ProSpec,CD207 Human,CD207 人重组PRO-2204

C-type lectin domain family 4 member K, CLEC4K, Langerin, CD207.

CD207 is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Moreover, CD207 is expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, the organelles present in the cytoplasm of Langerhans cells and comprised of superimposed and zippered membranes. CD207 is a C-type lectin with mannose binding specificity, and it has been suggested that mannose binding by the CD207 protein leads to internalization of antigen into Birbeck granules thus providing access to a nonclassical antigen-processing pathway.

CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。 Langerin 位于伯贝克颗粒中，该细胞器存在于朗格汉斯细胞的细胞质中，由重叠的拉链膜组成。 CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中，从而提供了进入非经典抗原加工途径的途径。

CD207 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids and having a molecular mass of 32.2kDa.
CD207 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CD207 Human Recombinant 是单条非糖基化多肽链，含有 287 个氨基酸，分子量为 32.2kDa。
CD207 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered clear solution.

CD207 protein solution containing 20mM Tris 8.0 and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEP.

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