducible cytokine B6.

Introduction

粒细胞趋化蛋白 2，也称为 GCP-2，是一种中性粒细胞趋化蛋白。 GCP-2 通过其受体的结合和激活发出信号。 GCP-2 除了具有趋化性和血管生成特性外，对革兰氏阳性菌和革兰氏阴性菌具有很强的抗菌活性。

Description

GCP-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9kDa.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

GCP-2 protein was lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized GCP-2 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 GCP-2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，GCP-2 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 10-50 ng/ml corresponding to a specific activity of 20,000-100,000 IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • GCP2 Bovine

ProSpec,CD207 Human,CD207 人重组PRO-2204

CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。ProSpec,CD207 Human,CD207 人重组PRO-2204

  • CD207 Human

  • CD207 Human Recombinant
  • PRO-2204

Catalogue number

PRO-2204

Synonyms

C-type lectin domain family 4 member K, CLEC4K, Langerin, CD207.

Introduction

CD207 is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Moreover, CD207 is expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, the organelles present in the cytoplasm of Langerhans cells and comprised of superimposed and zippered membranes. CD207 is a C-type lectin with mannose binding specificity, and it has been suggested that mannose binding by the CD207 protein leads to internalization of antigen into Birbeck granules thus providing access to a nonclassical antigen-processing pathway.
CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。 Langerin 位于伯贝克颗粒中，该细胞器存在于朗格汉斯细胞的细胞质中，由重叠的拉链膜组成。 CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中，从而提供了进入非经典抗原加工途径的途径。

Description

CD207 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids and having a molecular mass of 32.2kDa.
CD207 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD207 Human Recombinant 是单条非糖基化多肽链，含有 287 个氨基酸，分子量为 32.2kDa。
CD207 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

CD207 protein solution containing 20mM Tris 8.0 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEP.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD207 Human, sf9

ProSpec-ENA 78 Human/CHM-331,上皮中性粒细胞激活蛋白 78 人重组/CHM-331

ENA 78 Human

  • Epithelial Neutrophil-Activating Protein 78 Human Recombinant
  • CHM-331

Catalogue number

CHM-331

Synonyms

Small inducible cytokine B5, CXCL5, Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, ENA-78, chemokine ligand 5, SCYB5.

Introduction

趋化因子配体 5 是一种小细胞因子，属于 CXC 趋化因子家族，也称为上皮衍生的中性粒细胞激活肽 78。 它是在用炎性细胞因子 IL-1 或肿瘤坏死因子-α 刺激细胞后产生的。 在嗜酸性粒细胞中也观察到了 CXCL5 的表达，并且可以被 II 型 IFN 抑制。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。 CXCL5 基因在四个外显子上编码，位于人类第 4 号染色体上，与其他几个 CXC 趋化因子基因一起。 CXCL5 与结缔组织重塑有关。

Description

在大肠杆菌中产生的上皮中性粒细胞激活蛋白 78 人重组体是一种单一的、非糖基化的多肽链，含有 74 个氨基酸，分子量为 8020 道尔顿。
CXCL5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CXCL5 was lyophilized from a concentrated solution in water containing no additives.

Solubility

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized ENA78 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala- Ala -Val-Leu-Arg.

Biological Activity

The biological activity was determined by measuring the dose dependent mobilization of intracellular calcium with human neutrophils. Significant calcium mobilization is observed with 100ng/mL   of recombinant human ENA-78.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • ENA 78 Human
  • ENA 78 Rat
  • LIX Mouse
  • ENA 78 Mouse

ProSpec-CD207 Human sf9,CD207 人类重组体sf9 PRO-2317

ProSpec-CD207 Human sf9,CD207 人类重组体sf9 PRO-2317,CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中

  • CD207 Human, sf9

  • CD207 Human Recombinant, sf9
  • PRO-2317

Catalogue number

PRO-2317

Synonyms

C-type lectin domain family 4 member K, Langerin, CD207, CD207 Molecule, CD207 Molecule, Langerin, CD207 Antigen, Langerin, CLEC4K, Langerhans Cell Specific C-Type Lectin, Langerin.

