BDP 650/665 is a bright red emitting borondipyrromethene dye, compatible with Cy5 channel found on many instruments. This is azide derivative of BDP 650/665. It can be conjugated with terminal alkynes via copper catalyzed reaction, or with cycloalkynes via copper-free Click chemistry.
BDP 650/665 azide can be conjugated with various terminal alkynes using copper-catalyzed Click chemistry, or with cycloalkynes using a copper-free reaction.
Cy5.5 maleimide is a thiol reactive dye for protein labeling.
Cy5.5 马来酰亚胺是一种用于蛋白质标记的硫醇活性染料。
TAMRA azide, 5-isomer
TAMRA fluorescent dye azide for Click chemistry.
用于点击化学的 TAMRA 荧光染料叠氮化物。
BDP 630/650 maleimide
BDP 630/650 maleimide is a thiol reactive, borondipyrromethene based dye tuned to match the far red channel of Cyanine5 fluorophore.
BDP 630/650 马来酰亚胺是一种硫醇反应性、基于硼二吡咯亚甲基的染料，经过调整以匹配 Cyanine5 荧光团的远红通道。
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP 581/591 is a bright and versatile fluorophore that is relatively hydrophobic. It has a high brightness, significant two photon cross-section, and relatively long fluorescence lifetime.
The dye reacts with reactive oxygen species (ROS) with the change of its fluorescence. It can be therefore used for intracellular monitoring of ROS.
This is an azide derivative that can be used for the conjugation with both small molecules and biomolecules to construct tracers for fluorescence polarization assays and microscopy probes.
Alkyne dye for copper catalyzed Click chemistry, containing borondipyrromethene fluorophore BDP 630/650 for red channel.
用于铜催化点击化学的炔烃染料，含有用于红色通道的硼二吡咯亚甲基荧光团 BDP 630/650。
BDP 581/591 NHS ester
NHS ester derivative of BDP 581/591 borondipyrromethene fluorophore for the labeling of proteins, peptides, and other biomolecules. The dye is useful for fluorescence polarization and two-photon experiments, and as a ROS probe.
Amine reactive NHS ester of near infrared dye Cy7.
近红外染料 Cy7 的胺活性 NHS 酯。
General properties
Appearance:
dark solid
Molecular weight:
474.31
Molecular formula:
C25H25N6BF2O
Solubility:
good in DCM, alcohols, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP 558/568 azide is a borondipyrromethene dye with azide functional group for Click chemistry. Its spectra are close to Cyanine3 channel. The fluorophore has been used for lipid tracking as BDP 558/568 C12, but azide functional groups allow easy conjugation with a wide variety of other molecules of interest.
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基反应性 BDP FL，一种非常明亮且光稳定的荧光素通道染料。
Cyanine3 azide
Azide derivative of Cyanine3 fluorescent dye for Click Chemistry.
用于 Click Chemistry 的 Cy3 荧光染料的叠氮化物衍生物。
General properties
Appearance:
dark colored solid 深色固体
Mass spec M+ increment:
428.1
Molecular weight:
428.27
Molecular formula:
C19H19N6BF2OS
Solubility:
soluble in many organic solvents (DCM, acetone, alcohols, DMF, DMSO), low solubility in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
AF568 is a fluorescent dye. Its excitation peak is at 572 nm and its emission peak at 598 nm. AF568 azide is a photochemically stable, specific, and highly efficient tool for labeling biomolecules. It is water soluble and insensitive to pH changes between pH 4 and pH 10. The reaction conditions do not require high temperature or pressure.
Labeling with AF568 azide via Click Chemistry is a powerful technique for the production of bioconjugates. Thus, AF568 azide is an excellent tool for imaging purposes, including fluorescent microscopy and flow cytometry, where label brightness and photostability are essential.
AF488 NHS ester, a bright, photostable and hydrophilic fluorescent dye for green channel.
AF488 NHS 酯，一种用于绿色通道的明亮、光稳定性和亲水性荧光染料。
AF568 carboxylic acid
Non-reactive form of AF568 fluorescent dye
AF568 荧光染料的非反应性形式
AF488 azide
AF488 azide is a fluorophore with emission in the green spectrum range. It reacts with alkynes in copper-catalyzed cycloaddition reactions.
AF488 azide 是一种在绿色光谱范围内发射的荧光团。 它在铜催化的环加成反应中与炔烃反应。
General properties
Appearance:
dark colored solid
Mass spec M+ increment:
776.2
Molecular weight:
853.02
Molecular formula:
C36H34N6K2O10S2
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
AF488 is a fluorescent dye. AF488 is a fluorophore pH-insensitive over a broad pH range (from 4 to 10). It has an absorption maximum at 495 nm and an emission maximum at 519 nm in the green spectrum region. The dye is hydrophilic and can be used to introduce the fluorescent label into various molecules, including proteins and antibodies. Conjugates of molecules with AF488 have high brightness and photostability and are commonly used in flow cytometry and microscopy. This allows the detection of biological objects with high sensitivity at a longer imaging time.
AF488 azide interacts with alkynyl derivatives of biomolecules in Click Chemistry reactions either in the presence of copper (I) catalyst (with terminal alkynes) or without catalyst (with cyclooctynes), leading to the formation of stable adducts.
BDP R6G tetrazine is a borondipyrromethene dye with absorption and emission wavelengths similar to rhodamine 6G. It contains tetrazine fragment for iedDA ligation.
BDP R6G 四嗪是一种硼二吡咯亚甲基染料，其吸收和发射波长与罗丹明 6G 相似。 它包含用于 iedDA 连接的四嗪片段。
Amino-11-UTP
Uridine triphosphate labeled with amino group intended for indirect non-radioactive enzymatic RNA labeling.
用氨基标记的三磷酸尿苷，用于间接非放射性酶促 RNA 标记。
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.储存：收到后 24 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。
AF430 is a fluorescent dye. It can be excited by 405 nm violet laser or 445 nm laser paired, for example, with 510/80 nm bandpass filter.
Azide moiety allows quick and effective labeling and detection of terminal alkynes via a copper-catalyzed click reaction (CuAAC) or of strained cyclooctynes via a copper-free click chemistry reaction. Mild reaction conditions are suitable for most biomolecules, cells, and tissues. The product is water soluble and insensitive to pH changes between pH 4 and pH 10.
AF568 derivative for labeling proteins and other high- and low-molecular weight ligands with free amines.
AF568 衍生物，用于用游离胺标记蛋白质和其他高分子量和低分子量配体。
AF430 maleimide
AF430 is a green-yellow emitting fluorescent dye of coumarin series. This maleimide derivative allows to label thiolated biomolecules.
AF430是香豆素系列的绿-黄发光荧光染料。 这种马来酰亚胺衍生物可以标记硫醇化的生物分子。
AF430 carboxylic acid
Non-reactive form of AF430 fluorescent dye to be used as a reference standard
AF430 荧光染料的非反应性形式用作参考标准
General properties
Appearance:
yellow solid
Molecular weight:
623.69
Molecular formula:
C25H29N5F3KO6S
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
TAMRA (tetramethylrhodamine) is a xanthene dye of rhodamine series. This fluorophore is being used for quite a long time for the preparation of dual labeled qPCR TaqMan oligonucleotide probes containing TAMRA and fluorescein (FAM).
Just like many other xanthene fluorophores, TAMRA is a available as two isomers (5- and 6-isomer) which have nearly identical optical properties. This product is an isomerically pure 5-TAMRA.
TAMRA NHS is an amine reactive reagent. It can be used for the labeling of proteins, peptides, and modified oligonucleotides containing amine groups.
