ProSpec-4 1BBL Human, His

CD137L, CD137-L, 4-1BBL, 4-1BB Ligand, TNFSF9, Tumor Necrosis Factor Superfamily Member 9.

4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin

4-1BBL 是一种跨膜细胞因子，是肿瘤坏死因子配体家族的一部分。 4-1BBL 是一种双向信号传感器，可作为 TNFRSF9 的配体，TNFRSF9 是 T 淋巴细胞中的一种共刺激受体分子。 TNFSF9 及其 TNFRSF9 参与抗原呈递发展和细胞毒性 T 细胞的产生。 4-1BBR 在静息 T 淋巴细胞中不存在，但在抗原刺激后迅速表达。 TNFSF9 重新激活无反应性 T 淋巴细胞并促进 T 淋巴细胞增殖。 CD8 T 细胞中的最佳 CD8 反应需要 4-1BB 配体。 4-1BBL 在癌细胞系中表达，被认为与 T 细胞-肿瘤细胞相互作用有关。 4-1BBL 由活化的 B 细胞、巨噬细胞、树突细胞、活化的 T 细胞、神经元和星形胶质细胞表达。 4-1BB 与 TNFRSF9 的相互作用强烈调节免疫，并已根据对各种小鼠的研究提出优先控制 T 细胞反应

TNFSF9 Human Recombinant fused to 37 amino acids His tag at N-terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids and having a molecular mass of 23.8 kDa.
The TNFSF9 37 aa His tag fusion protein is purified by proprietary chromatographic techniques.

TNFSF9 Human Recombinant 融合了 37 个氨基酸 在 E.Coli 中产生的 N 端 His 标签是一条含有 222 个氨基酸且分子量为 23.8 kDa 的单一非糖基化多肽链。
TNFSF9 37 aa His 标签融合蛋白通过专有色谱技术纯化。

Escherichia Coli.

Sterile Filtered colorless solution.

Recombinant 4-1BBL solution contains 20mM Tris-HCl buffer pH-8, 100mM NaCl and 20% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 95.0% as determined by -PAGE

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTGGLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA  TVLGLFRVTP EIPAGLPSPR SE.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。