Introduction

CD207 is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Moreover, CD207 is expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, the organelles present in the cytoplasm of Langerhans cells and comprised of superimposed and zippered membranes. CD207 is a C-type lectin with mannose binding specificity, and it has been suggested that mannose binding by the CD207 protein leads to internalization of antigen into Birbeck granules thus providing access to a nonclassical antigen-processing pathway.
CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。 Langerin 位于伯贝克颗粒中，该细胞器存在于朗格汉斯细胞的细胞质中，由重叠的拉链膜组成。 CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中，从而提供了进入非经典抗原加工途径的途径。

Description

CD207 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 273 amino acids and having a molecular mass of 30.9kDa .
CD207 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD207 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEPHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD207 Human

ProSpec CHM-265,ENA 78 Human (8-78 a.a.),上皮中性粒细胞激活蛋白 78, 8-78 a.a. 人类重组

ProSpec CHM-265,ENA 78 Human (8-78 a.a.),上皮中性粒细胞激活蛋白 78, 8-78 a.a. 人类重组,在嗜酸性粒细胞中也观察到了 CXCL5 的表达，并且可以被 II 型干扰素 IFN-α 抑制。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。

  • ENA 78 Human

  • Epithelial Neutrophil-Activating Protein 78, 8-78 a.a. Human Recombinant
  • CHM-265

Catalogue number

CHM-265

Synonyms

Small inducible cytokine B5, CXCL5, Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, ENA-78, chemokine ligand 5, SCYB5.

Introduction

趋化因子配体 5 是一种小细胞因子，属于 CXC 趋化因子家族，也称为上皮衍生的中性粒细胞激活肽 78。 它是在用炎性细胞因子 IL-1 或肿瘤坏死因子-α 刺激细胞后产生的。 在嗜酸性粒细胞中也观察到了 CXCL5 的表达，并且可以被 II 型干扰素 IFN-α 抑制。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。 CXCL5 基因在四个外显子上编码，位于人类第 4 号染色体上，与其他几个 CXC 趋化因子基因一起。 CXCL5 与结缔组织重塑有关。

Description

在大肠杆菌中产生的上皮中性粒细胞激活蛋白 78 人重组体是一种单一的、非糖基化的多肽链，包含 71 个氨基酸，分子量为 7.8kDa。 CXCL5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1xPBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized ENA78 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N.

Biological Activity

The biological activity was determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • ENA 78 Mouse
  • ENA 78 Human
  • ENA 78 Rat
  • LIX Mouse

ProSpec CHM-365,ENA 78 Mouse,上皮中性粒细胞激活蛋白 78 小鼠重组

ProSpec CHM-365,ENA 78 Mouse,上皮中性粒细胞激活蛋白 78 小鼠重组,冻干的 ENA-78 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CXCL5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

  • ENA 78 Mouse

  • Epithelial Neutrophil-Activating Protein 78 Mouse Recombinant
  • CHM-365

Catalogue number

CHM-365

Synonyms

C-X-C motif chemokine 5, Small-inducible cytokine B5, Cytokine LIX, Cxcl5, Scyb5, LIX, GCP-2, Scyb6, ENA-78, AMCF-II.

Introduction

趋化因子配体 5 是一种小细胞因子，属于 CXC 趋化因子家族，也称为上皮衍生的中性粒细胞激活肽 78。 它是在用炎性细胞因子 IL-1 或肿瘤坏死因子-α 刺激细胞后产生的。 在嗜酸性粒细胞中也观察到了 CXCL5 的表达。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。 CXCL5 基因在四个外显子上编码，位于人类第 4 号染色体上，与其他几个 CXC 趋化因子基因一起。 CXCL5 与结缔组织重塑有关。

Description

在大肠杆菌中产生的上皮中性粒细胞激活蛋白 78 小鼠重组体是一条含有 93 个氨基酸且分子量为 9.8kDa 的单一非糖基化多肽链。
CXCL5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 20mM sodium phosphate buffer, pH 7.4 & 150mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

冻干的 ENA-78 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CXCL5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SVQ.

