Application: WB, IHC, IP
Clonality: Polyclonal
Host: Rabbit
Purification: Serum
Reactivity: Human, Mouse
Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal tails of core histones (H2A, H2B, H3 and H4). Histone deacetylation is a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5′-YTGAT-3′ sites. It is also involved in pseudohyphal growth.