ProSpec,MIP 1b Rat CHM-003,巨噬细胞炎症蛋白 1 β 大鼠重组CHM-003

C-C motif chemokine 4, Macrophage inflammatory protein 1-beta, MIP-1-beta, Small-inducible cytokine A4, Ccl4, Mip1b, Scya4.

Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1? and MIP-1? that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 , IL-6 and TNF-? from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.

巨噬细胞炎症蛋白属于称为趋化因子的趋化细胞因子家族。 在人类中，有两种主要形式，MIP-1？ 和 MIP-1？ 现在分别正式命名为 CCL3 和 CCL4。 两者都是巨噬细胞受到细菌内毒素刺激后产生的主要因子。 它们激活可导致急性中性粒细胞炎症的人类粒细胞。 它们还诱导其他促炎细胞因子如白细胞介素 1、IL-6 和 TNF-α 的合成和释放。 来自成纤维细胞和巨噬细胞。 CCL3 和 CCL4 的基因都位于人类第 17 号染色体上。

MIP-1b Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 69 amino acids and having a molecular mass of 7.8 kDa.
The MIP-1b is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Filtered and lyophilized from a concentrated solution in 30% Acetonitrile and 0.1% TFA.

It is recommended to reconstitute the lyophilized Mouse MIP-1b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized Mouse MIP-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 µg/ml.

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ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.