Biological Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • ENA 78 Human
  • ENA 78 Rat
  • LIX Mouse
  • ENA 78 Human

ProSpec,CD226 Human,CD226 人重组PRO-1353

ProSpec,CD226 Human,CD226 人重组PRO-1353,CD226 属于 Ig 超家族，包含 V 组的 2 个 Ig 样结构域。 CD226 是一种 65kDa 糖蛋白，在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达。

  • CD226 Human

  • CD226 Human Recombinant
  • PRO-1353

Catalogue number

PRO-1353

Synonyms

DNAM-1, PTA1, TLiSA1, CD226 antigen, DNAX accessory molecule 1, DNAM1, Recombinant Human CD226.

Introduction

CD226 belongs to the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 is a 65kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. CD226 facilitates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. CD226 also plays a role in megakaryocytic cell maturation.
CD226 属于 Ig 超家族，包含 V 组的 2 个 Ig 样结构域。 CD226 是一种 65kDa 糖蛋白，在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达。 CD226 促进血小板和巨核细胞与血管内皮细胞的细胞粘附。 CD226 还在巨核细胞成熟中起作用。

Description

CD226 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 259 amino acids and having a molecular mass of 29.4kDa.
CD226 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD226 protein solution containing 20mM Tris-HCl buffer , 0.4M UREA and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNQYTLFVA.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD226 Human, Sf9

ProSpec ENA 78 Rat,ENA 78 Rat,上皮中性粒细胞激活蛋白 78 大鼠重组

ProSpec ENA 78 Rat,ENA 78 Rat,上皮中性粒细胞激活蛋白 78 大鼠重组,在嗜酸性粒细胞中也观察到了 CXCL5 的表达。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。

  • ENA 78 Rat

  • Epithelial Neutrophil-Activating Protein 78 Rat Recombinant
  • CHM-267

Catalogue number

CHM-267

Synonyms

C-X-C motif chemokine 5, Small-inducible cytokine B5, Cytokine LIX, Cxcl5, Scyb5, LIX, GCP-2, Scyb6, ENA-78, AMCF-II.

Introduction

趋化因子配体 5 是一种小细胞因子，属于 CXC 趋化因子家族，也称为上皮衍生的中性粒细胞激活肽 78。 它是在用炎性细胞因子 IL-1 或肿瘤坏死因子-α 刺激细胞后产生的。 在嗜酸性粒细胞中也观察到了 CXCL5 的表达。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。 CXCL5 基因在四个外显子上编码，位于人类第 4 号染色体上，与其他几个 CXC 趋化因子基因一起。 CXCL5 与结缔组织重塑有关。

Description

Epithelial Neutrophil-Activating Protein 78 Rat Recombinant produced in E.Coli is a single,
non-glycosylated, polypeptide chain containing 93 amino acids and having a molecular mass of 10.0kDa.
The CXCL5 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized ENA-78 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APFSAMVATE LRCVCLTLAP RINPKMIANL EVIPAGPHCP KVEVIAKLKN QKDNVCLDPQ APLIKKVIQK ILGSENKKTK RNALALVRSA STQ.

Biological Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • ENA 78 Mouse
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  • ENA 78 Human
  • ENA 78 Human

ProSpec,CD226 Human Sf9,CD226 人重组体Sf9 PRO-2371

ProSpec,CD226 Human Sf9,CD226 人重组体Sf9 PRO-2371,在 Sf9 杆状病毒细胞中产生的 CD226 Human Recombinant 是单条糖基化多肽链，包含 471 个氨基酸，分子量为 53.2kDa。

  • Description

  • CD226 Human, Sf9

  • CD226 Human Recombinant, Sf9
  • PRO-2371

Catalogue number

PRO-2371

Synonyms

CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226 Molecule, CD226 Antigen, DNAX Accessory Molecule 1, DNAM-1, DNAM1, T Lineage-Specific Activation Antigen 1 Antigen, Platelet And T Cell Activation Antigen 1, DNAX Accessory Molecule-1, Adhesion Glycoprotein, TLiSA1, PTA1.

