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CD247 Human, Sf9
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CD247 Human Recombinant, Sf9
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PRO-2529
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Catalogue number
PRO-2529
Synonyms
CD247 Molecule, T-Cell Surface Glycoprotein CD3 Zeta Chain, T-Cell Receptor T3 Zeta Chain, CD247 Antigen, CD3Z, TCRZ, T3Z, T-Cell Antigen Receptor Complex, Zeta Subunit Of CD3, CD3Z Antigen, Zeta Polypeptide , CD3z Antigen, Zeta Polypeptide , CD247 Antigen, Zeta Subunit , TCR Zeta Chain, CD3zeta Chain, CD3-ZETA, IMD25, CD3H, CD3Q.
Introduction
T-cell surface glycoprotein CD3 zeta chain is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.
T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta,它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。 zeta 链在将抗原识别与几种细胞内信号转导途径偶联方面具有核心作用。 CD247 抗原的低表达导致免疫反应受损。
Description
CD247 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 122 amino acids and having a molecular mass of 14.1kDa. . CD247 is expressed with an 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Source
Physical Appearance
Formulation
CD247 protein solution contains 20mM Tris-HCl buffer , 50% glycerol, 1mM DTT, 1mM EDTA and 0.1M NaCl.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Purity
Greater than 90.0% as determined by -PAGE.
Amino acid sequence
ADPRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPRHHHH HH
Usage
Related Products
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CD247 Human