Decorin是一种普遍存在的小型ECM蛋白聚糖，与biglycan结构密切相关，属于小型富亮氨酸蛋白聚糖(SLRP)亚家族。其核心蛋白常与细胞表面相关，通常携带单个硫酸软骨素或硫酸皮链。其完全糖基化/糖基化形式的分子质量从90-240 kDa不等，而其未糖基化/未糖基化的核心蛋白的Mr约为45 kDa。Decorin与多种ECM成分相互作用，包括纤维胶原蛋白、纤维连接蛋白、血栓反应蛋白和C1q，并在胶原纤维形成中发挥作用。Decorin在癌症、炎症和变性组织中上调，并在伤口愈合中起关键作用。在实验性啮齿动物脊髓损伤中注入装饰蛋白已被证明能抑制瘢痕形成和促进轴突生长。Decorin通过下调参与细胞生长和存活的几种受体的活性来影响各种类型的癌症。装饰蛋白结合并调节表皮生长因子受体和ErbB受体酪氨酸激酶家族的其他成员的信号。它通过双重机制发挥其抗肿瘤活性:通过抑制这些关键受体通过其物理下调加上其信号的衰减，并通过结合和隔离tgf – β。Decorin还调节胰岛素样生长因子受体和低密度脂蛋白受体相关蛋白-1，间接影响tgf – β受体通路。修饰蛋白基因缺失导致皮肤缺陷，表现为真皮层的III型胶原原纤维形状不规则。装饰蛋白基因突变可引起先天性角膜基质营养不良。
Application: ELISA, IHC(p), WB
Clonality: Monoclonal
Host: Mouse
Purification: Supernatant
Reactivity: Bovine, Human
Decorin is a ubiquitous small ECM proteoglycan that is closely related in structure to, biglycan, and which belongs to the small leucine-rich proteoglycan (SLRP) subfamily. Its core protein may be found frequently associated with the cell surface and normally carries a single chondroitin sulfate or dermatan sulfate chain. Its molecular mass in fully glycosylated/glycanated form varies from 90-240 kDa, while its unglycosylated/unglycanated core protein has a Mr of about 45 kDa. Decorin interacts with several ECM components, including fibrillar collagens, fibronectin, thrombospondin and C1q and plays a role in collagen fibrillogenesis. Decorin is upregulated in cancer, inflammed and degenerating tissues, and is critically involved in wound-healing. Infusion of decorin into experimental rodent spinal cord injuries has been shown to suppress scar formation and promote axon growth. Decorin affects various types of cancer by down-regulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGF-beta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein-1, which indirectly affects the TGF-beta receptor pathway. Gene deletion of decorin causes skin defects, manifested as irregularly shaped collagen type III fibrils of the dermis. Mutations in the decorin gene cause congenital stromal corneal dystrophy.