用途及描述 ：科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。动物血清中免疫球蛋白(IgG)广泛应用于免疫学、分子生物学及医学等生命科学的各个研究领域，既可作为大分子球蛋白用于生物化学的研究，也可以作为抗原用于免疫学和医学研究。 使用方法推荐： Reconstitution ：The product is to be reconstituted to a minimum of 1 mg/ml with a 150 mM NaCl solution. Protein concentration should be determined after reconstitution by absorbance at 280nm (E280 1% = 14). Storage/Stability: Prior to reconstitution, store at 2-8 °C. After reconstitution, store aliquots at −20 °C. Repeated freezing and thawing is not recommended.
【注意】 ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。 ●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。 参考文献： 1. Importance of neonatal immunoglobulin transfer for hippocampal development and behaviour in the newborn pig. 2. The effect of methionine and aflatoxin on immune function in weanling pigs. 3. Placental transfer of IgG subclasses in a Japanese population.
Hexachlorofluorescein (HEX) is a hexachlorinated derivate of the fluorescent dye fluorescein. HEX-labeled oligonucleotides are used in PCR and the HEX channel is widely used in multiplex qPCR.
Oligonucleotides with a HEX label can be easily generated using HEX azide and alkyne-containing oligonucleotide via azide-alkyne cycloaddition.
HEX exhibits an excitation peak at 533 nm and an emission peak at 549 in green-yellow area, and it can serve as a substitute for JOE, BODIPY™ 530/550, VIC™ because of the similar spectral characteristics.
Haider, N.; Dutt, P.; van de Kooij, B.; Yaffe, M.B.; Stambolic, V. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. bioRxiv, preprint. doi: 10.1101/516971
FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent labels for various applications. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel.
With versatility of Click chemistry and this reagent, it is possible to attach this popular fluorophore to nearly any alkyne bearing molecule.
FAM azide is available both as solid compound, and as 10 mM solution in DMSO ready to use in our recommended labeling protocol. This product is a pure 5-isomer. FAM is a replacement for DyLight 488.
Haider, N.; Dutt, P.; van de Kooij, B.; Yaffe, M.B.; Stambolic, V. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. bioRxiv, preprint. doi: 10.1101/516971
Gueiderikh, A.; Maczkowiak-Chartois, F.; Rouvet, G.; Souquère-Besse, S.; Apcher, S.; Diaz, J.-J.; Rosselli, F. Fanconi anemia A protein participates in nucleolar homeostasis maintenance and ribosome biogenesis. Science Advances, 2021, 7(1), eabb5414. doi: 10.1126/sciadv.abb5414
Ramey-Ward, A.N.; Su, H.; Salaita, K. Mechanical stimulation of adhesion receptors using light-responsive nanoparticle actuators enhances myogenesis. ACS Applied Materials & Interfaces, 2020, 12(32), 35903–35917. doi: 10.1021/acsami.0c08871
标签：Cyanine7.5,Cy7.5, Azides, Near infrared (NIR) imaging
货号
规格
价格
货期
46030
1 mL, 10 mM in DMSO
410.00$
in stock
16030
100 uL, 10 mM/DMSO
110.00$
in stock
36030
500 uL, 10 mM/DMSO
210.00$
in stock
A6030
1 mg
110.00$
in stock
B6030
5 mg
210.00$
in stock
C6030
10 mg
310.00$
in stock
D6030
25 mg
410.00$
in stock
E6030
50 mg
695.00$
in stock
F6030
100 mg
1190.00$
in stock
Cyanine7.5 is a NIR dye with long-wave infrared fluorescence. This derivative is azide for Click Chemistry.
Can be used for the construction of various labeled biomolecules containing Cyanine7.5, near infrared fluorescent dye, and an improved analog of Cy7.5®. These conjugates can take advantage of NIR tissue transparency when used for in vivo imaging. This fluorophore is also useful for other fluorescent applications, especially requiring low fluorescent background.
Azide is available as DMSO solution, ready for general Click Chemistry labeling protocol, or in solid form for custom labeling applications.
Structure features rigid bridged polymethyne chain to increase quantum yield by 20%, allowing for brighter signal.
Water soluble Cyanine dye tetrazine derivative for TCO ligation with trans-cyclooctenes and other strained olefines.
水溶性花青染料四嗪衍生物，用于与反式环辛烯和其他应变烯烃的 TCO 连接。
Cyanine5 alkyne
Cyanine5 alkyne is an alkyne dye for Click Chemistry.
Cy5 炔烃是一种用于 Click Chemistry 的炔烃染料。
General properties
Appearance:
green powder / solution 绿色粉末/溶液
Molecular weight:
767.44
CAS number:
1628790-36-2; 1628897-78-8 (without anion)
Molecular formula:
C48H55ClN6O
Solubility:
soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Hellyer, S.D.; Aggarwal, S.; Chen, A.N.; Leach, K.; Lapinsky, D.J.; Gregory, K.J. Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes. ACS Chemical Neuroscience, 2020, 11(11), 1597–1609. doi: 10.1021/acschemneuro.0c00009
Retout, M.; Brunetti, E.; Valkenier, H.; Bruylants, G. Limits of thiol chemistry revealed by quantitative analysis of mixed layers of thiolated-PEG ligands grafted onto gold nanoparticles. Journal of Colloid and Interface Science, 2019, 557, 807–815. doi: 10.1016/j.jcis.2019.09.047
Pearce, H.A.; Qian, H.; Connell, T.U.; Huang, D.; Gottstein, C.; Donnelly, P.S.; Peter, K.; Gregorevic, P.; Hagemeyer, C.E. Site-specific glycation and chemo-enzymatic antibody sortagging for the retargeting of rAAV6 to inflamed endothelium. Molecular Therapy – Methods & Clinical Development, 2019, 14, 261–269. doi: 10.1016/j.omtm.2019.07.003
Kong, J.-N.; Zhu, Z.; Itokazu, Y.; Wang, G.; Dinkins, M.B.; Zhong, L.; Lin, H.-P.; Elsherbini, A.; Leanhart, S.; Jiang, X.; Qin, H.; Zhi, W.; Spassieva, S.D.; Bieberich, E. Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes. Journal of Lipid Research, 2018, 59(3), 488–506. doi: 10.1194/jlr.M081877
标签：Cyanine7,Cy7, Azides, Near infrared (NIR) imaging
货号
规格
价格
货期
15030
100 uL, 10 mM/DMSO
110.00$
in stock
35030
500 uL, 10 mM/DMSO
210.00$
in stock
45030
1 mL, 10 mM/DMSO
410.00$
in stock
A5030
1 mg
110.00$
in stock
B5030
5 mg
210.00$
in stock
C5030
10 mg
310.00$
in stock
D5030
25 mg
410.00$
in stock
E5030
50 mg
695.00$
in stock
Cyanine7 azide is a near-infrared fluorescent dye azide for Click Chemistry labeling, an analog of Cy7® azide.
This product can be used for the incorporation of Cyanine7 into various alkynylated biomolecules via Click Chemistry. Post-synthetic modification of oligonucleotides is also possible with this azide.
