分类： 无荧光叠氮化物 Non-fluorescent azides

Iodo-PEG3-Azide

Iodo-PEG3-Azide,Iodo-PEG3-Azide 含有一个高反应性的碘化物官能团，可以烷基化各种 C-、O-、N-、S-中心和其他亲核试剂。

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  • Iodo-PEG3-Azide

Iodo-PEG3-Azide

标签：Azides, PEG3 (triethylene glycol), Halogenides, Iodides
货号 规格 价格 货期
2163-1g 1 g 290.00$ in stock
2163-5g 5 g 590.00$ in stock
2163-25g 25 g 2490.00$ in stock

Iodo-PEG3-Azide contains a highly reactive iodide functional group which can alkylate a variety of C-, O-, N-, S-centered and other nucleophiles.

Organic iodides are roughly an order of magnitude more active than bromides, and four orders of magnitude more active than chlorides in SN2 reactions. This means that the same alkylation will take 10x less time with iodide than with bromide. Therefore, this molecule helps to effect very fast alkylation.

PEG3 is a moderately long hydrophilic linker. The azide group participates in Click chemistry reactions. It is also easily reduced to an amine group.

Iodo-PEG3-Azide 含有一个高反应性的碘化物官能团，可以烷基化各种 C-、O-、N-、S-中心和其他亲核试剂。

在 SN2 反应中，有机碘化物的活性大约比溴化物高一个数量级，比氯化物高四个数量级。 这意味着使用碘化物进行相同的烷基化反应所需的时间比使用溴化物的时间少 10 倍。 因此，这种分子有助于实现非常快速的烷基化。

PEG3 是中等长度的亲水接头。 叠氮基参与点击化学反应。 它也很容易被还原为胺基。

Iodo-PEG3-Azide相关产品

Sulfo-Cyanine5 tetrazine

Water soluble Cyanine dye tetrazine derivative for TCO ligation with trans-cyclooctenes and other strained olefines.

水溶性花青染料四嗪衍生物，用于与反式环辛烯和其他应变烯烃的 TCO 连接。

PEG3-tetrazine

PEG3 tetrazine is a mono-reactive triethyleneglycol with a tetrazine group for ied-DA conjugation with strained olefins.

PEG3 四嗪是一种具有四嗪基团的单反应性三甘醇，用于与应变烯烃的 ied-DA 缀合。

Iodo-PEG3-Acid

A bifunctional compound containing carboxylic acid functional group, and iodide, an active halogen group.

一种含有羧酸官能团和碘化物、活性卤素基团的双官能化合物。

General properties

Appearance: colorless to yellow oil 无色至黄色油状物
Molecular weight: 285.08
CAS number: 1309457-01-9
Molecular formula: C6H12N3IO2
IUPAC name: 1-(2-azidoethoxy)-2-(2-iodoethoxy)ethane
Solubility: soluble in water, polar organic solvents
Quality control: NMR 1H, GC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.

储存：收到后 24 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 干燥。
MSDS: Download
Product specifications

Chloro-PEG3-Azide

Chloro-PEG3-Azide,Chloro-PEG3-Azide 是一种异双功能接头，带有用于烷基化各种亲核基团的反应性氯化物。 由于氧的非嵌合辅助，该原子比正常的烷基氯化物更具反应性。 另一个反应基团是叠氮化物。 它可以通过点击化学结合，或还原为胺基，然后与反应性羰基化合物进行酰化。

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  • Chloro-PEG3-Azide

Chloro-PEG3-Azide

标签：Azides, PEG3 (triethylene glycol), Halogenides
货号 规格 价格 货期
2106-1g 1 g 490.00$ 21 days

Chloro-PEG3-Azide is a heterobifunctional linker bearing a reactive chloride for the alkylation of various nucleophilic groups. Due to anchimeric assistance from oxygen, this atom is more reactive than in normal alkyl chlorides. The other reactive group is azide. It can be conjugated via Click chemistry, or reduced to amine group to be later acylated with reactive carbonyl compounds.

PEG3 is a versatile hydrophilic linker for bioconjugation.