Introduction

CD226 belongs to the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 is a 65kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. CD226 facilitates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. CD226 also plays a role in megakaryocytic cell maturation.
CD226 属于 Ig 超家族，包含 V 组的 2 个 Ig 样结构域。 CD226 是一种 65kDa 糖蛋白，在 NK 细胞、血小板、单核细胞和 T 细胞亚群表面表达。 CD226 促进血小板和巨核细胞与血管内皮细胞的细胞粘附。 CD226 还在巨核细胞成熟中起作用。

Description

CD226 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 471 amino acids and having a molecular mass of 53.2kDa .

CD226 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD226 Human Recombinant 是单条糖基化多肽链，包含 471 个氨基酸，分子量为 53.2kDa。

CD226 在 C 末端与 239 个氨基酸的 hIgG-His-tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD226 protein solution containing Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

ADPEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD226 Human

ProSpec-LIX Mouse CHM-031,LIX 小鼠重组 CHM-031

ProSpec-LIX Mouse CHM-031,LIX 小鼠重组 CHM-031,在嗜酸性粒细胞中也观察到了 CXCL5 的表达，并且可以被 II 型 IFN 抑制。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。

  • LIX Mouse

  • LIX Mouse Recombinant
  • CHM-031

Catalogue number

CHM-031

Synonyms

C-X-C motif chemokine 5, Small-inducible cytokine B5, Cytokine LIX, Cxcl5, Scyb5, LIX, GCP-2, Scyb6, ENA-78, AMCF-II.

Introduction

趋化因子配体 5 是一种小细胞因子，属于 CXC 趋化因子家族，也称为上皮衍生的中性粒细胞激活肽 78。 它是在用炎性细胞因子 IL-1 或肿瘤坏死因子-α 刺激细胞后产生的。 在嗜酸性粒细胞中也观察到了 CXCL5 的表达，并且可以被 II 型 IFN 抑制。 这种趋化因子刺激嗜中性粒细胞的趋化性，具有血管生成特性。 它通过与细胞表面趋化因子受体 CXCR2 相互作用引发这些效应。 CXCL5 基因在四个外显子上编码，位于人类第 4 号染色体上，与其他几个 CXC 趋化因子基因一起。 CXCL5 与结缔组织重塑有关。

Description

LIX Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8kDa.
The LIX Mouse is expressed with 4 additional amino acids [VIAA] at n-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

LIX Mouse is lyophilized from a 0.2µm filtered solution in PBS.

Solubility

It is recommended to reconstitute the lyophilized LIX Mouse in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized LIX Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by -PAGE.

Amino acid sequence

VIAATELRCV CLTVTPKINP KLIANLEVIP AGPQCPTVEV IAKLKNQKEV CLDPEAPVIK KIIQKILGSD KKKA.

Biological Activity

The ED50, as measured by its ability to chemoattract human CXCR2-transfected mouse BaF3 cells, is less than 0.1µg/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • ENA 78 Human
  • ENA 78 Rat
  • ENA 78 Human
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ProSpec,CD244 Human,CD244 人重组PRO-1173

ProSpec,CD244 Human,CD244 人重组PRO-1173,ProSpec,CD244 Human,CD244 人重组PRO-1173,NK 细胞和靶细胞通过 CD244 受体的相互作用被认为可以调节 NK 细胞的溶细胞活性。

  • CD244 Human

  • CD244 Human Recombinant
  • PRO-1173

Catalogue number

PRO-1173

Synonyms

Natural killer cell receptor 2B4, NK cell activation-inducing ligand, NAIL, NK cell type I receptor protein 2B4, NKR2B4, h2B4, CD244, 2B4, Nmrk, SLAMF4.

