4-1BBR Mouse
Catalogue number
CYT-916
Synonyms
Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, T-cell antigen 4-1BB, CD137.
肿瘤坏死因子受体超家族成员9、4-1BB配体受体、T细胞抗原4-1BB、CD137。
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
该基因编码的蛋白质是 TNF 受体超家族的成员。 该受体有助于 T 细胞的克隆扩增、存活和发育。 它还可以诱导外周单核细胞增殖，增强 TCR/CD3 触发激活诱导的 T 细胞凋亡，并调节 CD28 共刺激以促进 Th1 细胞反应。 这种受体的表达是由淋巴细胞激活诱导的。 已显示 TRAF 衔接蛋白与该受体结合并转导导致 NF-kappaB 激活的信号。
Description
4-1BBR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 172 amino acids and having a molecular mass of 18.6kDa .
4-1BBR is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 4-1BBR 是单条糖基化多肽链，含有 172 个氨基酸，分子量为 18.6kDa。
4-1BBR 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。
4-1BBR 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。
Source
Sf9, Baculovirus cells.Sf9，杆状病毒细胞。
Physical Appearance
Sterile Filtered colorless solution.无菌过滤无色溶液。
Formulation
4-1BBR protein solution contains Phosphate Buffered Saline and 10% glycerol.
4-1BBR 蛋白质溶液含有磷酸盐缓冲液和 10% 甘油。
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。
Purity
Greater than 90.0% as determined by -PAGE.
大于 90.0%，由-PAGE 确定。
Amino acid sequence
VQNSCDNCQP GTFCRKYNPV CKSCPPSTFS SIGGQPNCNI CRVCAGYFRF KKFCSSTHNA ECECIEGFHC LGPQCTRCEK DCRPGQELTK QGCKTCSLGT FNDQNGTGVC RPWTNCSLDG RSVLKTGTTE KDVVCGPPVV SFSPSTTISV TPEGGPGGHS LQVLLEHHHH HH.
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。
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