ProSpec-MIP 3a Human His,巨噬细胞炎症蛋白 3 α 人重组CHM-252

S Small inducible cytokine A20 precursor, CCL20, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Liver and activation- regulated chemokine, CC chemokine LARC, Beta chemokine exodus-1, CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20.

CCL-20 is a chemotactic factor that draws lymphocytes & neutrophils, rathar than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL-20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL-20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria. MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.

CCL-20 是一种趋化因子，它比单核细胞更能吸引淋巴细胞和中性粒细胞。 MIP-3 α 在集落形成试验中抑制骨髓祖细胞的增殖。 MIP3A 通过将淋巴细胞和树突状细胞吸引到上皮细胞，在黏膜淋巴组织的形成和功能中发挥作用。 C-末端加工形式已被证明对白细胞具有同样的趋化活性。 CCL-20 具有抗菌活性 e.coli atcc 25922 和 s.aureus atcc 29213。CCL-20 基因转录由幽门螺杆菌激活，幽门螺杆菌通过涉及 IkappaB 激酶和 NF-kappaB 诱导激酶的细胞内信号通路激活 NF-kappaB . MIP-3 α 在幽门螺杆菌感染的胃炎症期间参与趋化因子介导的淋巴细胞运输。 CCL-20 表达参与将 CD45R0 阳性 T 细胞亚群募集到肠固有层中。 MIP-3A 负责通过募集 C-C 基序受体 6 表达淋巴细胞来促进牙髓炎症阴道上皮细胞通过分泌 MIP-3 α 对精液中存在的因子作出反应，这增加了 HIV 传播过程中朗格汉斯细胞的募集。

MIP 3a Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 91 amino acids and having a molecular mass of 10.3kDa. The MIP 3a is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered colorless solution.

The MIP 3a solution contains Phosphate Buffered Saline pH7.4 and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MASNFDCCLG YTDRILHPKF IVGFTRQLAN EGCDINAIIF HTKKKLSVCA NPKQTWVKYI VRLLSKKVKN M.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.