Storage: 12 months after receipt at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：NHS esters Near infrared (NIR) imaging sulfo-Cyanine7.5 Protein labeling
货号
规格
价格
货期
N6320
1 rxn
–
in stock
16320
1 mg
110.00$
in stock
26320
5 mg
290.00$
in stock
46320
25 mg
690.00$
in stock
56320
50 mg
1190.00$
in stock
66320
100 mg
1850.00$
in stock
Sulfo-Cyanine7.5 is a near infrared water soluble and hydrophilic dye for the NIR imaging applications. The structure and spectra of the dye resemble indocyanine green (ICG) that has been approved for use in humans for years. However, unlike ICG, sulfo-Cyanine7.5 contains a trimethylene bridge that increases its quantum yield compared to ICG, and also has a linker arm for its attachment to proteins, peptides, and other molecules. This derivative is an NHS ester for the modification of amine groups.
Absorption and emission spectra of sulfo-Cyanine7.5
Sulfo-Cy7.5 NHS ester相关产品
BDP FL NHS ester
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基反应性 BDP FL，一种非常明亮且光稳定的荧光素通道染料。
Cy3 carboxylic acid
Free Cyanine3 carboxylic acid.
游离Cy3羧酸。
Sulfo-Cyanine7.5 dicarboxylic acid
Sulfo-Cy7.5 dicarboxylic acid is a bifunctional cyanine dye with two carboxylic acid (COOH) groups. The molecule can be used to construct cross conjugates containing a near infrared emitting fluorophore.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
González, M.I.; González-Arjona, M.; Santos-Coquillat, A.; Vaquero, J.; Vázquez-Ogando, E.; de Molina, A.; Peinado, H.; Desco, M.; Salinas, B. Covalently Labeled Fluorescent Exosomes for In Vitro and In Vivo Applications. Biomedicines, 2021, 9, 81. doi: 10.3390/biomedicines9010081
Park, B.G.; Kim, Y.J.; Min, J.H.; Cheong, T.-C.; Nam, S.H.; Cho, N.-H.; Kim, Y.K.; Lee, K.B. Assessment of Cellular Uptake Efficiency According to Multiple Inhibitors of Fe3O4-Au Core-Shell Nanoparticles: Possibility to Control Specific Endocytosis in Colorectal Cancer Cells. Nanoscale Research Letters, 2020, 15, 165. doi: 10.1186/s11671-020-03395-w
Ruiz, A.; Bravo, D.; Duarte, A.; Adler, R.S.; Raya, J.G. Accuracy of Ultrasound-Guided versus Landmark-Guided Intra-articular Injection for Rat Knee Joints. Ultrasound in Medicine and Biology, 2019, 45(10), 2787–2796. doi: 10.1016/j.ultrasmedbio.2019.06.403
Sulfo-Cyanine7 bis-NHS ester is a water-soluble, bifunctional cross-linker that contains a core of near infrared, water soluble dye sulfo-Cyanine7, and two amine-reactive NHS ester groups.
BDP 630/650 is a borondipyrromethene fluorophore tuned to Cyanine5 excitation and emission channels. The dye is bright and highly photostable. It is useful for fluorescence polarization assays This is an amine-reactive NHS ester derivative.
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Cyanine5.5 NHS ester
Cyanine5.5 NHS is far-red / near-infrared amine-reactive dye.
Cy5.5 NHS 是远红/近红外胺活性染料。
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Sulfo-Cy5.5 azide
Sulfo-Cyanine5.5 azide is a derivative of water soluble far red emitting fluorescent cyanine dye. The azide group can be conjugated by either copper-catalyzed or copper free Click chemistry. The reagent possesses high aqueous solubility and hydrophilicity, and recommended for the labeling of biomolecules in aqueous environment.
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General properties
Appearance:
dark colored solid
Molecular weight:
1041.23
Molecular formula:
C50H57N4KO14S2
Solubility:
good in DMF, DMSO, water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：sulfo-Cy7 NHS esters Near infrared (NIR) imaging Protein labeling
货号
规格
价格
货期
15320
1 mg
110.00$
in stock
25320
5 mg
290.00$
in stock
45320
25 mg
690.00$
in stock
55320
50 mg
1270.00$
in stock
65320
100 mg
1990.00$
in stock
Water soluble near infrared dye sulfo-Cy7, an amine-reactive succinimide ester.
Sulfo-Cy7 is an improved analog of Cy7® fluorophore with quantum yield improved by 20%, and higher photostability. This fluorescent dye is especially useful for NIR imaging.
Near infrared fluorescent imaging takes advantage of transparency of biological tissues at particular range of wavelengths. The method is non-destructive, and allows to monitor distribution of various labeled molecules in live organisms.
Sulfo-Cyanine7 NHS ester reagent allows to prepare sulfo-Cyanine7-labeled biomolecules, such as proteins, with ease. Dye labeled molecules can be subsequently used for various research and drug design related experiments.
This reagent has high water solubility, and is especially useful for the labeling of delicate proteins, and proteins prone to denaturation. Non-sulfonated Cy7 NHS ester soluble in organic phase is also available.
AF430 is a hydrophilic coumarin dye with the emission in green-yellow range. The NHS ester is used for the labeling of amine groups.
AF430 是一种亲水性香豆素染料，发射在黄绿色范围内。 NHS 酯用于标记胺基。
Cyanine5 alkyne
Cyanine5 alkyne is an alkyne dye for Click Chemistry.
Cy5 炔烃是一种用于 Click Chemistry 的炔烃染料。
Pico488 dsDNA quantification reagent, 200x solution in DMSO
Pico488 is a dye for precise fluorescence based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.
Pico488 是一种染料，用于在存在 RNA、ssDNA 和其他杂质的情况下对 dsDNA 进行基于荧光的精确定量。 该染料在荧光素通道中显示出明亮的荧光，在低 pg/mL 至高 ng/mL 范围内对 DNA 浓度提供线性响应。
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
González, L.F.; Acuña, E.; Arellano, G.; Morales, P.; Sotomayor, P.; Oyarzun-Ampuero, F.; Naves, R. Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy. Journal of Controlled Release, 2021, 331, 443–459. doi: 10.1016/j.jconrel.2020.11.019
Shapoval, O.; Oleksa, V.; Šlouf, M.; Lobaz, V.; Trhlíková, O.; Filipová, M.; Janoušková, O.; Engstová, H.; Pankrác, J.; Modrý, A.; Herynek, V.; Ježek, P.; Šefc, L.; Horák, D. Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic. Nanomaterials, 2021, 11(1), 230. doi: 10.3390/nano11010230
标签：NHS esters Near infrared (NIR) imaging Microscopy Protein labeling sulfo-Cy5.5
货号
规格
价格
货期
17320
1 mg
110.00$
in stock
27320
5 mg
290.00$
in stock
47320
25 mg
690.00$
in stock
57320
50 mg
1190.00$
5 days
67320
100 mg
1850.00$
in stock
Sulfo-Cyanine5.5 NHS ester is an amine reactive activated ester of sulfonated far red Cyanine5.5 fluorophore, an analog of Cy5.5®. This is a reagent of choice for the labeling of antibodies, sensitive proteins, and others which require reactions in purely aqueous environment, or without any significant additions of organic co-solvents.
The dye is well suitable for non-invasive in vivo NIR imaging, and for the applications requiring low fluorescent background.
Absorption and emission spectra of sulfo-Cyanine5.5 fluorophore
Sulfo-Cy5.5 NHS ester相关产品
Sulfo-Cyanine5 alkyne
Sulfo-Cyanine5 is a water-soluble Cyanine5 dye alkyne for Click chemistry.
Sulfo-Cyanine5 是一种用于 Click 化学的水溶性 Cyanine5 染料炔烃。
Cyanine7 azide
Near-infrared fluorescent dye for Click Chemistry.
