ProSpec-RELM b Human, His/CYT-454

Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2.

RELM-beta is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin , RELM-alfa , RELM-beta and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents.
RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant.
The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice.

RELM-beta 是最近发现的一个分泌蛋白家族的成员，该家族含有一个保守的富含半胱氨酸的 C 末端。 RELM 家族由抵抗素、RELM-α、RELM-β 和 RELM-γ 组成。 在人类中仅发现了抵抗素和 RELM-beta，而在啮齿动物中发现了所有四个 RELM 家族成员。
RELM-beta 似乎仅由肠杯状细胞以同源二聚体形式产生，并且可以在粪便中大量发现。 值得注意的是，在无菌小鼠进入自然环境后发生细菌定植之前，展示无菌肠道的无菌小鼠粪便中不含 RELM-β。 一些（但不是全部）结肠癌细胞系将 RELM-β 分泌到细胞培养上清液中。
RELM-beta 的生理功能尚不清楚。 高剂量的重组 RELM-beta 显示出高血糖作用，包括降低小鼠的葡萄糖处理和增加肝葡萄糖的产生。

RELM-beta Human Recombinant is a His-Tagged Fusion Protein which is 11 kDa protein containing 90 amino acid residues of the RELM-beta human and 12 additional amino acid residues – HisTag .

RELM-beta Human Recombinant 是一种带 His 标签的融合蛋白，它是一种 11 kDa 的蛋白质，含有 RELM-beta 人的 90 个氨基酸残基和 12 个额外的氨基酸残基 – HisTag。

Escherichia Coli.

Filtered White lyophilized powder.

Filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.

Add 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10μg/ml. In higher concentrations the solubility of this antigen is limited.

加入 0.1M 醋酸缓冲液 pH-4，让冻干颗粒完全溶解。 为了转化为更高的 pH 值，我们建议使用相关缓冲液将其充分稀释至 10μg/ml 的浓度。 在较高浓度下，该抗原的溶解度是有限的。

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

将冻干蛋白储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

MGSTQCSLDS VMDKKIKDVL NSLEYSPSPI SKKLSCASVK SQGRPSSCPA GMAVTGCACG YGCGSWDVQLETTCHCQCSV VDWTTARCCH LTKLRSHHHH HH.

Greater than 95% as determined by -PAGE.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.