ProSpec-Resistin Human, His/CYT-256

Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RSTN, XCP1, RETN1, MGC126603, MGC126609.

Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF and FIZZ3 . Human resistin contains 108 amino acids as a prepeptide, and its hydrofobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26.
Resistin may be an important link between obesity and insulin resistance. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severly suppressed in obesity and is stimulated by several antidiabetic drugs.
Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.

抵抗素是RSTN基因的产物，是一种肽激素，属于富含半胱氨酸的分泌蛋白类，被称为RELM家族，也被描述为ADSF和FIZZ3。人抵抗素含有108个氨基酸的前肽，其疏水信号肽在分泌前被切割。抵抗素以二聚体蛋白的形式在人体血液中循环，该二聚体蛋白由两个 92 个氨基酸的多肽组成，它们通过 Cys26 二硫键连接。
抵抗素可能是肥胖和胰岛素抵抗之间的重要联系。由脂肪细胞特异性产生和分泌的小鼠抵抗素作用于骨骼肌肌细胞、肝细胞和脂肪细胞本身，从而降低它们对胰岛素的敏感性。 Steppan 等人。已经提出抵抗素抑制胰岛素刺激葡萄糖摄取的能力。他们还提出，肥胖小鼠血液中的抵抗素水平升高，并且被禁食和抗糖尿病药物下调。另一方面，Way 等人发现抵抗素的表达在肥胖症中受到严重抑制，并受到几种抗糖尿病药物的刺激。
其他研究表明，小鼠抵抗素在脂肪细胞分化过程中增加，但它似乎也抑制脂肪生成。相反，人类脂肪形成分化可能与抵抗素基因表达的下调有关。

Resistin Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing a 92 amino acids fragment of the mature Human Resistin, having a total molecular mass of 14.23kDa and fused with a 4.5kDa amino-terminal hexahistidine tag.
The Resistin is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Resistin Human Recombinant 是一种单一的、非糖基化的多肽链，含有成熟的 Human Resistin 的 92 个氨基酸片段，总分子量为 14.23kDa，并与 4.5kDa 的氨基末端六组氨酸标签融合。
Resistin 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile filtered colorless solution.

Resistin protein solution is supplied in 20mM Tris-HCl pH 8.0, 5mM EDTA and 50% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
请避免冻融循环。

Greater than 95% as determined by -PAGE.

Prospec’s products are furnished forLABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.