用于点击化学的近红外荧光染料。
General properties
Appearance:
dark blue solid
Mass spec M+ increment:
884.15
Molecular weight:
1114.37
CAS number:
2419286-92-1
Molecular formula:
C44H42N3K3O16S4
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Liu, Q.; Tian, J.; Liu, J.; Zhu, M.; Gao, Z.; Hu, X.; Midgley, A.C.; Wu, J.; Wang, Xi.; Kong, D.; Zhuang, J.; Liu, J.; Yan, X.; Huang, X. Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages. Advanced Materials, 2021, 33(39), 2103128. doi: 10.1002/adma.202103128
Lu, Z.; Zhang, Y.; Wang, Y.; Tan, G.-H.; Huang, F.-Y.; Cao, R.; He, N.; Zhang, L. A biotin-avidin-system-based virus-mimicking nanovaccine for tumor immunotherapy. Journal of Controlled Release, 2021, 332, 245–259. doi: 10.1016/j.jconrel.2021.02.029
Shramova, E.; Proshkina, G.; Shipunova, V.; Ryabova, A.; Kamyshinsky, R.; Konevega, A.; Schulga, A.; Konovalova, E.; Telegin, G.; Deyev, S. Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape. Cancers, 2020, 12(10), 3014. doi: 10.3390/cancers12103014
Peplau, E.; De Rose, F.; Reder, S.; Mittelhaeuser, M.; Scafetta, G.; Schwaiger, M.; Weber, W.A.; Bartolazzi, A.; Skerra, A.; D’Alessandria, C. Development of a chimeric Fab directed against human galectin-3 and validation as an immune-PET tracer for the sensitive in vivo imaging of thyroid cancer. Thyroid, 2020, 30(9), 1314–1326. doi: 10.1089/thy.2019.0670
A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
具有叠氮化物和胺基的双功能接头，位于 PEG3（三甘醇）的两侧
General properties
Appearance:
dark blue powder
Molecular weight:
975.14
Molecular formula:
C45H51KN4O14S2
Solubility:
good in DMF, DMSO, water
Quality control:
NMR 1H, HPLC-MS (895%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：sulfo-Cyanine5 NHS esters Microscopy Protein labeling
货号
规格
价格
货期
13320
1 mg
110.00$
in stock
23320
5 mg
210.00$
in stock
43320
25 mg
410.00$
in stock
53320
50 mg
695.00$
in stock
63320
100 mg
1190.00$
in stock
Cyanine 5 succinimidyl ester (SE), an equivalent of Cy5® NHS ester, for the labeling of various amine-containing molecules in aqueous phase without use of any organic co-solvent. This product is therefore particularly useful for the labeling of proteins which denature in the presence of organic co-solvents, as well as for proteins with low solubility.
Sulfo-Cyanine 5 is an analog of Cy5®, one of the most popular fluorophores which is compatible with various equipment such as plate readers, microscopes, and imagers.
This dye is highly hydrophilic and water-soluble. A non-sulfonated analog is also available.
Can be used as a replacement for Cy5®, DyLight 649 for all applications.
sulfo-Cyanine7.5 is a highly hydrophilic near infrared dye for in vivo imaging. This maleimide derivative is useful for the labeling of thiol groups of proteins and peptides.
sulfo-Cyanine7.5 是一种高度亲水的近红外染料，用于体内成像。 这种马来酰亚胺衍生物可用于标记蛋白质和肽的硫醇基团。
sulfo-Cyanine5 DBCO
Water soluble cycloalkyne for copper free Click chemistry reaction with azides. A derivative of sulfo-Cyanine5 aka Cy5.
水溶性环炔烃，用于与叠氮化物的无铜点击化学反应。 磺基-Cyanine5 又名 Cy5 的衍生物。
Cyanine5.5 azide
Far red / near infrared fluorescent Cyanine5.5 dye derivative for Click Chemistry.
用于 Click Chemistry 的远红/近红外荧光 Cyanine5.5 染料衍生物。
General properties
Appearance:
dark blue powder
Molecular weight:
777.95
CAS number:
2230212-27-6; 146368-14-1 (N-Ethyl)
Molecular formula:
C36H40N3KO10S2
Solubility:
very good in water, good in DMF and DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Grohme, M.; Frank, O.; Rink, J. Preparing Planarian Cells for High-content Fluorescence Microscopy Using RNA in situ Hybridization and Immunocytochemistry. preprints.org, preprint. doi: 10.20944/preprints202111.0256.v1
van Hest, J.C.; Song, S.; Mason, A.; Post, R.; de Corato, M.; Mestre, R.; Yewdall, A.; Cao, S.; van der Hofstad, R.; Sanchez, S.; Abdelmohsen, L. Engineering transient dynamics of artificial cells by stochastic distribution of enzymes. ChemRxiv, preprint. doi: 10.33774/chemrxiv-2021-02c1d
Lee, M.S.; Hyun, H.; Park, I.; Kim, S.; Jang, D.-H.; Kim, S.; Im, J.-K.; Kim, H.; Lee, J.H.; Kwon, T.; Kang, J.H. Quantitative fluorescence in situ hybridization (FISH) of magnetically confined bacteria enables rapid determination of early-stage human bacteremia. medRxiv, preprint. doi: 10.1101/2021.02.19.21251962
Cyanine3.5 is a fluorescent dye with absorption and emission intermediate between Cyanine3 and Cyanine5. Sulfonated version contains four sulfo groups which ensure high solubility and hydrophilicity of the fluorophore and labeled conjugates.
The NHS ester reactive group allows to label primary and secondary amine groups.
Absorption and emission spectra of sulfo-Cyanine3.5
Sulfo-Cy3.5 NHS ester相关产品
Cyanine5 NHS ester
Amine-reactive Cyanine5 activated ester for the labeling of proteins, peptides, and other molecules.
胺反应性 Cyanine5 活化酯，用于标记蛋白质、肽和其他分子。
Sulfo-Cyanine3 NHS ester
Water soluble sulfo-Cyanine3 SE activated ester for amino-biomolecule labeling.
用于氨基生物分子标记的水溶性磺基-Cyanine3 SE 活化酯。
Pico488 dsDNA quantification reagent, 200x solution in DMSO
Pico488 is a dye for precise fluorescence based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.
Pico488 是一种染料，用于在存在 RNA、ssDNA 和其他杂质的情况下对 dsDNA 进行基于荧光的精确定量。 该染料在荧光素通道中显示出明亮的荧光，在低 pg/mL 至高 ng/mL 范围内对 DNA 浓度提供线性响应。
General properties
Appearance:
deep purple powder
Molecular weight:
1088.33
CAS number:
2231670-91-8 (without cation)
Molecular formula:
C42H40N3K3O16S4
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：NHS esters Microscopy Protein labeling sulfo-Cyanine3
货号
规格
价格
货期
11320
1 mg
110.00$
in stock
21320
5 mg
210.00$
in stock
41320
25 mg
410.00$
in stock
51320
50 mg
695.00$
in stock
61320
100 mg
1190.00$
in stock
Water soluble, amino-reactive sulfo-Cyanine3 NHS ester. Efficiently labels proteins and peptides in purely aqueous solution, without need for organic co-solvent. Ideal for proteins with low solubility, and proteins prone to denaturation.
This is sulfonated, hydrophilic and water-soluble dye. Non-sulfonated Cyanine3 NHS ester is also available.
This product is an analog of Cy3® NHS ester. Sulfo-Cyanine3 NHS ester replaces Cy3® and DyLight 549 for all applications.
BDP FL is a bright and photostable borondipyrromethene dye for fluorescein channel. This is a dye azide for Click Chemistry.
BDP FL 是一种用于荧光素通道的明亮且光稳定的硼二吡咯亚甲基染料。 这是一种用于 Click Chemistry 的染料叠氮化物。
Cyanine3 maleimide
Cyanine3 maleimide is a thiol mono reactive dye.
