ProSpec,MIP 1a Human His CHM-347,巨噬细胞炎症蛋白-1 Alpha 人类重组CHM-347

Small inducible cytokine A3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Tonsillar lymphocyte LD78 alpha protein, G0/G1 switch regulatory protein 19-1, G0S19-1 protein, SIS-beta, PAT 464.1, chemokine ligand 3, MIP1A, SCYA3, G0S19-1, LD78ALPHA.

Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 , IL-6 and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.

巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。 在人类中，有两种主要形式，MIP-1a 和 MIP-1b，现在分别正式命名为 CCL3 和 CCL4。 两者都是巨噬细胞受到细菌内毒素刺激后产生的主要因子。 它们激活可导致急性中性粒细胞炎症的人类粒细胞。 它们还诱导成纤维细胞和巨噬细胞合成和释放其他促炎细胞因子，例如白细胞介素1、IL-6和TNF-α。 CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

MIP-1a Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 90 amino acids and having a molecular mass of 10.0kDa. MIP-1a is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MIP-1a 小鼠重组体是一条含有 90 个氨基酸且分子量为 10.0kDa 的单一非糖基化多肽链。 MIP-1a 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered clear solution.

MIP-1a protein solution containing 10mM Sodium Citrate buffer and 20% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MSLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQVCADPSEEWVQ KYVSDLELSA.

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