Chloro-PEG3-Azide 是一种异双功能接头，带有用于烷基化各种亲核基团的反应性氯化物。 由于氧的非嵌合辅助，该原子比正常的烷基氯化物更具反应性。 另一个反应基团是叠氮化物。 它可以通过点击化学结合，或还原为胺基，然后与反应性羰基化合物进行酰化。

PEG3 是用于生物偶联的多功能亲水接头。

Chloro-PEG3-Azide相关产品

Azide-PEG3-Amine

A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)

具有叠氮化物和胺基的双功能接头，位于 PEG3（三甘醇）的两侧

Iodo-PEG3-Iodide

Homobifunctional PEG3 based linker with halogen reactive groups is useful for the crosslinking of nucleophiles.

具有卤素反应基团的基于同双功能 PEG3 的接头可用于亲核试剂的交联。

Alkyne-PEG3-OH

Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.

Alkyne-PEG3-OH 是一种基于三甘醇的双功能接头，具有羟基和炔烃片段。

General properties

Appearance: colorless oil 无色油
Molecular weight: 193.63
Molecular formula: C6H12N3ClO2
IUPAC name: 1-(2-Azidoethoxy)-2-(2-chloroethoxy)ethane
Quality control: NMR 1H, GC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

储存：收到后 24 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。
MSDS: Download
Product specifications

Biotin-PEG3-Azide

Biotin-PEG3-Azide,生物素叠氮化物是与叠氮基共价结合的生物素（维生素 H）的衍生物。 该试剂允许用生物素标记各种炔基化分子（如 DNA、寡核苷酸和蛋白质）。 与亲和素或链霉亲和素结合的生物素可用于下游亲和应用，以分离生物素化分子或它们与链霉亲和素缀合物的结合。

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  • Biotin-PEG3-Azide

Biotin-PEG3-Azide

标签：Azides, PEG3 (triethylene glycol)
货号 规格 价格 货期
C3730 10 mg 40.00$ in stock
D3730 25 mg 90.00$ in stock
E3730 50 mg 140.00$ in stock
F3730 100 mg 180.00$ in stock

Biotin azide is a derivative of biotin (vitamin H) covalently bound with azide group. This reagent allows labeling of various alkynylated molecules (such as DNA, oligonucleotides, and proteins) with biotin. Biotin binding to avidin or streptavidin can be used in downstream affinity applications for the isolation of biotinylated molecules or their binding with streptavidin conjugates.

This structure of biotin azide features long hydrophilic linker which separates biotin residue from the target molecule for efficient binding with streptavidin. Its linker (PEG) also enhances aqueous solubility to facilitate conjugation.

The azide can be conjugated with various molecules using our recommended protocol.

生物素叠氮化物是与叠氮基共价结合的生物素（维生素 H）的衍生物。 该试剂允许用生物素标记各种炔基化分子（如 DNA、寡核苷酸和蛋白质）。 与亲和素或链霉亲和素结合的生物素可用于下游亲和应用，以分离生物素化分子或它们与链霉亲和素缀合物的结合。

生物素叠氮化物的这种结构具有长的亲水性接头，可将生物素残基与靶分子分开，从而与链霉亲和素有效结合。 它的接头 (PEG) 还增强了水溶性以促进结合。

使用我们推荐的方案，叠氮化物可以与各种分子结合。

Biotin-PEG3-Azide相关产品

Cyanine3 NHS ester

Amine-reactive Cyanine3 dye NHS ester.

胺反应性 Cy3 染料 NHS 酯。

PEP azide

PEP (phenylethynylpyrene), polyaromatic hydrocarbon fluorescent dye for Click-Chemistry labeling.

PEP（苯乙炔基芘），用于 Click-Chemistry 标记的多环芳烃荧光染料。

Cyanine3.5 azide

Cyanine3.5 azide for biomolecule labeling through Click Chemistry.

通过 Click Chemistry 用于生物分子标记的 Cy3.5 叠氮化物。

General properties

Appearance: colorless solid 无色固体
Molecular weight: 400.50
CAS number: 945633-30-7
Molecular formula: C16H28N6O4S
Solubility: soluble in DMF, DMSO, moderately soluble in water
Quality control: NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks.

