产品英文名称:A83-01
产品中文名称:A83-01
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A83-01 产品英文简述:
A selective inhibitor of ALK-4 （Activin/Nodal receptor）, ALK-5 （TGF-β type I receptor）, and ALK-7 （nodal receptor）. Only weakly inhibits ALK-1, -2, -3, and -6. 3-（6-METHYLPYRIDIN-2-YL）-1-PHENYLTHIOCARBAMOYL-4-QUINOLIN-4-YLPYRAZOLE
Ref: Tojo, M., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 96: 791-800, 2005.
Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: Not determined.