Introduction

Cluster of Differentiation 244 contains 2 Ig-like domains. CD244 is a cell surface receptor expressed on natural killer cells which mediate non-major histocompatibility complex restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis, and have a role in the pathophysiology of allergic rhinitis .
分化簇244包含2个Ig样结构域。 CD244 是一种在自然杀伤细胞上表达的细胞表面受体，可介导非主要组织相容性复合物限制性杀伤。 NK 细胞和靶细胞通过 CD244 受体的相互作用被认为可以调节 NK 细胞的溶细胞活性。 CD244分子在嗜酸性粒细胞粘附和趋化中起作用，并且在变应性鼻炎的病理生理学中起作用。

Description

CD244 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 230 amino acids and having a molecular mass of 25.5kDa.
CD244 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD244 protein solution containing 20mM Tris-HCl buffer, pH8.0 and 0.4M Urea.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSHGKGCQG SADHVVSISG VPLQLQPNSI QTKVDSIAWK KLLPSQNGFH HILKWENGSL PSNTSNDRFS FIVKNLSLLI KAAQQQDSGL YCLEVTSISG KVQTATFQVF VFDKVEKPRL QGQGKILDRG RCQVALSCLV SRDGNVSYAW YRGSKLIQTA GNLTYLDEEV DINGTHTYTC NVSNPVSWES HTLNLTQDCQ NAHQEFRFWP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD244 Human, Sf9

ProSpec-Eotaxin 2 Human CHM-238,Eotaxin-2 人重组体

ProSpec-Eotaxin 2 Human CHM-238,Eotaxin-2 人重组体,Eotaxin-2，也称为 MPIF2 和 Ckb6，是一种由活化的单核细胞和 T 淋巴细胞产生的新型 CC 趋化因子。

  • Eotaxin 2 Human

  • Eotaxin-2 Human Recombinant
  • CHM-238

Catalogue number

CHM-238

Synonyms

C-C motif chemokine 24, Small-inducible cytokine A24, Myeloid progenitor inhibitory factor 2, CK-beta-6, Eosinophil chemotactic protein 2, Eotaxin-2, CCL24, Ckb-6, MPIF2, MPIF-2, SCYA24, Eotaxin2, CCL-24.

Introduction

Eotaxin-2，也称为 MPIF2 和 Ckb6，是一种由活化的单核细胞和 T 淋巴细胞产生的新型 CC 趋化因子。 Eotaxin-2 选择性地趋化表达 CCR3 的细胞，包括嗜酸性粒细胞、嗜碱性粒细胞、Th2 T 细胞、肥大细胞和某些树突状细胞亚群。 此外，Eotaxin-2 抑制多能造血祖细胞的增殖。 包含 C 末端截短的成熟蛋白质包含 78 个氨基酸。
CCL24 用作静息 t 淋巴细胞和嗜酸性粒细胞的趋化因子。 CCL24 对中性粒细胞具有较低的趋化活性，但对单核细胞和活化的淋巴细胞则没有。 CCL24 是多能造血祖细胞系形成集落的强抑制因子，并与 CCR3 结合。

Description

CCL24 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 78 amino acids and having a molecular mass of 8.8 kDa.
The CCL24 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CCL24 protein was lyophilized from a concentrated sterile solution containing 20mM PBS pH-7.4 and 0.15M sodium chloride.

Solubility

It is recommended to reconstitute the lyophilized CCL24 Human Recombinant in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Eotaxin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL24 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKGGVIFTTKKGQQFCG
DPKQEWV QRYMKNLDAKQKKASPRARAVA.

Biological Activity

The activity is determined by the chemoattract of human PBE at a concentration between 50-100 ng/ml corresponding to a Specific Activity of 10,000-20,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin 2 Rat
  • Eotaxin 2 Mouse
  • Eotaxin 2 Antibody

ProSpec-CD244 Human Sf9,CD244 人重组体Sf9 PRO-2413

在 Sf9 昆虫细胞中产生的 CD244 Human Recombinant 是单条糖基化多肽链，包含 448 个氨基酸，分子量为 50.2kDa。ProSpec-CD244 Human Sf9,CD244 人重组体Sf9 PRO-2413

  • CD244 Human, Sf9

  • CD244 Human Recombinant, Sf9
  • PRO-2413

Catalogue number

PRO-2413

Synonyms

Natural killer cell receptor 2B4, NK cell activation-inducing ligand, NAIL, NK cell type I receptor protein 2B4, NKR2B4, h2B4, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2B4.