Cyclohexane-bridged polymethyne chain allows for 20% increase in quantum yield (compared to parent non-bridged structure).
Cyanine5 alkyne is an alkyne dye for Click Chemistry.
Cy5 炔烃是一种用于 Click Chemistry 的炔烃染料。
Sulfo-Cyanine7 amine
Water-soluble NIR dye amine, sulfonated derivative of Cyanine7 dye, for the modification via enzymatical transamination.
水溶性 NIR 染料胺，Cy7 染料的磺化衍生物，用于通过酶促氨基转移进行修饰。
Copper(II)-TBTA complex, 10 mM in 55% aq. DMSO
Catalyst for bioconjugate synthesis by Click Chemistry.
Click Chemistry 用于生物共轭合成的催化剂。
General properties
Appearance:
green powder / solution
Molecular weight:
667.33
CAS number:
1557149-65-1 (chloride), 1557397-59-7
Molecular formula:
C40H51ClN6O
Solubility:
soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Roberts, S.; Khera, E.; Choi, C.; Navaratna, T.; Grimm, J.; Thurber, G.M.; Reiner, T. Optoacoustic imaging of Glucagon-like Peptide 1 Receptor with a near-infrared exendin-4 analog. Journal of Nuclear Medicine, 2021, 62(6), 839–848. doi: 10.2967/jnumed.120.252262
Thauvin, C.; Maudens, P.; Allémann, E. Microwave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymers. Journal of Drug Delivery Science and Technology, 2021, 61, 102255. doi: 10.1016/j.jddst.2020.102255
Meka, R.R.; Venkatesha, S.H.; Moudgil, K.D. Peptide-directed liposomal delivery improves the therapeutic index of an immunomodulatory cytokine in controlling autoimmune arthritis. Journal of Controlled Release, 2018, 286, 279–288. doi: 10.1016/j.jconrel.2018.08.007
This Cyanine5.5 labeling reagent is a dye azide for Click Chemistry, available as 10 mM solution in DMSO, or in solid form. The dye possesses far red / near infrared emission, which allows to use it for NIR live organism imaging. Cyanine5.5 can replace Cy5.5® and DyLight 680.
Amine reactive NHS ester of near infrared dye Cyanine7.
近红外染料Cyanine7的胺活性NHS酯。
Cyanine7 hydrazide
Carbonyl reactive NIR fluorophore for the labeling of aldehydes, ketones, including glycoproteins subjected to periodate oxidation.
羰基反应性 NIR 荧光团，用于标记醛、酮，包括经过高碘酸盐氧化的糖蛋白。
General properties
Appearance:
dark blue powder / solution 深蓝色粉末/溶液
Molecular weight:
701.34
Molecular formula:
C43H49ClN6O
Solubility:
soluble in organic solvents (DMSO, DMF, dichloromethane), practically insoluble in water (1.6 uM, 1.2 mg/L)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Cyanine5 azide labeling reagent for Click Chemistry, available as 10 mM solution in DMSO, and in solid form.
This azide is soluble in organic solvents (e.g. DMSO, DMF), therefore the labeling reaction should be carried out with a small amount of an organic co-solvent. This azide can be used for the labeling of alkyne-modified biomolecules in mixtures of water with organic solvents. The solution in DMSO is ready for use in bioconjugation. A water-soluble sulfonated version of this reagent is also available.
Cyanine5 is an analog of Cy5®, one of the most commonly used fluorophores which is compatible with various instruments. Cyanine5 can also be used as a replacement for DyLight® 649.
用于 Click Chemistry 的 Cyanine5 叠氮化物标记试剂，以 10 mM DMSO 溶液和固体形式提供。
Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain promoted copper free Click chemistry (spAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
BDP 581/591 is a borondipyrromethene fluorophore which is useful for fluorescence polarization assays, microscopy, and two photon experiments. This alkyne is a derivative for copper-catalyzed Click chemistry.
Ascorbic acid for the reduction of Cu(II)-TBTA complex.
抗坏血酸用于还原 Cu(II)-TBTA 配合物。
General properties
Appearance:
dark blue powder / solution
Molecular weight:
601.22
CAS number:
1267539-32-1 (chloride)
Molecular formula:
C35H45ClN6O
Solubility:
soluble in organic solvents (DMSO, DMF, dichloromethane), very poorly soluble in water (0.63 mM, 110 mg/L)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Thauvin, C.; Maudens, P.; Allémann, E. Microwave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymers. Journal of Drug Delivery Science and Technology, 2021, 61, 102255. doi: 10.1016/j.jddst.2020.102255
Boersma, S.; Rabouw, H.H.; Bruurs, L.J.M.; Pavlovič, T.; van Vliet, A.L.W.; Beumer, J.; Clevers, H.; van Kuppeveld, F.J.M.; Tanenbaum, M.E. Translation and Replication Dynamics of Single RNA Viruses. Cell, 2020, 183(7), 1930–1945.e23. doi: 10.1016/j.cell.2020.10.019
Kim, S.M.; Park, J.; Kim, M.S.; Song, H.; Jo, A.; Park, H.; Kim, T.S.; Choi, S.H.; Park, S.B. Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR. ACS Infectious Diseases, 2020, 6(11), 3076–3082. doi: 10.1021/acsinfecdis.0c00587
von Döhren, J.; Kuhl, S. A simple method for long-term vital-staining of ciliated epidermal cells in aquatic larvae. Journal of Biological Methods, 2020, 7(2), e132. doi: 10.14440/jbm.2020.320
Davies J, et al. Inhibition of protein synthesis by spectinomycin. Science. 1965 Sep 3;149(3688):1096-8.
Brink MF, et al. Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res. 1994 Feb 11;22(3):325-31.
Park IK, et al. Spectinomycin inhibits the self-splicing of the group 1 intron RNA. BiochemBiophys Res Commun. 2000 Mar 16;269(2):574-9.
Madhura DB, et al. Pharmacokinetic profile of spectinomycin in rats. Pharmazie. 2013 Aug;68(8):675-6.
Cyanine3.5 labeling reagent, solid material and 10 mM solution in DMSO, for Click Chemistry.
Can replace Cy3.5®, DyLight 594.
Cyanine3.5 标记试剂、固体材料和 10 mM DMSO 溶液，用于 Click Chemistry。
可替代 Cy3.5®、DyLight 594。
Cy3.5 absorbance and emission spectra
Cy3.5 azide ,Cy3.5 染料叠氮化物相关产品
PEP azide
PEP (phenylethynylpyrene), polyaromatic hydrocarbon fluorescent dye for Click-Chemistry labeling.
PEP（苯乙炔基芘），用于 Click-Chemistry 标记的多环芳烃荧光染料。
Alkyne Phosphoramidite, 5′-terminal
Alkyne phosphoramidite for the synthesis of oligonucleotides ready for Click chemistry.
