ProSpec-4 1BBL Human

CD137L, CD137-L, 4-1BBL, 4-1BB Ligand, TNFSF9, Tumor Necrosis Factor Superfamily Member 9.

4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin.

4-1BBL 是一种跨膜细胞因子，是肿瘤坏死因子配体家族的一部分。 4-1BBL 是一种双向信号传感器，可作为 TNFRSF9 的配体，TNFRSF9 是 T 淋巴细胞中的一种共刺激受体分子。 TNFSF9 及其 TNFRSF9 参与抗原呈递发展和细胞毒性 T 细胞的产生。 4-1BBR 在静息 T 淋巴细胞中不存在，但在抗原刺激后迅速表达。 TNFSF9 重新激活无反应性 T 淋巴细胞并促进 T 淋巴细胞增殖。 CD8 T 细胞中的最佳 CD8 反应需要 4-1BB 配体。 4-1BBL 在癌细胞系中表达，被认为与 T 细胞-肿瘤细胞相互作用有关。 4-1BBL 由活化的 B 细胞、巨噬细胞、树突细胞、活化的 T 细胞、神经元和星形胶质细胞表达。 4-1BB 与 TNFRSF9 的相互作用强烈调节免疫，并且基于对各种小鼠的研究已被提议优先控制 T 细胞反应。

4 1BBL Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 19.5kDa.
The 4 1BBL is purified by proprietary chromatographic techniques.

4 由大肠杆菌产生的 1BBL Human Recombinant 是一条单一的、非糖基化的多肽链，包含 184 个氨基酸，分子量为 19.5kDa。
4 1BBL 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

It is recommended to reconstitute the lyophilized 4 1BBL in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized 4 1BBL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4 1BBL should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

冻干的 4 1BBL 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后 4 1BBL 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
请防止冻融循环。

Greater than 95.0% as determined by -PAGE.

REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS PRSE

Fully biologically active when compared to standard. Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10ng/ml corresponding to a Specific Activity of 100,000-200,000IU/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。