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- DBCO NHS ester
DBCO NHS ester
| 货号 | 规格 | 价格 | 货期 |
|---|---|---|---|
| 34720 | 10 mg | 60.00$ | in stock |
| 44720 | 25 mg | 95.00$ | in stock |
| 54720 | 50 mg | 145.00$ | in stock |
| 64720 | 100 mg | 210.00$ | in stock |
| 94720 | 1 g | 1190.00$ | in stock |
| K4720 | 5 g | 3570.00$ | in stock |
| N4720 | 25 g | please inquire | 21 days |
Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cycloalkynes for strain promoted alkyne azide cycloaddition (spAAC) – a copper free Click chemistry reaction.
This is an amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.
DBCO reacts instantly with azides. The rate of the reaction is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines – this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.
二苯并环辛炔 (ADIBO, DBCO) 是对应变促进炔烃叠氮化物环加成 (spAAC) 反应性最强的环炔烃之一 – 一种无铜点击化学反应。
这是一种胺反应性 NHS 酯，可将反应性部分轻松连接到几乎任何伯胺或仲胺基团，例如蛋白质、肽或小分子胺的基团。
DBCO 立即与叠氮化物发生反应。 该反应的速率远高于铜催化的反应，以及与许多其他环辛炔的反应。 与其他一些环辛炔不同，DBCO 不与四嗪反应 – 这允许叠氮化物与 DBCO 以及反式环辛烯与四嗪的正交共轭。
DBCO NHS ester相关产品
FAM azide, 6-isomer
FAM (fluorescein) azide, 6-isomer is a commonly used fluorescent dye azide for Click Chemistry.
FAM（荧光素）叠氮化物，6 异构体是 Click Chemistry 中常用的荧光染料叠氮化物。
Sulfo-Cyanine5.5 carboxylic acid
Water soluble far red fluorescent dye sulfo-Cyanine5.5, free non-activated carboxylic acid. Useful for the calibration, and as a non-reactive control.
水溶性远红荧光染料sulfo-Cy5.5，游离非活化羧酸。 用于校准，并作为非反应控制。
Cyanine3.5 NHS ester
Cyanine3.5 dye NHS ester derivative.
Cy3.5染料NHS酯衍生物。
General properties
| Appearance: | off white solid |
| Mass spec M+ increment: | 315.1 |
| Molecular weight: | 430.45 |
| CAS number: | 1384870-47-6 |
| Molecular formula: | C25H22N2O5 |
| IUPAC name: | 6-{2-Azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-6-oxohexanamide |
| Solubility: | good in DCM, DMF, DMSO |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
储存：收到后 12 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。 |
| MSDS: | Download |
| Product specifications |
相关文献：
- Adams, M.R.; Moody, C.T.; Sollinger, J.L.; Brudno, Y. Extracellular Matrix-Anchored Click Motifs for Specific Tissue Targeting. Molecular Pharmaceutics, 2020, 17(2), 392–403. doi: 10.1021/acs.molpharmaceut.9b00589
- Alshanski, I.; Blaszkiewicz, J.; Mervinetsky, E.; Rademann, J.; Yitzchaik, S.; Hurevich, M. Sulfation Patterns of Saccharides and Heavy Metal Ions Binding. Chemistry, 2019, 25(52), 12083–12090. doi: 10.1002/chem.201901538
- Andersen, V.L.; Vinther, M.; Kumar, R.; Ries, A.; Wengel, J.; Nielsen, J.S.; Kjems, J. A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine. Theranostics, 2019, 9(9), 2662–2677. doi: 10.7150/thno.32060