ProSpec-TARC Human His,胸腺和活化调节的趋化因子人重组CHM-359

C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273.

TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1a, MIP-1b, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.

TARC cDNA 编码一个 94 个氨基酸的前体蛋白和一个 23 个氨基酸残基的信号肽，该信号肽被切割掉以产生 71 个氨基酸残基的成熟分泌蛋白。与 CC 趋化因子家族成员一起，CCL-17 与 RANTES、MIP-1a、MIP-1b、MCP-1、MCP-2、MCP-3 和 I-309 具有大约 24-29% 的氨基酸序列同一性。 TARC 在胸腺中表达，在肺、结肠和小肠中表达水平较低。此外，TARC 在受刺激的外周血单核细胞中瞬时表达。重组 TARC 已被证明对 T 细胞系具有趋化性，但对单核细胞或中性粒细胞没有。 CCL-17 最近被确定为 CCR4 的特异性功能配体，CCR4 是一种选择性表达于 T 细胞上的受体。 CCL17 是聚集在 16 号染色体 q 臂上的大量 Cys-Cys 细胞因子基因之一。CCL17 对 T 淋巴细胞显示趋化活性，但对单核细胞或粒细胞没有趋化活性。 CCL17 与趋化因子受体 CCR4 和 CCR8 结合。这种趋化因子在胸腺 T 细胞发育以及成熟 T 细胞的运输和激活中起重要作用。

TARC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 92 amino acids and having a molecular mass of 10.3 kDa.
The TARC is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 TARC 人重组体是一种非糖基化的多肽链，含有 92 个氨基酸，分子量为 10.3 kDa。
TARC 在 N 末端与 20 个氨基酸 His-Tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile filtered colorless solution.

The TARC protein contains 1xPBS and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 95% as determined by Analysis by -PAGE.

MGSSHHHHHH SSGLVPRGSH MARGTNVGRE CCLEYFKGAI PLRKLKTWYQ TSEDCSRDAI VFVTVQGRAI CSDPNNKRVK NAVKYLQSLE RS.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.