储存：-20°C 收货后 24 个月。 运输：在室温下长达 3 周。
MSDS: Download
Product specifications

相关文献：

  1. Dettling, S.E.; Ahmadi, M.; Lin, Z.; He, L.; Matthews, M.L. Discovery of Electrophiles and Profiling of Enzyme Cofactors. Current Protocols in Chemical Biology, 2020, 12(4), e86. doi: 10.1002/cpch.86
  2. Wang, Y.; Dattmore, D.A.; Wang, W:; Pohnert, G.; Wolfram, S.; Zhang, J.; Yang, R.; Decker, E.A.; Lee, K.S.S.; Zhang, G. trans, trans-2,4-decadienal, a lipid peroxidation product, induces inflammatory responses via Hsp90- or 14–3-3ζ-dependent mechanisms. Journal of Nutritional Biochemistry, 2020, 76, 108286. doi: 10.1016/j.jnutbio.2019.108286
  3. Shen, Y.; Yang, S.; Hu, X.; Zhang, M.; Ma, X.; Wang, Z.; Hou, Y.; Bai, G. Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells. Journal of Functional Foods, 2019, 55, 296–304. doi: 10.1016/j.jff.2019.02.035
  4. Wang, E.; Hunter, C.P. SID-1 Functions in Multiple Roles To Support Parental RNAi in Caenorhabditis elegans. Genetics, 2017, 207(2), 547–557. doi: 10.1534/genetics.117.300067

Azidobutyric acid NHS ester

Azidobutyric acid NHS ester,使用该试剂将您的蛋白质和肽转化为 Click Chemistry 反应形式。

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  • Azidobutyric acid NHS ester

Azidobutyric acid NHS ester

标签：NHS esters, Protein labeling, Cross linking reagents
货号 规格 价格 货期
53720 50 mg 60.00$ in stock
63720 100 mg 95.00$ in stock
73720 1 g please inquire in stock
83720 5 g please inquire in stock

Convert your proteins and peptides into Click Chemistry reactive form with this reagent.

While Click Chemistry involves reaction between terminal alkyne and azide, both azides and alkynes are very uncommon in nature. However, there are reagents to attach these fragments to abundant amino groups which are ubiquitous in the world of biomolecules. This azido-NHS ester is designed for the conversion of proteins, peptides, amino-DNA, and other amines into Click Chemistry reactive azides.

使用该试剂将您的蛋白质和肽转化为 Click Chemistry 反应形式。

虽然 Click Chemistry 涉及末端炔烃和叠氮化物之间的反应，但叠氮化物和炔烃在自然界中都非常罕见。 然而，有一些试剂可以将这些片段连接到丰富的氨基上，这些氨基在生物分子的世界中无处不在。 这种叠氮基-NHS 酯设计用于将蛋白质、肽、氨基-DNA 和其他胺转化为 Click Chemistry 反应性叠氮化物。

Azidobutyric acid NHS ester相关产品

Cyanine7 carboxylic acid

Non-reactive, near-infrared fluorescent dye.

非反应性近红外荧光染料。

TAMRA azide, 5-isomer

TAMRA fluorescent dye azide for Click chemistry.

用于点击化学的 TAMRA 荧光染料叠氮化物。

Cyanine5 azide

Cyanine5 azide is a reagent for Click Chemistry labeling with Cyanine5, a popular fluorescent dye.

Cy5 azide 是一种用 Cy5（一种流行的荧光染料）进行 Click Chemistry 标记的试剂。

General properties

Appearance: colorless solid 无色固体
Mass spec M+ increment: 111.0
Molecular weight: 226.19
CAS number: 943858-70-6
Molecular formula: C8H10N4O4
IUPAC name: Butanoic acid, 4-​azido-​, 2,​5-​dioxo-​1-​pyrrolidinyl ester
Solubility: soluble in organic solvents (DMF, DMSO)
Quality control: NMR 1H (95%), HPLC
Storage conditions: Storage: 12 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.