Introduction

Cluster of Differentiation 244 contains 2 Ig-like domains. CD244 is a cell surface receptor expressed on natural killer cells which mediate non-major histocompatibility complex restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis, and have a role in the pathophysiology of allergic rhinitis .

分化簇244包含2个Ig样结构域。 CD244 是一种在自然杀伤细胞上表达的细胞表面受体，可介导非主要组织相容性复合物限制性杀伤。 NK 细胞和靶细胞通过 CD244 受体的相互作用被认为可以调节 NK 细胞的溶细胞活性。 CD244分子在嗜酸性粒细胞粘附和趋化中起作用，并且在变应性鼻炎的病理生理学中起作用。

Description

CD244 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 448 amino acids and having a molecular mass of 50.2kDa . CD244 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 昆虫细胞中产生的 CD244 Human Recombinant 是单条糖基化多肽链，包含 448 个氨基酸，分子量为 50.2kDa。 CD244 在 C 末端用 239 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Insect cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD244 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

ADLGKGCQGS ADHVVSISGV PLQLQPNSIQ TKVDSIAWKK LLPSQNGFHH ILKWENGSLP SNTSNDRFSF IVKNLSLLIK AAQQQDSGLY CLEVTSISGK VQTATFQVFV FDKVEKPRLQ GQGKILDRGR CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN VSNPVSWESH TLNLTQDCQN AHQEFRFWPL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD244 Human

ProSpec-Eotaxin 2 Mouse,Eotaxin-2 小鼠重组CHM-368

Eotaxin-2，也称为 MPIF2 和 Ckb6，是一种由活化的单核细胞和 T 淋巴细胞产生的新型 CC 趋化因子。ProSpec-Eotaxin 2 Mouse,Eotaxin-2 小鼠重组CHM-368

  • Eotaxin 2 Mouse

  • Eotaxin-2 Mouse Recombinant
  • CHM-368

Catalogue number

CHM-368

Synonyms

C-C motif chemokine 24, Small-inducible cytokine A24, Myeloid progenitor inhibitory factor 2, CK-beta-6, Eosinophil chemotactic protein 2, Eotaxin-2, CCL24, Ckb-6, MPIF2, MPIF-2, SCYA24, Eotaxin2, CCL-24.

Introduction

Eotaxin-2，也称为 MPIF2 和 Ckb6，是一种由活化的单核细胞和 T 淋巴细胞产生的新型 CC 趋化因子。 Eotaxin-2 选择性地趋化表达 CCR3 的细胞，包括嗜酸性粒细胞、嗜碱性粒细胞、Th2 T 细胞、肥大细胞和某些树突状细胞亚群。 此外，Eotaxin-2 抑制多能造血祖细胞的增殖。 包含 C 末端截短的成熟蛋白质包含 78 个氨基酸。
CCL24 用作静息 t 淋巴细胞和嗜酸性粒细胞的趋化因子。 CCL24 对中性粒细胞具有较低的趋化活性，但对单核细胞和活化的淋巴细胞则没有。 CCL24 是多能造血祖细胞系形成集落的强抑制因子，并与 CCR3 结合。

Description

CCL24 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of 10.3 kDa.
The CCL24 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The CCL24 protein was lyophilized from a concentrated sterile solution containing 20mM Phosphate buffer pH-7.4 and 0.15M sodium chloride.

Solubility

It is recommended to reconstitute the lyophilized CCL24 Mouse Recombinant in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Eotaxin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL24 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Purity

Greater than 97.0% as determined by: Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV.

Biological Activity

Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Eotaxin 2 Human
  • Eotaxin 2 Rat
  • Eotaxin 2 Antibody