ProSpec,CD74 Human,CD74人重组PRO-1467

DHLAG, HLADG, Ia-GAMMA, li, HLA-DR antigens-associated invariant chain, p33, Ia antigen-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, Gamma Chain Of Class II Antigens, MHC HLA-DR Gamma Chain.

CD74 , is a transmembrane protein which is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. CD74 upregulated in several cancers and is also expressed by non immune cells during inflammation. Diseases related with CD74 include thymic epithelial neoplasm and gastroduodenitis. Among its related super-pathways are Immune System and Immune response Antigen presentation by MHC class II. In addition CD74 functions as cell surface receptor for the cytokine MIF.

CD74 是一种跨膜蛋白，它是陪伴 MHC II 类二聚体从内质网到细胞表面的不变链。 CD74 由 T 淋巴细胞和 B 淋巴细胞谱系的细胞表达。 CD74 在几种癌症中上调，并且在炎症期间也由非免疫细胞表达。 与 CD74 相关的疾病包括胸腺上皮肿瘤和胃十二指肠炎。 其相关的超级途径包括 MHC II 类的免疫系统和免疫反应抗原呈递。 此外，CD74 作为细胞因子 MIF 的细胞表面受体发挥作用。

Escherichia Coli.

Sterile Filtered clear solution.

CD74 protein solution containing 20mM Tris-HCl buffer , 0.1M NaCl, 30% glycerol and 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSQQQGRLD KLTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP MGALPQGPMQ NATKYGNMTE DHVMHLLQNA DPLKVYPPLK GSFPENLRHL KNTMETIDWK VFESWMHHWL LFEMSRHSLE QKPTDAPPKE SLELEDPSSG LGVTKQDLGP VPM

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