Cyanine3 马来酰亚胺是一种硫醇单活性染料。
BDP 630/650 tetrazine
BDP 630/650 is a borondipyrromethene dye for Cyanine5 channel. This is a tetrazine derivative for the coupling with strained cycloalkenes.
BDP 630/650 是用于 Cyanine5 通道的硼二吡咯亚甲基染料。 这是一种用于与应变环烯烃偶联的四嗪衍生物。
3H-Indolium, 2-[3-(1,3-dihydro-1,3,3-trimethyl-5-sulfo-2H-indol-2-ylidene)-1-propen-1-yl]-1-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-3,3-dimethyl-5-sulfo-, inner salt, sodium salt
Solubility:
soluble in water (0.62 M = 47 g/L), in polar organic solvents (DMF, DMSO)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Grohme, M.; Frank, O.; Rink, J. Preparing Planarian Cells for High-content Fluorescence Microscopy Using RNA in situ Hybridization and Immunocytochemistry. preprints.org, preprint. doi: 10.20944/preprints202111.0256.v1
Futamata, H.; Fukuda, M.; Umeda, R.; Yamashita, K.; Takahashi, S.; Shikakura, Ta.; Hayashi, S.; Homma, K.; Nishizawa, T.; Nureki, O. Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifier. Research Square, preprint. doi: 10.21203/rs.3.rs-927386/v1
Lee, M.S.; Hyun, H.; Park, I.; Kim, S.; Jang, D.-H.; Kim, S.; Im, J.-K.; Kim, H.; Lee, J.H.; Kwon, T.; Kang, J.H. Quantitative fluorescence in situ hybridization (FISH) of magnetically confined bacteria enables rapid determination of early-stage human bacteremia. medRxiv, preprint. doi: 10.1101/2021.02.19.21251962
Baker, Y.; Yuan, L.; Chen J.; Belle, R.; Carlisle, R.; El-Sagheer, A.; Brown, T. Expanding the Chemical Repertoire of DNA Nanomaterials Generated by Rolling Circle Amplification. ChemRxiv, preprint. doi: 10.26434/chemrxiv.12566963.v1
标签：ROX (Rhodamine X, Rhodamine 101) NHS esters Microscopy Protein labeling
货号
规格
价格
货期
12220
1 mg
110.00$
in stock
22220
5 mg
210.00$
in stock
42220
25 mg
410.00$
in stock
52220
50 mg
695.00$
in stock
62220
100 mg
1190.00$
in stock
ROX (rhodamine X aka R101) is a highly fluorescent, and photostable rhodamine dye for various applications. ROX labeled oligonucleotide probes are often used in qPCR, and qPCR instruments have ROX channel.
ROX（罗丹明X又名R101）是一种高荧光、耐光的罗丹明染料，适用于各种应用。ROX标记的寡核苷酸探针通常用于qPCR，qPCR仪器具有ROX通道。
This is reactive dye for the labeling of amino-groups in peptides, proteins, and amino-oligonucleotides. Pure single isomer.
这是一种活性染料，用于标记肽、蛋白质和氨基寡核苷酸中的氨基。纯单一异构体。
Absorption and emission spectra of ROX dye
ROX NHS ester, 6- isomer相关产品
Pico488 dsDNA quantification reagent, 200x solution in DMSO
Pico488 is a dye for precise fluorescence based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.
Pico488是一种染料，用于在存在RNA、单链DNA和其他杂质的情况下对双链DNA进行精确的荧光定量。该染料在荧光素通道中表现出明亮的荧光，在低pg/mL到高ng/mL范围内对DNA浓度提供线性响应。
Biotin-PEG3-Azide
Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe.
叠氮生物素是一种用生物素（一种著名的亲和探针）进行点击化学标记的试剂。
DusQ1 CPG 500
Controlled pore glass (CPG) 500 solid support for synthesis of oligonucleotides with 3’-terminal DusQ1 quencher. Compatible with standard deblocking conditions.
控制孔玻璃（CPG）500固体载体，用于合成带有3′-末端DusQ1猝灭剂的寡核苷酸。与标准去块条件兼容。
General properties
Appearance:
dark crimson powder
Mass spec M+ increment:
516.2
Molecular weight:
631.67
CAS number:
117491-83-5; 1890922-83-4; 216699-36-4
Molecular formula:
C37H33N3O7
Solubility:
good in polar organic solvents (DMF, DMSO), low in water
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
ROX (rhodamine X) is a bright rhodamine dye for ROX channel. Carboxy rhodamines come as two isomers.
ROX（罗丹明X）是一种用于ROX通道的明亮罗丹明染料。羧基罗丹明有两种异构体。
Products
Reactive dyes
Dye NHS esters
ROX NHS ester, 5-isomer
ROX NHS ester, 5-isomer
ROX (Rhodamine X, Rhodamine 101) NHS esters
货号
规格
价格
货期
11220
1 mg
110.00$
in stock
21220
5 mg
210.00$
in stock
41220
25 mg
410.00$
in stock
51220
50 mg
695.00$
in stock
61220
100 mg
1190.00$
in stock
ROX (rhodamine X) is a bright rhodamine dye for ROX channel. Carboxy rhodamines come as two isomers.
ROX（罗丹明X）是一种用于ROX通道的明亮罗丹明染料。羧基罗丹明有两种异构体。
This product is a derivative of pure 5-carboxy-ROX.
本品是纯5-羧基-ROX的衍生物。
Absorption and emission spectra of ROX dye
Customers also purchased with this product
BDP FL NHS ester
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基活性BDP FL，一种非常明亮且可光照的荧光素通道染料。
Alkyne dT phosphoramidite
Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.
磷酰胺改性剂，用于合成链中含有炔烃修饰的寡核苷酸。
Cyanine5 alkyne
Cyanine5 alkyne is an alkyne dye for Click Chemistry.
氰基5炔烃是一种用于化学的炔烃染料。
General properties
Appearance:
dark red solid
Mass spec M+ increment:
516.2
Molecular weight:
631.67
CAS number:
209734-74-7; 344402-35-3
Molecular formula:
C37H33N3O7
Solubility:
good in DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (80%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Pyrene is a polyaromatic hydrocarbon which exhibits fluorescence in blue range of the spectrum. When two pyrene residues are closely spaced, excimer fluorescence is observed at longer wavelength. Therefore, pyrene is useful as a proximity label.
Pyrene exhibits affinity to graphite, and can be used as an anchor group for graphite. This reagent can be conjugated with biomolecules for their subsequent immobilization on graphite surfaces.
This NHS ester allows to label biomolecules with amino groups, such as proteins, peptides, amino-DNA and other molecules.
good in DCM, chloroform, moderate in DMF, DMSO, low in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Nekrasov, N.; Jaric, S.; Kireev, D.; Emelianov, A.V.; Orlov, A.V.; Gadjanski, I.; Nikitin, P.I.; Akinwande, D.; Bobrinetskiy, I. Real-time detection of ochratoxin A in wine through insight of aptamer conformation in conjunction with graphene field-effect transistor. Biosensors and Bioelectronics, 2022, 200, 113890. doi: 10.1016/j.bios.2021.113890
标签：FAM (Fluorescein) NHS esters Fluorescence polarization Microscopy Protein labeling
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规格
价格
货期
25120
5 mg
–
in stock
45120
25 mg
140.00$
in stock
55120
50 mg
240.00$
in stock
65120
100 mg
370.00$
in stock
85120
1 g
please inquire
in stock
95120
5 g
please inquire
in stock
Fluorescein (FAM) is a bright fluorophore that has found an extremely wide application in life science research. The fluorophore is hydrophilic and its derivatives possess good solubility in aqueous buffers.
Fluorescein is compatible with a wide variety of fluorescent instrumentation – most instruments are equipped with FAM channel filters.
This product contains the pure 6-isomer of fluorescein.