用于合成寡核苷酸的炔亚磷酰胺，可用于点击化学。
Coumarin 343 X NHS ester
Coumarin 343 is a blue emitting dye that can serve as a FRET donor for fluorescein (FAM). This structure features a linker between Coumarin 343 fluorophore, and the functional group. It provides better solubility, and spatial separation between the dye, and the functional group.
soluble in organic solvents (DMF, DMSO, dichloromethane), insoluble in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Jandl, B.; Sedghiniya, S.; Carstens, A.; Astakhova, K. Peptide–Fluorophore Hydrogel as a Signal Boosting Approach in Rapid Detection of Cancer DNA. ACS Omega, 2019, 4(9), 13889–13895. doi: 10.1021/acsomega.9b01586
Gaitzsch, J.; Delahaye, M.; Poma, A.; Du Prez, F.; Battaglia, G. Comparison of metal free polymer-dye conjugation strategies in protic solvents. Polymer Chemistry, 2016, 7(17), 3046–3055;. doi: 10.1039/c6py00518g
Astakhova, I.K.; Wengel, J. Interfacing Click Chemistry with Automated Oligonucleotide Synthesis for the Preparation of Fluorescent DNA Probes Containing Internal Xanthene and Cyanine Dyes. Chemistry – a European Journal, 2013, 19(3), 1112-1122. doi: 10.1002/chem.201202621
【注意】 ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。 ●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。 参考文献： 1. Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity. 2. Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. 3. Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
Cyanine3 dye azide for Click Chemistry, an analog of Cy3® azide. Cy3® is one of the most broadly used fluorophores which can be detected by various fluorometers, imagers, and microscopes. Due to inherently high extinction coefficient, Cyanine3 is also easily detected by naked eye on gels, and in solution. This is non-sulfonated dye which requires organic co-solvent (DMF, DMSO, or other) for efficient labeling in water. Water-soluble version of this reagent is also available.
Product is available both as solid compound, and as 10 mM solution in DMSO which is ready to use in our recommended protocol.
Cyanine3 fluorescent properties are identical to Cy3®, and similar to DyLight 549.
BDP 581/591 is a borondipyrromethene fluorophore which is useful for fluorescence polarization assays, microscopy, and two photon experiments. This alkyne is a derivative for copper-catalyzed Click chemistry.
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get free express delivery
General properties
Appearance:
red powder / solution 红粉/溶液
Molecular weight:
575.19
CAS number:
1167421-28-4 (chloride)
Molecular formula:
C33H43N6OCl
Solubility:
soluble in organic solvents (DMF, DMSO, dichloromethane), practically insoluble in water (40 mg/L = 60 uM)
Quality control:
NMR 1H and HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Kim, S.M.; Park, J.; Kim, M.S.; Song, H.; Jo, A.; Park, H.; Kim, T.S.; Choi, S.H.; Park, S.B. Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR. ACS Infectious Diseases, 2020, 6(11), 3076–3082. doi: 10.1021/acsinfecdis.0c00587
Saqr, A.; Vakili, M.R.; Huang, Y.-H.; Lai, R.; Lavasanifar, A. Development of Traceable Rituximab-Modified PEO-Polyester Micelles by Postinsertion of PEG-phospholipids for Targeting of B-cell Lymphoma. ACS Omega, 2019, 4(20), 18867–18879. doi: 10.1021/acsomega.9b02910
Morimoto, K.; Cole, K.S.; Kourelis, J.; Witt, C.H.; Brown, D.; Krahn, D.; Stegmann, M.; Kaschani, F.; Kaiser, M.; Burton, J.; Mohammed, S.; Yamaguchi-Shinozaki, K.; Weerapana, E.; van der Hoorn, R.A.L. Triazine Probes Target Ascorbate Peroxidases in Plants. Plant Physiology, 2019, 180(4), 1848–1859. doi: 10.1104/pp.19.00481
【注意】 ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。 ●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。 参考文献： 1. Serotonin (5-HT) inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation. 2. Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity. 3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
Coumarin 343 X azide,Coumarin 343 X 叠氮化物,香豆素 343 是一种蓝色荧光团，最大发射波长约为 480 nm。 这种染料与荧光素形成 FRET 对，并可以收集蓝光能量用于随后转移到其他荧光团。
Products
Reactive dyes
Dye azides
Coumarin 343 X azide
Coumarin 343 X azide
标签：Azides, Coumarin 343
货号
规格
价格
货期
12630
1 mg
110.00$
in stock
22630
5 mg
210.00$
in stock
42630
25 mg
410.00$
in stock
52630
50 mg
695.00$
in stock
62630
100 mg
1190.00$
in stock
Coumarin 343 is a blue emitting fluorophore with an emission maximum around 480 nm. This dye forms a FRET pair with fluorescein, and can harvest blue light energy for the subsequent transfer to other fluorophores.
The azide derivative can be conjugated with alkynes in a copper-catalyzed and copper-free Click chemistry reactions. The molecule contains a long aminohexanoyl linker that provides separation between the dye, and the azide function.
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
This is an azide for copper catalyzed and copper free Click chemistry labeling with BDP TR, a bright red emitting fluorophore. BDP TR is an alternative to ROX. This fluorophore is based on borondipyrromethene scaffold, and contains aryl substituents to match its absorption and emission to ROX channel.
ROX dye is prone to oxidation, BDP TR is much more resilient to oxidants. Its brightness and photostability is also very high.
JOE dye phosphoramidite for synthesis of labeled oligonucleotides. JOE absorption and emission maxima are between maxima of FAM and TAMRA/ROX dyes.
JOE 染料亚磷酰胺用于合成标记的寡核苷酸。 JOE 吸收和发射最大值介于 FAM 和 TAMRA/ROX 染料的最大值之间。
Cyanine3 NHS ester
Amine-reactive Cyanine3 dye NHS ester.
胺反应性 Cy3 染料 NHS 酯。
ROX azide, 5- isomer
ROX (aka rhodamine X or rhodamine 101) azide for biomolecule labeling through Click Chemistry.
ROX（又名罗丹明 X 或罗丹明 101）叠氮化物，用于通过 Click Chemistry 进行生物分子标记。
General properties
Appearance:
dark colored solid 深色固体
Mass spec M+ increment:
506.2
Molecular weight:
506.34
CAS number:
2183473-27-8
Molecular formula:
C24H21N6BF2O2S
Solubility:
good in DMF, DMSO, DCM
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP TMR is a borondipyrromethene fluorophore (analog of BODIPY® TMR) with excitation and emission wavelengths matching TAMRA dye channels. The dye has a long fluorescence lifetime.
This derivative is an azide for Click chemistry labeling.
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get free express delivery
Coumarin 343 X azide
Coumarin 343 is a blue emitting fluorophore that can serve as a FRET donor for fluorescein (FAM). This azide derivative can be conjugated with alkynes by Click chemistry. An extended linker arm between the fluorophore and the azide group enhances solubility, and provides spatial separation between the dye and the biomolecule.
Add this product to your cart and
get free express delivery
Coumarin 343 X NHS ester
Coumarin 343 is a blue emitting dye that can serve as a FRET donor for fluorescein (FAM). This structure features a linker between Coumarin 343 fluorophore, and the functional group. It provides better solubility, and spatial separation between the dye, and the functional group.
