Application: FC
Clonality: Polyclonal
Host: Mouse
Purification: Serum
Reactivity: Mouse
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain.[5] In humans, the translocator protein is encoded by the TSPO gene.[6][7] It belongs to family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed.[8] In animals, TSPO (PBR) is a mitochondrial protein usually located in the outer mitochondrial membrane and characterized by its ability to bind a variety of benzodiazepine-like drugs, as well as to dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. TSPO has many proposed functions depending on the tissue.[9] The most studied of these include roles in the immune response, steroid synthesis and apoptosis. [from: Wikipedia contributors. (2019, April 29). Translocator protein. In Wikipedia, The Free Encyclopedia. Retrieved 18:37, June 4, 2019, from https://en.wikipedia.org/w/index.php?title=Translocator_protein&oldid=894679824]