ProSpec,CD14 Human,CD14人重组PRO-1975

Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14.

CD14 receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol and functions as a high affinity receptor for complexes of LPS and LPS binding protein . Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.

CD14 受体）在单核细胞和巨噬细胞上强烈表达，在中性粒细胞表面表达较弱。 CD14 通过与糖基磷脂酰肌醇连接而锚定在细胞上，并作为 LPS 和 LPS 结合蛋白复合物的高亲和力受体发挥作用。 可溶性 CD14 也与 LPS 结合，在生理浓度下作为 LPS 激动剂起作用，并且在较高浓度下，在细胞活化中具有 LPS 拮抗作用。 CD14 已显示与凋亡细胞结合。

CD14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids and having a molecular mass of 37.9kDa.
CD14is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CD14 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 353 个氨基酸，分子量为 37.9kDa。
CD14 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

E.coli.

Sterile Filtered colorless solution.

CD14 protein solution containing 20mM Tris-HCl buffer , 30% glycerol 0.15M NaCl and 1mM DTT.

Greater than 90% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSTTPEPCE LDDEDFRCVC NFSEPQPDWS EAFQCVSAVE VEIHAGGLNL EPFLKRVDAD ADPRQYADTV KALRVRRLTV GAAQVPAQLL VGALRVLAYS RLKELTLEDL KITGTMPPLP LEATGLALSS LRLRNVSWAT GRSWLAELQQ WLKPGLKVLS IAQAHSPAFS CEQVRAFPAL TSLDLSDNPG LGERGLMAAL CPHKFPAIQN LALRNTGMET PTGVCAALAA AGVQPHSLDL SHNSLRATVN PSAPRCMWSS ALNSLNLSFA GLEQVPKGLP AKLRVLDLSC NRLNRAPQPD ELPEVDNLTL DGNPFLVPGT ALPHEGSMNS GVV.

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