储存：-20°C 收货后 12 个月。 运输：在室温下长达 3 周。 干燥。
MSDS: Download
Product specifications

相关文献：

  1. Wang, Y.; Yao, J.; Cai, L.; Liu, T.; Wang, X.; Zhang, Y.; Zhou, Z.; Li, T.; Liu, M.; Lai, R.; Liu, X. Bone-targeted extracellular vesicles from mesenchymal stem cells for osteoporosis therapy. Research Square, preprint. doi: 10.21203/rs.3.rs-18279/v1
  2. Kleinpenning, F.; Steigenberger, B.; Wu, W.; Heck, A.J.R. Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications, 2020, 11, 3244. doi: 10.1038/s41467-020-17010-0
  3. Blanchard, A.T.; Bazrafshan, A.S.; Yi, J.; Eisman, J.T.; Yehl, K.M.; Bian, T.; Mugler, A.; Salaita, K. Highly Polyvalent DNA Motors Generate 100+ pN of Force via Autochemophoresis. Nano Letters, 2019, 19(10), 6977–6986. doi: 10.1021/acs.nanolett.9b02311
  4. Hou, W.; Li, Y.; Kang, W.; Wang, X.; Wu, X.; Wang, S.; Liu, F. Real-time analysis of quantum dot labeled single porcine epidemic diarrhea virus moving along the microtubules using single particle tracking. Scientific Reports, 2019, 9, 1307. doi: 10.1038/s41598-018-37789-9

AmdU (5-azidomethyl-2′-deoxyuridine)

AmdU (5-azidomethyl-2′-deoxyuridine),叠氮甲基-dU (AmdU) 是一种含有叠氮基的核苷。 核苷的结构类似于胸苷，它通过细胞聚合酶掺入新生DNA中，类似于EdU。

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  • AmdU (5-azidomethyl-2′-deoxyuridine)

AmdU (5-azidomethyl-2′-deoxyuridine)

标签：Azides, Copper free Click chemistry
货号 规格 价格 货期
B1540 5 mg 120.00$ in stock
D1540 25 mg 255.00$ in stock
F1540 100 mg 890.00$ in stock</td

Azidomethyl-dU (AmdU) is a nucleoside that contains an azide group. The structure of the nucleoside is similar to thymidine, and it is incorporated into nascent DNA by cellular polymerases, similarly to EdU.

Unlike EdU that needs to be further modified with azides in the presence of copper catalyst, AmdU can also react in the absence of copper catalyst using spAAC Click Chemistry with strained cycloalkynes, such as cyclooctynes. This enables detection of nascent DNA in benign, copper free conditions.

叠氮甲基-dU (AmdU) 是一种含有叠氮基的核苷。 核苷的结构类似于胸苷，它通过细胞聚合酶掺入新生DNA中，类似于EdU。

与需要在铜催化剂存在下用叠氮化物进一步改性的 EdU 不同，AmdU 也可以在没有铜催化剂的情况下使用 spAAC Click Chemistry 与应变的环炔烃（例如环辛炔）发生反应。 这使得在良性、无铜条件下检测新生 DNA 成为可能。

AmdU (5-azidomethyl-2′-deoxyuridine)相关产品

Sulfo-Cyanine3 alkyne

A water soluble dye alkyne for copper-catalyzed Click Chemistry. The fluorophore Sulfo-Cyanine3 is a bright and photostable dye for the Cy3® channel.

一种用于铜催化点击化学的水溶性染料炔烃。 荧光团 Sulfo-Cy3 是一种用于 Cy3® 通道的明亮且光稳定的染料。

Cyanine3.5 NHS ester

Cyanine3.5 dye NHS ester derivative.

Cy3.5染料NHS酯衍生物。

AF488 azide

AF488 azide is a fluorophore with emission in the green spectrum range. It reacts with alkynes in copper-catalyzed cycloaddition reactions.

AF488 azide 是一种在绿色光谱范围内发射的荧光团。 它在铜催化的环加成反应中与炔烃反应。

General properties

Appearance: white / off white solid 白色/米白色固体
Molecular weight: 283.24
Molecular formula: C10H13N5O5
IUPAC name: 5-Azidomethyl-2′-deoxyuridine
Solubility: good in water, alcohols, DMSO, DMF
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

储存：收到后 24 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。
MSDS: Download
Product specifications