ProSpec PRO-2491,CD1D Human,CD1D人重组PRO-2491

ProSpec PRO-2491,CD1D Human,CD1D人重组PRO-2491,CD1d 呈递的脂质抗原在与存在于 NKT 膜上的 T 细胞受体相互作用期间激活一类特殊的 T 细胞，即自然杀伤 T 细胞。

  • CD1D Human

  • CD1D Human Recombinant
  • PRO-2491

Catalogue number

PRO-2491

Synonyms

Antigen-presenting glycoprotein CD1d, R3G1, CD antigen: CD1d, Differentiation Antigen CD1-Alpha-3, T-Cell Surface Glycoprotein CD1d, Thymocyte Antigen CD1D, CD1A, R3, CD1d Molecule, CD1D Antigen, D Polypeptide, CD1d Antigen, R3G1, HMC Class I, Antigen-Like Glycoprotein CD1D, Antigen-Presenting Glycoprotein CD1d.

Introduction

CD1D, also known as antigen-presenting glycoprotein CD1d, is a transmembrane glycoprotein which belongs to the CD1 family of glycolipid antigen-presenting MHC-like molecules. CD1d-presented lipid antigens activate a special class of T cells, familiar as natural killer T cells, during the interaction with the T-cell receptor present on NKT membranes. Once activated, NKT cells rapidly produce Th1 &Th2 cytokines, usually represented by interleukin 4 production.

CD1D又称为抗原呈递糖蛋白CD1d，是一种跨膜糖蛋白，属于糖脂类抗原呈递MHC分子CD1家族。 CD1d 呈递的脂质抗原在与存在于 NKT 膜上的 T 细胞受体相互作用期间激活一类特殊的 T 细胞，即自然杀伤 T 细胞。 一旦被激活，NKT 细胞会迅速产生 Th1 和 Th2 细胞因子，通常以白细胞介素 4 的产生为代表。

Description

CD1D produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 290 amino acids and having a molecular mass of 32.9kDa .

CD1Dis expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Insect cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD1D protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage, it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

EVPQRLFPLR CLQISSFANS SWTRTDGLAW LGELQTHSWS NDSDTVRSLK PWSQGTFSDQ QWETLQHIFR VYRSSFTRDV KEFAKMLRLS YPLELQVSAG CEVHPGNASN NFFHVAFQGK DILSFQGTSW EPTQEAPLWV NLAIQVLNQD KWTRETVQWL LNGTCPQFVS GLLESGKSEL
KKQVKPKAWL SRGPSPGPGR LLLVCHVSGF YPKPVWVKWM RGEQEQQGTQ PGDILPNADE TWYLRATLDV VAGEAAGLSC RVKHSSLEGQ DIVLYWGGSY TSLEHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.