Add this product to your cart and
get free express delivery
General properties
Appearance:
orange to brown solid 橙色至棕色固体
Mass spec M+ increment:
480.2
Molecular weight:
480.32
CAS number:
2183473-25-6; 2373346-19-9
Molecular formula:
C24H27BF2N6O2
Solubility:
good in most organic solvents
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
用途及描述：科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。肉碱是自然存在于大多数哺乳动物组织中的一种四胺。它在骨骼肌和心脏中以相对高的浓度存在，参与调节能量代谢。它将葡萄糖代谢从糖酵解转变为糖原储存，并促进长链脂肪酸向线粒体的运输，长链脂肪酸在线粒体中被氧化以产生能量。肉碱是赖氨酸生物合成的。它可能与支链氨基酸的能量产生有关。L-肉碱盐酸盐已被用于研究麦角硫因素转运蛋白SLC22A4和肉毒碱转运蛋白SLC22A5。 它还被用于使棕榈酸进入线粒体。 【注意 】 ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。 ●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。 参考文献： 1. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Ahmad S, et.al Kidney International 38(5), 912-918, (1990) 2. Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: Gain-of-function by interchange of selected amino acids Petra Bacher. et.al Biochimica et Biophysica Acta 1788(12), 2594-2602, (2009) 3. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Koeth RA, et.al Nature Medicine 19(5), 576-585, (2013)
Borondipyrromethene (BDP) dyes are high performance flurophores that exhibit excellent photostability and brightness. A number of BDP dyes is available that are tuned to match excitation and emission channels of classical xanthene and cyanine dyes.
BDP R6G is matched to R6G dye excitation and emission wavelengths. The fluorophore is an excellent alternative to R6G for various applications, including microscopy, fluorescence polarization assays, and two photon experiments.
Azide functional group allows to conjugate the fluorophore easily with various biomolecules, small molecules, and polymers using CuAAC or spAAC Click chemistry reactions.
HEX phosphoramidite for synthesis of 5’-labeled oligonucleotides.
用于合成 5′ 标记寡核苷酸的 HEX 亚磷酰胺。
Pyrene azide 1
Reagent for fluorescent labeling with pyrene polycyclic aromatic hydrocarbon via Click Chemistry.
通过 Click Chemistry 用芘多环芳烃进行荧光标记的试剂。
BDP 650/665 X NHS ester
Amine reactive of BDP 650/665, a borondipyrromethene dye for Cy5 channel, possessing a high molar extinction coefficient, and a good emission quantum yield.
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP FL azide is an analog of BODIPY® FL azide, a Click-chemistry capable bright and photostable dye for FAM channel.
This green-emitting fluorophore is compatible with all types of fluorescence measuring instruments for FAM (fluorescein).
The fluorophore is a representative of borondipyrromethene class of fluorescent dyes, which possess high quantum yields in aqueous environments, and high stability towards photobleaching.
BDP 650/665 is a bright red emitting borondipyrromethene dye, compatible with Cy5 channel found on many instruments. This is azide derivative of BDP 650/665. It can be conjugated with terminal alkynes via copper catalyzed reaction, or with cycloalkynes via copper-free Click chemistry.
BDP 650/665 azide can be conjugated with various terminal alkynes using copper-catalyzed Click chemistry, or with cycloalkynes using a copper-free reaction.
Cy5.5 maleimide is a thiol reactive dye for protein labeling.
Cy5.5 马来酰亚胺是一种用于蛋白质标记的硫醇活性染料。
TAMRA azide, 5-isomer
TAMRA fluorescent dye azide for Click chemistry.
用于点击化学的 TAMRA 荧光染料叠氮化物。
BDP 630/650 maleimide
BDP 630/650 maleimide is a thiol reactive, borondipyrromethene based dye tuned to match the far red channel of Cyanine5 fluorophore.
BDP 630/650 马来酰亚胺是一种硫醇反应性、基于硼二吡咯亚甲基的染料，经过调整以匹配 Cyanine5 荧光团的远红通道。
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP 581/591 is a bright and versatile fluorophore that is relatively hydrophobic. It has a high brightness, significant two photon cross-section, and relatively long fluorescence lifetime.
The dye reacts with reactive oxygen species (ROS) with the change of its fluorescence. It can be therefore used for intracellular monitoring of ROS.
This is an azide derivative that can be used for the conjugation with both small molecules and biomolecules to construct tracers for fluorescence polarization assays and microscopy probes.
Alkyne dye for copper catalyzed Click chemistry, containing borondipyrromethene fluorophore BDP 630/650 for red channel.
用于铜催化点击化学的炔烃染料，含有用于红色通道的硼二吡咯亚甲基荧光团 BDP 630/650。
BDP 581/591 NHS ester
NHS ester derivative of BDP 581/591 borondipyrromethene fluorophore for the labeling of proteins, peptides, and other biomolecules. The dye is useful for fluorescence polarization and two-photon experiments, and as a ROS probe.
Amine reactive NHS ester of near infrared dye Cy7.
近红外染料 Cy7 的胺活性 NHS 酯。
General properties
Appearance:
dark solid
Molecular weight:
474.31
Molecular formula:
C25H25N6BF2O
Solubility:
good in DCM, alcohols, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
BDP 558/568 azide is a borondipyrromethene dye with azide functional group for Click chemistry. Its spectra are close to Cyanine3 channel. The fluorophore has been used for lipid tracking as BDP 558/568 C12, but azide functional groups allow easy conjugation with a wide variety of other molecules of interest.
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基反应性 BDP FL，一种非常明亮且光稳定的荧光素通道染料。
Cyanine3 azide
Azide derivative of Cyanine3 fluorescent dye for Click Chemistry.
用于 Click Chemistry 的 Cy3 荧光染料的叠氮化物衍生物。
General properties
Appearance:
dark colored solid 深色固体
Mass spec M+ increment:
428.1
Molecular weight:
428.27
Molecular formula:
C19H19N6BF2OS
Solubility:
soluble in many organic solvents (DCM, acetone, alcohols, DMF, DMSO), low solubility in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
AF568 is a fluorescent dye. Its excitation peak is at 572 nm and its emission peak at 598 nm. AF568 azide is a photochemically stable, specific, and highly efficient tool for labeling biomolecules. It is water soluble and insensitive to pH changes between pH 4 and pH 10. The reaction conditions do not require high temperature or pressure.
Labeling with AF568 azide via Click Chemistry is a powerful technique for the production of bioconjugates. Thus, AF568 azide is an excellent tool for imaging purposes, including fluorescent microscopy and flow cytometry, where label brightness and photostability are essential.
AF488 NHS ester, a bright, photostable and hydrophilic fluorescent dye for green channel.
AF488 NHS 酯，一种用于绿色通道的明亮、光稳定性和亲水性荧光染料。
AF568 carboxylic acid
Non-reactive form of AF568 fluorescent dye
AF568 荧光染料的非反应性形式
AF488 azide
AF488 azide is a fluorophore with emission in the green spectrum range. It reacts with alkynes in copper-catalyzed cycloaddition reactions.
