Chiral columns, a range of chiral phases from MACHEREY-NAGEL

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Chiral columns, a range of chiral phases from MACHEREY-NAGEL

For Technical InformationChiral columns, a range of chiral phases from MACHEREY-NAGEL Chiral columns, a range of chiral phases from MACHEREY-NAGEL
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
Explore the range of MACHEREY-NAGEL chiral columns
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
MACHEREY-NAGEL manufactures a range of chiral columns. These include NUCLEODEX (cyclodextrin cavity), RESOLVOSIL (protein-bound), Chiral-1 (ligand exchange) and the new NUCLEOCEL ALPHA and DELTA (polysaccharide) columns Chiral columns, a range of chiral phases from MACHEREY-NAGEL
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
MACHEREY-NAGEL chiral phases include
  • Cyclodextrin cavity
  • BSA protein-bound
  • Ligand exchange
  • Polysaccharide
Chiral columns, a range of chiral phases from MACHEREY-NAGEL

Material Characteristics
Material   Description Particle Size (µm) Pore Size (Å)
NUCLEODEX β-OH β-Cyclodextrin cavity 5 100
NUCLEODEX α-PM Permethylated α-cyclodextrin cavity 5 100
NUCLEODEX β-PM Permethylated β-cyclodextrin cavity 5

100
NUCLEODEX γ-PM Permethylated γ-cyclodextrin cavity 5 100
RESOLVOSIL BSA-7 Bovine serum albumin (BSA) protein 7 300
NUCLEOSIL Chiral-1 L-Hydroxyproline-Cu2 complex ligand exchange 5 120
NUCLEOCEL ALPHA and ALPHA-RP Amylose-tris-3,5-(dimethylphenyl)-carbamate 5 –
NUCLEOCEL DELTA and DELTA-RP Cellulose-tris-3,5-(dimethylphenyl)-carbamate 5, 10 –

Chiral columns, a range of chiral phases from MACHEREY-NAGEL

  

NUCLEODEX®
NUCLEODEX® phases are manufactured by chemically bonding one of three cyclodextrins to NUCLEOSIL 100 silica. Cyclodextrins are cyclic oligosaccharides. The size of the chiral ring and interaction of racemic mixtures with the chiral sugar units control the enantiomeric separation process. In the permethylated cyclodextrins all hydroxy groups are replaced by methoxy groups. Alternative selectivities are obtained.
NUCLEODEX® screening kits for rapid and economical method development are available. Each kit contains a 30 x 4mm cartridge of each of the four NUCLEODEX materials, β-OH, α-PM, β-PM and γ-PM, together with a holder.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL

RESOLVOSIL®
RESOLVOSIL® BSA-7 was one of the first commercially available protein-bound columns to demonstrate optical resolution.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL

NUCLEOSIL® chiral-1

NUCLEOSIL® chiral-1 is a unique material offering separation of racemic molecules by ligand exchange HPLC. An L-hydroxyproline Cu2+ complex is chemically bonded to NUCLEOSIL 120 silica. Molecules containing two correctly spaced polar functional groups, such as α-amino acids can be optically resolved by this column through the formation of diastereomeric complexes of differing stability.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL

NUCLEOCEL Chiral Phases
  • Polysaccharide-coated phases
  • Separate wide range of chiral compounds
  • Columns for NP and RP applications
  • High loadability for up-scaling
  • Pressure stable to 2000psi
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
MACHEREY-NAGEL have introduced the NUCLEOCEL series of polysaccharide chiral stationary phases. The chiral selector of NUCLEOCEL DELTA is cellulose-tris-3,5-(dimethylphenyl) carbamate and together with the supramolecular helical
polysaccharide surface structure is mainly responsible for the chiral recognition mechanism. For NUCLEOCEL ALPHA the amylose counterpart of tris-3,5-(dimethylphenyl) carbamate performs this task.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
The NUCLEOCEL product line includes columns for normal-phase and reversed-phase applications. The NUCLEOCEL DELTA and ALPHA phases are intended for analyses using normal-phase eluents, typically heptane – IPA. The NUCLEOCEL DELTA-RP and ALPHA-RP phases are designed for use under reversed-phase conditions either in polar organic mode or with eluents containing high concentrations of chaotropic salts such as perchlorate.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
In addition to the 10μm phases (DELTA and DELTA-RP), higher resolution 5μm phases are available for these and for the ALPHA and ALPHA-RP phases.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL Chiral columns, a range of chiral phases from MACHEREY-NAGEL
NUCLEOCEL chiral stationary phases offer high loading capacities and thus are suitable for scale-up methods. The stable silica support protects the coated polysaccharide and tolerates high flow rates with a maximum operating pressure up to 2000 psi.
Chiral columns, a range of chiral phases from MACHEREY-NAGEL
Application range:

  • Pharmaceutical active compounds
  • Chiral pollutants, eg. herbicides, PCBs
  • Chiral compounds in foodstuffs, dyes, preservatives
  • Chiral catalysts and bio-organic compounds
Chiral columns, a range of chiral phases from MACHEREY-NAGEL

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