BDP TR X NHS ester is a derivative of BDP TR containing a long linker based on aminohexanoic acid (C6). The dye has absorption and emission close to ROX. The NHS ester function can be used for the conjugation with proteins and peptides.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Iurova, E.; Beloblov, I.; Beloborodov, E.; Rastorgueva, E.; Pogodina, E.; Tazintseva, E.; Saenko, Y.; Fomin, A. Use of Natural Peptides with a Cysteine Knot of Arthropods as a Carrier of a Peptide Tropic to Glutamate Carboxypeptidase II. Systematic Reviews in Pharmacy, 2020, 11(9), 503–509. doi: 10.31838/srp.2020.9.73
Pinals, R.L.; Yang, D.; Lui, A.; Cao, W.; Landry, M.P. Corona exchange dynamics on carbon nanotubes by multiplexed fluorescence monitoring. Journal of the American Chemical Society, 2020, 142(3), 1254–1264. doi: 10.1021/jacs.9b09617
标签：Cyanine7.5 NHS esters Near infrared (NIR) imaging Protein labeling
货号
规格
价格
货期
16020
1 mg
110.00$
in stock
26020
5 mg
210.00$
in stock
46020
25 mg
410.00$
in stock
56020
50 mg
695.00$
in stock
66020
100 mg
1190.00$
5 days
Cyanine7.5 is a NIR dye with very long-wave emission. This product is amine-reactive derivative of this fluorophore.
Near infrared radiation readily penetrates tissues and can be used for imaging applications in vivo.
This product can be used for the labeling of various biomolecules containing amine groups, such as proteins and peptides, to track their distribution in organism in vivo by NIR imaging.
Increased rigidity of central polymethyne moiety allows to increase quantum yield by 20% compared to parent structure of Cy7.5® NHS.
Cyanine7.5 是一种具有非常长波发射的 NIR 染料。 该产品是该荧光团的胺反应性衍生物。
近红外辐射很容易穿透组织，可用于体内成像应用。
该产品可用于标记各种含胺基的生物分子，如蛋白质和多肽，通过近红外成像追踪它们在体内的分布。
与 Cy7.5® NHS 的母体结构相比，中心聚甲炔部分的刚性增加允许将量子产率提高 20%。
Cy7.5 absorbance and emission spectra
Cyanine7.5 NHS ester相关产品
Cyanine7.5 tetrazine
Cyanine7.5 is a NIR fluorescent dye with absorption and emission spectra similar to ICG (indocyanine green), but possessing a higher fluorescence quantum yield. This derivative is a tetrazine derivative for the TCO ligation reaction.
Cyanine7.5 是一种近红外荧光染料，其吸收和发射光谱类似于 ICG（吲哚菁绿），但具有更高的荧光量子产率。 该衍生物是用于 TCO 连接反应的四嗪衍生物。
Sulfo-Cyanine3 tetrazine
Water soluble sulfo-Cyanine3 dye tetrazine derivative for TCO ligation labeling with trans-cyclooctenes.
水溶性磺基-Cyanine3 染料四嗪衍生物，用于用反式环辛烯进行 TCO 连接标记。
soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Kumar, A.; Singam, A.; Swaminathan, G.; Killi, N.; Tangudu, N.K.; Jose, J.; Rathna G.V.N.; Kumar, L.D. Combinatorial therapy using RNAi and curcumin nano-architectures regresses tumors in breast and colon cancer models. Nanoscale, 2022, 14(2), 492–505. doi: 10.1039/D1NR04411G
Tamarov, K.; Wang, J.T.W.; Kari, J.; Happonen, E.; Vesavaara, I.; Niemelä, M.; Perämäki, P.; Al-Jamal, K.T.; Xu, W.; Lehto, V.-P. Comparison between Fluorescence Imaging and Elemental Analysis to Determine Biodistribution of Inorganic Nanoparticles with Strong Light Absorption. ACS Applied Materials & Interfaces, 2021, 13(34), 40392–40400. doi: 10.1021/acsami.1c11875
Babity, S.; Polomska, A.K.; Couture, F.; Bonmarin, M.; Fehr, D.; Detmar, M.; Brambilla, D. Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function. Journal of Controlled Release, 2020, 327, 350–359. doi: 10.1016/j.jconrel.2020.08.017
Wang, Y.; Li, L.; Ma, Y.; Tang, Y.; Zhao, Y.; Li, Z.; Pu, W.; Huang, B.; Wen, X.; Cao, X.; Chen, J.; Chen, W.; Zhou, Y.; Zhang, J. A Multifunctional Supramolecular Hydrogel for Prevention of Epidural Adhesion after Laminectomy. ACS Nano, 2020, 14(7), 8202–8219. doi: 10.1021/acsnano.0c01658
标签：Cyanine7 NHS esters Near infrared (NIR) imaging Protein labeling
货号
规格
价格
货期
15020
1 mg
110.00$
in stock
25020
5 mg
210.00$
5 days
45020
25 mg
410.00$
in stock
55020
50 mg
695.00$
in stock
65020
100 mg
1190.00$
in stock
Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.
NIR fluorophores can be used to take advantage of near infrared window of biological tissues – increased transparency of tissues in this spectral region allows to carry out in vivo imaging.
This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.
The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.
This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.
AF488 NHS ester, a bright, photostable and hydrophilic fluorescent dye for green channel.
AF488 NHS 酯，一种用于绿色通道的明亮、光稳定性和亲水性荧光染料。
sulfo-Cyanine7.5 maleimide
sulfo-Cyanine7.5 is a highly hydrophilic near infrared dye for in vivo imaging. This maleimide derivative is useful for the labeling of thiol groups of proteins and peptides.
sulfo-Cyanine7.5 是一种高度亲水的近红外染料，用于体内成像。 这种马来酰亚胺衍生物可用于标记蛋白质和肽的硫醇基团。
DMF (dimethylformamide), labeling grade
Dry high purity amine free solvent for NHS ester labeling.
用于 NHS 酯标记的干燥高纯度无胺溶剂。
soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Poreba, M.; Groborz, K.; Rut, W.; Pore, M.; Snipas, S.J.; Vizovisek, M.; Turk, B.; Kuhn, P.; Drag, M.; Salvesen, G.S. The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes). bioRxiv, preprint. doi: 10.1101/775627
Song, J.W.; Nam, H.S.; Ahn, J.W.; Park, H.-S.; Kang, D.O.; Kim, H.J.; Kim, Y.H.; Han, J.; Choi, J.Y.; Lee, S.-Y.; Kim, S.; Oh, W.-Y.; Yoo, H.; Park, K.; Kim, J.W. Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque. Theranostics, 2021, 11(18), 8874–8893. doi: 10.7150/thno.59759
标签：Cyanine5.5 NHS esters Microscopy Protein labeling
货号
规格
价格
货期
17020
1 mg
110.00$
in stock
27020
5 mg
210.00$
in stock
47020
25 mg
410.00$
in stock
57020
50 mg
695.00$
in stock
67020
100 mg
1190.00$
in stock
Cyanine5.5 NHS ester is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides, an analog of Cy5.5® NHS ester.
Cy5.5 is a far-red (and near-infrared) emitting dye which is ideal for fluorescence measurements where background fluorescence is a concern. It is also suitable for in vivo NIR imaging experiments.
This reagent can replace NHS esters of Cy5.5® and DyLight 680.
