ProSpec,MCP1 Human HEK CHM-048,CHM-048,单核细胞趋化蛋白 1/MCAF 人重组体HEK

CCL2, C-C motif chemokine 2, GDCF-2, HSMCR30, JE, HC11, MCAF, MCP-1, MCP1, Scya2, Sigje, SMC-CF, Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Small-inducible cytokine A2.

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B .CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection.This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans.The cell surface receptors that bind CCL2 are CCR2 and CCR5

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。 它存在于牙齿萌出和骨骼退化的部位。 在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 ?B 的控制。CCL2 将免疫细胞（如单核细胞）募集到组织损伤和感染部位。这种趋化因子作为含有信号的蛋白质前体产生 23个氨基酸的肽和76个氨基酸的成熟肽。 它是一种单体多肽，分子量约为 13kDa。 与许多其他 CC 趋化因子一样，CCL2 位于人类 17 号染色体上。结合 CCL2 的细胞表面受体是 CCR2 和 CCR5

MCP1 Human HEK Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 82 amino acids and having a molecular mass of 9.5 kDa.
MCP1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 HEK293 细胞中产生的 MCP1 Human HEK Recombinant 是一条糖基化多肽链，包含 82 个氨基酸，分子量为 9.5 kDa。
MCP1 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

HEK293 Cells.

Sterile filtered colorless solution.

The MCP1 solution contains phosphate buffered saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by -PAGE.

Measured its ability to chemoattract using THP-1 human acute monocytic leukemia cells. The ED50 range ≤ 30 ng/ml.

QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKTHHHH HH

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