AF488 azide 是一种在绿色光谱范围内发射的荧光团。 它在铜催化的环加成反应中与炔烃反应。
General properties
Appearance:
dark colored solid
Mass spec M+ increment:
776.2
Molecular weight:
853.02
Molecular formula:
C36H34N6K2O10S2
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
AF488 is a fluorescent dye. AF488 is a fluorophore pH-insensitive over a broad pH range (from 4 to 10). It has an absorption maximum at 495 nm and an emission maximum at 519 nm in the green spectrum region. The dye is hydrophilic and can be used to introduce the fluorescent label into various molecules, including proteins and antibodies. Conjugates of molecules with AF488 have high brightness and photostability and are commonly used in flow cytometry and microscopy. This allows the detection of biological objects with high sensitivity at a longer imaging time.
AF488 azide interacts with alkynyl derivatives of biomolecules in Click Chemistry reactions either in the presence of copper (I) catalyst (with terminal alkynes) or without catalyst (with cyclooctynes), leading to the formation of stable adducts.
BDP R6G tetrazine is a borondipyrromethene dye with absorption and emission wavelengths similar to rhodamine 6G. It contains tetrazine fragment for iedDA ligation.
BDP R6G 四嗪是一种硼二吡咯亚甲基染料，其吸收和发射波长与罗丹明 6G 相似。 它包含用于 iedDA 连接的四嗪片段。
Amino-11-UTP
Uridine triphosphate labeled with amino group intended for indirect non-radioactive enzymatic RNA labeling.
用氨基标记的三磷酸尿苷，用于间接非放射性酶促 RNA 标记。
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.储存：收到后 24 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。
AF430 is a fluorescent dye. It can be excited by 405 nm violet laser or 445 nm laser paired, for example, with 510/80 nm bandpass filter.
Azide moiety allows quick and effective labeling and detection of terminal alkynes via a copper-catalyzed click reaction (CuAAC) or of strained cyclooctynes via a copper-free click chemistry reaction. Mild reaction conditions are suitable for most biomolecules, cells, and tissues. The product is water soluble and insensitive to pH changes between pH 4 and pH 10.
AF568 derivative for labeling proteins and other high- and low-molecular weight ligands with free amines.
AF568 衍生物，用于用游离胺标记蛋白质和其他高分子量和低分子量配体。
AF430 maleimide
AF430 is a green-yellow emitting fluorescent dye of coumarin series. This maleimide derivative allows to label thiolated biomolecules.
AF430是香豆素系列的绿-黄发光荧光染料。 这种马来酰亚胺衍生物可以标记硫醇化的生物分子。
AF430 carboxylic acid
Non-reactive form of AF430 fluorescent dye to be used as a reference standard
AF430 荧光染料的非反应性形式用作参考标准
General properties
Appearance:
yellow solid
Molecular weight:
623.69
Molecular formula:
C25H29N5F3KO6S
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
TAMRA (tetramethylrhodamine) is a xanthene dye of rhodamine series. This fluorophore is being used for quite a long time for the preparation of dual labeled qPCR TaqMan oligonucleotide probes containing TAMRA and fluorescein (FAM).
Just like many other xanthene fluorophores, TAMRA is a available as two isomers (5- and 6-isomer) which have nearly identical optical properties. This product is an isomerically pure 5-TAMRA.
TAMRA NHS is an amine reactive reagent. It can be used for the labeling of proteins, peptides, and modified oligonucleotides containing amine groups.
Storage: 12 months after receipt at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：NHS esters Near infrared (NIR) imaging sulfo-Cyanine7.5 Protein labeling
货号
规格
价格
货期
N6320
1 rxn
–
in stock
16320
1 mg
110.00$
in stock
26320
5 mg
290.00$
in stock
46320
25 mg
690.00$
in stock
56320
50 mg
1190.00$
in stock
66320
100 mg
1850.00$
in stock
Sulfo-Cyanine7.5 is a near infrared water soluble and hydrophilic dye for the NIR imaging applications. The structure and spectra of the dye resemble indocyanine green (ICG) that has been approved for use in humans for years. However, unlike ICG, sulfo-Cyanine7.5 contains a trimethylene bridge that increases its quantum yield compared to ICG, and also has a linker arm for its attachment to proteins, peptides, and other molecules. This derivative is an NHS ester for the modification of amine groups.
Absorption and emission spectra of sulfo-Cyanine7.5
Sulfo-Cy7.5 NHS ester相关产品
BDP FL NHS ester
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基反应性 BDP FL，一种非常明亮且光稳定的荧光素通道染料。
Cy3 carboxylic acid
Free Cyanine3 carboxylic acid.
游离Cy3羧酸。
Sulfo-Cyanine7.5 dicarboxylic acid
Sulfo-Cy7.5 dicarboxylic acid is a bifunctional cyanine dye with two carboxylic acid (COOH) groups. The molecule can be used to construct cross conjugates containing a near infrared emitting fluorophore.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
González, M.I.; González-Arjona, M.; Santos-Coquillat, A.; Vaquero, J.; Vázquez-Ogando, E.; de Molina, A.; Peinado, H.; Desco, M.; Salinas, B. Covalently Labeled Fluorescent Exosomes for In Vitro and In Vivo Applications. Biomedicines, 2021, 9, 81. doi: 10.3390/biomedicines9010081
Park, B.G.; Kim, Y.J.; Min, J.H.; Cheong, T.-C.; Nam, S.H.; Cho, N.-H.; Kim, Y.K.; Lee, K.B. Assessment of Cellular Uptake Efficiency According to Multiple Inhibitors of Fe3O4-Au Core-Shell Nanoparticles: Possibility to Control Specific Endocytosis in Colorectal Cancer Cells. Nanoscale Research Letters, 2020, 15, 165. doi: 10.1186/s11671-020-03395-w
Ruiz, A.; Bravo, D.; Duarte, A.; Adler, R.S.; Raya, J.G. Accuracy of Ultrasound-Guided versus Landmark-Guided Intra-articular Injection for Rat Knee Joints. Ultrasound in Medicine and Biology, 2019, 45(10), 2787–2796. doi: 10.1016/j.ultrasmedbio.2019.06.403
Sulfo-Cyanine7 bis-NHS ester is a water-soluble, bifunctional cross-linker that contains a core of near infrared, water soluble dye sulfo-Cyanine7, and two amine-reactive NHS ester groups.
BDP 630/650 is a borondipyrromethene fluorophore tuned to Cyanine5 excitation and emission channels. The dye is bright and highly photostable. It is useful for fluorescence polarization assays This is an amine-reactive NHS ester derivative.
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Cyanine5.5 NHS ester
Cyanine5.5 NHS is far-red / near-infrared amine-reactive dye.
Cy5.5 NHS 是远红/近红外胺活性染料。
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Sulfo-Cy5.5 azide
Sulfo-Cyanine5.5 azide is a derivative of water soluble far red emitting fluorescent cyanine dye. The azide group can be conjugated by either copper-catalyzed or copper free Click chemistry. The reagent possesses high aqueous solubility and hydrophilicity, and recommended for the labeling of biomolecules in aqueous environment.
