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Alkyne hydrazide

Alkyne hydrazide bifunctional linker reagent is an adapter molecule which is useful to attach terminal alkyne group to a carbonyl group of aldehydes and ketones. Carbonyl groups are encountered in proteins subjected to oxidative stress. Many small natural molecules are also carbonyl compounds. Most saccharides, as well as RNAs contain 1,2-diol fragments which can be oxidized with periodate to aldehydes, which in turn react with hydrazides.

炔烃酰肼双功能接头试剂是一种衔接分子，可用于将末端炔基连接到醛和酮的羰基上。 在遭受氧化应激的蛋白质中会遇到羰基。 许多小的天然分子也是羰基化合物。 大多数糖类以及 RNA 都含有 1,2-二醇片段，这些片段可以被高碘酸盐氧化成醛类，醛类又与酰肼反应。