ProSpec-Acrp30 Human, Trimeric-CYT-233

Acrp30, AdipoQ, GBP-28, APM-1, ACDC.

Adiponectin is a hormone exclusively expressed from adipose tissue.
Many studies demonstrate that Adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. APM-1 can increase insulin sensitivity of skeletal muscle. Attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells.
In the circulation, Adiponectin is present as three different oligomeric complexes, including the high molecular weight , the middle molecular weight and low molecular weigh forms 8. Different oligomeric complex of Adiponectin activates different signaling pathways and exerts distinct functions.

脂联素是一种仅由脂肪组织表达的激素。
许多研究表明，脂联素具有直接的抗糖尿病、抗动脉粥样硬化和抗炎功能。 APM-1可以增加骨骼肌的胰岛素敏感性。 减弱肝脏脂肪生成和糖异生，调节内皮细胞中 NO 的产生，抑制平滑肌细胞的增殖并防止巨噬细胞的脂质积累。
在循环中，脂联素以三种不同的寡聚体形式存在，包括高分子量、中分子量和低分子量的8种。不同的脂联素寡聚体激活不同的信号通路，发挥不同的功能。

Trimeric form of Adiponectin Human trimeric form was expressed in HEK293 cells. The cysteine 39 was replaced with Alanine 9. hAd-C39A can only form a trimer, but not a hexamer or an HMW form.

脂联素的三聚体形式 人三聚体形式在 HEK293 细胞中表达。 半胱氨酸 39 被丙氨酸 9 取代。hAd-C39A 只能形成三聚体，而不能形成六聚体或 HMW 形式。

HEK293 .

Filtered White lyophilized powder.

过滤的白色冻干粉末。

Filtered and lyophilized from 0.5mg/ml in 0.05M phosphate buffer, 0.075M NaCl, pH 7.4.

Add deionized water to a working volume of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

加入去离子水至工作体积为 0.5mg/ml，让冻干颗粒完全溶解。 产品不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Store lyophilized Adiponectin at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

将冻干的脂联素储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

Greater than 95% as determined by -PAGE.

ED50= 3-8.5 μg/ml, as determined by its ability to inhibit proliferation of HASMCs induced by HB EGF.

ETTTQGPGVL LPLPKGAATG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHIVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTNDYKDD DDK.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。