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CD68 Human
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CD68 Human Recombinant
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PRO-1209
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Catalogue number
PRO-1209
Synonyms
Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236.
Introduction
CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
CD68 编码一种 110-kD 的跨膜糖蛋白，在人类单核细胞和组织巨噬细胞中高度表达。 它是溶酶体/内体相关膜糖蛋白家族的成员。 该蛋白质主要定位于溶酶体和内体，其中一小部分循环到细胞表面。 它是一种 I 型整合膜蛋白，具有高度糖基化的细胞外结构域，可与组织和器官特异性凝集素或选择素结合。 该蛋白质也是清道夫受体家族的成员。 清道夫受体通常起到清除细胞碎片、促进吞噬作用和介导巨噬细胞募集和活化的作用。 选择性剪接导致多个转录本编码不同的亚型。
Description
CD68 Human Recombinant produced in E. coli is a single polypeptide chain containing 323 amino acids and having a molecular mass of 34.1 kDa.
CD68 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CD68 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
E.coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The CD68 solution contains 20mM Tris-HCl buffer , 0.1M NaCl, 1M Urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
Purity
Greater than 85% as determined by -PAGE.
Amino acid sequence
MGSSHPLHHH SSGLVPRGSH MGSHMNDCPH KKSATLLPSF TVTPTVTEST GTTSHRTTKS HKTTTHRTTT TGTTSHGPTT ATHNPTTTSH GNVTVHPTSN STATSQGPST ATHSPATTSH GNATVHPTSN STATSPGFTS SAHPEPPPPS PSPSPTSKET IGDYTWTNGS QPCVHLQAQI QIRVMYTTQG GGEAWGISVL NPNKTKVQGS CEGAHPHLLL SFPYGHLSFG FMQDLQQKVV YLSYMAVEYN VSFPHAAQWT FSAQNASLRD LQAPLGQSFS CSNSSIILSP AVHLDLLSLR LQAAQLPHTG VFGQSFSCPS DRS
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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