ProSpec,CD3e Human,CD3e人重组PRO-1317

T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E, TCRE.

CD3-epsilonpolypeptide along with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, creates the T-cell receptor-CD3 complex. This complex has an imperative role in coupling antigen recognition to a number of intracellular signal-transduction pathways. The genes encoding the epsilon, gamma delta polypeptides are found in the same cluster on chromosome 11. The epsilon polypeptide plays a vital role in T-cell development. CD3E gene defects cause immunodeficiency. CD3E is also linked to a susceptibility to type I diabetes in women.

CD3-ε 多肽与 CD3-γ、-δ 和 -zeta 以及 T 细胞受体 α/β 和 γ/δ 异二聚体一起产生 T 细胞受体-CD3 复合物。 这种复合物在将抗原识别与许多细胞内信号转导途径耦合方面具有重要作用。 在 11 号染色体上的同一簇中发现了编码 epsilon、gamma delta 多肽的基因。epsilon 多肽在 T 细胞发育中起着至关重要的作用。 CD3E基因缺陷导致免疫缺陷。 CD3E 还与女性对 I 型糖尿病的易感性有关。

CD3e Human Recombinant produced in E. coli is a single polypeptide chain containing 127 amino acids and having a molecular mass of 14.1kDa.
CD3e is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CD3e Human Recombinant 是单条多肽链，含有 127 个氨基酸，分子量为 14.1kDa。
CD3e 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

E.coli.

Sterile Filtered colorless solution.

The CD3e solution contains 20mM Tris-HCl buffer , 0.2M NaCl and 10% glycerol.

Greater than 90% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMD.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.