ProSpec,CD1E Human PRO-1907,CD1E人重组PRO-1907

CD1A, R2, T-cell surface glycoprotein CD1e, membrane-associated, R2G1, sCD1e.

CD1E belongs to the CD1 family of transmembrane glycoproteins which are structurally associated to the main MHC proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome is comprised of 5 CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are belief to differ in their cellular localization and specificity for particular lipid ligands. CD1E localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a steady soluble form. The soluble form is necessary for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.

CD1E 属于跨膜糖蛋白 CD1 家族，在结构上与主要 MHC 蛋白相关，并与 β-2-微球蛋白形成异二聚体。 CD1 蛋白主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。 人类基因组由 1 号染色体上的 5 个 CD1 家族基因组成。CD1 家族成员相信其细胞定位和对特定脂质配体的特异性不同。 CD1E 定位在高尔基体、内体和溶酶体中，并被切割成稳定的可溶形式。 可溶形式对于将一些糖脂在细胞内加工成可由其他 CD1 家族成员呈递的形式是必需的。

CD1E Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids and having a molecular mass of 33.1kDa.CD1E is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered clear solution.

CD1E protein solution contains 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSEEQLSFR MLQTSSFANH SWAHSEGSGW LGDLQTHGWD TVLGTIRFLK PWSHGNFSKQ ELKNLQSLFQ LYFHSFIQIV QASAGQFQLE YPFEIQILAG CRMNAPQIFL NMAYQGSDFL SFQGISWEPS PGAGIRAQNI CKVLNRYLDI KEILQSLLGH TCPRFLAGLM EAGESELKRK VKPEAWLSCG PSPGPGRLQL VCHVSGFYPK PVWVMWMRGE QEQRGTQRGD VLPNADETWY LRATLDVAAG EAAGLSCRVK HSSLGGHDLI IHWGGYS.

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