ProSpec,sCD40L Human His Active,可溶性 CD40 配体/TRAP His 标签活性人重组CYT-1190

CD40 ligand, CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP.

CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2.

CD40L 或 CD154 是在 T 细胞表面表达的膜糖蛋白和分化抗原。 CD40 配体在细胞因子存在的情况下刺激 B 细胞增殖和所有免疫球蛋白同种型的分泌。 CD40 配体已显示在外周血单核细胞中诱导细胞因子产生和杀肿瘤活性。 它还共同刺激活化 T 细胞的增殖，并伴随着 IFN-γ、TNF-α 和 IL2 的产生。

sCD40L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids and having a molecular mass of 18.3kDa.
sCD40L is fused to a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered colorless solution.

sCD40L protein contains 20mM Tris-HCl buffer , 0.2M NaCl, 1mM DTT and 40% glycerol.

Greater than 95.0% as determined by -PAGE.

Measured by its binding ability in a functional ELISA with Human CD40/TNFRSF5.

MGSSHHHHHH SSGLVPRGSH MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LCLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL

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