Cyanine5.5 NHS 酯是一种活性染料，用于标记肽、蛋白质和寡核苷酸中的氨基，是 Cy5.5® NHS 酯的类似物。
soluble in organic solvents (DMSO, DMF, dichloromethane), practically insoluble in water (< 1 uM, < 1 mg/L)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Zahid, M.; McCandless, K.; Mishra, S.; Stiltner, J.; Feldman, K.; Yagi, H.; Yurko, R.; Islam, K.; Brown, J.; Frizzell, R. Novel Lung Targeting Cell Penetrating Peptides as Vectors for Delivery of Therapeutics. Research Square, preprint. doi: 10.21203/rs.3.rs-1056707/v1
Chung, I.J.; Moon, H.; Jeon, S.I.; Lee, H.J.; Ahn, C.-H. Ultrasound-triggered imaging and drug delivery using microbubble-self-aggregate complexes. Journal of Biomaterials Science, Polymer Edition, 2022, 33(1), 57–76. doi: 10.1080/09205063.2021.1976362
Guo, H.; Liu, L.; Hu, Q.; Dou, H. Monodisperse ZIF-8@dextran nanoparticles co-loaded with hydrophilic and hydrophobic functional cargos for combined near-infrared fluorescence imaging and photothermal therapy. Acta Biomaterialia, 2022, 137, 290–304. doi: 10.1016/j.actbio.2021.10.006
Stepanova, I.A.; Lebedeva, A.N.; Shik, A..V.; Skorobogatov, E.V.; Beklemishev, M.K. Recognition and Determination of Sulfonamides by Near-IR Fluorimetry Using Their Effect on the Rate of the Catalytic Oxidation of a Carbocyanine Dye by Hydrogen Peroxide. Journal of Analytical Chemistry, 2021, 76(12), 1399–1407. doi: 10.1134/S1061934821120121
标签：Cyanine5 NHS esters Microscopy Protein labeling
货号
Quantity
Price
Lead time
13020
1 mg
110.00$
in stock
23020
5 mg
210.00$
in stock
43020
25 mg
410.00$
in stock
53020
50 mg
695.00$
in stock
63020
100 mg
1190.00$
in stock
During the last years, Cyanine5 (an analog of Cy5®) has become an incredibly popular label in life science research and diagnostics. The fluorophore has its emission maximum in the red region, where many CCD detectors exhibit maximum sensitivity, and biological objects show low background. The dye color is very intense, therefore quantities as small as 1 nmol can be detected in gel electrophoresis by naked eye.
This Cyanine5 NHS ester (analog to Cy5® NHS ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires a small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reactions (please see our recommended for more details). This reagent is ideal for very cost-efficient labeling of soluble proteins as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. For more sophisticated targets such as easily degradable proteins, when the use of DMF or DMSO is undesirable, consider using water-soluble sulfo-Cyanine 5 NHS ester which does not require any co-solvent, and features very similar fluorescent properties.
Cyanine5 fluorophore is compatible with various instrumentation including many fluorescent microscopes, imagers, scanners, and fluorescence readers. A number of various Cyanine5 analogs exist – Cyanine5 NHS ester can replace activated esters of Cy5® and DyLight 649.
very poorly soluble in water (0.19 mM = 127 mg/L), good in polar (DMSO, DMF) and chlorinated (DCM, chloroform) organic solvents
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Gruenke, P.R.; Aneja, R.; Welbourn, S.; Ukah, O.B.; Sarafianos, S.G.; Burke, D.H.; Lange, M.J. Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication. Nucleic Acids Research, in press. doi: 10.1093/nar/gkab1293
Janiszewski, T.; Kołt, S.; Kaiserman, D.; Snipas, S.; Li, S.; Kulbacka, J.; Saczko, J.; Bovenschen, N.; Salvesen, G.; Drąg, M.; Bird, P.I.; Kasperkiewicz, P. Noninvasive optical detection of Granzyme B from natural killer cells using enzyme-activated fluorogenic probes. bioRxiv, preprint. doi: 10.1101/2019.12.16.875070
Poreba, M.; Groborz, K.; Rut, W.; Pore, M.; Snipas, S.J.; Vizovisek, M.; Turk, B.; Kuhn, P.; Drag, M.; Salvesen, G.S. The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes). bioRxiv, preprint. doi: 10.1101/775627
Mu, Q.; Lin, G.; Jeon, M.; Wang, H.; Chang, F.-C.; Revia, R.A.; Yu, J.; Zhang, M. Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer. Materials Today, 2021, 50, 149–169. doi: 10.1016/j.mattod.2021.08.002
Cyanine3.5 NHS ester absorbance and emission spectra
Cyanine3.5 NHS ester相关产品
Sulfo-Cyanine5.5 maleimide
Sulfo-Cyanine5.5 is a water-soluble far red emitting dye. This is a thiol reactive maleimide derivative of sulfo-Cyanine5.5. It is recommended for the labeling of sensitive proteins.
Near infrared dye Cyanine7.5 with free amino group.
具有游离氨基的近红外染料Cyanine7.5。
ROX azide, 5- isomer
ROX (aka rhodamine X or rhodamine 101) azide for biomolecule labeling through Click Chemistry.
ROX（又名罗丹明 X 或罗丹明 101）叠氮化物，用于通过 Click Chemistry 进行生物分子标记。
General properties
Appearance:
dark purple solid
Molecular weight:
741.62
CAS number:
2231670-85-0
Molecular formula:
C42H44N3BF4O4
Solubility:
soluble in organic solvents (DMF, DMSO, dichloromethane), insoluble in water
Quality control:
NMR 1H and HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Lee, S.A.; Biteen, J.S. Spectral Reshaping of Single Dye Molecules Coupled to Single Plasmonic Nanoparticles. Journal of Physical Chemistry Letters, 2019, 10, 5764–5769. doi: 10.1021/acs.jpclett.9b02480
Kravchuk, O.I.; Lyupina, Y.V.; Erokhov, P.A.; Finoshin, A.D.; Adameyko, K.I.; Mishyna, M.Y.; Moiseenko, A.V.; Sokolova, O.S.; Orlova, O.V.; Beljelarskaya, S.N.; Serebryakova, M.V.; Indeykina, M.I.; Bugrova, A.E.; Kononikhin, A.S.; Mikhailov, V.S. Characterization of the 20S proteasome of the lepidopteran, Spodoptera frugiperda. Biochimica et Biophysica Acta – Proteins and Proteomics, 2019, 1867(9), 840–853. doi: 10.1016/j.bbapap.2019.06.010
标签：Cyanine3 NHS esters Microscopy Protein labeling
Cat. #
Quantity
Price
Lead time
11020
1 mg
110.00$
in stock
21020
5 mg
210.00$
in stock
41020
25 mg
410.00$
in stock
51020
50 mg
695.00$
in stock
61020
100 mg
1190.00$
in stock
Cyanine3 NHS ester is a reactive dye for the labeling of amino-groups in biomolecules, an analog of Cy3® NHS ester. This reagent is ideal for the labeling of soluble proteins, peptides, and oligonucleotides/DNA. For delicate proteins consider using water-soluble sulfo-Cyanine3 NHS ester which does not require use of any co-solvent.
Cyanine3 NHS ester is a replacement for NHS esters of Cy3® and DyLight 549.
poorly soluble in water (2.3 mM = 1.5 g/L), soluble in organic solvents (DMF, DMSO, dichloromethane)
Quality control:
NMR 1H and HPLC-MS (95+%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Huo, S.; Zhao, P.; Shi, Z.; Zou, M.; Yang, X.; Warszawik, E.; Loznik, M.; Göstl, R.; Herrmann, A. Mechanochemical bond scission for the activation of drugs. Nature Chemistry, 2021, 13, 131–139. doi: 10.1038/s41557-020-00624-8
Blue emitting Coumarin 343 dye can form a FRET pair with fluorescein (FAM). An amine reactive form, activated NHS ester.
This amine-reactive NHS ester contains an aminohexanoyl linker between the fluorophore, and the reactive group. This linker provides better solubility and spatial separation between the fluorophore, and the target molecule being labeled.
This reagent can be used to design FRET based assays with FAM as acceptor, and to construct systems which harvest blue light energy.