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General properties
Appearance:
dark colored solid
Molecular weight:
1041.23
Molecular formula:
C50H57N4KO14S2
Solubility:
good in DMF, DMSO, water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：sulfo-Cy7 NHS esters Near infrared (NIR) imaging Protein labeling
货号
规格
价格
货期
15320
1 mg
110.00$
in stock
25320
5 mg
290.00$
in stock
45320
25 mg
690.00$
in stock
55320
50 mg
1270.00$
in stock
65320
100 mg
1990.00$
in stock
Water soluble near infrared dye sulfo-Cy7, an amine-reactive succinimide ester.
Sulfo-Cy7 is an improved analog of Cy7® fluorophore with quantum yield improved by 20%, and higher photostability. This fluorescent dye is especially useful for NIR imaging.
Near infrared fluorescent imaging takes advantage of transparency of biological tissues at particular range of wavelengths. The method is non-destructive, and allows to monitor distribution of various labeled molecules in live organisms.
Sulfo-Cyanine7 NHS ester reagent allows to prepare sulfo-Cyanine7-labeled biomolecules, such as proteins, with ease. Dye labeled molecules can be subsequently used for various research and drug design related experiments.
This reagent has high water solubility, and is especially useful for the labeling of delicate proteins, and proteins prone to denaturation. Non-sulfonated Cy7 NHS ester soluble in organic phase is also available.
AF430 is a hydrophilic coumarin dye with the emission in green-yellow range. The NHS ester is used for the labeling of amine groups.
AF430 是一种亲水性香豆素染料，发射在黄绿色范围内。 NHS 酯用于标记胺基。
Cyanine5 alkyne
Cyanine5 alkyne is an alkyne dye for Click Chemistry.
Cy5 炔烃是一种用于 Click Chemistry 的炔烃染料。
Pico488 dsDNA quantification reagent, 200x solution in DMSO
Pico488 is a dye for precise fluorescence based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.
Pico488 是一种染料，用于在存在 RNA、ssDNA 和其他杂质的情况下对 dsDNA 进行基于荧光的精确定量。 该染料在荧光素通道中显示出明亮的荧光，在低 pg/mL 至高 ng/mL 范围内对 DNA 浓度提供线性响应。
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
González, L.F.; Acuña, E.; Arellano, G.; Morales, P.; Sotomayor, P.; Oyarzun-Ampuero, F.; Naves, R. Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy. Journal of Controlled Release, 2021, 331, 443–459. doi: 10.1016/j.jconrel.2020.11.019
Shapoval, O.; Oleksa, V.; Šlouf, M.; Lobaz, V.; Trhlíková, O.; Filipová, M.; Janoušková, O.; Engstová, H.; Pankrác, J.; Modrý, A.; Herynek, V.; Ježek, P.; Šefc, L.; Horák, D. Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic. Nanomaterials, 2021, 11(1), 230. doi: 10.3390/nano11010230
标签：NHS esters Near infrared (NIR) imaging Microscopy Protein labeling sulfo-Cy5.5
货号
规格
价格
货期
17320
1 mg
110.00$
in stock
27320
5 mg
290.00$
in stock
47320
25 mg
690.00$
in stock
57320
50 mg
1190.00$
5 days
67320
100 mg
1850.00$
in stock
Sulfo-Cyanine5.5 NHS ester is an amine reactive activated ester of sulfonated far red Cyanine5.5 fluorophore, an analog of Cy5.5®. This is a reagent of choice for the labeling of antibodies, sensitive proteins, and others which require reactions in purely aqueous environment, or without any significant additions of organic co-solvents.
The dye is well suitable for non-invasive in vivo NIR imaging, and for the applications requiring low fluorescent background.
Absorption and emission spectra of sulfo-Cyanine5.5 fluorophore
Sulfo-Cy5.5 NHS ester相关产品
Sulfo-Cyanine5 alkyne
Sulfo-Cyanine5 is a water-soluble Cyanine5 dye alkyne for Click chemistry.
Sulfo-Cyanine5 是一种用于 Click 化学的水溶性 Cyanine5 染料炔烃。
Cyanine7 azide
Near-infrared fluorescent dye for Click Chemistry.
用于点击化学的近红外荧光染料。
General properties
Appearance:
dark blue solid
Mass spec M+ increment:
884.15
Molecular weight:
1114.37
CAS number:
2419286-92-1
Molecular formula:
C44H42N3K3O16S4
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Liu, Q.; Tian, J.; Liu, J.; Zhu, M.; Gao, Z.; Hu, X.; Midgley, A.C.; Wu, J.; Wang, Xi.; Kong, D.; Zhuang, J.; Liu, J.; Yan, X.; Huang, X. Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages. Advanced Materials, 2021, 33(39), 2103128. doi: 10.1002/adma.202103128
Lu, Z.; Zhang, Y.; Wang, Y.; Tan, G.-H.; Huang, F.-Y.; Cao, R.; He, N.; Zhang, L. A biotin-avidin-system-based virus-mimicking nanovaccine for tumor immunotherapy. Journal of Controlled Release, 2021, 332, 245–259. doi: 10.1016/j.jconrel.2021.02.029
Shramova, E.; Proshkina, G.; Shipunova, V.; Ryabova, A.; Kamyshinsky, R.; Konevega, A.; Schulga, A.; Konovalova, E.; Telegin, G.; Deyev, S. Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape. Cancers, 2020, 12(10), 3014. doi: 10.3390/cancers12103014
Peplau, E.; De Rose, F.; Reder, S.; Mittelhaeuser, M.; Scafetta, G.; Schwaiger, M.; Weber, W.A.; Bartolazzi, A.; Skerra, A.; D’Alessandria, C. Development of a chimeric Fab directed against human galectin-3 and validation as an immune-PET tracer for the sensitive in vivo imaging of thyroid cancer. Thyroid, 2020, 30(9), 1314–1326. doi: 10.1089/thy.2019.0670
A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
具有叠氮化物和胺基的双功能接头，位于 PEG3（三甘醇）的两侧
General properties
Appearance:
dark blue powder
Molecular weight:
975.14
Molecular formula:
C45H51KN4O14S2
Solubility:
good in DMF, DMSO, water
Quality control:
NMR 1H, HPLC-MS (895%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：sulfo-Cyanine5 NHS esters Microscopy Protein labeling
货号
规格
价格
货期
13320
1 mg
110.00$
in stock
23320
5 mg
210.00$
in stock
43320
25 mg
410.00$
in stock
53320
50 mg
695.00$
in stock
63320
100 mg
1190.00$
in stock
Cyanine 5 succinimidyl ester (SE), an equivalent of Cy5® NHS ester, for the labeling of various amine-containing molecules in aqueous phase without use of any organic co-solvent. This product is therefore particularly useful for the labeling of proteins which denature in the presence of organic co-solvents, as well as for proteins with low solubility.
