ProSpec-PF 4 Protein,人类血小板因子4 CHM-234

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，它从活化的血小板的 α 颗粒中释放出来，并以高亲和力与肝素结合。 它的主要生理作用似乎是中和血管内皮表面的肝素样分子，从而抑制局部抗凝血酶 III 活性并促进凝血。 作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。 人 PF4 用于证明肝素诱导的血小板减少症。 此外，它还用作肿瘤治疗期间血管生成的抑制剂。

Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.

Human Platelets.

Sterile Filtered white lyophilized powder.

The CXCL4 protein was lyophilized in PBS buffer pH-7.4.

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.

Binding of HIT-antibodies.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.