ProSpec,TARC Macaque,胸腺和活化调节的趋化因子恒河猴重组CHM-036

C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273.

TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1a, MIP-1b, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 is a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of a few Cys-Cys cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.

TARC cDNA 编码一个 94 个氨基酸的前体蛋白和一个 23 个氨基酸残基的信号肽，该信号肽被切割掉以产生 71 个氨基酸残基的成熟分泌蛋白。与 CC 趋化因子家族成员一起，CCL-17 与 RANTES、MIP-1a、MIP-1b、MCP-1、MCP-2、MCP-3 和 I-309 具有大约 24-29% 的氨基酸序列同一性。 TARC 在胸腺中表达，在肺、结肠和小肠中表达水平较低。此外，TARC 在受刺激的外周血单核细胞中瞬时表达。重组 TARC 已被证明对 T 细胞系具有趋化性，但对单核细胞或中性粒细胞没有。 CCL-17 是 CCR4 的特异性功能配体，CCR4 是一种在 T 细胞上选择性表达的受体。 CCL17 是聚集在 16 号染色体 q 臂上的少数 Cys-Cys 细胞因子基因之一。CCL17 对 T 淋巴细胞显示趋化活性，但对单核细胞或粒细胞不显示。 CCL17 与趋化因子受体 CCR4 和 CCR8 结合。这种趋化因子在胸腺 T 细胞发育以及成熟 T 细胞的运输和激活中起重要作用。

Thymus and Activation Regulated Chemokine Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 71 amino acid and having a molecular mass of approximately 8.1kDa.
TRAC is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的胸腺和活化调节的趋化因子恒河猴重组体是一种非糖基化多肽链，含有 71 个氨基酸，分子量约为 8.1kDa。
TRAC 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, 0.02 % Tween-20 and 300mM NaCl, pH 7.4.

It is recommended to reconstitute the lyophilized Thymus and Activation Regulated Chemokine Rhesus Macaque in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized TRAC although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymus and Activation Regulated Chemokine Rhesus Macaque should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

ARGTNVGREC CLKYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQNKAIC SDPNDKKVKK ALKYLQSLER S.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.