Sulfo-Cyanine 5 is an analog of Cy5®, one of the most popular fluorophores which is compatible with various equipment such as plate readers, microscopes, and imagers.
This dye is highly hydrophilic and water-soluble. A non-sulfonated analog is also available.
Can be used as a replacement for Cy5®, DyLight 649 for all applications.
sulfo-Cyanine7.5 is a highly hydrophilic near infrared dye for in vivo imaging. This maleimide derivative is useful for the labeling of thiol groups of proteins and peptides.
sulfo-Cyanine7.5 是一种高度亲水的近红外染料，用于体内成像。 这种马来酰亚胺衍生物可用于标记蛋白质和肽的硫醇基团。
sulfo-Cyanine5 DBCO
Water soluble cycloalkyne for copper free Click chemistry reaction with azides. A derivative of sulfo-Cyanine5 aka Cy5.
水溶性环炔烃，用于与叠氮化物的无铜点击化学反应。 磺基-Cyanine5 又名 Cy5 的衍生物。
Cyanine5.5 azide
Far red / near infrared fluorescent Cyanine5.5 dye derivative for Click Chemistry.
用于 Click Chemistry 的远红/近红外荧光 Cyanine5.5 染料衍生物。
General properties
Appearance:
dark blue powder
Molecular weight:
777.95
CAS number:
2230212-27-6; 146368-14-1 (N-Ethyl)
Molecular formula:
C36H40N3KO10S2
Solubility:
very good in water, good in DMF and DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Grohme, M.; Frank, O.; Rink, J. Preparing Planarian Cells for High-content Fluorescence Microscopy Using RNA in situ Hybridization and Immunocytochemistry. preprints.org, preprint. doi: 10.20944/preprints202111.0256.v1
van Hest, J.C.; Song, S.; Mason, A.; Post, R.; de Corato, M.; Mestre, R.; Yewdall, A.; Cao, S.; van der Hofstad, R.; Sanchez, S.; Abdelmohsen, L. Engineering transient dynamics of artificial cells by stochastic distribution of enzymes. ChemRxiv, preprint. doi: 10.33774/chemrxiv-2021-02c1d
Lee, M.S.; Hyun, H.; Park, I.; Kim, S.; Jang, D.-H.; Kim, S.; Im, J.-K.; Kim, H.; Lee, J.H.; Kwon, T.; Kang, J.H. Quantitative fluorescence in situ hybridization (FISH) of magnetically confined bacteria enables rapid determination of early-stage human bacteremia. medRxiv, preprint. doi: 10.1101/2021.02.19.21251962
Cyanine3.5 is a fluorescent dye with absorption and emission intermediate between Cyanine3 and Cyanine5. Sulfonated version contains four sulfo groups which ensure high solubility and hydrophilicity of the fluorophore and labeled conjugates.
The NHS ester reactive group allows to label primary and secondary amine groups.
Absorption and emission spectra of sulfo-Cyanine3.5
Sulfo-Cy3.5 NHS ester相关产品
Cyanine5 NHS ester
Amine-reactive Cyanine5 activated ester for the labeling of proteins, peptides, and other molecules.
胺反应性 Cyanine5 活化酯，用于标记蛋白质、肽和其他分子。
Sulfo-Cyanine3 NHS ester
Water soluble sulfo-Cyanine3 SE activated ester for amino-biomolecule labeling.
用于氨基生物分子标记的水溶性磺基-Cyanine3 SE 活化酯。
Pico488 dsDNA quantification reagent, 200x solution in DMSO
Pico488 is a dye for precise fluorescence based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.
Pico488 是一种染料，用于在存在 RNA、ssDNA 和其他杂质的情况下对 dsDNA 进行基于荧光的精确定量。 该染料在荧光素通道中显示出明亮的荧光，在低 pg/mL 至高 ng/mL 范围内对 DNA 浓度提供线性响应。
General properties
Appearance:
deep purple powder
Molecular weight:
1088.33
CAS number:
2231670-91-8 (without cation)
Molecular formula:
C42H40N3K3O16S4
Solubility:
good in water, DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
标签：NHS esters Microscopy Protein labeling sulfo-Cyanine3
货号
规格
价格
货期
11320
1 mg
110.00$
in stock
21320
5 mg
210.00$
in stock
41320
25 mg
410.00$
in stock
51320
50 mg
695.00$
in stock
61320
100 mg
1190.00$
in stock
Water soluble, amino-reactive sulfo-Cyanine3 NHS ester. Efficiently labels proteins and peptides in purely aqueous solution, without need for organic co-solvent. Ideal for proteins with low solubility, and proteins prone to denaturation.
This is sulfonated, hydrophilic and water-soluble dye. Non-sulfonated Cyanine3 NHS ester is also available.
This product is an analog of Cy3® NHS ester. Sulfo-Cyanine3 NHS ester replaces Cy3® and DyLight 549 for all applications.
BDP FL is a bright and photostable borondipyrromethene dye for fluorescein channel. This is a dye azide for Click Chemistry.
BDP FL 是一种用于荧光素通道的明亮且光稳定的硼二吡咯亚甲基染料。 这是一种用于 Click Chemistry 的染料叠氮化物。
Cyanine3 maleimide
Cyanine3 maleimide is a thiol mono reactive dye.
Cyanine3 马来酰亚胺是一种硫醇单活性染料。
BDP 630/650 tetrazine
BDP 630/650 is a borondipyrromethene dye for Cyanine5 channel. This is a tetrazine derivative for the coupling with strained cycloalkenes.
BDP 630/650 是用于 Cyanine5 通道的硼二吡咯亚甲基染料。 这是一种用于与应变环烯烃偶联的四嗪衍生物。
3H-Indolium, 2-[3-(1,3-dihydro-1,3,3-trimethyl-5-sulfo-2H-indol-2-ylidene)-1-propen-1-yl]-1-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-3,3-dimethyl-5-sulfo-, inner salt, sodium salt
Solubility:
soluble in water (0.62 M = 47 g/L), in polar organic solvents (DMF, DMSO)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Grohme, M.; Frank, O.; Rink, J. Preparing Planarian Cells for High-content Fluorescence Microscopy Using RNA in situ Hybridization and Immunocytochemistry. preprints.org, preprint. doi: 10.20944/preprints202111.0256.v1
Futamata, H.; Fukuda, M.; Umeda, R.; Yamashita, K.; Takahashi, S.; Shikakura, Ta.; Hayashi, S.; Homma, K.; Nishizawa, T.; Nureki, O. Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifier. Research Square, preprint. doi: 10.21203/rs.3.rs-927386/v1
Lee, M.S.; Hyun, H.; Park, I.; Kim, S.; Jang, D.-H.; Kim, S.; Im, J.-K.; Kim, H.; Lee, J.H.; Kwon, T.; Kang, J.H. Quantitative fluorescence in situ hybridization (FISH) of magnetically confined bacteria enables rapid determination of early-stage human bacteremia. medRxiv, preprint. doi: 10.1101/2021.02.19.21251962
Baker, Y.; Yuan, L.; Chen J.; Belle, R.; Carlisle, R.; El-Sagheer, A.; Brown, T. Expanding the Chemical Repertoire of DNA Nanomaterials Generated by Rolling Circle Amplification. ChemRxiv, preprint. doi: 10.26434/chemrxiv.12566963.v1
标签：ROX (Rhodamine X, Rhodamine 101) NHS esters Microscopy Protein labeling
货号
规格
价格
货期
12220
1 mg
110.00$
in stock
22220
5 mg
210.00$
in stock
42220
25 mg
410.00$
in stock
52220
50 mg
695.00$
in stock
62220
100 mg
1190.00$
in stock
ROX (rhodamine X aka R101) is a highly fluorescent, and photostable rhodamine dye for various applications. ROX labeled oligonucleotide probes are often used in qPCR, and qPCR instruments have ROX channel.
