ProSpec-ANGPT2 Human/CYT-1103

Angiopoietin-2, Angiopoietin2, ANGPT2, ANG2, ANG-2, ANGPT-2.

ANGPT2 aka Angiopoietin-2 competes for binding to the TIE2 receptor and blocks angiopoietin-1 aka ANGPT1 induced TIE2 autophosphorylation during vasculogenesis. ANGPT-2 is a naturally occurring antagonist of ANGPT-1. ANGPT2 induces tyrosine phosphorylation of TEK/TIE2 in the lack of Angiopoietin-2. In the deficiency of VEGF an angiogenic inducer, ANGPT-2 induces endothelial cell apoptosis resulting in vascular regression. ANGPT2 along with VEGF enable endothelial cell migration and proliferation, resulting in permissive angiogenic signal.

ANGPT2 aka Angiopoietin-2 竞争结合 TIE2 受体并阻断血管生成过程中 angiopoietin-1 aka ANGPT1 诱导的 TIE2 自磷酸化。 ANGPT-2 是一种天然存在的 ANGPT-1 拮抗剂。 ANGPT2 在缺乏血管生成素-2 的情况下诱导 TEK/TIE2 的酪氨酸磷酸化。 在血管生成诱导剂 VEGF 的缺乏中，ANGPT-2 诱导内皮细胞凋亡，导致血管退化。 ANGPT2 与 VEGF 一起使内皮细胞迁移和增殖，从而产生允许的血管生成信号。

ANGPT2 produced in Chinese hamster ovary cells by recombinant DNA technology is a single, polypeptide chain and fused to a 6 aa His Tag at C-terminus containing a total of 484 amino acids and having a molecular mass of 55.7kDa.
ANGPT2 shows multiple bands between 50-100kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.

通过重组DNA技术在中国仓鼠卵巢细胞中产生的ANGPT2是一条多肽链，在C端融合了一个6个氨基酸的His标签，共含有484个氨基酸，分子量为55.7kDa。
ANGPT2 在 -PAGE、还原条件和专有色谱技术纯化后显示 50-100kDa 之间的多个条带。

Chinese Hamster Ovary Cells .

Sterile filtered colorless solution.

ANGPT2 protein solution contains Phosphate buffered saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 90.0% as determined by -PAGE.

YNNFRKSMDS IGKKQYQVQH GSCSYTFLLP EMDNCRSSSS PYVSNAVQRD APLEYDDSVQ
RLQVLENIME NNTQWLMKLE NYIQDNMKKEMVEIQQNAVQ NQTAVMIEIG TNLLNQTAEQ
TRKLTDVEAQ VLNQTTRLEL QLLEHSLSTN KLEKQILDQT SEINKLQDKN
SFLEKKVLAMEDKHIIQLQS IKEEKDQLQV LVSKQNSIIE ELEKKIVTAT VNNSVLQKQQ
HDLMETVNNL LTMMSTSNSA KDPTVAKEEQ ISFRDCAEVFKSGHTTNGIY TLTFPNSTEE
IKAYCDMEAG GGGWTIIQRR EDGSVDFQRT WKEYKVGFGN PSGEYWLGNE FVSQLTNQQR
YVLKIHLKDWEGNEAYSLYE HFYLSSEELN YRIHLKGLTG TAGKISSISQ PGNDFSTKDG
DNDKCICKCS QMLTGGWWFD ACGPSNLNGM YYPQRQNTNKFNGIKWYYWK GSGYSLKATT MMIRPADFHH HHHH

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Prospec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。