AF568 derivative for labeling proteins and other high- and low-molecular weight ligands with free amines.
AF568 衍生物，用于用游离胺标记蛋白质和其他高分子量和低分子量配体。
Sulfo-Cyanine3 tetrazine
Water soluble sulfo-Cyanine3 dye tetrazine derivative for TCO ligation labeling with trans-cyclooctenes.
水溶性磺基-Cyanine3 染料四嗪衍生物，用于用反式环辛烯进行 TCO 连接标记。
BDP 581/591 carboxylic acid
BDP 581/591 is a multi purpose fluorophore, that can also be used to probe reactive oxygen species (ROS). This is a carboxylic acid derivative with a free COOH group.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP TR is a borondipyrromethene dye which has absorption and emission wavelengths close to ROX dye. The fluorophore is bright, moderately hydrophobic, and has low molecular weight. An extra linker based on aminocaproic acid (C6) provide better separation between the dye, and the biomolecule.
The NHS ester function can be used for the conjugation with proteins, peptides, and other molecules possessing amine group.
AF568 derivative for labeling proteins and other high- and low-molecular weight ligands with free amines.
AF568 衍生物，用于用游离胺标记蛋白质和其他高分子量和低分子量配体。
Sulfo-Cyanine3 NHS ester
Water soluble sulfo-Cyanine3 SE activated ester for amino-biomolecule labeling.
用于氨基生物分子标记的水溶性磺基-Cyanine3 SE 活化酯。
BDP R6G NHS ester
BDP R6G is a borondipyrromethene dye which has absorption and emission spectra similar to R6G.
BDP R6G 是一种硼二吡咯亚甲基染料，其吸收和发射光谱与 R6G 相似。
General properties
Appearance:
dark colored solid
Mass spec M+ increment:
519.2
Molecular weight:
634.46
CAS number:
197306-80-2
Molecular formula:
C31H29N4BF2O6S
Solubility:
good in DMF, DMSO, DCM
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
This product is discontinued, and no longer available. But we have some stock (see below)
We recommend BDP TR X NHS ester as a substitute
该产品已停产，不再提供。 但我们有一些库存（见下文）
我们推荐 BDP TR X NHS 酯作为替代品
标签：NHS esters BDP TR Fluorescence polarization Microscopy Protein labeling
货号
规格
价格
货期
13420
1 mg
110.00$
in stock (1 pcs)
53420
50 mg
695.00$
in stock (2 pcs)
63420
100 mg
1190.00$
in stock (4 pcs)
BDP TR is a bright and photostable borondipyrromethene dye, which is especially suitable for microscopy applications. The dye has a long excited state lifetime, and is therefore is useful for fluorescence polarization assays. Its large two-photon cross section makes this dye useful for two-photon spectroscopy.
This NHS ester is an amine-reactive form of the dye.
BDP TR borondipyrromethene dye with a free amine group for the conjugation with electrophilic reagents and enzymatic transamination reaction. BDP TR is a bright dye for ROX channel.
带有游离胺基的 BDP TR 硼二吡咯亚甲基染料，用于与亲电试剂偶联和酶促转氨反应。 BDP TR 是 ROX 通道的明亮染料。
Sulfo-Cyanine7 amine
Water-soluble NIR dye amine, sulfonated derivative of Cyanine7 dye, for the modification via enzymatical transamination.
水溶性 NIR 染料胺，Cyanine7 染料的磺化衍生物，用于通过酶促氨基转移进行修饰。
BDP 650/665 alkyne
BDP 650/665 alkyne is a red emitting BODIPY dye derivative carrying a terminal alkyne group for a copper catalyzed conjugation with azides. Absorption and emission spectra of BDP 650/665 are designed to fit Cy5 channel of various instruments.
BDP 650/665 炔烃是一种发红光的 BODIPY 染料衍生物，带有一个末端炔烃基团，用于铜催化与叠氮化物的共轭。 BDP 650/665 的吸收和发射光谱旨在适应各种仪器的 Cy5 通道。
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：NHS esters Fluorescence polarization Microscopy Protein labeling BDP TMR
货号
规格
价格
货期
12420
1 mg
110.00$
in stock
22420
5 mg
210.00$
in stock
42420
25 mg
410.00$
in stock
52420
50 mg
695.00$
in stock
62420
100 mg
1190.00$
in stock
BDP TMR is a borondipyrromethene dye, analog of BODIPY® TMR. This is an amine-reactive NHS ester for the labeling of proteins, peptides, and other molecules with amino groups.
BDP TMR is a dye for TAMRA channel, which is however much brighter than TAMRA. Because of rather long life time of excited state, this fluorophore is a good choice for fluorescence anisotropy measurements, especially with the short linker offered. Fluorescence polarization is an excellent method for high throughput binding assays.
Activated ester for azido labeling of peptides and proteins.
用于肽和蛋白质的叠氮基标记的活化酯。
BDP FL NHS ester
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基反应性 BDP FL，一种非常明亮且光稳定的荧光素通道染料。
Cyanine5 maleimide
Cyanine5 maleimide reacts with thiols to give dye labeled conjugates.
Cyanine5 马来酰亚胺与硫醇反应生成染料标记的偶联物。
General properties
Appearance:
purple solid
Mass spec M+ increment:
380.2
Molecular weight:
495.28
CAS number:
485397-12-4
Molecular formula:
C25H24BF2N3O5
Solubility:
good in most organic solvents (DMF, DMSO, DCM, acetone, etc.)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Nascimento, A.; Pedro, M.N.S.; Pinto, I.F.; Aires-Barros, M.R.; Azevedo, A.M. Microfluidics as a high-throughput solution for chromatographic process development – The complexity of multimodal chromatography used as a proof of concept. Journal of Chromatography A, 2021, 1658, 462618. doi: 10.1016/j.chroma.2021.462618
BDP R6G NHS ester is an amine-reactive borondipyrromethene dye (an analog of BODIPY® R6G NHS ester) that has absorption and emission spectra similar to R6G.
BDP R6G is a bright and photostable dye that exhibits long living fluorescence that has little pH dependence. Due to the long fluorescence lifetime, this dye is useful for fluorescence polarization assays, and for two-photon experiments.
The NHS ester function can be conjugated with various amine groups, including those present in proteins and peptides.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Lee, S.A.; Biteen, J.S. Spectral Reshaping of Single Dye Molecules Coupled to Single Plasmonic Nanoparticles. Journal of Physical Chemistry Letters, 2019, 10, 5764–5769. doi: 10.1021/acs.jpclett.9b02480
标签：BDP FL NHS esters Fluorescence polarization Microscopy Protein labeling
货号
规格
价格
货期
11420
1 mg
110.00$
in stock
21420
5 mg
210.00$
in stock
41420
25 mg
410.00$
in stock
51420
50 mg
695.00$
in stock
61420
100 mg
1190.00$
in stock
BDP FL NHS ester is an advanced dye for 488 nm channel, a replacement for fluorescein, a molecule identical to BODIPY FL® NHS ester. An amino-reactive dye for the labeling of proteins and peptides.
While the absorbance and emission spectra of this molecule stay within FAM excitation and emission channels, this dye provides much better photostability, and outstanding brightness. The fluorescence spectrum of BODIPY-FL is narrower than that of FAM. This provides a better brightness for monochromator based instruments, when emission wavelength can be tuned to dye maximum.
The dye is neutral, possesses low molecular weight, and retains high quantum yield in conjugates.
The dye is a good replacement for fluorescein (FAM), BODIPY-FL, DyLight 488, Cy2, and other 488 nm dyes.
Cyanine5 azide is a reagent for Click Chemistry labeling with Cyanine5, a popular fluorescent dye.
Cyanine5 azide 是一种用 Cyanine5（一种流行的荧光染料）进行 Click Chemistry 标记的试剂。
Phosphate CPG 500 solid support
CPG solid support for the synthesis of 3′-phosphorylated oligonucleotides.