ROX（罗丹明X又名R101）是一种高荧光、耐光的罗丹明染料，适用于各种应用。ROX标记的寡核苷酸探针通常用于qPCR，qPCR仪器具有ROX通道。
This is reactive dye for the labeling of amino-groups in peptides, proteins, and amino-oligonucleotides. Pure single isomer.
这是一种活性染料，用于标记肽、蛋白质和氨基寡核苷酸中的氨基。纯单一异构体。
Absorption and emission spectra of ROX dye
ROX NHS ester, 6- isomer相关产品
Pico488 dsDNA quantification reagent, 200x solution in DMSO
Pico488 is a dye for precise fluorescence based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.
Pico488是一种染料，用于在存在RNA、单链DNA和其他杂质的情况下对双链DNA进行精确的荧光定量。该染料在荧光素通道中表现出明亮的荧光，在低pg/mL到高ng/mL范围内对DNA浓度提供线性响应。
Biotin-PEG3-Azide
Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe.
叠氮生物素是一种用生物素（一种著名的亲和探针）进行点击化学标记的试剂。
DusQ1 CPG 500
Controlled pore glass (CPG) 500 solid support for synthesis of oligonucleotides with 3’-terminal DusQ1 quencher. Compatible with standard deblocking conditions.
控制孔玻璃（CPG）500固体载体，用于合成带有3′-末端DusQ1猝灭剂的寡核苷酸。与标准去块条件兼容。
General properties
Appearance:
dark crimson powder
Mass spec M+ increment:
516.2
Molecular weight:
631.67
CAS number:
117491-83-5; 1890922-83-4; 216699-36-4
Molecular formula:
C37H33N3O7
Solubility:
good in polar organic solvents (DMF, DMSO), low in water
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
ROX (rhodamine X) is a bright rhodamine dye for ROX channel. Carboxy rhodamines come as two isomers.
ROX（罗丹明X）是一种用于ROX通道的明亮罗丹明染料。羧基罗丹明有两种异构体。
Products
Reactive dyes
Dye NHS esters
ROX NHS ester, 5-isomer
ROX NHS ester, 5-isomer
ROX (Rhodamine X, Rhodamine 101) NHS esters
货号
规格
价格
货期
11220
1 mg
110.00$
in stock
21220
5 mg
210.00$
in stock
41220
25 mg
410.00$
in stock
51220
50 mg
695.00$
in stock
61220
100 mg
1190.00$
in stock
ROX (rhodamine X) is a bright rhodamine dye for ROX channel. Carboxy rhodamines come as two isomers.
ROX（罗丹明X）是一种用于ROX通道的明亮罗丹明染料。羧基罗丹明有两种异构体。
This product is a derivative of pure 5-carboxy-ROX.
本品是纯5-羧基-ROX的衍生物。
Absorption and emission spectra of ROX dye
Customers also purchased with this product
BDP FL NHS ester
Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.
氨基活性BDP FL，一种非常明亮且可光照的荧光素通道染料。
Alkyne dT phosphoramidite
Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.
磷酰胺改性剂，用于合成链中含有炔烃修饰的寡核苷酸。
Cyanine5 alkyne
Cyanine5 alkyne is an alkyne dye for Click Chemistry.
氰基5炔烃是一种用于化学的炔烃染料。
General properties
Appearance:
dark red solid
Mass spec M+ increment:
516.2
Molecular weight:
631.67
CAS number:
209734-74-7; 344402-35-3
Molecular formula:
C37H33N3O7
Solubility:
good in DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (80%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Pyrene is a polyaromatic hydrocarbon which exhibits fluorescence in blue range of the spectrum. When two pyrene residues are closely spaced, excimer fluorescence is observed at longer wavelength. Therefore, pyrene is useful as a proximity label.
Pyrene exhibits affinity to graphite, and can be used as an anchor group for graphite. This reagent can be conjugated with biomolecules for their subsequent immobilization on graphite surfaces.
This NHS ester allows to label biomolecules with amino groups, such as proteins, peptides, amino-DNA and other molecules.
good in DCM, chloroform, moderate in DMF, DMSO, low in water
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Nekrasov, N.; Jaric, S.; Kireev, D.; Emelianov, A.V.; Orlov, A.V.; Gadjanski, I.; Nikitin, P.I.; Akinwande, D.; Bobrinetskiy, I. Real-time detection of ochratoxin A in wine through insight of aptamer conformation in conjunction with graphene field-effect transistor. Biosensors and Bioelectronics, 2022, 200, 113890. doi: 10.1016/j.bios.2021.113890
标签：FAM (Fluorescein) NHS esters Fluorescence polarization Microscopy Protein labeling
货号
规格
价格
货期
25120
5 mg
–
in stock
45120
25 mg
140.00$
in stock
55120
50 mg
240.00$
in stock
65120
100 mg
370.00$
in stock
85120
1 g
please inquire
in stock
95120
5 g
please inquire
in stock
Fluorescein (FAM) is a bright fluorophore that has found an extremely wide application in life science research. The fluorophore is hydrophilic and its derivatives possess good solubility in aqueous buffers.
Fluorescein is compatible with a wide variety of fluorescent instrumentation – most instruments are equipped with FAM channel filters.
This product contains the pure 6-isomer of fluorescein.
BDP TR X NHS ester is a derivative of BDP TR containing a long linker based on aminohexanoic acid (C6). The dye has absorption and emission close to ROX. The NHS ester function can be used for the conjugation with proteins and peptides.
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Iurova, E.; Beloblov, I.; Beloborodov, E.; Rastorgueva, E.; Pogodina, E.; Tazintseva, E.; Saenko, Y.; Fomin, A. Use of Natural Peptides with a Cysteine Knot of Arthropods as a Carrier of a Peptide Tropic to Glutamate Carboxypeptidase II. Systematic Reviews in Pharmacy, 2020, 11(9), 503–509. doi: 10.31838/srp.2020.9.73
Pinals, R.L.; Yang, D.; Lui, A.; Cao, W.; Landry, M.P. Corona exchange dynamics on carbon nanotubes by multiplexed fluorescence monitoring. Journal of the American Chemical Society, 2020, 142(3), 1254–1264. doi: 10.1021/jacs.9b09617
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