RIG-I样受体(RLRs)是DExD/H盒RNA解旋酶家族，在病毒RNA中作为病原体相关分子模式(PAMPs)的细胞质传感器(Onoguchi, Yoneyama et al. 2011)进行了综述。RLRs信号下游转录因子激活驱动1型干扰素(IFN)生产和抗病毒基因表达，引发细胞内免疫反应以控制病毒感染。迄今为止，已经确定了三个RLR成员:RIG-I(维甲酸诱导基因I) -该家族的创始成员，因此是该家族的最佳特征，MDA5(黑色素瘤分化相关因子5)，和LGP2(遗传和生理学实验室2，小鼠D11lgp2的同源物)。抗RIG-I抗体是由小鼠RIG-I c端16个氨基酸肽免疫获得的大鼠单克隆抗体。该抗体可用于小鼠RIG-I免疫印迹检测。
Cosmo Bio抗体,Anti Probable ATP-Dependent RNA Helicase DDX58 (RIG-I/RLR-1) mAb (Clone SS1A),CAC-SU-IZ-M02
Application: WB
Clonality: Monoclonal
Host: Rat
Purification: IgG
Reactivity: Mouse
RIG-I like receptors (RLRs) are a family of DExD/H box RNA helicases that function as cytoplasmic sensors of pathogen-associated molecular patterns (PAMPs) within viral RNA (reviewed in (Onoguchi, Yoneyama et al. 2011)). The RLRs signal downstream transcription factor activation to drive type 1 interferon (IFN) production and antiviral gene expression that elicits an intracellular immune response to control virus infection. To date, three RLR members have been identified: RIG-I (retinoic acid-inducible gene I) – the founding member and therefore best characterized of this family, MDA5 (melanoma differentiation associated factor 5), and LGP2 (laboratory of genetics and physiology 2 and a homolog of mouse D11lgp2). Anti-RIG-I antibody is a rat monoclonal antibody obtained from immunization with a 16 amino acid peptide from the C-terminus of mouse RIG-I. This antibody can be used for the detection of mouse RIG-I by immunoblotting.