用于合成 3′-磷酸化寡核苷酸的 CPG 固体支持物。
Good in organic solvents (DMF, DMSO, dichlromethane), limited in water
Quality control:
NMR 1H, HPLC-MS (95+%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Nascimento, A.; Pedro, M.N.S.; Pinto, I.F.; Aires-Barros, M.R.; Azevedo, A.M. Microfluidics as a high-throughput solution for chromatographic process development – The complexity of multimodal chromatography used as a proof of concept. Journal of Chromatography A, 2021, 1658, 462618. doi: 10.1016/j.chroma.2021.462618
González, M.I.; González-Arjona, M.; Santos-Coquillat, A.; Vaquero, J.; Vázquez-Ogando, E.; de Molina, A.; Peinado, H.; Desco, M.; Salinas, B. Covalently Labeled Fluorescent Exosomes for In Vitro and In Vivo Applications. Biomedicines, 2021, 9, 81. doi: 10.3390/biomedicines9010081
Volz, J.; Kusch, C.; Beck, S.; Popp, M.; Vögtle, T.; Meub, M.; Scheller, I.; Heil, H.S.; Preu, J.; Schuhmann, M.K.; Hemmen, K.; Premsler, T.; Sickmann, A.; Heinze, K.G.; Stegner, D.; Stoll, G.; Braun, A.; Sauer, M.; Nieswandt, B. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. Journal of Clinical Investigation, 2020, 130(11), 6064–6079. doi: 10.1172/JCI136457
BDP 650/665 X NHS ester,BDP 650/665 是一种具有远红色激发和发射的硼二吡咯亚甲基染料。 该染料具有良好的摩尔消光系数和发射量子产率。
Products
Reactive dyes
Dye NHS esters
BDP 650/665 X NHS ester
BDP 650/665 X NHS ester
标签：NHS esters BDP 650/665
货号
规格
价格
货期
1E420
1 mg
110.00$
in stock
2E420
5 mg
210.00$
in stock
4E420
25 mg
410.00$
in stock
5E420
50 mg
695.00$
in stock
6E420
100 mg
1190.00$
in stock
BDP 650/665 is a borondipyrromethene dye with far red excitation and emission. The dye has a good molar extinction coefficient and emission quantum yield.
The NHS ester can be conjugated with amine groups of proteins, peptides, and other molecules. The molecule contains an additional aminohexanoic acid linker.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP 630/650 X NHS ester,BDP 630/650 是一种硼二吡咯亚甲基荧光团，具有高摩尔消光系数、出色的量子产率和相对较长的激发态寿命。 因此，这种荧光团可用于荧光偏振测定，以检测分子之间的结合。
Products
Reactive dyes
Dye NHS esters
BDP 630/650 X NHS ester
BDP 630/650 X NHS ester
标签：NHS esters Fluorescence polarization Microscopy BDP 630/650 Protein labeling
货号
规格
价格
货期
15420
1 mg
110.00$
in stock
25420
5 mg
210.00$
in stock
45420
25 mg
410.00$
in stock
55420
50 mg
695.00$
in stock
65420
100 mg
1190.00$
in stock
BDP 630/650 is a borondipyrromethene fluorophore that has a high molar extinction coefficient, excellent quantum yield, and a relatively long lifetime of the excited state. Due to it, this fluorophore is useful for fluorescence polarization assays that allow to detect binding between molecules.
This is an amine reactive NHS ester. It contains an aminohexanoyl linker between the fluorophore and the reactive group.
BDP TR X NHS ester is a derivative of BDP TR containing a long linker based on aminohexanoic acid (C6). The dye has absorption and emission close to ROX. The NHS ester function can be used for the conjugation with proteins and peptides.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：NHS esters Fluorescence polarization BDP 581/591 Protein labeling
货号
规格
价格
货期
16420
1 mg
110.00$
in stock
26420
5 mg
210.00$
in stock
46420
25 mg
410.00$
in stock
56420
50 mg
695.00$
in stock
66420
100 mg
1190.00$
in stock
BDP 581/591 is a borondipyrromethene dye that has relatively long fluorescence lifetime and two photon excitation cross section. It is useful for fluorescence polarization assays. Due to the presence of a diene system, it can react with reactive oxygen species (ROS) with a change of fluorescence.
This is the NHS ester derivative for the conjugation with primary and secondary amine groups of proteins, peptides, and other molecules.
Amine reactive NHS ester of near infrared dye Cyanine7.
近红外染料Cyanine7的胺活性NHS酯。
General properties
Appearance:
dark colored solid
Mass spec M+ increment:
374.1
Molecular weight:
489.28
CAS number:
150152-70-8
Molecular formula:
C26H22N3BF2O4
Solubility:
good in DMF, DMSO, DCM
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Brachi, G.; Ruiz-Ramírez, J.; Dogra, P.; Wang, Z.; Cristini, V.; Ciardelli, G.; Rostomily, R.C.; Ferrari, M.; Mikheev, A.M.; Blanco, E.; Mattu, C. Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma. Nanoscale, 2020, 12(46), 23838–23850. doi: 10.1039/d0nr05053a
Tabe, H.; Sukenobe, K.; Kondo, T.; Sakurai, A.; Maruo, M.; Shimauchi, A.; Hirano, M.; Uno, S.-N.; Kamiya, M.; Urano, Y.; Matsushita, M.; Fujiyoshi, S. Cryogenic Fluorescence Localization Microscopy of Spectrally Selected Individual FRET Pairs in a Water Matrix. The Journal of Physical Chemistry B, 2018, 122(27), 6906–6911. doi: 10.1021/acs.jpcb.8b03977
BDP 576/589 (a BODIPY™ 576/589 analog) is a boron dipyrromethene dye. This hydrophobic dye has high quantum yield and long excited-state lifetime (about 5 nanoseconds). It can be used for measuring fluorescence lifetime and fluorescence polarization and in two-photon laser scanning microscopy.
This reagent is an activated N-hydroxysuccinimide ester of the dye with reactivity to primary and secondary amino groups.
BDP TR X NHS ester is a derivative of BDP TR containing a long linker based on aminohexanoic acid (C6). The dye has absorption and emission close to ROX. The NHS ester function can be used for the conjugation with proteins and peptides.
BDP TR X NHS 酯是 BDP TR 的衍生物，含有一个基于氨基己酸 (C6) 的长接头。 该染料具有接近ROX的吸收和发射。 NHS 酯功能可用于与蛋白质和肽的结合。
Coumarin 343 X NHS ester
Coumarin 343 is a blue emitting dye that can serve as a FRET donor for fluorescein (FAM). This structure features a linker between Coumarin 343 fluorophore, and the functional group. It provides better solubility, and spatial separation between the dye, and the functional group.
香豆素 343 是一种蓝色发射染料，可用作荧光素 (FAM) 的 FRET 供体。 这种结构的特点是香豆素 343 荧光团和官能团之间有一个接头。 它提供了更好的溶解性，以及染料和官能团之间的空间分离。
FAM amine, 5-isomer
Amino derivative of fluorescein, pure 5-isomer. Contains a linker arm between the aliphatic amine group, and the fluorophore. Useful for the labeling via enzymatic transamination, for the reactions with electrophilic reagents, and for reductive amination.
荧光素的氨基衍生物，纯 5-异构体。 在脂肪胺基团和荧光团之间包含一个连接臂。 可用于通过酶促氨基转移进行标记、与亲电子试剂的反应以及还原胺化。
General properties
Appearance:
dark colored crystals
Mass spec M+ increment:
328.1
Molecular weight:
426.18
CAS number:
201998-61-0
Molecular formula:
C20H17N4BF2O4
Solubility:
soluble in polar organic solvents
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
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