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• Biotin phosphoramidite (hydroxyprolinol)

Biotin phosphoramidite (hydroxyprolinol)

Non-nucleosidic modifier reagent for the synthesis of biotinylated oligos based on a hydroxyprolinol core. This phosphoramidite contains a dimethoxytrityl protective group for the purification of the resulting oligos on C₁₈ cartridges, and reverse phase HPLC. This modifier reagent can be used to introduce biotin onto 5′-position, 3′-position (using universal CPG), and internal oligo sites.

This amidite does not require special condensation and deprotection conditions.

用于合成基于羟脯氨酸核心的生物素化寡核苷酸的非核苷修饰剂。 这种亚磷酰胺含有一个二甲氧基三苯甲基保护基团，用于在 C18 小柱和反相 HPLC 上纯化所得的寡核苷酸。 该修饰剂试剂可用于将生物素引入 5′-位、3′-位（使用通用 CPG）和内部寡核苷酸位点。

这种亚酰胺不需要特殊的缩合和脱保护条件。